34 research outputs found
Comparative Transcriptomic Analysis Identifies a Range of Immunologically Related Functional Elaborations of Lymph Node Associated Lymphatic and Blood Endothelial Cells
- Author
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/04/2019
- Field of study
Lymphatic and blood vessels are formed by specialized lymphatic endothelial cells (LEC) and blood endothelial cells (BEC), respectively. These endothelial populations not only form peripheral tissue vessels, but also critical supporting structures in secondary lymphoid organs, particularly the lymph node (LN). Lymph node LEC (LN-LEC) also have been shown to have important immunological functions that are not observed in LEC from tissue lymphatics. LN-LEC can maintain peripheral tolerance through direct presentation of self-antigen via MHC-I, leading to CD8 T cell deletion; and through transfer of self-antigen to dendritic cells for presentation via MHC-II, resulting in CD4 T cell anergy. LN-LEC also can capture and archive foreign antigens, transferring them to dendritic cells for maintenance of memory CD8 T cells. The molecular basis for these functional elaborations in LN-LEC remain largely unexplored, and it is also unclear whether blood endothelial cells in LN (LN-BEC) might express similar enhanced immunologic functionality. Here, we used RNA-Seq to compare the transcriptomic profiles of freshly isolated murine LEC and BEC from LN with one another and with freshly isolated LEC from the periphery (diaphragm). We show that LN-LEC, LN-BEC, and diaphragm LEC (D-LEC) are transcriptionally distinct from one another, demonstrating both lineage and tissue-specific functional specializations. Surprisingly, tissue microenvironment differences in gene expression profiles were more numerous than those determined by endothelial cell lineage specification. In this regard, both LN-localized endothelial cell populations show a variety of functional elaborations that suggest how they may function as antigen presenting cells, and also point to as yet unexplored roles in both positive and negative regulation of innate and adaptive immune responses. The present work has defined in depth gene expression differences that point to functional specializations of endothelial cell populations in different anatomical locations, but especially the LN. Beyond the analyses provided here, these data are a resource for future work to uncover mechanisms of endothelial cell functionality
Rare and low-frequency coding variants alter human adult height
- Author
- A Boyd
- A Dauber
- A Moayyeri
- AC Karaplis
- Adam E. Locke
- Adam S. Butterworth
- Ailith Pirie
- AL Price
- Albert Vernon Smith
- Alex P. Reiner
- Alex W. Hewitt
- Alexander Teumer
- Aliki-Eleni Farmaki
- Alisa K. Manning
- Alison M. Dunning
- Alison Pattie
- Allan Linneberg
- Amanda J. Cox
- Amber A. Burt
- Andres Metspalu
- Andrew D. Morris
- Andrew P. Morris
- Andrew R. Wood
- Andrew T. Hattersley
- Andries R. Van Der Leij
- André G. Uitterlinden
- Anette Varbo
- Angela L. Mazul
- Aniruddh P. Patel
- Anke Tönjes
- Anna Morgan
- Anne E. Justice
- Anne Tybjaerg-Hansen
- Anne U. Jackson
- Anneke I. den Hollander
- Antonietta Robino
- Anubha Mahajan
- AR Wood
- Artitaya Lophatananon
- Asif Rasheed
- Audrey Y. Chu
- Ayush Giri
- B Pasaniuc
- Bernhard Banas
- Betina H. Thuesen
- Beverley Balkau
- BJ Frey
- BK Bulik-Sullivan
- Bratati Kahali
- Børge G. Nordestgaard
- C Fuchsberger
- C Gyrup
- C Oxvig
- C Sidore
- Carel B. Hoyng
- Carl D. Langefeld
- Carol A. Wang
- Carolina Medina-Gomez
- Caroline Hayward
- Carsten A. Böger
- Cecilia M. Lindgren
- Charles Kooperberg
- Chris J. Packard
- Christopher P. Nelson
- CJ Willer
- Claudia Langenberg
- Claudia Schurmann
- Claus Oxvig
- Colin N. A. Palmer
- Cora E. Lewis
- Cornelia M. van Duijn
- Craig E. Pennell
- Cramer Christensen
- Cristen J. Willer
- D Lamparter
- Dajiang J. Liu
- Daniel I. Chasman
- Daniel R. Witte
- Danielle Posthuma
- Danish Saleheen
- David A. Mackey
- David J. Carey
- David Lamparter
- Deborah J. Thompson
- Dennis O. Mook-Kanamori
- Dermot F. Reilly
- Dewan S. Alam
- Diego Vozzi
- Digna R. Velez Edwards
- DJ Liu
- Dominique Arveiler
- Donald W. Bowden
- Douglas F. Easton
- Eirini Marouli
- Ele Ferrannini
- Eleftheria Zeggini
- Elizabeth K. Speliotes
- Ellen W. Demerath
- Emanuele Di Angelantonio
- Emil V. Appel
- Emmanouil Tsafantakis
- Eric B. Larson
- Eric Boerwinkle
- Erik Ingelsson
- Erwin P. Bottinger
- Ethan M. Lange
- Eva Albrecht
- Evangelos Evangelou
- F Danjou
- Feijie Wang
- Fernando Rivadeneira
- Folkert W. Asselbergs
- Fotios Drenos
- Francis S. Collins
- Frank Kee
- Fredrik Karpe
- Frida Renström
- G. Kees Hovingh
- Gabriel Cuellar-Partida
- Gail Davies
- Gail P. Jarvik
- Gaëlle Marenne
- George Dedoussis
- Gerard Pasterkamp
- Gerard Tromp
- Gerome Breen
- Gert J. de Borst
- Gina M. Peloso
- Giorgia Girotto
- Goncalo Abecasis
- Gorm B. Jensen
- Gudmar Thorleifsson
- Guillaume Lettre
- GV Kryukov
- H Ito
- H Lango Allen
- Hanieh Yaghootkar
- He Zheng
- Heather M. Highland
- Heather M. Stringham
- Heikki Oksa
- Heiner Boeing
- Helen R. Warren
- Helena Kuivaniemi
- Henrik Vestergaard
- Hidetoshi Kitajima
- Honghuang Lin
- HS Wei
- Huaixing Li
- I-Te Lee
- Ian Ford
- Ian J. Deary
- Igor Rudan
- Ilaria Gandin
- Ingrid B. Borecki
- Ioanna Ntalla
- Iris M. Heid
- Ivan Brandslund
- J Flannick
- J Gudmundsson
- J Mastaitis
- J Yang
- J Yang
- J Yang
- J. Wouter Jukema
- JA Tennessen
- Jaakko Kaprio
- Jaakko Tuomilehto
- Jaana Lindström
- James A. Perry
- James G. Wilson
- James P. Cook
- Jan-Håkan Jansson
- Janie Corley
- Jaspal S. Kooner
- Jean Ferrieres
- Jean-Claude Tardif
- Jeffrey R. O'Connel
- Jennifer A. Smith
- Jennifer Kriebel
- Jennifer Wessel
- Jerome I Rotter
- Jessica D. Faul
- Jessica van Setten
- Jette Bork-Jensen
- JI Goldstein
- Jian'an Luan
- Jie Yao
- Jin Li
- Jing Hua Zhao
- Joanna M. M. Howson
- Joe G. Dennis
- Joel N. Hirschhorn
- Johanna Kuusisto
- John C. Chambers
- John D. Rioux
- John Danesh
- John M. Starr
- John R. B. Perry
- Jonathan Marten
- Jonathan P. Tyrer
- Jordi Corominas Galbany
- Jose C. Florez
- Jukka Kontto
- Jussi Hernesniemi
- K Silventoinen
- Karen L. Mohlke
- Kari E. North
- Kari Stefansson
- Karina Meidtner
- Katharine R. Owen
- Katherine E. Tansey
- Katherine S. Ruth
- Kathleen E. Stirrups
- Kathleen Mullan Harris
- Katja K. Aben
- Kauko Heikkilä
- Ken Sin Lo
- Kent D. Taylor
- Kerrin S. Small
- Kevin Sandow
- Kirsten B. Kluivers
- Kjell Nikus
- Kristian Hveem
- Kristin L. Young
- Kristine H. Allin
- Lambertus A. Kiemeney
- Lars Lind
- Laura M. Yerges-Armstrong
- Lawrence F. Bielak
- Leen M. ‘t Hart
- Leo-Pekka Lyytikäinen
- Leslie A. Lange
- Li-An Lin
- Lia E. Bang
- Liang He
- Linda Broer
- Linda S. Adair
- Loes M. Olde Loohuis
- Lori L. Bonnycastle
- Lorraine Southam
- Lynne J. Hocking
- M Nikpay
- M. Arfan Ikram
- Maggie C. Y. Ng
- Manuel A. Rivas
- Marcelo P. Segura-Lepe
- Marco M. Ferrario
- Maria Karaleftheri
- Mariaelisa Graff
- Marianne Benn
- Marit E. Jørgensen
- Marjanka K. Schmidt
- Mark C. H. de Groot
- Mark I. McCarthy
- Mark J. Caulfield
- Mark Walker
- Markku Laakso
- Markus Perola
- Martina La Bianca
- Martina Müller-Nurasyid
- Mary F. Feitosa
- Massimiliano Cocca
- Mathias Gorski
- Matt Neville
- Matthew Allison
- Matthias B. Schulze
- Matthias Blüher
- Matthias Nauck
- MB Lanktree
- MC Wu
- Megan L. Grove
- Mengmeng Du
- Mette Hollensted
- Michael Boehnke
- Michael O. Woods
- Michael Stumvoll
- Michiel L. Bots
- Mika Kähönen
- Mike A. Nalls
- Min A. Jhun
- ML Grove
- MR Jepsen
- MT Overgaard
- Murray H. Brilliant
- Myriam Fornage
- NA Sims
- Nancy L. Heard-Costa
- Natasja M. van Schoor
- Naveed Sattar
- NB Schwartz
- Neil Robertson
- Nicholas G. D. Masca
- Nicholas G. Martin
- Nicholas J. Wareham
- Niels Grarup
- Nilesh J. Samani
- O Zuk
- Oddgeir L. Holmen
- Olli T. Raitakari
- Olov Rolandsson
- Oluf Pedersen
- Ozren Polasek
- Pamela A. F. Madden
- Pamela J. Schreiner
- Pang Yao
- Panos Deloukas
- Paolo Gasparini
- Patricia B. Munroe
- Patrick T. Ellinor
- Paul Elliott
- Paul I. W. de Bakker
- Paul L. Auer
- Paul L. Huang
- Paul M. Ridker
- Paul Mitchell
- Paul W. Franks
- Peggy L. Peissig
- Pekka Jousilahti
- Penny Gordon-Larsen
- Peter Kovacs
- Philippe Amouyel
- Pia R. Kamstrup
- Pirjo Komulainen
- Poorva Mudgal
- PR Loh
- Praveen Surendran
- Pål R. Njølstad
- RA Fisher
- Rainer Rauramaa
- Rajiv Chowdhury
- Rebecca S. Fine
- Renske Keeman
- René S. Kahn
- Renée de Mutsert
- Robert A. Scott
- Robin Young
- Roel A. Ophoff
- Rohit Varma
- RS Fehrmann
- Rudolf Uher
- Ruifang Li-Gao
- Ruth Frikke-Schmidt
- Ruth J. F. Loos
- S Feng
- Sailaja Vedantam
- Sander W. van der Laan
- Sandosh Padmanabhan
- Sara M. Willems
- Satu Männistö
- Scott D. Gordon
- Sekar Kathiresan
- Sharon L. R. Kardia
- Sheila Ulivi
- Shuai Wang
- Shuang Feng
- Simon de Denus
- Sina Rüeger
- Sita H. Vermeulen
- SM Purcell
- Stavroula Kanoni
- Stefan Gustafsson
- Stefan Johansson
- Stella Trompet
- Steven A. Lubitz
- Sune F. Nielsen
- Suthesh Sivapalaratnam
- Svati Shah
- Sven Bergmann
- Sébastien Küry
- T Wakahara
- Tamara B. Harris
- Tapani Ebeling
- Terho Lehtimäki
- Tessel E. Galesloot
- TH Pers
- Thomas F. Vogt
- Thomas Kocher
- Thomas N. Person
- Thomas W. Winkler
- Tibor V. Varga
- Timo A. Lakka
- Timothy D. Spector
- Timothy M. Frayling
- Todd L. Edwards
- Torben Hansen
- Torben Jørgensen
- Troels R. Kjaer
- Tugce Karaderi
- Tune H. Pers
- TW Winkler
- Tõnu Esko
- Unnur Thorsteinsdottir
- V Steinthorsdottir
- Valgerdur Steinthorsdottir
- Valérie Turcot
- Veikko Salomaa
- Veronique Vitart
- Vilmantas Giedraitis
- Vilmundur Gudnason
- Wei Gan
- Wei Zhao
- Wei Zhao
- Wei Zhou
- Weihua Zhang
- Xiaowei Zhan
- Xiuqing Guo
- Xu Lin
- Xuejuan Jiang
- Xueling Sim
- Y Kawano
- Y Takeuchi
- Yadav Sapkota
- Yeheng Liu
- Yii-Der Ida Chen
- Ying Wu
- Yingchang Lu
- Yiqin Wang
- Yongmei Liu
- Yucheng Jia
- Zoltán Kutalik
- Øyvind Helgeland
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 16/12/2016
- Field of study
Height is a highly heritable, classic polygenic trait with ~700 common associated variants identified so far through genome - wide association studies . Here , we report 83 height - associated coding variants with lower minor allele frequenc ies ( range of 0.1 - 4.8% ) and effects of up to 2 16 cm /allele ( e.g. in IHH , STC2 , AR and CRISPLD2 ) , >10 times the average effect of common variants . In functional follow - up studies, rare height - increasing alleles of STC2 (+1 - 2 cm/allele) compromise d proteolytic inhibition of PAPP - A and increased cleavage of IGFBP - 4 in vitro , resulting in higher bioavailability of insulin - like growth factors . The se 83 height - associated variants overlap genes mutated in monogenic growth disorders and highlight new biological candidates ( e.g. ADAMTS3, IL11RA, NOX4 ) and pathways ( e.g . proteoglycan/ glycosaminoglycan synthesis ) involved in growth . Our results demonstrate that sufficiently large sample sizes can uncover rare and low - frequency variants of moderate to large effect associated with polygenic human phenotypes , and that these variants implicate relevant genes and pathways
The James Webb Space Telescope Mission
- Author
- Abbott Randy
- Abell James S.
- Abernathy Mark
- Abney Faith E.
- Abraham John G.
- Abraham Roberto
- Abul-Huda Yasin M.
- Acton Scott
- Adams Cynthia K.
- Adams Evan
- Adler David S.
- Adriaensen Maarten
- Aguilar Jonathan Albert
- Ahmed Mansoor
- Ahmed Nasif S.
- Ahmed Tanjira
- Alarcon Rafael Ramos
- Albat Rüdeger
- Albert Loïc
- Alberts Stacey
- Aldridge David
- Allen Mary Marsha
- Allen Shaune S.
- Altenburg Martin
- Altunc Serhat
- Alvarez Jose Lorenzo
- Ambrose Leslie L.
- Anandakrishnan Satya M.
- Andersen Gregory C.
- Anderson Harry James
- Anderson Jay
- Anderson Kristen
- Anderson Sara M.
- Aprea Julio
- Archer Benita J.
- Arenberg Jonathan W.
- Argyriou Ioannis
- Arribas Santiago
- Artigau Étienne
- Arvai Amanda Rose
- Atcheson Paul
- Atkinson Charles B.
- Averbukh Jesse
- Aymergen Cagatay
- Bacinski John J.
- Baggett Wayne E.
- Bagnasco Giorgio
- Baker Lynn L.
- Balzano Vicki Ann
- Banks Kimberly A.
- Baran David A.
- Barker Elizabeth A.
- Barrett Larry K.
- Barringer Bruce O.
- Barto Allison
- Bast William
- Baudoz Pierre
- Baum Stefi
- Beatty Thomas G.
- Beaulieu Mathilde
- Bechtold Kathryn
- Beck Tracy
- Beddard Megan M.
- Beichman Charles
- Bellagama Larry
- Bely Pierre
- Berger Timothy W.
- Bergeron Louis E.
- Bertch Maria D.
- Beskow Charlotte
- Betz Laura E.
- Biagetti Carl P.
- Birkmann Stephan
- Bjorklund Kurt F.
- Blackwood James D.
- Blazek Ronald Paul
- Blossfeld Stephen
- Bluth Marcel
- Boccaletti Anthony
- Boegner Jr. Martin E.
- Bohlin Ralph C.
- Boia John Joseph
- Bonaventura N.
- Bond Nicholas A.
- Bosley Kari Ann
- Boucarut Rene A.
- Bouchet Patrice
- Bouwman Jeroen
- Bower Gary
- Bowers Ariel S.
- Bowers Charles W.
- Boyce Leslye A.
- Boyer Christine T.
- Boyer Martha L.
- Boyer Michael
- Boyer Robert
- Bradley Larry D.
- Brady Gregory R.
- Brandl Bernhard R.
- Brannen Judith L.
- Breda David
- Bremmer Harold G.
- Brennan David
- Bresnahan Pamela A.
- Bright Stacey N.
- Broiles Brian J.
- Bromenschenkel Asa
- Brooks Brian H.
- Brooks Keira J.
- Brown Bob
- Brown Bruce
- Brown Thomas M.
- Bruce Barry W.
- Bryson Jonathan G.
- Bujanda Edwin D.
- Bullock Blake M.
- Bunker A. J.
- Bureo Rafael
- Burt Irving J.
- Bush James Aaron
- Bushouse Howard A.
- Bussman Marie C.
- Böker Torsten
- Cabaud Olivier
- Cale Steven
- Calhoon Charles D.
- Calvani Humberto
- Canipe Alicia M.
- Caputo Francis M.
- Cara Mihai
- Carey Larkin
- Case Michael Eli
- Cesari Thaddeus
- Cetorelli Lee D.
- Chance Don R.
- Chandler Lynn
- Chaney Dave
- Chapman George N.
- Charlot S.
- Chayer Pierre
- Cheezum Jeffrey I.
- Chen Bin
- Chen Christine H.
- Cherinka Brian
- Chichester Sarah C.
- Chilton Zachary S.
- Chittiraibalan Dharini
- Clampin Mark
- Clark Charles R.
- Clark Kerry W.
- Clark Stephanie M.
- Claybrooks Edward E.
- Cleveland Keith A.
- Cohen Andrew L.
- Cohen Lester M.
- Coleman Benee L.
- Colina Luis
- Colón Knicole D.
- Comber Brian J.
- Comeau Thomas M.
- Comer Thomas
- Connolly Dennis C.
- Conroy Kyle E.
- Contos Adam R.
- Contreras James
- Cook Neil J.
- Cooper James L.
- Cooper Rachel Aviva
- Correia Michael F.
- Correnti Matteo
- Cossou Christophe
- Costanza Brian F.
- Costas Maria Begoña Vila
- Coulais Alain
- Cox Colin R.
- Coyle Ray T.
- Cracraft Misty M.
- Crew Keith A.
- Curtis Gary J.
- Cusveller Bianca
- Dailey Christopher T.
- Darveau-Bernier Antoine
- Daugeron Frédéric
- Davidson Greg S.
- Davies James E.
- Davis Katherine Anne
- Davis Michael S.
- Day Ratna
- de Chambure Daniel
- de Jong Pauline
- De Marchi Guido
- De Meester Wim
- de Oliveira Catarina Alves
- Dean Bruce H.
- Decker John E.
- del Pino Bruno Rodríguez
- Delisa Amy S.
- Dell Lawrence C.
- Dellagatta Gail
- Dembinska Franciszka
- Demosthenes Sandor
- Dencheva Nadezhda M.
- Deneu Philippe
- DePriest William W.
- Deschenes Jeremy
- Dethienne Nathalie
- Detre Örs Hunor
- Diaz Rosa Izela
- Dicken Daniel
- DiFelice Audrey S.
- Dillman Matthew
- Disharoon Maureen O.
- Dixon William V.
- Doggett Jesse B.
- Dominguez Keisha L.
- Donaldson Thomas S.
- Doria-Warner Cristina M.
- Doty Heather
- Douglas Jr. Robert E.
- Doyon René
- Dressler Alan
- Driggers Jennifer
- Driggers Phillip A.
- Dunn Jamie L.
- DuPrie Kimberly C.
- Dupuis Jean
- Durning John
- Dutta Sanghamitra B.
- Earl Nicholas M.
- Eccleston Paul
- Ecobichon Pascal
- Egami Eiichi
- Ehrenwinkler Ralf
- Eisenhamer Jonathan D.
- Eisenhower Michael
- Eisenstein Daniel J.
- Elie Michelle L.
- Elliott James
- Elliott Kyle Wesley
- Engesser Michael
- Espinoza Néstor
- Etienne Odessa
- Etxaluze Mireya
- Evans Leah
- Fabreguettes Luce
- Falcolini Massimo
- Falini Patrick R.
- Fatig Curtis
- Feeney Matthew
- Feinberg Lee D.
- Fels Raymond
- Ferdous Nazma
- Ferguson Henry C.
- Ferrarese Laura
- Ferreira Marie-Héléne
- Ferruit Pierre
- Ferry Malcolm
- Filippazzo Joseph Charles
- Firre Daniel
- Fix Mees
- Flagey Nicolas
- Flanagan Kathryn A.
- Fleming Scott W.
- Florian Michael
- Flynn James R.
- Foiadelli Luca
- Fontaine Mark R.
- Fontanella Erin Marie
- Forshay Peter Randolph
- Fortner Elizabeth A.
- Fox Ori D.
- Framarini Alexandro P.
- Francisco John I.
- Franck Randy
- Franx Marijn
- Franz David E.
- Friedman Scott D.
- Friend Katheryn E.
- Frost James R.
- Fu Henry
- Fullerton Alexander W.
- Gaillard Lionel
- Galkin Sergey
- Gallagher Ben
- Galyer Anthony D.
- Gardner Jonathan P.
- Gardner Lisa E.
- Garland Dennis
- Garrett Bruce Albert
- Gasman Danny
- Gastaud René
- Gaudreau Daniel
- Gauthier Peter Timothy
- Geers Vincent
- Geithner Paul H.
- Gennaro Mario
- Gerber John
- Gereau John C.
- Giampaoli Robert
- Giardino Giovanna
- Gibbons Paul C.
- Gilbert Karolina
- Gilman Larry
- Girard Julien H.
- Giuliano Mark E.
- Gkountis Konstantinos
- Glasse Alistair
- Glassmire Kirk Zachary
- Glauser Adrian Michael
- Glazer Stuart D.
- Goldberg Joshua
- Golimowski David A.
- Gonzaga Shireen P.
- Gordon Karl D.
- Gordon Shawn J.
- Goudfrooij Paul
- Gough Michael J.
- Graham Adrian J.
- Grau Christopher M.
- Green Joel David
- Greene Gretchen R.
- Greene Thomas P.
- Greenfield Perry E.
- Greenhouse Matthew A.
- Greve Thomas R.
- Greville Edgar M.
- Grimaldi Stefano
- Groe Frank E.
- Groebner Andrew
- Grumm David M.
- Grundy Timothy
- Guillard Pierre
- Guldalian John
- Gunn Christopher A.
- Gurule Anthony
- Gutman Irvin Meyer
- Guy Paul D.
- Guyot Benjamin
- Gáspár András
- Güdel Manuel
- Hack Warren J.
- Haderlein Peter
- Hagan James B.
- Hagedorn Andria
- Hainline Kevin
- Haley Craig
- Hamel Zaky El
- Hami Maryam
- Hamilton Forrest Clifford
- Hammann Jeffrey
- Hammel Heidi B.
- Hanley Christopher J.
- Hansen Carl August
- Hardy Bruce
- Harnisch Bernd
- Harr Michael Hunter
- Harris Pamela
- Hart Jessica Ann
- Hartig George F.
- Hasan Hashima
- Hashim Kathleen Marie
- Hashimoto Ryan
- Haskins Sujee J.
- Hawkins Robert Edward
- Hayden Brian
- Hayden William L.
- Healy Mike
- Hecht Karen
- Heeg Vince J.
- Hejal Reem
- Helm Kristopher A.
- Hengemihle Nicholas J.
- Henning Thomas
- Henry Alaina
- Henry Ronald L.
- Henshaw Katherine
- Hernandez Scarlin
- Herrington Donald C.
- Heske Astrid
- Hesman Brigette Emily
- Hickey David L.
- Hilbert Bryan N.
- Hines Dean C.
- Hinz Michael R.
- Hirsch Michael
- Hitcho Robert S.
- Hodapp Klaus
- Hodge Philip E.
- Hoffman Melissa
- Holfeltz Sherie T.
- Holler Bryan Jason
- Hoppa Jennifer Rose
- Horner Scott
- Howard Joseph M.
- Howard Richard J.
- Huber Jean M.
- Hunkeler Joseph S.
- Hunter Alexander
- Hunter David Gavin
- Hurd Spencer W.
- Hurst Brendan J.
- Hutchings John B.
- Hylan Jason E.
- Ignat Luminita Ilinca
- Illingworth Garth
- Irish Sandra M.
- Isaacs III John C.
- Jackson Jr. Wallace C.
- Jaffe Daniel T.
- Jahic Jasmin
- Jahromi Amir
- Jakobsen Peter
- James Bryan
- James John C.
- James LeAndrea Rae
- Jamieson William Brian
- Jandra Raymond D.
- Jayawardhana Ray
- Jedrzejewski Robert
- Jeffers Basil S.
- Jensen Peter
- Joanne Egges
- Johns Alan T.
- Johnson Carl A.
- Johnson Eric L.
- Johnson Patricia
- Johnson Phillip Stephen
- Johnson Thomas K.
- Johnson Timothy W.
- Johnstone Doug
- Jollet Delphine
- Jones Danny P.
- Jones Gregory S.
- Jones Olivia C.
- Jones Ronald A.
- Jones Vicki
- Jordan Ian J.
- Jordan Margaret E.
- Jue Reginald
- Jurkowski Mark H.
- Justis Grant
- Justtanont Kay
- Kaleida Catherine C.
- Kalirai Jason S.
- Kalmanson Phillip Cabrales
- Kaltenegger Lisa
- Kammerer Jens
- Kan Samuel K.
- Kanarek Graham Childs
- Kao Shaw-Hong
- Karakla Diane M.
- Karl Hermann
- Kassin Susan A.
- Kauffman David D.
- Kavanagh Patrick
- Kelley Leigh L.
- Kelly Douglas M.
- Kendrew Sarah
- Kennedy Herbert V.
- Kenny Deborah A.
- Keski-Kuha Ritva A.
- Keyes Charles D.
- Khan Ali
- Kidwell Richard C.
- Kimble Randy A.
- King James S.
- King Richard C.
- Kinzel Wayne M.
- Kirk Jeffrey R.
- Kirkpatrick Marc E.
- Klaassen Pamela
- Klingemann Lana
- Klintworth Paul U.
- Knapp Bryan Adam
- Knight Scott
- Knollenberg Perry J.
- Knutsen Daniel Mark
- Koehler Robert
- Koekemoer Anton M.
- Kofler Earl T.
- Kontson Vicki L.
- Kovacs Aiden Rose
- Kozhurina-Platais Vera
- Krause Oliver
- Kriss Gerard A.
- Krist John
- Kristoffersen Monica R.
- Krogel Claudia
- Krueger Anthony P.
- Kulp Bernard A.
- Kumari Nimisha
- Kwan Sandy W.
- Kyprianou Mark
- Labador Aurora Gadiano
- Labiano Álvaro
- Lafrenière David
- Lagage Pierre-Olivier
- Laidler Victoria G.
- Laine Benoit
- Laird Simon
- Lajoie Charles-Philippe
- Lallo Matthew D.
- Lam May Yen
- LaMassa Stephanie Marie
- Lambros Scott D.
- Lampenfield Richard Joseph
- Lander Matthew Ed
- Langston James Hutton
- Larson Kirsten
- Larson Melora
- LaVerghetta Robert Joseph
- Law David R.
- Lawrence Jon F.
- Lee David W.
- Lee Janice
- Lee Yat-Ning Paul
- Leisenring Jarron
- Leveille Michael Dunlap
- Levenson Nancy A.
- Levi Joshua S.
- Levine Marie B.
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- Lewis Nikole
- Libralato Mattia
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- Lilly Simon
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- Lubskiy Michael
- Luers Edward B.
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- Lund III James M.
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- Lynch Richard J.
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- Lützgendorf Nora
- MacDonald Alex J.
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- Murray Katherine T.
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- Nikolov Nikolay K.
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- Ottens Richard
- Ouellette Nathalie N. -Q.
- Outlaw Daria J.
- Owens Beverly A.
- Pacifici Camilla
- Page James Christophe
- Paranilam James G.
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- Patapis Polychronis
- Patel Jignasha
- Patrick Keith
- Pattishall Jr. Robert A.
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- Penanen Konstantin
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- Richon Joel G.
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- Ridgaway Michael
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- Robberto Massimo
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- Rohrbach Scott O.
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- Romelfanger Frederick J.
- Romo Jr. Felipe P.
- Rosales Jose J.
- Rose Perry
- Roteliuk Anthony F.
- Roth Marc N.
- Rothwell Braden Quinn
- Rouzaud Sylvain
- Rowe Jason
- Rowlands Neil
- Roy Arpita
- Royer Pierre
- Rui Chunlei
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- Russ Melissa L.
- Ryan Michael B.
- Ryan Richard M.
- Saad Karl
- Sabata Modhumita
- Sabatino Rick
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- Sabia Stephen
- Sahu Kailash C.
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- Salvignol Jean-Christophe
- Samara-Ratna Piyal
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- Sanders Felicia A.
- Santos Tony Dos
- Sappington Bradley
- Sargent B. A.
- Sauer Arne
- Savadkin Bruce J.
- Sawicki Marcin
- Schappell Tina M.
- Scheffer Caroline
- Scheithauer Silvia
- Scherer Ron
- Schiff Conrad
- Schlawin Everett
- Schmeitzky Olivier
- Schmitz Tyler S.
- Schmude Donald J.
- Schneider Analyn
- Schreiber Jürgen
- Schroeven-Deceuninck Hilde
- Schultz John J.
- Schwab Ryan
- Schwartz Curtis H.
- Scoccimarro Dario
- Scott John F.
- Scott Michelle B.
- Seaton Bonita L.
- Seely Bruce S.
- Seery Bernard
- Seidleck Mark
- Sembach Kenneth
- Shanahan Clare Elizabeth
- Shaughnessy Bryan
- Shaw Richard A.
- Shay Christopher Michael
- Sheehan Even
- Sheth Kartik
- Shih Hsin-Yi
- Shivaei Irene
- Siegel Noah
- Sienkiewicz Matthew G.
- Simmons Debra D.
- Simon Bernard P.
- Sirianni Marco
- Sivaramakrishnan Anand
- Slade Jeffrey E.
- Sloan G. C.
- Slocum Christine E.
- Slowinski Steven E.
- Smith Corbett T.
- Smith Eric P.
- Smith Erin C.
- Smith Koby
- Smith Robert
- Smith Stephanie J.
- Smolik John L.
- Soderblom David R.
- Sohn Sangmo Tony
- Sokol Jeff
- Sonneborn George
- Sontag Christopher D.
- Sooy Peter R.
- Soummer Remi
- Southwood Dana M.
- Spain Kay
- Sparmo Joseph
- Speer David T.
- Spencer Richard
- Sprofera Joseph D.
- Stallcup Scott S.
- Stanley Marcia K.
- Stansberry John A.
- Stark Christopher C.
- Starr Carl W.
- Stassi Diane Y.
- Steck Jane A.
- Steeley Christine D.
- Stephens Matthew A.
- Stephenson Ralph J.
- Stewart Alphonso C.
- Stiavelli Massimo
- Stockman Jr. Hervey
- Strada Paolo
- Straughn Amber N.
- Streetman Scott
- Strickland David Kendal
- Strobele Jingping F.
- Stuhlinger Martin
- Stys Jeffrey Edward
- Such Miguel
- Sukhatme Kalyani
- Sullivan Joseph F.
- Sullivan Pamela C.
- Sumner Sandra M.
- Sun Fengwu
- Sunnquist Benjamin Dale
- Swade Daryl Allen
- Swam Michael S.
- Swenton Diane F.
- Swoish Robby A.
- Tamas Laszlo
- Tao Andrew
- Taylor David K.
- Taylor Joanna M.
- Teague Kelly K.
- Telfer Randal C.
- Temim Tea
- Texter Scott C.
- Thatte Deepashri G.
- Thompson Christopher Lee
- Thompson Linda M.
- Thomson Shaun R.
- Thronson Harley
- Tierney C. M.
- Tikkanen Tuomo
- Tinnin Lee
- Tippet William Thomas
- Todd Connor William
- Tran Hien D.
- Trauger John
- Trejo Edwin Gregorio
- Truong Justin Hoang Vinh
- Tsukamoto Christine L.
- Tufail Yasir
- Tumlinson Jason
- Tustain Samuel
- Tyra Harrison
- Ubeda Leonardo
- Underwood Kelli
- Uzzo Michael A.
- Vaclavik Steven
- Valenduc Frida
- Valenti Jeff A.
- Van Campen Julie
- van de Wetering Inge
- Van Der Marel Roeland P.
- van Dishoeck Ewine F.
- van Haarlem Remy
- Van Tea Mason
- Vandenbussche Bart
- Vanterpool Dona D.
- Vernoy Michael R.
- Volk Kevin
- Voorzaat Piet
- Voyton Mark F.
- Vydra Ekaterina
- Waddy Darryl J.
- Waelkens Christoffel
- Wahlgren Glenn Michael
- Walker Jr. Frederick E.
- Wander Michel
- Warfield Christine K.
- Warner Gerald
- Wasiak Francis C.
- Wasiak Matthew F.
- Wehner James
- Weiler Kevin R.
- Weilert Mark
- Weiss Stanley B.
- Wells Martyn
- Welty Alan D.
- Wheate Lauren
- Wheeler Thomas P.
- White Christy L.
- Whitehouse Paul
- Whiteleather Jennifer Margaret
- Whitman William Russell
- Williams Christina C.
- Willmer Christopher N. A.
- Willott Chris J.
- Willoughby Scott P.
- Wilson Andrew
- Wilson Debra
- Wilson Donna V.
- Windhorst Rogier
- Wislowski Emily Christine
- Wolfe David J.
- Wolfe Michael A.
- Wolff Schuyler
- Wondel Amancio
- Woo Cindy
- Woods Robert T.
- Worden Elaine
- Workman William
- Wright Gillian S.
- Wu Carl
- Wu Chi-Rai
- Wun Dakin D.
- Wymer Kristen B.
- Yadetie Thomas
- Yan Isabelle C.
- Yang Keith C.
- Yates Kayla L.
- Yeager Christopher R.
- Yerger Ethan John
- Young Erick T.
- Young Gary
- Yu Gene
- Yu Susan
- Zak Dean S.
- Zeidler Peter
- Zepp Robert
- Zhou Julia
- Zincke Christian A.
- Zonak Stephanie
- Zondag Elisabeth
- Álvarez-Márquez Javier
- Östlin Göran
- Publication venue
- Publication date
- 10/04/2023
- Field of study
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least 4m.
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the 6.5m James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
New insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aarsland Dag
- Abdelnour Carla
- ADGC .
- Ahmad Shahzad
- Alarcón-Martín Emilio
- Alcolea Daniel
- Alegret Montserrat
- Allende Irene Rosas
- Alvarez Ignacio
- Amin Najaf
- Amouyel Philippe
- Andrade Victor
- Andreassen Ole A
- Antúnez Carmen
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Armstrong Nicola J
- Arosio Beatrice
- Athanasiu Lavinia
- Bailly Henri
- Banaj Nerisa
- Baquero Miquel
- Barral Sandra
- Beiser Alexa
- Bellenguez Céline
- Below Jennifer E
- Benchek Penelope
- Benussi Luisa
- Berr Claudine
- Besse Céline
- Bessi Valentina
- Biessels Geert Jan
- Binetti Giuliano
- Bis Joshua C
- Bizarro Alessandra
- Blesa Rafael
- Boada Mercè
- Boerwinkle Eric
- Boland Anne
- Borroni Barbara
- Boschi Silvia
- Bossù Paola
- Bresner Catherine
- Bressler Jan
- Brodaty Henry
- Broeckhoven Christine Van
- Brookes Keeley J
- Brusco Luis Ignacio
- Bråthen Geir
- Buiza-Rueda Dolores
- Bullido María J
- Burholt Vanessa
- Bush William S
- Bûrger Katharina
- Calero Miguel
- Campos-Martin Rafael
- Cantwell Laura B
- Carracedo Ángel
- Cecchetti Roberta
- Cervera-Carles Laura
- Chapuis Julien
- Charbonnier Camille
- CHARGE .
- Chen Hung-Hsin
- Chene Geneviève
- Chillotti Caterina
- Chung Jaeyoon
- Ciccone Simona
- Claassen Jurgen AHR
- Clarimon Jordi
- Clark Christopher
- Conti Elisa
- Corma-Gómez Anaïs
- Costa Marcos R
- Costantini Emanuele
- Cuccaro Michael L
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Damotte Vincent
- Daniele Antonio
- Dardiotis Efthimios
- Dartigues Jean-François
- de Deyn Peter Paul
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Paiva Lopes Katia
- de Rojas Itziar
- de Witte Lot D
- Debette Stéphanie
- Deckert Jürgen
- DEGESCO .
- Del Ser Teodoro
- Deleuze Jean-François
- Demgene .
- Denning Nicola
- DeStefano Anita
- Dichgans Martin
- Diehl-Schmid Janine
- Diez-Fairen Mónica
- Djurovic Srdjan
- Dongen Jasper Van
- Dufouil Carole
- Duron Emmanuelle
- Düzel Emrah
- EADB .
- EADI .
- Eiriksdottir Gudny
- Engelborghs Sebastiaan
- Escott-Price Valentina
- Espinosa Ana
- Ewers Michael
- Faber Kelley M
- Fabrizio Tagliavini
- Fardo David W
- Farotti Lucia
- Farrer Lindsay A
- Fenoglio Chiara
- Fernández-Fuertes Marta
- Ferrari Raffaele
- Ferreira Catarina B
- Ferri Evelyn
- Fin Bertrand
- FinnGen .
- Fischer Peter
- Fladby Tormod
- Fließbach Klaus
- Fongang Bernard
- Fornage Myriam
- Foroud Tatiana M
- Fortea Juan
- Fostinelli Silvia
- Fox Nick C
- Franco-Macías Emlio
- Frank-García Ana
- Frikke-Schmidt Ruth
- Froelich Lutz
- Fulton-Howard Brian
- Galimberti Daniela
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas Guillermo
- García-Alberca Jose Maria
- García-González Pablo
- GERAD .
- Ghanbari Mohsen
- Ghidoni Roberta
- Giedraitis Vilmantas
- Giegling Ina
- Giorgio Giaccone
- Goate Alison M
- Goldhardt Oliver
- Gomez-Fonseca Duber
- González-Pérez Antonio
- GR@ACE .
- Graff Caroline
- Grande Giulia
- Green Emma
- Grenier-Boley Benjamin
- Grimmer Timo
- Grunin Michelle
- Grünblatt Edna
- Gudnason Vilmundur
- Guetta-Baranes Tamar
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Haines Jonathan L
- Hamilton-Nelson Kara L
- Hampel Harald
- Hanon Olivier
- Hardy John
- Hartmann Annette M
- Harwood Janet
- Hausner Lucrezia
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T
- Hernández Isabel
- Herrmann Martin J
- Hiltunen Mikko
- Hoffmann Per
- Holmans Peter A
- Holmes Clive
- Holstege Henne
- Hort Jakub
- Hulsman Marc
- Humphrey Jack
- Ikram M Arfan
- Ingelsson Martin
- Jansen Iris E
- Jessen Frank
- Jian Xueqiu
- Johansson Charlotte
- Juan Pascual Sánchez
- Jun Gyungah R
- Kastumata Yuriko
- Kauwe John
- Kehoe Patrick G
- Kilander Lena
- Kivipelto Miia
- Kleineidam Luca
- Koivisto Anne
- Kornhuber Johannes
- Kosmidis Mary H
- Kuksa Pavel P
- Kukull Walter A
- Kunkle Brian W
- Kuulasmaa Teemu
- Kuzma Amanda B
- Küçükali Fahri
- Lage Carmen
- Lambert Jean-Charles
- Laukka Erika J
- Launer Lenore
- Lauria Alessandra
- Lee Chien-Yueh
- Lehtisalo Jenni
- Lerch Ondrej
- Lleó Alberto
- Longstreth William
- Lopez Oscar
- Love Seth
- Luckcuck Lauren
- Lunetta Kathryn L
- Löwemark Malin
- Ma Yiyi
- MacLeod Catherine A
- Macías Juan
- Maier Wolfgang
- Mangialasche Francesca
- Marquié Marta
- Marshall Rachel
- Martin Eden R
- Masullo Carlo
- Mather Karen
- Mayeux Richard
- Mead Simon
- Mecocci Patrizia
- Medina Miguel
- Meggy Alun
- Mehrabian Shima
- Mendoza Silvia
- Menéndez-González Manuel
- Mir Pablo
- Moebus Susanne
- Mol Merel
- Molina-Porcel Laura
- Montes Angel Martín
- Montrreal Laura
- Morelli Laura
- Moreno Fermin
- Moreno-Grau Sonia
- Morgan Kevin
- Mosley Thomas
- Muchnik Carolina
- Mukherjee Shubhabrata
- Nacmias Benedetta
- Naj Adam C
- Ngandu Tiia
- Nicolas Gael
- Nielsen Sune Fallgaard
- Nordestgaard Børge G
- Nöthen Markus M
- Olaso Robert
- Orellana Adelina
- Orsini Michela
- Ortega Gemma
- Padovani Alessandro
- Paolo Caffarra
- Papenberg Goran
- Parnetti Lucilla
- Pasquier Florence
- Pastor Alfonso Arias
- Pastor Ana Belén
- Pastor Pau
- Peloso Gina
- Pericak-Vance Margaret A
- Pericard Pierre
- Peters Oliver
- Pijnenburg Yolande AL
- Pineda Juan A
- Pisanu Claudia
- Piñol-Ripoll Gerard
- Polak Thomas
- Popp Julius
- Posthuma Danielle
- Priller Josef
- Prokic Ivana
- Psaty Bruce M
- Puerta Raquel
- Pérez-Cordón Alba
- Pérez-Tur Jordi
- Quenez Olivier
- Quintela Inés
- Rainero Innocenzo
- Raj Towfique
- Rajabli Farid
- Ramakers Inez
- Ramirez Alfredo
- Real Luis M
- Reinders Marcel JT
- Reitz Christiane
- Reyes-Dumeyer Dolly
- Ridge Perry
- Riedel-Heller Steffi
- Riederer Peter
- Roberto Natalia
- Rodriguez-Rodriguez Eloy
- Rodríguez Carmen Martínez
- Rongve Arvid
- Rosende-Roca Maitée
- Rossi Giacomina
- Rossi Paolo Dionigi
- Royo Jose Luis
- Rubino Elisa
- Ruiz Agustín
- Rujescu Dan
- Rábano Alberto
- Sachdev Perminder
- Sakka Paraskevi
- Saltvedt Ingvild
- Sanabria Ángela
- Sanchez-Garcia Florentino
- Sando Sigrid B
- Sarnowski Chloé
- Satizabal Claudia L
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Schellenberg Gerard D
- Scheltens Philip
- Scherbaum Norbert
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Schott Jonathan M
- Selbæk Geir
- Seripa Davide
- Serrano Manuel
- Seshadri Sudha
- Sha Jin
- Shadrin Alexey A
- Sims Rebecca
- Skrobot Olivia
- Sleegers Kristel
- Slifer Susan
- Snijders Gijsje JL
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solomon Alina
- Song Yeunjoo
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Stordal Eystein
- Ståhlbom Anne Kinhult
- Sáez María Eugenia
- Sánchez-Arjona María Bernal
- Sánchez-Valle Raquel
- Tartan Juan Pablo
- Tesí Niccolo
- Thalamuthu Anbupalam
- Thomas Tegos
- Thomassen Jesper Qvist
- Tosto Giuseppe
- Traykov Latchezar
- Tremolizzo Lucio
- Tsolaki Anthoula
- Tsolaki Magda
- Tybjærg-Hansen Anne
- Tárraga Lluís
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Valero Sergi
- Valladares Otto
- van der Flier Wiesje M
- van der Lee Sven J
- van der Lugt Aad
- van Duijn Cornelia M
- van Rooij Jeroen
- van Swieten John
- Vance Jeffery
- Vandenberghe Rik
- Vardarajan Badri N
- Verhey Frans
- Vidal Jean-Sébastien
- Vilas Raquel Huerto
- Vogelgsang Jonathan
- Vyhnalek Martin
- Wagner Michael
- Wallon David
- Wang Li-San
- Wang Ruiqi
- Weinhold Leonie
- Williams Julie
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Yang Qiong
- Yannakoulia Mary
- Yaqub Amber
- Zare Habil
- Zhang Xiaoling
- Zhao Yi
- Zhu Congcong
- Zulaica Miren
- Álvarez Victoria
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2022
- Field of study
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
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- Krawczyk Marie-Claude
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- Kremmidiotis Gabriel
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- Kruchowski Scott S.
- Kube Michael
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- Wray Paul
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- Wright Debbie
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- Wright Rita A.
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- Wu Jung-Rung
- Wu Kevin
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- Wu Qingfa
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- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
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- Xiong Yuqing
- Xu Alex
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- Xu Ruqin
- Xu Shuhua
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- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
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- Yang Shudong
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- Yang Xiaonan
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- Yao Zhijian
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- Ye Chen
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- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
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- Adamali H.
- Adeloye D
- Adeyemi Oluwaseun
- Adrego Rita
- Aguilar Jimenez Laura A.
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- Ahmad Shanaz
- Ahmed R
- Ahwireng Nyarko
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- Alamoudi Asma
- Alfaro-Almagro Fidel
- Ali Mariam
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- Almeida Paula
- Altmann Danny
- Alvarez Corral Maria
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- Stockdale Sue
- Stockley J
- Stoker Wendy
- Stone Roisin
- Storrar Will
- Storrie Andrew
- Storton Kim
- Stringer E
- Strong-Sheldrake Sophia
- Stroud Natalie
- Subbe Christian
- Sudlow C L
- Suleiman Z
- Summers C
- Summersgill C
- Sutherland Debbie
- Sykes D.L.
- Sykes R.
- Talbot Nick
- Tan Ai Lyn
- Tarusan Lawrence
- Tavoukjian Vera
- Taylor Abigail
- Taylor Chris
- Taylor Jessica
- Te Amelie
- Tedd H.
- Tee Caroline
- Teixeira J
- Tench Helen
- Terry Sarah
- Thackray-Nocera Susannah
- Thaivalappil Favas
- Thamu B
- Thickett D
- Thomas Andrew K.
- Thomas Caradog
- Thomas David C.
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- Thompson T
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- Tilley Jo
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- Turnbull A
- Turner E
- Turner Kim
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- Turner Victoria
- Turney Sharon
- Turtle Lance
- Turton Helena
- Ugoji Jacinta
- Ugwuoke R
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- Valabhji J.
- Ventura M
- Vere Joanne
- Vickers Carinna
- Vinson B
- Wade Elaine
- Wade Phillip
- Wain Louise V
- Wainwright Tania
- Wajero Lilian O.
- Walder S
- Walker S
- Walker S.
- Wall E
- Wallis T
- Walmsley S
- Walsh J.A.
- Walsh S.
- Warburton Louise
- Ward T J C
- Warwick Katie
- Wassall Helen
- Waterson Samuel
- Watson Ekaterina
- Watson James
- Watson L.
- Webster M
- Weir-McCall Jonathan R
- Welch C
- Welch H.
- Welsh B.
- Wessely S.
- West Sophie
- Weston Heather
- Wheeler H
- White Sonia
- Whitehead Victoria
- Whitney J.
- Whittaker S
- Whittam Beverley
- Whitworth V
- Wight A
- Wild James M
- Wilkins M.
- Wilkinson D
- Williams B
- Williams Jenny
- Williams N
- Williams Nick
- Williams-Howard S.A.
- Willicombe M.
- Willis Gemma
- Willoughby J
- Wilson Ann
- Wilson D
- Wilson Imogen
- Window Nicola
- Witham M.
- Wolf-Roberts Rebecca
- Wood Chloe
- Woodhead F
- Woods Janet
- Wootton Daniel G.
- Wormleighton J
- Worsley J.
- Wraith D
- Wrey Brown Caroline
- Wright C.
- Wright L
- Wright S.
- Wyles J.
- Wynter Inez
- Xie Cheng
- Xu M
- Yasmin Najira
- Yasmin S
- Yates Tom
- Yip K P
- Young A.
- Young B.
- Young Susan
- Yousuf A J
- Zawia Amira
- Zeidan Lisa
- Zhao Bang
- Zheng Bang
- Zongo O.
- Publication venue
- Elsevier
- Publication date
- 22/09/2023
- Field of study
Introduction:
The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures.
Methods:
In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025.
Findings:
Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation.
Interpretation:
After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification
Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
- Author
- Aarsland Dag
- Aarsland Dag
- Abdelnour Carla
- Abraham Richard
- Abraham Richard
- Adarmes-Gómez A.D.
- Adarmes-Gómez Ad
- Aguilera N.
- Aguilera Nuria
- Ahmad Shahzad
- Al-Chalabi Ammar
- Al-Chalabi Ammar
- Alarcon E.
- Alarcón-Martín E.
- Alarcón-Martín Emilio
- Alcolea Daniel
- Alegret M.
- Alegret Montserrat
- Alonso M.D.
- Alvarez Ignacio
- Alvarez Victoria
- Ambati Aditya
- Amer-Ferrer G.
- Amin Najaf
- Amouyel Philippe
- Amouyel Philippe
- Amouyel Phillippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Andreoni Simona
- Annuar Azlina Ahmad
- Antequera M.
- Anthoula Tsolaki
- Antikainen Riitta
- Antonell Anna
- Antúnez C.
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arfan Ikram M.
- Arias Pastor Alfonso
- Ariel Prestia Federico
- Armstrong Nicola J.
- Arosio Beatrice
- Arosio Beatrice
- Assogna Francesca
- Athanasiu Lavinia
- Athanasiu Lavinia
- Au Wing-Lok
- Bahrami Shahram
- Bailly Henri
- Banaj Nerisa
- Baquero M.
- Baquero Miquel
- Bass Nicholas J.
- Bass Nick
- Bastiani Patrizia
- Bayer Anthony
- Becker Tim
- Belezhanska Diyana
- Bellenguez Céline
- Bellenguez Céline
- Bellenguez Céline
- Belloy Michael E.
- Belén Pastor Ana
- Ben-Shlomo Yoav
- Benussi Alberto
- Benussi Luisa
- Benussi Luisa
- Bergh Sverre
- Bernal M.
- Bernardo-Harrington Mateus
- Berr Claudine
- Berr Claudine
- Besse Céline
- Bessi Valentina
- Binetti Giuliano
- Bizarro Alessandra
- Bjerke Maria
- Blennow Kaj
- Blesa R.
- Blesa Rafael
- Boada M.
- Boada M.
- Boada Mercè
- Boada Mercè
- Boecker Henning
- Boland Anne
- Boland Anne
- Borroni Barbara
- Borroni Barbara
- Boschi Silvia
- Bosnes Ingunn
- Bossù Paola
- Brayne Carol
- Brayne Carol
- Bresner Catherine
- Brice Alexis
- Brodaty Henry
- Brookes Keeley J.
- Brown Kristelle
- Brown Kristelle S.
- Bråthen Geir
- Bråthen Geir
- Buendia M.
- Buendia Mar
- Buiza-Rueda D.
- Buiza-Rueda Dolores
- Bullido M.J.
- Bullido María J.
- Bullido María J.
- Burguera J.A.
- Burholt Vanessa
- BÛrger Katharina
- Caffarra Paolo
- Calero M.
- Calero Miguel
- campion Dominique
- Campos-Martin Rafael
- Cano A.
- Carracedo A.
- Carracedo Ángel
- Carrillo F.
- Carrillo F.
- Carrion-Claro M.
- Carrión-Claro M.
- Casajeros M.J.
- Castaño Eduardo M.
- Castillo Morales Atahualpa
- Cañabate P.
- Cañabate Pilar
- Cecchetti Roberta
- Cervera-Carles Laura
- Chan Anne Y.Y.
- Chao Yinxia
- Chapuis Julien
- Charbonnier Camille
- Chen Ling
- Chen Yongping
- Chene Geneviève
- Chew Elaine Guo Yan
- Chillotti Caterina
- Chipi Elena
- Chung Sun Ju
- Ciccone Simona
- Ciullo Valentina
- Claassen Jurgen A.H.R.
- Clarimon Jordi
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- Clarimón J.
- Clark Christopher
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- Collinge John
- Conti Elisa
- Corbatón-Anchuelo A.
- Cores Valeria
- Corma-Gómez Anaïs
- Costa Marcos R
- Costantini Emanuele
- Craig David
- Craig David
- Cruz-Gamero J.M.
- Cuesta Carolina
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Damotte Vincent
- Damotte Vincent
- Daniele Antonio
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- Dardiotis Efthimios
- Darling Daniel
- Dartigues Jean-Francois
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- de Rojas Itziar
- de Rojas Itziar
- Debette Stéphanie
- Debette Stéphanie
- Deckert Jürgen
- del Ser T.
- del Ser Teodoro
- Del Zompo Maria
- Deleuze Jean-François
- Deleuze Jean-François
- Deloukas Panagiotis
- Deloukas Pangiotis
- den Bussche Hendrik
- Denning Nicola
- Denning Nicola
- Deramecourt Vincent
- Dermecourt Vincent
- Dichgans Martin
- Dichgans Martin
- Dichgans Martin
- Diego S.
- Diego Susana
- Diehl-Schmid Janine
- Diez-Fairen M.
- Diez-Fairen Mónica
- Dionigi Rossi Paolo
- Djurovic Srdjan
- Djurovic Srdjan
- Dolores Alonso María
- Dowzell Kimberley
- Drichel Dmitriy
- Dubois Bruno
- Dufouil Carole
- Dufouil Carole
- Dufouil Carole
- During Emmanuel
- Duron Emmanuelle
- Düzel Emrah
- Düzel Emrah
- Engelborghs Sebastiaan
- Epelbaum Jacques
- Escott-Price Valentina
- Escott-Price Valentina
- Escuela R.
- Escuela R.
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- Espinosa Ana
- Etchepareborda Ignacio
- Eugenia Sáez María
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- Fallgaard Nielsen Sune
- Farotti Lucia
- Fenoglio Chiara
- Fernández-Fuertes Marta
- Ferrarese Carlo
- Ferreira Catarina B
- Ferri Evelyn
- Feulner Thomas
- Fievet Nathalie
- Fievet Nathalie
- Fin Bertrand
- Fischer Peter
- Fisher Elizabeth
- Fladby Tormod
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- Fließbach Klaus
- Foo Jia Nee
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- Forsell Charlotte
- Fortea J.
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- Fox Nick
- Fox Nick C.
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- Franco E.
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- Frank-García A.
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- Frikke-Schmidt Ruth
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- Froelich Lutz
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- Gailhajenet A.
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- Galeano Pablo
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- Garcia-Madrona Sebastian
- Garcia-Ribas G.
- Garcia-Ribas Guillermo
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- García-Alberca J.M.
- García-Alberca José María
- García-González P.
- García-González Pablo
- García-González Pablo
- Garrote-Espina L.
- Garrote-Espina L.
- Germani Sandra
- Gerrish Amy
- Gerrish Amy
- Ghanbari Mohsen
- Ghidoni Roberta
- Giedraitis Vilmantas
- Giedraitis Vilmantas
- Giegling Ina
- Giegling Ina
- Gill Michael
- Gill Michael
- Gill Michael
- Gim Jungsoo
- Giorgio Giaccone
- Goldhardt Oliver
- Goldhardt Oliver
- González-Péerez A.
- González-Pérez Antonio
- Graff Caroline
- Graff Caroline
- Grande Giulia
- Green Emma
- Greicius Michael D.
- Grenier-Boley Benjamin
- Grenier-Boley Benjamin
- Grenier-Boley Benjamin
- Grimmer Timo
- Grünblatt Edna
- Grünblatt Edna
- Gu Wei
- Guerreiro Rita
- Guetta-Baranes Tamar
- Guitart M.
- Guitart Marina
- Gurling Hugh
- Gwilliam Rhian
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- Gómez-Garre P.
- Gómez-Garre P.
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Hampel Harald
- Hampel Harald
- Hannequin Didier
- Hanon Olivier
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- Hanon Olivier
- Hardy John
- Hardy John
- Hardy John
- Harold Denise
- Harold Denise
- Hartmann Annette M.
- Hartmann Annette M.
- Harwood Janet
- Hausner Lucrezia
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- He Zihuai
- Heilmann-Heimbach Stefanie
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T.
- Hernández Isabel
- Herold Christine
- Herrmann Martin J.
- Heun Reinhard
- Heuser Isabella
- Hevilla S.
- Hiltunen Mikko
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- Hodges Angela
- Hoffmann Per
- Hoffmann Per
- Hollingworth Paul
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- Holmans Peter
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- Holmes Clive
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- Holstege Henne
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- Huerto Vilas Raquel
- Hulsman Marc
- Hüll Michael
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- Ignacio Bacha Juan
- Ignacio Brusco Luis
- Ikeuchi Takeshi
- Ingelsson Martin
- Ingelsson Martin
- Ingino Carlos
- Jan Biessels Geert
- Janowitz Daniel
- Jansen Iris
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- Jessen Frank
- Jessen Frank
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- Johansson Charlotte
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- Jones Lesley
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- Jung Yoo Jin
- Jöckel Karl-Heinz
- Jürgen Deckert
- Kauwe John
- Kehoe Patrick
- Kehoe Patrick G.
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- Kern Silke
- Khor Chiea Chuen
- Kilander Lena
- Kinhult Ståhlbom Anne
- Kivipelto Miia
- Kleineidam Luca
- Klopp Norman
- Kochen Silvia
- Koh Woon-Puay
- Kohler Eduardo
- Kohler Matias
- Koivisto Anne
- Kornhuber Johannes
- Kornhuber Johannes
- Kosmidis Mary H.
- Kuulasmaa Teemu
- Kuulasmaa Teemu
- Kölsch Heike
- Küçükali Fahri
- Küçükali Fahri
- Laatikainen Tiina
- Labrador Espinosa M.A.
- Labrador Ma
- Lacidogna Giordano
- Lacour ndré
- Laczo Jan
- Lafuente A.
- Lafuente Asunción
- Lage C.
- Lage Carmen
- Lage Carmen
- Lambert Jean-Charles
- Lambert Jean-Charles
- Lambert Jean-Charles
- Laske Christoph
- Laukka Erika J
- Lauria Alessandra
- Lawlor Brian
- Lawlor Brian
- Le Guen Yann
- Lee Kun Ho
- Legaz A.
- Lehtisalo Jenni
- Lerch Ondrej
- Lian Michelle M.
- Lian Michelle Mulan
- Lim Jia Lun
- Lim Shen-Yang
- Lin Juei-Jueng
- Lin Ling
- Lindström Jaana
- Lis Palacio Dana
- Lisso Julieta
- Liu Chunfeng
- Liu Jianjun
- Livingston Gill
- Livingston Gill
- Lleó Alberto
- Lleóo A.
- Lord Jenny
- Love Seth
- Love Seth
- Lovestone Simon
- Lovestone Simon
- Luckcuck Lauren
- Luckcuck Lauren
- Luis Royo Jose
- Luo Guo
- Lupton Michelle
- Lupton Michelle
- Luís Royo Jose
- Lynch Aoibhinn
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- Macías Juan
- Magda Tsolaki
- Maier Wolfgang
- Maier Wolfgang
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- Mangialasche Francesca
- Mangone Carlos
- Mann David
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- Manzanares S.
- Mao Chengjie
- Marco Spallazzi
- Maria García-Alberca Jose
- Maroñas O.
- Marquié M.
- Marquié M.
- Marquié Marta
- Marshall Rachel
- Marshall Rachel
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- Martín Elvira
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- Mauleón Ana
- Mayhaus Manuel
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- McGuinness Bernadette
- McGuinness Bernadette
- McQuillin Andrew
- McQuillin Andrew
- Mead Simon
- Mead Simon
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- Menéndez-González Manuel
- Mignot Emmanuel
- Mir P.
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- Miyashita Akinori
- Moebus Susanne
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- Moebus Susanne
- Mok Shi Qi
- Mok Vincent
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- Morelli Laura
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- Naito Tatsuhiko
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- Niida Shumpei
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- Ozaki Kouichi
- Pablo Tartan Juan
- Padovani Alessandro
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- Papenberg Goran
- Papenberg Goran
- Papma Janne
- Park Hyeonseul
- Parnetti Lucilla
- Parnetti Lucilla
- Parveen Kayenat
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- Pasquier Florence
- Pasquier Florence
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- Passmore Peter
- Passmore Peter
- Pastor P.
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- Patel Yogen
- Pei Zhong
- Peixoto Leal Thiago
- Pelejà E.
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- Peltonen Markku
- Peng Rong
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- Perneczky Robert
- Peters Oliver
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- Politis Daniel G.
- Popp Julius
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- Porcel Laura Molina
- Posthuma Danielle
- Powell John
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- Prakash Kumar-M.
- Preckler S.
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- Priller Josef
- Proitsi Petra
- Proitsi Petra
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- Quenez Olivier
- Quintela I.
- Quintela Inés
- Qvist Thomassen Jesper
- Rainero Innocenzo
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- Ramakers Inez
- Ramakers Inez
- Ramirez Alfredo
- Ramirez Alfredo
- Ramirez Alfredo
- Real de Asúa D.
- Real L.M.
- Real Luis M.
- Real Luis M.
- Reinders Marcel J.T.
- Reyes Toso Carlos
- Riedel-Heller Steffi
- Riedel-Heller Steffi
- Riedel-Heller Steffi
- Riederer Peter
- Riemenschneider Matthias
- Rios Mario
- Ritchie Karen
- Roberto Natalia
- Rodrigo S.
- Rodrigo-Herrero Silvia
- Rodriguez-Rodriguez Eloy
- Rodriguez-Rodriguez Eloy
- Rodríguez-Rodríguez E.
- Rojo Matias
- Rong Zhang Bao
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- Rosende-Roca M.
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- Ross Owen A.
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- Rossor Martin
- Rossor Martin
- Roveta Fausto
- Royo J.L.
- Rubino Elisa
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- Ruiz A.
- Ruiz A.
- Ruiz Agustín
- Ruiz Agustín
- Rujescu Dan
- Rujescu Dan
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- Ryan Natalie S.
- Ryan Nathalie
- Ráabano A.
- Rábano Alberto
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- Saenz Aldo
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- Sala Gessica
- Saltvedt Ingvild
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- Sanabria A.
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- Sanchez Abalos Mariana
- Sanchez del Valle Díaz R.
- Sanchez-Garcia Florentino
- Sando Sigrid B.
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- Sastre Merlín Isabel
- Sastre I.
- Satake Wataru
- Scamosci Michela
- Scarmeas Nikolaos
- Scarmeas Nikolaos
- Scarpini Elio
- Scheltens Philip
- Scheltens Philip
- Scherbaum Norbert
- Scherbaum Norbert
- Scherer Martin
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Schneider Anja
- Schott Jonathan M.
- Schott Jonathan M.
- Schürmann Britta
- Selbæk Geir
- Selbæk Geir
- Selnes Per
- Sempere Vicente
- Seripa Davide
- Seripa Davide
- Serpente Maria
- Serrano-Rios M.
- Sevillano Zulma
- Shadrin Alexey A.
- Shadrin Alexey A.
- Shang Hui-Fang
- Shaw Christopher E.
- Shaw Christopher E.
- Shi Chang-He
- Shofany Jacob
- Sims Rebecca
- Sims Rebecca
- Sims Rebecca
- Singleton Andrew B.
- Skoog Ingmar
- Skrobot Olivia
- Sleegers Kristel
- Sleegers Kristel
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solfrizzi Vincenzo
- Solis Patricia
- Solomon Alina
- Song Kyuyoung
- Sorbi Sandro
- Sotolongo-Grau O.
- Sotolongo-Grau O.
- Sotolongo-Grau Oscar
- Spalletta Gianfranco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Squassina Alessio
- Stordal Eystein
- Stordal Eystein
- Strandberg Timo
- Sussams Rebecca
- Sáez M.E.
- Sánchez Juan Pascual
- Sánchez-Arjona María Bernal
- Sánchez-Juan P.
- Sánchez-Juan Pascual
- Sánchez-Valle Raquel
- Sánchez-Valle Raquel
- Takalo Mari
- Talyansky Seth D.
- Tan Ai Huey
- Tan Eng-King
- Tan Eng-King
- Tan Louis C.S.
- Tandiono Moses
- Tegos Thomas
- Teipel Stefan
- Teresa Martínez-Larrad María
- Tesí Niccolo
- Teunissen Charlotte
- Thalamuthu Anbupalam
- Thomas Charlene
- Thomas Tegos
- Thomassen Jesper Qvist
- Thonberg Håkan
- Toda Tatsushi
- Todd Stephen
- Todd Stephen
- Traykov Latchezar
- Tremolizzo Lucio
- Tremolizzo Lucio
- Tsolaki Magda
- Tsolaki Magda
- Tuomilehto Jaakko
- Turton James
- Tybjærg-Hansen Anne
- Tzourio Christophe
- Táarraga L.
- Tárraga Lluís
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Ulstein Ingun
- Uphill James
- Vacca Alessandro
- Valero S.
- Valero S.
- Valero Sergi
- Van Broeckhoven Christine
- van der Flier Wiesje
- van der Flier Wiesje M.
- van der Lee Sven J.
- van der Lugt Aad
- Van Dongen Jasper
- van Duijn Cornelia M.
- Van Duin Cornelia
- van Rooij Jeroen
- van Swieten John
- van Swieten John
- Vandenberghe Rik
- Vardy Emma
- Vargas L.
- Vargas Liliana
- Verhey Frans
- Verhey Frans
- Vicente M.P.
- Vidal Jean-Sébastien
- Vigo-Ortega R.
- Vigo-Ortega R.
- Vivancos L.
- Vogelgsang Jonathan
- Vyhnalek Martin
- Vyhnalek Martin
- Waern Margda
- Wagner Michael
- Wallon David
- Wallon David
- Warden Donald
- Warner Nick
- Warren Jason D.
- Weber Heike
- Weinhold Leonie
- Wichmann H-Erich
- Wilcock Gordon
- Williams Amy
- Williams Julie
- Williams Julie
- Williams Julie
- Wiltfang Jens
- Wiltfang Jens
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Wu Yih-Ru
- Xu Renshi
- Xu Yu-ming
- Yan Yaping
- Yang Jing
- Yannakoulia Mary
- Yaqub Amber
- Yogeshwar Selina Maria
- Yonkova Mihova Kalina
- Yu Eric
- Zetterberg Henrik
- Zettergren Anna
- Zhang Jing
- Zulaica Miren
- Álvarez I.
- Álvarez V.
- Álvarez Victoria
- Publication venue
- National Academy of Sciences
- Publication date
- 29/08/2023
- Field of study
Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
- Beane Abi
- Beane Abigail
- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
- Beavis Sarah
- Beddows Seonaid
- Bedford Caroline
- Beer Deborah
- Beer Sally
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Belletti Allesandro
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Bentley Andrew
- Benyon Sarah
- Benzekri Dalila
- Beqai Besa
- Berdaguer Fernando
- Beresford Stephanie
- Bergin Colin
- Berry Lindsay R.
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bharaj Kiranjit
- Bhattarai Bina
- Bhattarai Binita
- Bhonagiri Deepak
- Biddie Simon
- Bigas Judit
- Bihari Shailesh
- Bin Hasan Mohd Shahnaz
- Bindels Manon
- Binnie Alexandra
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- Birch Janine
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- Birkinshaw Isobel
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- Boivin Anne-Hélène
- Bojunga Jörg
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- Bongaerts Katherine
- Bonner Stephen
- Bonten Marc J. M.
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
- Boschert Catherine
- Bossard Isabelle
- Bothma Pieter
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- Bounab Rania
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- Bourne Richard
- Boutin Mireille
- Bouvier Elodie
- Bouw-Ruiter Marianne
- Boué Yvonnick
- Bowen James
- Bowler Helen
- Boyd Craig
- Boyles Rebecca
- Bracke Stephanie
- Bradbury Charlotte A.
- Bradley Paul
- Brady Kara
- Brailsford Jane
- Brain Matthew
- Brakké Karen
- Brant Emily
- Brasselet Aurélie
- Breen Patrick
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- Brugman Curt
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- Brunkhorst Frank M.
- Brunskill Nigel
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- Castelain Vincent
- Castle James
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- Catorze Nuno José Teodoro Amaro dos Santos
- Cattelan Jessy
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- Chartier Delphine
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- Chassé Michaël
- Chen Jonathan
- Chen Lixian
- Chen Yan
- Cheng Allen C.
- Cherian Shiney
- Chhablani Manish
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- Chukkambotla Sri
- Ciccarelli Michele
- Cirstea Emanuel
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- Clermont Gilles
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- Cook Tim
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- Cornell Thomas
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- D?Aragon Frédérick
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- Daher Rana
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- Darnell Robert
- Darreau Cedric
- Daugherty Jason
- Davey Miriam
- Davidson Neil
- Davies Ellie
- Davies Gwyneth
- Davies Jennifer
- Davies Louisa
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- Davies Rhys
- Dawson Laura Ann
- Dawvda Ashlish
- Day Christopher
- Da Rocha Joana
- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
- de Jonge Evert
- De Keulenaer Bart
- de la Torre Cisneros Julian
- de Man Angelique
- De Neef Mark
- De Smeytere Anouska
- Deacon Bethan
- Dean Steven
- Dean Tessa
- Dearden Joy
- Dechert William
- Declercq Pierre-Louis
- Degracia Anna
- del Sorbo Lorenzo
- Dela Rosa Arnold
- Delaney Kirsha
- Dell Abbie
- del Prado Michael
- Demetriou Carrie
- Dempster Debra
- Denham Lynn
- Denmade Craig
- Dent Martin
- Depante Maria
- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie P. G.
- Deshpande Kush
- Detry Michelle A.
- Deye Nicolas
- de la Fuente Carmen
- De Waele Jan
- Dheke Krishan
- Di Lucca Giuseppe
- Dias Priya
- Dice Julie
- Digby Stephen
- Diridis Kristina
- Distler Michael
- Dobell-Brown Kelsey
- Doble Patricia
- Dobson Jade
- Doherty Kaleigh
- Doherty Ronan
- Doi Yohei
- Dolman Rozzie
- Domingo-Marco Joana
- Donadee Chenell
- Donaldson Kate
- Dondrop Arjen
- Donegan Clare
- Donlon Sinead
- Donnelly Adrian
- Donnelly Kieran
- Donnison Phil
- Doonan Reece
- Doran Peter
- Dore Rachael
- Dormand Natalie
- Dos Santos Filipa
- Douillard Thomas
- Drake Chelsea
- Drapola Debra
- Drayss Maria
- Drummond Andrew
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- Duffy Oscar
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- Duke Zoe
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- Dunsavage Janice
- Duplaix Mathilde
- Duric Natalie
- Duroux Maree
- Dushianthan Ahilanandan
- Dyas Sarah
- Eapen Beena
- Eastgate Christine
- Ebenezer R
- Edmunds Natasha
- Edwards Alexandra
- Efford Georgia
- Egreteau Pierre
- Ehrmann Stephan
- Eichenauer Dennis
- Eisenbeis Simone
- Ekhérian Jean-Michel
- El-Khawas Khaled
- Elender Corinna
- Elgendy Ahmad
- Elhassan Munzir
- Ellervee Anneli
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- Epelman¸ Slava
- Eroglu Ege
- Estcourt Lise J.
- Estensen Kristen
- Evans Amy
- Evans Andrew
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- Ezekowitz Justin
- Fagan Laura
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- Godement Mathieu
- Godoy Lucas C.
- Goebeler M.E.
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- Goldman John
- Goligher Ewan
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- Goralski Patricia
- Gordon Anthony C.
- Gosbell Iain
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- Guerineau Elodie
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- Gómez Francisco
- Göpel Siri
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- Haider Nafeesah
- Haider Syeda
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- Hakak Sheeba
- Halden Sandra
- Haldeos Anne
- Hall Alistair S
- Hall Amelia
- Hall Andrew
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- Hall Rebecca
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- Harrison Susan
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- Harvala-Simmonds Heli
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- Hashmi Madiha
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- Hawcutt Daniel
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- Headlam Evie
- Healey Gail
- Hegazy Ahmed
- Hegazy Mohamed
- Heinonen Jonna
- Helms Julie
- Heming Nicholas
- Henderson Kelly
- Henderson Steven
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- Hernandez Erik
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- Hey Samuel
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- Hierons Sarah
- Higgins Alisa M.
- Hill Claire
- Hill Dianne
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- Hindle Grace
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- Hornsby James
- Horton Michelle
- Horvat Christopher M.
- Howcroft Clare
- Howell Alice
- Hower Martin
- Howie Lucy
- Howle Ryan
- Hoxha Elvira
- Huang David T.
- Hughes Debbie
- Hugill Keith
- Huijbens Danique
- Hullegie Sebastiaan
- Hulley Amanda
- Hulme Jonathan
- Hulse Sarah
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- Jafarzadeh Mina
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- McGuinness Shay P.
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- van Amerongen Roosmarijn
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- van Bree Sjoerd
- van de Veerdonk Frank L.
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- van der Eng Hetty
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- van Gulik Laura
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- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
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- Yates David
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- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
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- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
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- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
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- Alvarez Josep Trenado
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- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
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- Yang Yanping
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- Yao Xiuying
- Yao Yanlan
- Yao Zhiru
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- Yeon-Joo Lee
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- Yilmaz Hakan
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- Yu Min
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- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- 'Organisation for Economic Co-Operation and Development (OECD)'
- Publication date
- 26/02/2021
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
Recommended from our members
Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
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- Mickelsson Ulrica
- Microys Sherissa
- Migliorino Pina
- Mihaljevic Slobodan
- Mikaszewska-Sokolewicz Malgorzata
- Mikkelsen Sanne
- Milic Morena
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- Milner Wendy
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- Nava Claudia Lizbeth Lopez
- Nava Luis Pedro Ambriz
- Navarro Berenice
- Navarro José Alejandro
- Negro Alessandra
- Nestora Konstantina
- Newby Lynette
- Ngo Delphine
- Ni Dongshu
- Nieto Montserrat Venturas
- Nikolaou Charikleia
- Nishime Yoshimasa
- Noblezada-Uy Debbie
- Nocheretti Mariangeles Gabriela
- Noguchi Ayako
- Nogueira Paula Cristina
- Nor Basri Mat
- Nor Mohd Basri Mat
- North Samantha
- Nshimyumuremyi Isaac
- Nunes Catarina
- Nuñez Cesar Rodriguez
- Nyhus Marit
- Nzarora Josue
- Ochoa Maria-Elena
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- Ogbeide Vongayi
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- Owens Daniel
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- O’Brien Catherine
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- Pagella Gonzalo
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- Palo Jose Emmanuel
- Pan Fuqun
- Pang Xuelian
- Panka Bernardo
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- Papadopoulos Dimitrios
- Papageorgiou Eirini
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- Parag Nivisha
- Parente Isabel
- Park Jisoo
- Park Seung Yong
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- Park Sunghoon
- Park Tai Sun
- Parke Rachael
- Parkin Emma
- Parsons Leanne
- Parsons Penny
- Pascual-Bielsa Ana
- Pastore Beatrice
- Pastores Stephen M.
- Pathak Sabina Dhakal
- Patrichi Tatiana
- Patsalos Artemis
- Patsiou Eirini-Chysovalanto
- Pavlisa Gordana
- Pedersen Anne Sofie Bomholt
- Pedersen Karin Rehnholt
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- Peratoner Alberto
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- Peterson Jessica
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- Petrisor Cristina
- Petrushin Maxim
- Pečenković Suzana
- Philippart François
- Piergentili Federica
- Pili-Floury Sébastien
- Pillard Cindy
- Pineda Ana Alícia Velarde
- Pinheiro Cristiana Mota
- Pinto Susana
- Pinto Vitor Manuel Vaz
- Piradov Michael
- Pires Filpe
- Pivkina Alexandra
- Piza Petr
- Piñan Isabel Santín
- Plantefève Gaëtan
- Pleitinckx Vincianne
- Polgarova Petra
- Polo Ana Belén Curto
- Popescu Mihai
- Popescu Monica
- Potestio Christopher
- Powell Madeleine
- Preda Gabriel
- Prol-Silva Estefanía
- Prowle John
- Psarulis Konstantinos
- Pulak Paul
- Pulletz Mark
- Putruele Sofia
- Qawasmeh Khaled Al
- Qiao Hongmei
- Quagliotto Catia
- Quaini Attilio
- Quintard Hervé
- Quiroga Cristian
- Rabarova Daria
- Radavidson Anthony
- Radivojevic Renata Curic
- Rahim Azmin Huda Abdul
- Raimondo Arena
- Raitsiou Bogdan
- Raizman Rose
- Raj Ashok Sundai
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- Ramaker Bart
- Ramalho Aline
- Ramirez Mario
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- Ran Qiong
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- Ratnam Shanthi
- Ratnam Shanti
- Ravani Ifigenia
- Reece-Anthony Rosie
- Reidinga Auke
- Reijntjens Jennifer
- Remor Natalie
- Ren Aiua
- Reyes Amylkar Garay
- Reyes Amylkar José Garay
- Reyes Laura Martinez
- Reyes Paul Eric
- Reynolds Claire
- Ribas Antoni Margarit
- Ribas Antonio Margarit
- Riera Alba
- Riessen Reimer
- Ringdal Mona
- Rinket Martin
- Ripolles-Melchor Javier
- Rita Clara Santa
- Rivas Juan Carlos
- Rivas Noelia
- Riveiro Marilyn
- Rizzo Antonino
- Rocco Monica
- Rocha Pamela
- Rodriguez Gabriel Enrique
- Rojas-Suarez José
- Rokosh Ella
- Roller Martin
- Roman-Pognuz Erik
- Romero-Gonzalez Juan P.
- Ronchini Ana Lucia Vitti
- Rooney Glenda
- Rosado Ines
- Rosalia Rodney
- Rosati Moris
- Rose Bernd Oliver
- Rose Louise
- Rostello Oscar Fernández
- Rothenfusser Monika
- Rubulotta Francesca
- Rubulotta Giorgia
- Rygvadottir Brynja
- Saager Leif
- Sabbag Ignacio
- Saha Rajnish
- Sakki Jenni-Katarina
- Sakuramoto Hideaki
- Salazar Janel
- Salberg Armorel
- Salman Fatema
- Salo Swagotika
- Salvà-Costa Vicent
- Samat Noryani Mohd
- Sanchez Losune Cano
- Sanchez Maria Angeles Hurtado
- Sanchez-Hurtado Luis Alejandro
- Sandberg Ulla
- Sandesc Dorel
- Sankar-Maharaj Sasha
- Sankey Babangida John
- Santiago Eleanor
- Santos Jacinta
- Santos Rayanne
- Sanz Luz Coronado
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- Sarkar Nikki
- Saul Pablo
- Sawawiboon Chaiwut
- Schaller Stefan
- Schallom Marilyn
- Schefold Joerg C.
- Schmidt Raysa Cristina
- Schmollgruber Shelley
- Schmukler Armando
- Schmutz René
- Schulze Tobias
- Schüppel Sebastian
- Scire Giovanni
- Scutariu Monica Adriana
- Sellami Walid
- Sepulveda Maria Idalia
- Sergeev Dmitry
- Serin Sibel Ocak
- Seromenho Vanda
- Serpa Leticia
- Sertznig Claude
- Setten Mariano
- Shah Bhagyesh
- Shao Hongyan
- Shaw David
- Shawish Sabah Abu
- Shayamano Rosina
- Sheehan Christine
- Shen Yanling
- Sherwin James
- Shi Guanxiu
- Shi Zeya
- Shime Nobuaki
- Shimizu Masako
- Short Jack
- Shosholcheva Mirjana
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- Sierra Rafael
- Sills Martin
- Silva Pedro
- Sim Yun Su
- Simi Marcelo
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- Singh Keevan
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- Slobodianiuk Gari
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- Smiley Kathleen Ann
- Smith Catherine
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- Stones Elizabeth
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- Tababa Osama Wanees Emhemid
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- Tapia Fernando
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- Tejeda-Huezo Brigitte
- Telleria Vanesa Mercado
- Templeton Mae
- Terry Dorothy
- Tervo-Heikkinen Tarja
- Thankamma Bindu
- Theisen Christian
- Thix Cyril
- Tholioti Thomai
- Thoma Giannoula
- Thomas Beverley
- Thompson Amy
- Thompson Lorraine
- Thomsen Tina Damgaar
- Thorpe Elaine
- Tian Eryun
- Tian Xiao Fang
- Tian Yani
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- Timsit Jean-Francois
- Tingsvik Catarina
- Tirado Celia
- Toellefsen Annette
- Tokareva Ekaterina
- Tokur Murat Emre
- Tole Eunice
- Tomescu Dana
- Tong Jenny May Geok
- Tonkovic Dinko
- Toppin Patrick
- Torlinski Tomasz
- Traina Lidia
- Tranello Francesca Paola
- Tribulev Maksim
- Tridente Ascanio
- Triki Ahmed Ramadan
- Tripathy Swagata
- Trongtrakul Konlawij
- Trongtratul Konlawij
- Trposak Angela
- Trudvang Siw
- Trueman-Dawkins Treiza
- Tsarev Alexander
- Tsikriki Syragoula
- Tsikritsaki Kyriaki
- Tsujimoto Mayumi
- Tubacka Marta
- Tuinstra Binny
- Tuo Lili
- Turan Can
- Turan Sema
- Turc Jean
- Turner Sarah Jane
- Turčan Anton
- Tutillo Diego Rolando Morocho
- Twagirumugabe Theogene
- Twiggs Hilary
- Uba Stella
- Uccelli Francesco
- Udiljak Nikolina
- Ugwu Innocent
- Umek Nejc
- Undar Hasan Nabi
- Vakalos Aristeidis
- Valerio Idália
- Valgolio Emanuel
- Valta Maija
- Valta Maija Anniina
- van Axel Alisha
- Van Cotthem Ilse
- Van de Velde Stijn
- Van Den Berg Lettie
- Van Den Brink Mark
- Van Den Elst Arlette
- van der Kuil Mark
- Van Gulik Laura
- Van Regenmortel Niels
- Van Vliet Peter
- Vanroest Margijske
- Varela Maria
- Vaschetto Rosanna
- Vasquez Alexandra
- Vaughan-Jones Nicola
- Velickovic Jelena
- Veličković Dejan
- Ventour Dale
- Vermeijden Jan Wytze
- Vieira João
- Villa Robert
- Villafuerte Missael Vladimir Espinoza
- Villanueva Ximena
- Villegas Paula
- Viveiros Abel
- Vizcaychipi Marcela
- Vlaovic Janko
- Vochin Ana
- Volta Carlo Alberto
- von der Osten Ingrid
- Von Der Osten Ingrid
- von Lewinski Dirk
- Vosylius Saulius
- Vuković Anita
- Vullum Sylvi
- Vymazal Tamas
- Vymazal Tomas
- Wahab Sherliza
- Wahlbom Ewa
- Waibel Hansjoerg
- Wallin Ewa
- Walsh Amy
- Wan Jianhong
- Wan Yan
- Wang Damei
- Wang Fanglan
- Wang GuoXian
- Wang Hai Yun
- Wang Haiyan
- Wang Jing
- Wang Kefang
- Wang LingLing
- Wang RuiXia
- Wang Shuhui
- Wang Shuo
- Wang Wei
- Wang Wenmei
- Wang Xiaomin
- Wang Yan
- Wang Ying
- Wang Yingli
- Wang Yuping
- Wang Yuxia
- Watts Stacey
- Waweru-Siika Wangari
- Wei Dongfang
- Wei Wei
- Wei Xiyan
- Wei Ying
- Welters Ingeborg D.
- White Joanne
- White Nigel
- Whiteley Simon
- Whitticase Richard
- Wiborg Elisabeth
- Wijnands Patricia
- Wilby Liz
- Williams Anne
- Williams Ged
- Williams Helen
- Williams Karen
- Williams Lynne
- Wilting Rob
- Wise Robert
- Woods Justin
- Wright Kerry
- Wu Juan
- Wu ShiFen
- Wu Xiaojun
- Wu Xiaoying
- Wu Yang
- Wu Yun
- Wu Zijing
- Xhindi Nordian
- Xia Chun Jie
- Xia Xinhua
- Xiao Lina
- Xiao Min
- Xiao Yan
- Xiaoyan Yang
- Xie Yan
- Xing Cynthia
- Xiong Yunfeng
- Xixi Li
- Xu Lina
- Xu Xiao
- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
- Yang Lei
- Yang Qiao
- Yang Shunzhu
- Yang Yanping
- Yang YongXia
- Yao Xiuying
- Yao Yanlan
- Yao Zhiru
- Ye Man
- Ye Mei
- Yeni Nomhle Princess
- Yeon-Joo Lee
- Yildiz İsmail
- Yilmaz Hakan
- Yin Hai
- Yin Li
- Young Charlotte
- Young-Jae Cho
- Yu Jing
- Yu Min
- Yu Tingting
- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- Intensive Care Medicine
- Publication date
- 09/04/2021
- Field of study
The original version of this article unfortunately contained a mistake