Análisis de los canales de vídeo de las asociaciones médicas españolas

Internet es la principal fuente de búsqueda de información y cada vez con más frecuencia contenidos sobre salud. Por esta razón, el objetivo principal de este trabajo es el de realizar un primer análisis de los contenidos audiovisuales que se encuentran en las plataformas de vídeo (YouTube) de las asociaciones médicas españolas. Para llevar a cabo esta investigación se ha seleccionado la muestra de análisis entre los clips de video de los canales de estas asociaciones y se ha analizado su contenido. Las principales conclusiones del estudio muestran que las asociaciones médicas utilizan sus canales para contenidos muy diversos.Internet is the main source of information search and increasingly frequent also health content. Therefore the main objective of this work is to perform an initial analysis of audiovisual content present in video platforms (YouTube) from the Spanish medical associations. To carry out this research it has been selected sample analysis between video clips channels from these associations and it has been analysed by their contents. The main conclusions of the study show that medical associations use their channels for very different content

Assessment of the Use of a Selection of Natural Deep Eutectic Solvents in the Extraction of Polar Bioactive Compounds from Orange Peel

[EN] The reuse of food chain residues is topical. This revaluation can extract bioactive compounds from these residues. However, extraction involves chemicals that cause environmental damage. In the present work, an experimental design with natural deep eutectic solvents (NADES) has been carried out for extracting bioactive compounds from orange peel residues. NADES have a very low environmental impact. The tests were performed with five different NADES, mixed with 70% water. The results were compared with ethanol¿water 50%, v:v, showing that NADES solvents provided better extraction of phenolic compounds and antioxidant capacity. The shelf-life of the extracts was also evaluated, based on the above tests, for 4 weeks, finding significant changes from day 15 of storage at 4 ¿C.This work was financially supported by Ministry of Science and Innovation (Spain) -State Research Agency (PID-2019-111331RB-I00/AEI/10.13039/501100011033).Tejero, A.; Martín-Esparza, M.; López-Malo, D.; Esteve, MJ.; Frigola, A.; Blesa, J. (2021). Assessment of the Use of a Selection of Natural Deep Eutectic Solvents in the Extraction of Polar Bioactive Compounds from Orange Peel. Biology and Life Sciences Forum. 6(1):1-7. https://doi.org/10.3390/Foods2021-11102S176

La huella de las oscilaciones globales del nivel del mar durante los últimos 530000 años en el Golfo de León y su variabilidad durante el estadio isotópico marino 3

El sondeo PRGL1-4, recuperado en el talud superior, ha proporcionado un registro único, continuo y de larga duración para la investigación del impacto de las oscilaciones del nivel del mar de escala glacial/interglacial durante el Pleistoceno Superior en la construcción del margen continental del Golfo de León, dominado por aportaciones sedimentarias de origen fluvial. El estudio en detalle de los cambios del tamaño de grano y la composición elemental del sedimento, junto con una robusta cronoestratigrafía basada en el registro de isótopos de oxígeno en foraminíferos planctónicos, ha permitido reinterpretar la sismoestratigrafia del margen para los últimos 530 ka. El sondeo PRGL1-4 comprende el apilamiento formado por cinco unidades depositadas durante las bajadas del nivel del mar de los últimos cinco ciclos glacial/interglacial de 100 ka. La extensa plataforma del Golfo de León ha jugado un papel determinante en el desarrollo del margen profundo puesto que las oscilaciones del nivel del mar, además de modificar el espacio de acomodación, influyeron directamente en cambios cíclicos del modelo deposicional a través de la activación y desactivación de procesos con gran capacidad erosiva y de transporte de sedimento más allá de la plataforma. El registro del sondeo PRGL1-4 también muestra el impacto de las oscilaciones del nivel del mar a escala milenaria durante el MIS 3, con evidencias claras de la ocurrencia de niveles del mar altos durante la fase inicial de todos y cada uno de los interestadios cálidos de los ciclos de Dansgaard-Oeschger. El registro PRGL1-4 supone, por tanto, la primera evidencia de un acoplamiento consistente entre las oscilaciones del nivel del mar y la variabilidad climática rápida de escala milenaria asociada a los ciclos de Dansgaard-Oeschger

Was there a common hydrological pattern in the Iberian Peninsula region during the Medieval Climate Anomaly?

Depto. de Geodinámica, Estratigrafía y PaleontologíaFac. de Ciencias GeológicasTRUEpu

Holocene changes in deep-water circulation of the Western Mediterranean Basin, links to North Atlantic climate variability

preliminary results from multicores recovered in the Minorca sediment drift, south of the Western Mediterranean Deep Water formation area, reveal changes in deep-water circulation during the last 2500 yr. Records of grain-size and SST Mg/Ca derived from G. bulloides show oscillations in deep-water current intensities that could be related to cool periods on land, i.e. the Little Ice Age, but also denote some relationship with changes in sea surface salinity likely associated with changes in continental humid conditions

Holocene climate variability in the Western Mediterranean region from a deep water sediment record

The detailed analysis of the International Marine Past Global Changes Study core MD99-2343 recovered from a sediment drift at 2391 m water depth north of the island of Minorca illustrates the effects of climate variability on thermohaline circulation in the western Mediterranean during the last 12 kyr. Geochemical ratios associated with terrigenous input resulted in the identification of four phases representing different climatic and deepwater overturning conditions in the Western Mediterranean Basin during the Holocene. Superimposed on the general trend, eight centennial- to millennial-scale abrupt events appear consistently in both grain size and geochemical records, which supports the occurrence of episodes of deepwater overturning reinforcement in the Western Mediterranean Basin. The observed periodicity for these abrupt events is in agreement with the previously defined Holocene cooling events of the North Atlantic region, thus supporting a strong Atlantic-Mediterranean climatic link at high-frequency time intervals during the last 12 kyr. The rapid response of the Mediterranean thermohaline circulation to climate change in the North Atlantic stresses the importance of atmospheric teleconnections in transferring climate variability from high latitudes to midlatitudes

A submarine volcanic eruption leads to a novel microbial habitat

Postprin

Síndrome de West: factores etiológicos

Este artículo recoge los resultados de un estudio retrospectivo de 20 niños diagnosticados con Síndrome de West entre 1993 y 2001. Se analizan las causas y se describen los métodos diagnósticos empleados, tratamiento y evolución. Se comparan los resultados con otro estudio realizado entre 1975 y 1986 en el mismo hospital

High levels of chromosomal aberrations negatively associate with benefit to checkpoint inhibition in NSCLC

Immunotherapy; Lung neoplasms; Tumor biomarkersImmunoteràpia; Càncer de pulmó; Biomarcadors tumoralsInmunoterapia; Cáncer de pulmón; Biomarcadores tumoralesBackground Immune checkpoint inhibitors (ICIs) targeting the programmed cell death 1/programmed death-ligand 1 axis have transformed the management of advanced non-small cell lung cancer (NSCLC). However, many patients do not benefit from this type of treatment, and thus several molecular biomarkers of benefit have been explored. The value of somatic copy number alterations (SCNAs) burden remains elusive. Patients and methods We assembled a cohort of 109 patients with NSCLC treated with ICIs and available tumor samples. We performed shallow whole-genome sequencing on 89 patients to determine genome-wide SCNAs and targeted gene expression analysis on 63 patients to study immune infiltration. We analyzed SCNAs burden in different ways (ie, the fraction of the genome altered or number of events) and studied their association with ICIs benefit based on survival analysis. We correlated SCNAs burden and immune infiltration on 35 patients of our cohort and on patients with lung adenocarcinoma from The Cancer Genome Atlas (TCGA). Results High SCNAs burden, computed in diverse ways, is negatively associated with ICIs progression-free survival (PFS), with the fraction of the genome altered (FGA) by arm and chromosome events showing the strongest association with PFS (p=0.002) (n=77). Nevertheless, we found differences in SCNAs across some clinicopathological features (sample site origin). A multivariate analysis adjusted for relevant characteristics showed that the FGA of arm and chromosome alterations was strongly associated with PFS (HR=2.21, p=3.3 x 10−5). Finally, we confirmed that SCNAs burden negatively correlates with tumor immune infiltration (n=35), although this correlation was not found for the males studied. Similar results were observed in the TCGA cohort. Conclusions SCNAs burden is a potential biomarker of benefit to ICIs in patients with NSCLC, although there appear to be some nuances worth consideration. Further studies will be needed to establish its role as a biomarker of benefit to ICIs.This work was supported by Merck Healthcare KGaA, Darmstadt, Germany (Grant for Oncology Innovation to the Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain), Fundación Cientifica Asociación Española Contra el Cancer-AECC (grant number GCB14142170 to EF); the Catalan Government/AGAUR (2017–SGR–1738 to EF). Merck Healthcare KGaA reviewed the manuscript for medical accuracy only before journal submission

Was there a common hydrological pattern in the Iberian Peninsula region during the medieval Climate anomaly?

Climate variability reconstructions for the last millennium from several Iberian lake and marine records shed light on the spatial and temporal hydroclimate and associated climate mechanisms during the Medieval Climate Anomaly