San Francisco Lithographer: African American Artist Grafton Tyler Brown

Review of San Francisco Lithographer: African American Artist Grafton Tyler Brown, Reviewed July 2014 by Amy De Simone, Research Consultant, Kansas State University, [email protected]

Incorporating Culture: How Indigenous People are Reshaping the Northwest Coast Art Industry

Review of Incorporating Culture: How Indigenous People are Reshaping the Northwest Coast Art Industry, Reviewed March 2019 by Amy De Simone, Research Consultant, [email protected]

The Coast & the Sea: Marine and Maritime Art in America at the New-York Historical Society

Review of The Coast & the Sea: Marine and Maritime Art in America at the New-York Historical Society, Reviewed January 2015 by Amy De Simone, Research Consultant, Kansas State University, [email protected]

A Land Beyond the Stars

Review of A Land Beyond the Stars, Reviewed February 2017 by Amy De Simone Research Consultant [email protected]

Virtuality and the Art of Exhibition: Curatorial Design for the Multimedia Museum

Book Review of Virtuality and the Art of Exhibition: Curatorial Design for the Multimedia Museum, by Vince Dziekan. ISBN 9781841504766 by Reviewed by: Amy De Simone

Native Fashion Now: North American Indian Style

Review of Native Fashion Now: North American Indian Style, Reviewed May 2016 by Amy De Simone, Research Associate, College of Human Ecology, Kansas State University, [email protected]

Crossing the Gap:Older Adults Do Not Create Less Challenging Stepping Stone Configurations Than Young Adults

Background Despite the known health benefits of physical activity, the number of older adults exercising regularly remains low in many countries. There is a demand for public open space interventions that can safely train balance, muscular strength, and cardiovascular fitness. In this participatory design study, older adults and young adults were to create their own stepping stones configurations. We provided them with six stepping stones, and examined the gap widths that each group of participants created and how they used the configurations. Results The created absolute gap distances by the older adults were smaller than those of the younger adults. Yet, the amount of challenge (in terms of the created gap widths relative to a person's estimated stepping capability) did not significantly differ between the young and older adults. Furthermore, both groups created non-standardized stepping stone configurations in which the number of different gap widths did not significantly differ between the young and older adults. Interestingly, while using their personalized design, older adults made significantly more gap crossings than younger adults over a given timespan. This finding tentatively suggests that personalized design invites physical activity in older adults. Conclusion The present study demonstrated that older adults are not more conservative in designing their own stepping stone configuration than young adults. Especially in light of the public health concern to increase physical activity in seniors, this is a promising outcome. However, field tests are needed to establish whether the older adults' stepping stones designs also invite physical activity in their daily environment

Socio-eco-evolutionary dynamics in cities

Cities are uniquely complex systems regulated by interactions and feedbacks between nature and human society. Characteristics of human society-including culture, economics, technology and politics-underlie social patterns and activity, creating a heterogeneous environment that can influence and be influenced by both ecological and evolutionary processes. Increasing research on urban ecology and evolutionary biology has coincided with growing interest in eco-evolutionary dynamics, which encompasses the interactions and reciprocal feedbacks between evolution and ecology. Research on both urban evolutionary biology and eco-evolutionary dynamics frequently focuses on contemporary evolution of species that have potentially substantial ecological-and even social-significance. Still, little work fully integrates urban evolutionary biology and eco-evolutionary dynamics, and rarely do researchers in either of these fields fully consider the role of human social patterns and processes. Because cities are fundamentally regulated by human activities, are inherently interconnected and are frequently undergoing social and economic transformation, they represent an opportunity for ecologists and evolutionary biologists to study urban "socio-eco-evolutionary dynamics." Through this new framework, we encourage researchers of urban ecology and evolution to fully integrate human social drivers and feedbacks to increase understanding and conservation of ecosystems, their functions and their contributions to people within and outside cities

Urinary amine and organic acid metabolites evaluated as markers for childhood aggression : the ACTION biomarker study

Biomarkers are of interest as potential diagnostic and predictive instruments in personalized medicine. We present the first urinary metabolomics biomarker study of childhood aggression. We aim to examine the association of urinary metabolites and neurotransmitter ratios involved in key metabolic and neurotransmitter pathways in a large cohort of twins (N = 1,347) and clinic-referred children (N = 183) with an average age of 9.7 years. This study is part of ACTION (Aggression in Children: Unraveling gene-environment interplay to inform Treatment and InterventiON strategies), in which we developed a standardized protocol for large-scale collection of urine samples in children. Our analytical design consisted of three phases: a discovery phase in twins scoring low or high on aggression (N = 783); a replication phase in twin pairs discordant for aggression (N = 378); and a validation phase in clinical cases and matched twin controls (N = 367). In the discovery phase, 6 biomarkers were significantly associated with childhood aggression, of which the association of O-phosphoserine (beta = 0.36; SE = 0.09; p = 0.004), and gamma-L-glutamyl-L-alanine (beta = 0.32; SE = 0.09; p = 0.01) remained significant after multiple testing. Although non-significant, the directions of effect were congruent between the discovery and replication analyses for six biomarkers and two neurotransmitter ratios and the concentrations of 6 amines differed between low and high aggressive twins. In the validation analyses, the top biomarkers and neurotransmitter ratios, with congruent directions of effect, showed no significant associations with childhood aggression. We find suggestive evidence for associations of childhood aggression with metabolic dysregulation of neurotransmission, oxidative stress, and energy metabolism. Although replication is required, our findings provide starting points to investigate causal and pleiotropic effects of these dysregulations on childhood aggression

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.

We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis