Adiponectin: Obesity and Development of Different Diseases

Revisión bibliográfica de la relación entre adiponectina, obesidad y desarrollo de diferentes enfermedadesAdiponectin is an adipokine abundantly expressed in adipose tissue, which has been well characterized, demonstrating its beneficial effect on human health, circulates in the bloodstream in various isoforms, playing different roles in the balance of energy homeostasis. Adiponectin is an insulin sensitizing hormone that exerts its action through AdipoR1, AdipoR2 and T-cadherin receptors. AdipoR1 is abundantly expressed in muscle, whereas AdipoR2 is expressed predominantly in the liver. Adiponectin is inversely proportional to obesity, diabetes and other states of insulin resistance; this review presents current findings regarding regulation, production and biological effects. Adiponectin acts by activating AMPk (AMP-activated protein kinase) and thus the enzymatic modulation so that the signaling pathways play an important role in the regulation, in addition to the above it has been demonstrated that the deregulation in the biogenesis and function of the miRNAs contributes to the appearance and development of diverse diseases

Proyecto para implementar la gestión de documentos en un ERP (Enterprise Resource Planning)

Aquest article explica una experiència d’implementar un sistema de gestió de documents per un ERP (Enterprise Resour-ce Planning) que ja incorpora un EDMS (Electronic Document Management System) que no compleix els requisits d’un EDRMS (Electronic Document and Record Management System). És un projecte pensat i desenvolupat per una empresa privada, Oficina Ponti, SLP, liderat pel Servei d’Arxiu i Gestió de Documents d’Oficina Ponti, SLP amb la col·laboració de Sistemes d’Informació i de Comunicació d’Oficina Ponti, SLP. El projecte te com a objectiu integrar el cicle complet de la documentació, des de que ingressa al sistema i es classifica, passant per la validació i, finalment, per la preservació i/o eliminació.This paper explains the implementation of a document management system in an ERP (Enterprise Resource Planning). This ERP although has already incorporated an EDMS (Electronic Document Management System), it fails to comply with the requirements of a EDRMS (Electronic Document and Record Management System). This project has been designed and developed by a private company – Oficina Ponti, SLP – leadered by its Archival and Records Management Service and Information and Communication Systems. The aim of this project is integrating the documentation life cycle considering the registration of a record in the records system, its classification, appraisal, disposition and finally preservation or destruction.Este artículo explica una experiencia de implementar un sistema de gestión de documentos para un ERP (Enterprise Re-source Planning) que ya incorpora un EDMS (Electronic Document Management System) que no cumple los requisitos de un EDRMS (Electronic Document and Record Management System). Es un proyecto pensado y desarrollado por una em-presa privada, Oficina Ponti, SLP, liderado por el Servicio de Archivo y Gestión de Documentos de Oficina Ponti, SLP con la colaboración de Sistemas de Información y de Comunicación de Oficina Ponti, SLP. El proyecto tiene como objetivo integrar el ciclo completo de la documentación, desde que ingresa al sistema y se clasifica, pasando por la validación y, finalmente, para la preservación y / o eliminación

Oral candidiasis in patients with renal transplants

Objectives: Oral candidiasis (OC) is a frequent oral lesion in renal transplant patients (RTPs). Despite the in - creased prevalence of OC in RTPs, no study has examined related risk factors. The aims of this study were to analyze the prevalence of and risk factors for OC in RTPs compared with age- and gender-matched healthy control group (HC) as well as determine the incidence of OC after transplantation. Study D esing: We analyzed the prevalence and risk factors of OC in a group of 500 RTPs (307 men, 193 women, mean age 53.63 years) and 501 HC subjects (314 men, 187 women, mean age 52.25 years). Demographic and pharmacological data were recorded for all subjects. Incident cases of OC were ascertained retrospectively from outpatient clinical records only in the RTP group. Results: The prevalence of OC was 7.4% in RTPs compared with 4.19% in HC (P<0.03). The most frequent type of OC in the two groups was denture stomatitis. Statistical association was found between OC and age, mycophe - nolate mofetil dose and blood levels, dentures and tobacco. The multiple logistic regression model only chose for denture variable. According to the outpatient clinical records, 24 RTPs suffered OC during the first moth post- transplant. Severe lesions affecting the oral cavity and pharynx appeared in 79% of the OC cases. Conclusions: This study shows a lower prevalence of OC in RTPs than previous reports. Denture stomatitis was the most frequent OC prevalence form described in RTPs. Severe candidiasis is more frequent in the immediate posttransplant period. The presence of denture is an important risk factor of OC. These results emphasise the importance of adequate pre- and post-transplant oral health and denture cleaning and adjustment is recommended for these subjects to prevent this infection

The family of DOF transcription factors in Brachypodium distachyon: phylogenetic comparison with rice and barley DOFs and expression profiling

ABSTRACT: Transcription factors (TFs) are proteins that have played a central role both in evolution and in domestication, and are major regulators of development in living organisms. Plant genome sequences reveal that approximately 7% of all genes encode putative TFs. The DOF (DNA binding with One Finger) TF family has been associated with vital processes exclusive to higher plants and to their close ancestors (algae, mosses and ferns). These are seed maturation and germination, light-mediated regulation, phytohormone and plant responses to biotic and abiotic stresses, etc. In Hordeum vulgare and Oryza sativa, 26 and 30 different Dof genes, respectively, have been annotated. Brachypodium distachyon has been the first Pooideae grass to be sequenced and, due to its genomic, morphological and physiological characteristics, has emerged as the model system for temperate cereals, such as wheat and barley. RESULTS: Through searches in the B. distachyon genome, 27 Dof genes have been identified and a phylogenetic comparison with the Oryza sativa and the Hordeum vulgare DOFs has been performed. To explore the evolutionary relationship among these DOF proteins, a combined phylogenetic tree has been constructed with the Brachypodium DOFs and those from rice and barley. This phylogenetic analysis has classified the DOF proteins into four Major Cluster of Orthologous Groups (MCOGs). Using RT-qPCR analysis the expression profiles of the annotated BdDof genes across four organs (leaves, roots, spikes and seeds) has been investigated. These results have led to a classification of the BdDof genes into two groups, according to their expression levels. The genes highly or preferentially expressed in seeds have been subjected to a more detailed expression analysis (maturation, dry stage and germination). CONCLUSIONS: Comparison of the expression profiles of the Brachypodium Dof genes with the published functions of closely related DOF sequences from the cereal species considered here, deduced from the phylogenetic analysis, indicates that although the expression profile has been conserved in many of the putative orthologs, in some cases duplication followed by subsequent divergence may have occurred (neo-functionalization)

Características de la demanda no urgente en el servicio de emergencia de un hospital de la seguridad social en el Perú: Characteristics of the non-urgent demand in the emergency service of a social Security hospital in Peru

Objective: To describe the characteristics of patients with non-urgent demand to the emergency room of an urban social security hospital. Methods: Observational study in a referral hospital. Stratified random sampling, 120 patients older than 14 years of priority IV (patients without commitment to vital functions or risk of immediate complication, which can be attended in outpatient room or decentralized offices). A validated predesigned questionnaire was applied. Performing descriptive statistics with IBM SPSS 24. Results: 66% of patients were female, most frequent ages over 65 years and between 20-40 years. 47% were active workers, with high school level or higher 86%, they had 83% personal cell phone and 73% wire TV or internet at home. 63% arrived at the public transport emergency, the delay time to the hospital was 30-60 minutes in 50% of cases and &amp;lt;30 minutes in 28%. He did not know his primary care center 33%, he was never treated before in this 57% and did not go to another health facility prior to his 87% emergency arrival. Most frequent symptoms: malaise, odynophagia, diarrhea and low back pain; with presentation time between hours and days in 91% of cases. Conclusion: Non-urgent consultation patients in the emergency room are predominantly female, young and old people, who are active in work, with a high level of education and access to communications technology, reside near the hospital and do not know their primary care center.Objetivo: Describir las características de pacientes con demanda no urgente en el departamento de emergencia de un hospital urbano de la seguridad social en el Perú. Métodos: Estudio observacional realizado en un hospital nacional de referencia. Muestreo aleatorio estratificado en una semana, 120 pacientes mayores de 14 años de prioridad IV (signos vitales estables, sin riesgo de complicación inmediata y de consulta externa general). Se aplicó un cuestionario prediseñado validado. Resultados: El 66% de pacientes fue de sexo femenino. Las edades más frecuentes fueron mayores de 65 años y el grupo de 20 a 40 años. El 47% fueron trabajadores activos, con nivel de instrucción secundaria o superior en 86% de casos. El 83% contaban con teléfono celular personal y el 73% con televisión por cable o internet en su domicilio. El 63% llegó a emergencia en transporte público. El tiempo de demora hasta el hospital fue 30-60 minutos en el 50% de casos y &amp;lt; 30minutos en 28%. El 33% no conocía su centro de atención primaria y el 87% no acudió a otro establecimiento de salud previo a su arribo a emergencia. Los síntomas más frecuentes incluyeron malestar general, odinofagia, diarrea y lumbalgia. El tiempo de enfermedad fue de horas a días en el 91% de casos. Conclusión: Los pacientes de consulta no urgente que acuden al servicio de emergencia son predominantemente de sexo femenino, adultos jóvenes y mayores, laboralmente activos, con alto nivel educativo y acceso a tecnología de comunicaciones, residentes en áreas cercanas al hospital y sin conocimiento de su centro de atención primaria

Classroom Indoor Environment Assessment through Architectural Analysis for the Design of Efficient Schools

[Abstract] Optimization of environmental performance is one of the standards to be achieved towards designing sustainable buildings. Many researchers are focusing on zero emission building|nhowever, it is essential that the indoor environment favors the performance of the building purpose. Empirical research has demonstrated the influence of architectural space variables on student performance, but they have not focused on holistic studies that compare how space influences different academic performance, such as Mathematics and Arts. This manuscript explores, under self-reported data, the relationship between learning space and the mathematics and art performance in 583 primary school students in Galicia (Spain). For this, the Indoor Physical Environment Perception scale has been adapted and validated and conducted in 27 classrooms. The results of the Exploratory Factor Analysis have evidenced that the learning space is structured in three categories: Workspace comfort, natural environment and building comfort. Multiple linear regression analyses have supported previous research and bring new findings concerning that the indoor environment variables do not influence in the same way different activities of school architecture

6-hydroxydopamine and ovariectomy has no effect on heart rate variability parameters of females

OBJECTIVES: In addition to the classic motor symptoms of Parkinson’s disease (PD), patients also present with non-motor symptoms, such as autonomic dysfunction, which is present in almost 90% of patients with PD, affecting the quality of life and mortality. Regarding sex differences in prevalence and presentation, there is increasing concern about how sex affects autonomic dysfunction. However, there are no previous data on autonomic cardiac function in females after 6-hydroxydopamine (6-OHDA) striatal injection. METHODS: Wistar female rats were ovariectomized. After 20 days, the animals received bilateral injections of 6-OHDA (total dose per animal: 48 mg) or a vehicle solution in the striatum. Thirty days after 6-OHDA injection, subcutaneous electrodes were implanted for electrocardiogram (ECG) recording. Ten days after electrode implantation, ECG signals were recorded. Analyses of heart rate variability (HRV) parameters were performed, and the 6-OHDA lesion was confirmed by analyzing the number of tyrosine hydroxylase-positive neurons in the substantia nigra pars compacta (SNpc). RESULTS: A high dose of 6-OHDA did not affect HRV of females, independent of ovariectomy. As expected, ovariectomy did not affect HRV or lesions in the SNpc after 6-OHDA injection. CONCLUSIONS: We suggest that females with 6-OHDA present with cardioprotection, independent of ovarian hormones, which could be related to female vagal predominance

Dental conditions in rheumatic diseases.

Objectives. Review oral manifestations of rheumatic diseases since these can be a diagnostic challenge.Procedures. We performed a PubMed search using terms of rheumatic diseases, autoimmune disease and oral manifestations and also reviewed related guidelines and classifications.Results. We describe the clinical presentations of rheumatic diseases, such as scleroderma, rheumatoid arthritis, Sjögren's syndrome, Systemic lupus erythematosus and others that present specific oral manifestations. We also review the association between periodontal disease and autoimmunity that has been recently described in the literature.Conclusions. The oral manifestations of rheumatic diseases are diverse and can represent a challenge for medical and dental professionals