Ultrasonographic-based predictive factors influencing successful return to racing after superficial digital flexor tendon injuries in flat racehorses: a retrospective cohort study in 469 Thoroughbred racehorses in Hong Kong

Background: Superficial digital flexor tendon (SDFT) injury is an important health and welfare concern in racehorses. It is generally diagnosed with ultrasonography, predictive ultrasonographic features have not been reported. Objectives: To determine ultrasonographic features of forelimb SDFT injury at initial presentation in Thoroughbred racehorses, that could predict a successful return to racing (completing > or = 5 races). Study Design: Retrospective cohort study. Methods: Digitised ultrasonographic images of 469 horses with forelimb SDFT injuries from the Hong Kong Jockey Club (2003-2014) were evaluated, using a previously validated ultrasonographic scoring system. Six ultrasonographic parameters were evaluated (type and extent of the injury, location, echogenicity, cross-sectional area and longitudinal fiber pattern of the maximal injury zone (MIZ)), as well as horse signalment, retirement date and number of races before and after injury. Data was analysed by generalized linear regression with significance at P<0.05. Results: Cases were divided in two groups: 1) For cases of SDFT tendonitis with core lesions, cross-sectional area at the MIZ was the most significant factor determining a successful return to racing (p=0.03). If the lesion was or > or = 50% this decreased to 11-16%. 2) For cases of SDFT tendonitis without a core lesion, longitudinal fiber pattern at the MIZ best predicted a successful return to racing (P=0.002); if the affected longitudinal fiber pattern was or = 75% this decreased to 14%. Main Limitations: Prognostic information may not be applicable to other breeds/disciplines. Conclusions: This is the first study to describe ultrasonographic features of forelimb SDFT injuries at initial presentation that were predictive of successful return to racing. The outcomes will assist with early, evidence-based decisions on prognosis in Thoroughbred racehorses

El proyecto Flying Challenge, una experiencia de interconexión universidad-empresa utilizando mentoría entre iguales

Congreso Universitario de Innovación Educativa En las Enseñanzas Técnicas, CUIEET (26º. 2018. Gijón

Ultrasonographic-based predictive factors influencing successful return to racing after superficial digital flexor tendon injuries in flat racehorses: a retrospective cohort study in 469 Thoroughbred racehorses in Hong Kong

Background: Superficial digital flexor tendon (SDFT) injury is an important health and welfare concern in racehorses. It is generally diagnosed with ultrasonography, predictive ultrasonographic features have not been reported. Objectives: To determine ultrasonographic features of forelimb SDFT injury at initial presentation in Thoroughbred racehorses, that could predict a successful return to racing (completing > or = 5 races). Study Design: Retrospective cohort study. Methods: Digitised ultrasonographic images of 469 horses with forelimb SDFT injuries from the Hong Kong Jockey Club (2003-2014) were evaluated, using a previously validated ultrasonographic scoring system. Six ultrasonographic parameters were evaluated (type and extent of the injury, location, echogenicity, cross-sectional area and longitudinal fiber pattern of the maximal injury zone (MIZ)), as well as horse signalment, retirement date and number of races before and after injury. Data was analysed by generalized linear regression with significance at P<0.05. Results: Cases were divided in two groups: 1) For cases of SDFT tendonitis with core lesions, cross-sectional area at the MIZ was the most significant factor determining a successful return to racing (p=0.03). If the lesion was or > or = 50% this decreased to 11-16%. 2) For cases of SDFT tendonitis without a core lesion, longitudinal fiber pattern at the MIZ best predicted a successful return to racing (P=0.002); if the affected longitudinal fiber pattern was or = 75% this decreased to 14%. Main Limitations: Prognostic information may not be applicable to other breeds/disciplines. Conclusions: This is the first study to describe ultrasonographic features of forelimb SDFT injuries at initial presentation that were predictive of successful return to racing. The outcomes will assist with early, evidence-based decisions on prognosis in Thoroughbred racehorses

Design of modular, CFRP-encased electrical power systems for more-electric aircraft applications

Decarbonisation of aviation is directly supported by the twin trends of electrification of aircraft, and use of light-weight, carbon fibre reinforced polymer (CFRP) aircraft structures. The concept of creating a modularised electrical power system (EPS), with EPS equipment encased in CFRP opens up new design opportunities for electrification of aircraft systems; reduced weight and volume, reduced time out-of-service due to maintenance. Such systems necessitate an understanding of how electrical and structural systems interact, and the design boundary between the CFRP providing combined electrical and structural functionality, versus CFRP with a purely structural functionality, with a separate electrical system encased in CFRP. A power electronic converter (PEC) is an enabling technology for the more-electric aircraft EPS. The paper identifies the key design interdependencies, trades and integrated systems design levers for design of a CFRP casing for a PEC module through a conceptual case study. This includes the capture of high and low frequency electrical functionality, thermal management requirements, and their interdependencies with the topology and functional role of the PEC and the wider EPS architecture. This knowledge is combined to present a design methodology for the design of composite casings for PEC in modularised, on-board electrical power systems

The Campo de Dalias GNSS Network Unveils the Interaction between Roll-Back and Indentation Tectonics in the Gibraltar Arc

The Gibraltar Arc includes the Betic and Rif Cordilleras surrounding the Alboran Sea; it is formed at the northwest–southeast Eurasia–Nubia convergent plate boundary in the westernmost Mediterranean. Since 2006, the Campo de Dalias GNSS network has monitored active tectonic deformation of the most seismically active area on the north coast of the Alboran Sea. Our results show that the residual deformation rates with respect to Eurasia range from 1.7 to 3.0 mm/year; roughly homogenous west-southwestward displacements of the northern sites occur, while the southern sites evidence irregular displacements towards the west and northwest. This deformation pattern supports simultaneous east-northeast–west-southwest extension, accommodated by normal and oblique faults, and north-northwest–south-southeast shortening that develops east-northeast–west-southwest folds. Moreover, the GNSS results point to dextral creep of the main northwest–southeast Balanegra Fault. These GNNS results thus reveal, for the first time, present-day interaction of the roll-back tectonics of the Rif–Gibraltar–Betic slab in the western part of the Gibraltar Arc with the indentation tectonics affecting the eastern and southern areas, providing new insights for improving tectonic models of arcuate orogens.Junta de Andalucia; European Regional Development Fund; grant numbers: AGORA P18-RT-3275, PAPEL B-RNM-301-UGR18. Programa Operativo FEDER-Andalucia 2014–2020 Project ref. 1263446; University of Jaén; CEACTEMA; grant number: POAIUJA 21/22. Junta de Andalucía (Andalusian Board); grant numbers: RNM-148, RNM-282, RNM-370. V.T.S. was supported by the FPU PhD grant (16/04038)

Geodetic fault slip rates on active faults in the Baza sub-Basin (SE Spain): Insights for seismic hazard assessment

One of the most significant parameters for seismic hazard assessment analyses is the fault slip rate. The combination of both geological (long-term) and geodetic (short-term) data offers a more complete characterization of the seismic potential of active faults. Moreover, geodetic data are also a helpful tool for the analysis of geodynamic processes. In this work, we present the results of a local GPS network from the Baza sub-Basin (SE Spain). This network, which includes six sites, was established in 2008 and has been observed for seven years. For the first time, we obtain short-term slip rates for the two active faults in this area. For the normal Baza Fault, we estimate slip rates ranging between 0.3 ± 0.3 mm/yr and 1.3 ± 0.4 mm/yr. For the strike-slip Galera Fault, we quantify the slip rate as 0.5 ± 0.3 mm/yr. Our GPS study shows a discrepancy for the Baza Fault between the short-term slip rates and previously reported long-term rates. This discrepancy indicates that the fault could be presently in a period with a displacement rate higher than the mean of the magnitude 6 seismic cycle. Moreover, the velocity vectors that we obtained also show the regional tectonic significance of the Baza Fault, as this structure accommodates one-third of the regional extension of the Central Betic Cordillera. Our GPS-related slip rates form the basis for future seismic hazard analysis in this area. Our results have further implications, as they indicate that the Baza and Galera Faults are kinematically coherent and they divide the Baza sub-Basin into two tectonic blocks. This points to a likely physical link between the Baza and Galera Faults; hence, a potential complex rupture involving both faults should be considered in future seismic hazard assessment studies.We acknowledge the comments of Editor Prof. Irina M. Artemieva and two anonymous reviewers, which significantly improved the quality of this paper. This research was funded by the Spanish Ministry of Science, Innovation and University (Research Projects: RTI2018-100737-BI00 and CGL2016-80687-R), the University of Alicante (Research Project: VIGROB053), the University of Jaén (PAIUJA 2019-2020 and Programa Operativo FEDER Andalucía 2014-2020 - call made by UJA 2018), the University of Granada (B-RNM-301-UGR18) and the Junta de Andalucía regional government (RNM148, RNM282, and RNM370 and P18-RT-3275 research groups). We thank all observers who collected the data of survey-mode GPS measurements

Randomized, controlled clinical trial of the DIALIVE liver dialysis device versus standard of care in patients with acute-on- chronic liver failure

Background & Aims Acute-on-chronic liver failure (ACLF) is characterized by severe systemic inflammation, multi-organ failure and high mortality rates. Its treatment is an urgent unmet need. DIALIVE is a novel liver dialysis device that aims to exchange dysfunctional albumin and remove damage- and pathogen-associated molecular patterns. This first-in-man randomized-controlled trial was performed with the primary aim of assessing the safety of DIALIVE in patients with ACLF, with secondary aims of evaluating its clinical effects, device performance and effect on pathophysiologically relevant biomarkers. Methods Thirty-two patients with alcohol-related ACLF were included. Patients were treated with DIALIVE for up to 5 days and end points were assessed at Day 10. Safety was assessed in all patients (n = 32). The secondary aims were assessed in a pre-specified subgroup that had at least three treatment sessions with DIALIVE (n = 30). Results There were no significant differences in 28-day mortality or occurrence of serious adverse events between the groups. Significant reduction in the severity of endotoxemia and improvement in albumin function was observed in the DIALIVE group, which translated into a significant reduction in the CLIF-C (Chronic Liver Failure consortium) organ failure (p = 0.018) and CLIF-C ACLF scores (p = 0.042) at Day 10. Time to resolution of ACLF was significantly faster in DIALIVE group (p = 0.036). Biomarkers of systemic inflammation such as IL-8 (p = 0.006), cell death [cytokeratin-18: M30 (p = 0.005) and M65 (p = 0.029)], endothelial function [asymmetric dimethylarginine (p = 0.002)] and, ligands for Toll-like receptor 4 (p = 0.030) and inflammasome (p = 0.002) improved significantly in the DIALIVE group. Conclusions These data indicate that DIALIVE appears to be safe and impacts positively on prognostic scores and pathophysiologically relevant biomarkers in patients with ACLF. Larger, adequately powered studies are warranted to further confirm its safety and efficacy. Impact and implications This is the first-in-man clinical trial which tested DIALIVE, a novel liver dialysis device for the treatment of cirrhosis and acute-on-chronic liver failure, a condition associated with severe inflammation, organ failures and a high risk of death. The study met the primary endpoint, confirming the safety of the DIALIVE system. Additionally, DIALIVE reduced inflammation and improved clinical parameters. However, it did not reduce mortality in this small study and further larger clinical trials are required to re-confirm its safety and to evaluate efficacy. Clinical trial number NCT03065699

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac