Роль физической культуры и спорта в жизни воцерковленного человека

В данной статье автор рассматривает отношение Православной Церкви к физической культуре и спорту, значение физической культуры и спорта в духовном воспитании человека; анализирует взаимодействие физического и духовного в жизни верующего человека.У данiй статтi автор розглядає вiдношення Православної Церкви до фiзичної культури i спорту, значення фiзичної культури i спорту в духовному вихованнi людини; аналізує взаємодію фiзичного i духовного в життi вiруючої людини.In this article an author examines attitude of the Orthodox Church toward a physical culture and sport. A value of physical culture and sport is in spiritual education of man. Interaction of physical and spiritual in life believing man

Association between C-reactive protein with all-cause mortality in ELSA-Brasil cohort

Background: High-sensitive C-reactive protein (hsCRP) has been proposed as a marker of incident cardiovascular disease and vascular mortality, and it may also be a marker of non-vascular mortality. However, most evidence comes from either North American or European cohorts. The present proposal aims to investigate the association of high-sensitive C-reactive protein with the risk of all-cause mortality in a multi-ethnic Brazilian population Methods: Cohort data from baseline (2008–2010) of 14 792 subjects participating in the Brazilian Longitudinal Study of Adult Health were used. HsCRP was assayed with Immunochemistry. The association of baseline covariates with all-cause mortality was calculated by Cox regression for univariate model and adjusted for different confounders after mean follow-up of 8.0 ± 1.1 years. The final model was adjusted for age, sex, self-rated race/ethnicity, schooling, health behaviours and prevalent chronic disease. Results: The risk of death increased steadily by quartiles of hsCRP from 1.45 (95% Confidence Interval: 1.05, 2.01) in Quartile 2 to 1.95 (1.42, 2.69) in Quartile 4 compared to Quartile 1. Furthermore, the persistence of a significant graded association after the exclusion of deaths in the first year of follow-up suggests that these results are unlikely to be due to reverse causality. Finally, the hazard ratios were unaffected by the exclusion of participants that had self-reported past medical history for diabetes, cancer and chronic obstructive pulmonary disease. Conclusions: Our study shows that hsCRP levels is associated with mortality in a highly admixed population, independently of a large set of lifestyle and clinical variables

Avaliação de genótipos de feijoeiro comum do grupo comercial carioca cultivados nas épocas das águas e do inverno em Uberlândia, Estado de Minas Gerais.

O feijoeiro é uma das principais culturas do país, e o Estado de Minas Gerais é um dos maiores produtores, representando cerca de 15% da produção nacional. O objetivo deste trabalho foi testar o desempenho de linhagens de feijoeiro comum cultivadas nas épocas das águas e do inverno, na região do Triângulo Mineiro, Minas Gerais. No cultivo das águas (semeadura em dezembro de 2005) e do inverno (semeadura em maio de 2006), as linhagens/cultivares testadas foram BRS Horizonte, CNFC 8059, CNFC 8065, CNFC 8075, VC-6, VC-7, VC-8, VC-9, VC-10, VC-11, VC-12, CNFC 10443, CNFC 10453, CNFC 10476, MA-I-2.5, MA-I-8.9, MA-I-18.13, RC-I-8, CV-46, CV-55 e Z-22, além das testemunhas BRSMG Majestoso, Pérola e BRSMG Talismã e VC-3. Em cada experimento, o delineamento experimental foi o de blocos casualizados com 25 tratamentos, em três repetições, a parcela útil foi de 4 m². No cultivo das águas, os rendimentos das linhagens mais produtivas variaram entre 2,69 e 2,78 t ha-1 (VC-9 e VC-10, respectivamente) e, no inverno, alcançaram 3 t ha-1 (3,01 e 3,00 t ha-1, CNFC 8065 e Z-22, respectivamente). De maneira geral, as linhagens foram mais produtivas no cultivo do inverno, embora a interação entre linhagens e época de cultivo tenha indicado desempenho distinto entre elas em relação à época

Static, dynamic and creep behaviour of a full-scale GFRP-SFRSCC hybrid footbridge

A three-year research project (Pontalumis) was carried out for the development of an innovative simply supported hybrid footbridge, with 11 m of length and 2 m of width. The footbridge is composed of two pultruded I-shaped glass fibre reinforced polymer (GFRP) girders (400×200(×15) mm2) bonded and bolted to a 37.5 mm thick deck in steel fibre reinforced self-compacting concrete (SFRSCC). The present paper describes the material/structural concept of this footbridge, its design and construction process, and summarizes the response of the prototype when submitted to static short and long-term load tests, and dynamic load tests. The prototype was simple and fast to execute, presenting a reduced dead-weight of only about 3 tonf. The static and dynamic behaviour of the prototype as well as its long-term deflection fulfil standards’ requirements for footbridge structures and are in good agreement with conventional analytical and numerical design tools.AD

Pastagens consorciadas: procedimentos, técnicas e cuidados no estabelecimento.

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Visceral leishmaniasis in the State of Maranhão, Brazil: evolution of an epidemic

The authors provide a brief report on the historical evolution of visceral leishmaniasis in the State of Maranhão, Brazil, evaluating possible factors for growth of the disease in the State and control measures by the Brazilian Ministry of Health to integrate health services finto the maintenance of control programs.Os autores fazem um breve relato da evolução histórica da leishmaniose visceral no Estado do Maranhão, Brasil, avaliando as possíveis causas da expansão da referida doença no Estado, assim como as medidas de controle adotadas pelo Ministério da Saúde objetivando a diminuição da incidência da mesma.Universidade Federal do Maranhão Faculdade de Medicina Departamento de PatologiaEscola Paulista de MedicinaUNIFESP, EPMSciEL

Auxin-dependent cell cycle reactivation through transcriptional regulation of Arabidopsis E2Fa by lateral organ boundary proteins

Multicellular organisms depend on cell production, cell fate specification, and correct patterning to shape their adult body. In plants, auxin plays a prominent role in the timely coordination of these different cellular processes. A well-studied example is lateral root initiation, in which auxin triggers founder cell specification and cell cycle activation of xylem pole-positioned pericycle cells. Here, we report that the E2Fa transcription factor of Arabidopsis thaliana is an essential component that regulates the asymmetric cell division marking lateral root initiation. Moreover, we demonstrate that E2Fa expression is regulated by the LATERAL ORGAN BOUNDARY DOMAIN18/LATERAL ORGAN BOUNDARY DOMAIN33 (LBD18/LBD33) dimer that is, in turn, regulated by the auxin signaling pathway. LBD18/LBD33 mediates lateral root organogenesis through E2Fa transcriptional activation, whereas E2Fa expression under control of the LBD18 promoter eliminates the need for LBD18. Besides lateral root initiation, vascular patterning is disrupted in E2Fa knockout plants, similarly as it is affected in auxin signaling and lbd mutants, indicating that the transcriptional induction of E2Fa through LBDs represents a general mechanism for auxin-dependent cell cycle activation. Our data illustrate how a conserved mechanism driving cell cycle entry has been adapted evolutionarily to connect auxin signaling with control of processes determining plant architecture

Pontalumis : ponte pedonal mista GFRP-betão : descrição da solução, ensaios e modelação

Este artigo descreve o desenvolvimento de um protótipo de ponte pedonal à escala real utilizando um sistema estrutural misto inovador com longarinas em perfis pultrudidos de polímero reforçado com fibra de vidro (GFRP) e tabuleiro em betão auto-compactável reforçado com fibras de aço (SFRSCC), no âmbito do projeto PONTALUMIS. O protótipo apresenta um comprimento total de 11.0 m e uma secção transversal composta por dois perfis de GFRP em I e uma laje fina (38 mm) em SFRSCC. Neste trabalho são apresentados os resultados dos ensaios (i) estáticos, (ii) de fluência e (iii) dinâmicos, bem como as simulações numérica e analítica. Os resultados obtidos revelaram uma boa resposta da estrutura, em concordância com os modelos de previsão, confirmando o elevado potencial do sistema estrutural proposto

Virus-like particles (VLPs) as a platform for the development of yellow fever and Zika virus vaccine candidate

Flaviviruses are arboviruses that have been posing serious challenges to global health since 2015. Zika virus (ZIKV) emerged in 2015 in Brazil and quickly spread to over 60 countries in Africa, Asia and the Americas, causing Guillain-Barré syndrome in adults and serious congenital malformations in fetuses of infected mothers. Besides mosquito-borne transmission, zika virus can persist for months in sexual fluids and thus poses risk also to non-endemic countries due to sexual transmission of returning travelers. Although the number of cases decreased significantly due to herd immunity in affected countries, development of a vaccine for ZIKV is of great importance to avoid future resurgence of the virus in endemic areas or future spread to currently non-endemic regions. Yellow fever (YF) is a “historically devastating disease” (Paules and Fauci, 2017), which in past centuries killed approximately 10% of the population of cities like Philadelphia and Barcelona. Although a very effective vaccine exists for YFV, it can cause fatal adverse effects in a small proportion of vaccinees, and recent outbreaks have shown that due to its limited production in embryonated eggs the risk of serious vaccine shortages is high. Fractionating the vaccine dosis (1/5) was the emergency solution introduced by the WHO in 2016 to stop an outbreak in Africa, and is currently being adopted for mass vaccination in Brazil to try to stop the serious outbreak ongoing since 2017. The potential risk of YFV spreading to highly populated areas with no vaccination coverage, where the mosquito vector is present, such as Asia, makes urgent the development of new YFV vaccines. In this context, virus-like particles (VLPs) can be a promising platform for developing safe and effective vaccines for YFV, ZIKV and other flaviviruses. In this work, we developed stable recombinant cell lines constitutively expressing the structural prM (pre-membrane) and E (envelope) proteins of ZIKV and YFV. Sucrose cushion ultracentrifugation and TEM images have confirmed that VLPs resembling in both size and shape the respective native viruses are formed. In order to optimize expression, cell transfection protocol was optimized using different transfection reagents, media and host cell lines, including CHO, HEK293, BHK, MDCK and Vero cells. Stable cell lines derived from CHO-K1 and HEK293-3F6 gave the most promising results and were followed for up to 20 weeks post-transfection in the presence and absence of the selection marker, showing that cells grow to high densities with high viabilities and keeping the expression of VLPs. The use of FACS to sort for high producer cells allowed obtaining enriched cell pools producing significantly higher amounts of VLPs and confirmed the hypothesis that secreted VLPs can be transiently detected on the cell membrane surface. Kinetic studies to evaluate different culture media and cultivation conditions under batch, pseudoperfusion and perfusion mode were carried out with the final aim of increasing productivity and reducing production costs. Ongoing studies are focusing, on one hand, to purify the ZIKV and YFV VLPs for immunogenicity studies and, on the other hand, to express VLPs of other flaviviruses circulating in the Americas, as preparedness measure for future threats. VLPs of DENV 1, 2, 3 and 4, as well as of Saint Louis encephalitis (SLEV), Ilheus (ILHV) and Cacipacore (CPCV) viruses have already been successfully expressed by transient transfection. Acknowledgements: The authors wish to gratefully acknowledge the Vaccine Research Center of NIAID/NIH (USA) for transferring the DENV, SLEV, ILHV and CPCV gene constructs developed during a sabbatical work of L. R. Castilho and used in this work. References: Paules CI, Fauci AS (2017), Yellow Fever - Once Again on the Radar Screen in the Americas, N Engl J Med 376:1397-1399, doi: 10.1056/NEJMp1702172

Análise de desempenho econômico da produção orgânica de leite: estudo de caso no Distrito Federal

Neste trabalho, objetivou-se analisar economicamente a produção orgânica de leite. Para esta avaliação foram utilizados os dados obtidos em uma propriedade certificada como orgânica, localizada no Distrito Federal, durante os períodos de 2002 e 2003. A Renda Líquida (RL) por litro de leite foi positiva no ano de 2002 e negativa no de 2003, considerando-se o preço do leite a R$0,40/ L, (preço histórico pago ao produtor de leite convencional na região), apresentando resultados positivos com o preço simulado de R$ 0,80/L (preço pago aos produtores orgânicos nas Regiões Sul e Sudeste do país). Os índices de produtividade foram semelhantes aos observados nas propriedades convencionais. A produção orgânica de leite pode ser uma alternativa economicamente viável para a pecuária, desde que haja uma remuneração superior à praticada para o leite convencional