The development of an earth resources information system using aerial photographs and digital computers

Analytical photogrammetry demonstrated that automatic three dimensional mapping of forest terrain was technically feasible. The examples were black and white photography at scales of 1:10,000 and 1:24,000. The major improvement in terrain modelling was the addition of the capability of joining small quadrangles together to form one large model about equal to the effective area of the pair of photographs. Improvements of somewhat lesser importance include: (1) the use of up to 16 grey levels; (2) the elimination of several coordinate transformations; and (3) the annotation of three-tone hysocline maps with elevations

Intestinal Dipeptide Absorption Is Preserved During Thermal Injury and Cytokine Treatment

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142293/1/jpen0520.pd

Permeability and clearance views of drug absorption: A commentary

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45051/1/10928_2006_Article_BF02354289.pd

Mechanistic Oral Absorption Modeling and Simulation for Formulation Development and Bioequivalence Evaluation: Report of an FDA Public Workshop

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138394/1/psp412204.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138394/2/psp412204_am.pd

Lack of Interaction Between the Peptidomimetic Substrates Captopril and Cephradine

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97250/1/0091270008329554.pd

Dextran and its potential use as tablet excipient

Dextrans are a class of carbohydrate polymers extensively applied in pharmaceutical applications, particularly as drug conjugate macromolecular carriers or drug delivery systems. These polysaccharides improve the stability of the therapeutics enabling also the control of their release, via either the parenteral and or oral routes. In the latter case, due to their gel forming ability they may have potential as hydrophilic matrix tablets for sustained drug release. In this paper, we investigated the behaviour of different molecular weight (1, 40, 500 and 2300 kDa) dextrans as tabletting excipients. Powder particle size and hygroscopic studies have been reported, together with tabletability, tablet stability and tablet swelling. Moreover we use tramadol as model compound to evaluate the ability of dextrans to control drug dissolution. The results suggest that dextrans with lower molecular weights may be a promising excipient to be used as filler for immediate release tablets, due to their good tabletability and fast dissolution rate, while dextrans with higher molecular weights could be an efficient disintegrant due to their swelling ability

Steady‐state pharmacokinetics of delavirdine in HIV‐positive patients: Effect on erythromycin breath test

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109837/1/cptclpt199754.pd

Advanced Technologies for Oral Controlled Release: Cyclodextrins for oral controlled release

Cyclodextrins (CDs) are used in oral pharmaceutical formulations, by means of inclusion complexes formation, with the following advantages for the drugs: (1) solubility, dissolution rate, stability and bioavailability enhancement; (2) to modify the drug release site and/or time profile; and (3) to reduce or prevent gastrointestinal side effects and unpleasant smell or taste, to prevent drug-drug or drug-additive interactions, or even to convert oil and liquid drugs into microcrystalline or amorphous powders. A more recent trend focuses on the use of CDs as nanocarriers, a strategy that aims to design versatile delivery systems that can encapsulate drugs with better physicochemical properties for oral delivery. Thus, the aim of this work was to review the applications of the CDs and their hydrophilic derivatives on the solubility enhancement of poorly water soluble drugs in order to increase their dissolution rate and get immediate release, as well as their ability to control (to prolong or to delay) the release of drugs from solid dosage forms, either as complexes with the hydrophilic (e.g. as osmotic pumps) and/ or hydrophobic CDs. New controlled delivery systems based on nanotechonology carriers (nanoparticles and conjugates) have also been reviewed

A method to predict infinity values for biexponential processes

An equation is presented which allows infinity values for biexponential processes to be predicted in the early nonlinear phase when samples are taken at equal time intervals. This equation is independent of the value or ratio of the rate constants involved in the process. However, this method is very sensitive to noise normally associated with urine data.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45077/1/10928_2005_Article_BF01062539.pd