Tomasso Campanella: ¿escolástico o renacentista?

_A partir de una revisión de las ideas de Tomasso Campanella, autor de La ciudad del sol, en este ensayo se argumenta en favor de que el proyecto utópico de este hombre del Renacimiento contiene más rasgos escolásticos y teocráticos que renacentistas

Retórica filosófica y retórica fisiológica

_Se exponen dos tendencias respecto a la concepción de la retórica: la primera se da en torno al planteamiento aristotélico, donde se le considera como una extensión de la filosofía, que se vincula con la dialéctica, la lógica y la ética; la segunda ocurre en torno la la concepción nietzscheana, la cual plantea que la retórica no tiene como fin convencer, sino conmover, además de que se considera que la retórica es la esencia misma del lenguaje, no un ornato

LA POSIBILIDAD DE EDIFICACIÓN14 O BILDUNG A PARTIR DE LA HERMENÉUTICA ANALÓGICA.

ResumenEste artículo versa sobre mi preocupación en torno a la actualsituación de las instituciones educativas y de los procesos deeducación. Se hace una exposición de la crítica que lleva a caboNietzsche en 1872 respecto a este tópico, con lo cual se deja ver quelos síntomas señalados por aquél continúan presentes en nuestrapropia época. Propongo como una vía de solución la aplicación de lahermenéutica analógica como instrumento que coadyuve en lasdinámicas de culturización. Con ella se tratará de mantener la guardia ante una educación autoritaria o la permisiva; así como ante actitudes pesimistas-apocalípticas o su opuesto, el optimismo ramplón que lleva a integrar todo. AbstractThe analogical hermeneutics is an offer that one presents as a bridgeto give response to a series of problems different fields of the knowledge. The education is one of them. I think that with theanalogical hermeneutics we might tint the ends that they damage toour educational systems. We should construct paradigms that help toeradicate the permissiveness or the authoritarianism in theeducational models; as well as the professionals' massive productionwhich mission is the pure usefulness or productivity, provided that itdestroys any authentic cultur

Tumor de apéndice cecal

Introducción: La apendicectomía es un procedimiento ampliamente utilizado en todo el mundo, o que sea como consecuencia de signos y síntomas sugestivos de apendicitis aguda. El estudio de la pieza quirúrgica es frecuente, a pesar de la baja incidencia de hallazgos inusuales en esta. Los tumores del apéndice cecal constituyen el 0,5 % de todas las neoplasias gastrointestinales. Los mucoceles apendiculares son tumores de aparición infrecuente. Representan aproximadamente el 0,3 % de todas las apendicectomías.Objetivo: Describir el caso de un tumor mucinoso del apéndice cecal como hallazgo incidental por apendicetomía de urgencia.Caso clínico: Se expone el caso de una paciente de 54 años de edad, femenina, con antecedentes de salud, que acude al servicio de cirugía general por dolor abdominal en fosa iliaca derecha de 24 horas de evolución, náuseas y vómitos asociados. Se diagnostica apendicitis aguda y en el transoperatorio se constata una tumoración quística de la punta del apéndice cecal que en el análisis histopatológico informa un cistoadenoma mucinoso del apéndice.Discusión: El cistoadenoma mucinoso de apéndice es una neoplasia benigna rara, Se define como un falso tumor mucinoso del peritoneo, pues casi siempre se identifica un tumor mucinoso del apéndice como sitio primario de la enfermedad, que puede ser asintomático, simular una apendicitis aguda o presentarse como masa palpable con dolor abdominal, pérdida de peso y cambios del hábito intestinal; pero la mayoría son asintomáticos y generalmente constituyen un hallazgo transoperatorio, radiológico o laparoscópico.Conclusiones: Los tumores mucinosos de apéndice con frecuencia son hallazgos incidentales y el tratamiento puede comprender desde una apendicectomía hasta una cirugía citoreductiva, dependiendo del grado histológico del tumor y de la diseminación peritoneal

Discrepancies Between Nitroglycerin and NO-Releasing Drugs on Mitochondrial Oxygen Consumption, Vasoactivity, and the Release of NO

It has been generally acknowledged that the actions of glyceryl trinitrate (GTN) are a result of its bioconversion into NO. However, recent observations have thrown this idea into doubt, with many studies demonstrating that NO is present only when there are high concentrations of GTN. We have explored this discrepancy by developing a new approach that uses confocal microscopy to directly detect NO. Intracellular levels of NO in the rat aortic vascular wall have been compared with those present after incubation with 3 different NO donors (DETA-NO, 3 morpholinosydnonimine, and S-nitroso-N-acetylpenicillamine), endothelial activation with acetylcholine, or administration of GTN. We have also evaluated the relaxant effects of these treatments on isolated rings of aorta following activation of the enzyme soluble guanylyl cyclase and their inhibitory action on mitochondrial respiration, which is an index of the interaction of NO with the enzyme of the electron transport chain cytochrome C oxidase. In the case of the various NO donors and acetylcholine, we detected a concentration-dependent relationship in the intensity of vascular relaxation and degree of NO fluorescence and an increase in the Michaelis constant (Km) for O2. GTN did not produce similar effects, and although clinically relevant concentrations of this compound caused clear, concentration-related relaxations, there was neither any increase in NO-related fluorescence nor an augmented Km for O2. The nature of these differences suggests that these concentrations of GTN do not release free NO but probably a different species that, although it interacts with soluble guanylyl cyclase in vascular smooth muscle, does not inhibit O2 consumption by vascular mitochondria.Victor Gonzalez, Victor Manuel, [email protected] ; Esplugues Mota, Juan Vicente, [email protected] ; d'Ocon Navaza, Maria Pilar, [email protected]

Predictive Value of Carcinoembryonic Antigen in Symptomatic Patients without Colorectal Cancer: A Post-Hoc Analysis within the COLONPREDICT Cohort

We aimed to assess the risk of cancer in patients with abdominal symptoms after a complete colonoscopy without colorectal cancer (CRC), according to the carcinoembryonic antigen (CEA) concentration, as well as its diagnostic accuracy. For this purpose, we performed a post-hoc analysis within a cohort of 1431 patients from the COLONPREDICT study, prospectively designed to assess the fecal immunochemical test accuracy in detecting CRC. Over 36.5 +/- 8.4 months, cancer was detected in 115 (8%) patients. Patients with CEA values higher than 3 ng/mL revealed an increased risk of cancer (HR 2.0, 95% CI 1.3-3.1), CRC (HR 4.4, 95% CI 1.1-17.7) and non-gastrointestinal cancer (HR 1.7, 95% CI 1.0-2.8). A new malignancy was detected in 51 (3.6%) patients during the first year and three variables were independently associated: anemia (OR 2.8, 95% CI 1.3-5.8), rectal bleeding (OR 0.3, 95% CI 0.1-0.7) and CEA level >3 ng/mL (OR 3.4, 95% CI 1.7-7.1). However, CEA was increased only in 31.8% (95% CI, 16.4-52.7%) and 50% (95% CI, 25.4-74.6%) of patients with and without anemia, respectively, who would be diagnosed with cancer during the first year of follow-up. On the basis of this information, CEA should not be used to assist in the triage of patients presenting with lower bowel symptoms who have recently been ruled out a CRC

Opportunistic screening for atrial fibrillation versus detecting symptomatic patients aged 65 years and older: a cluster-controlled clinical trial.

Objective: The goal of this study was to assess the effectiveness of opportunistic screening through pulse palpation in the early detection of atrial fibrillation in subjects aged ≥ 65 years versus detection through an active search for patients with symptoms and/or complications and sequelae associated. -Material and methods: This was a cluster randomized controlled trial performed in 48 primary care centers of the Spanish National Healthcare System. A total of 368 physicians and nurses were randomized. The researchers in the Experimental Group (EG) performed opportunistic screening for auricular fibrillation, whereas the researchers in the Control Group (CG) actively searched for symptomatic patients. An ECG was performed on patients found to have an irregular heartbeat to confirm the diagnosis of auricular fibrillation. -Results: A total of 5,465 patients with a mean age of 75.61 were recruited for the EG, and 1,525 patients with a mean age of 74.07 were recruited for the CG. Of these, 58.6% were female, without significant differences between groups. Pulse was irregular in 4.3% and 15.0% of the patients in the EG and the CG, respectively (p<0.001). A total of 165 new cases of atrial fibrillation were detected (2.3%), 1.1% in the EG and 6.7% in the CG (adjusted OR: 0.29; 95%CI: 0.18-0.45). -Conclusions: Case finding for atrial fibrilation in patients aged ≥ 65 years with symptoms or signs suggestive of atrial fibrilation is a more effective strategy than opportunistic screening through pulse palpation in asymptomatic patients.pre-print325 K

Opportunistic detection of atrial fibrillation in subjects aged 65 years or older in primare care: a randomised clinical trial of efficacy. DOFA-AP study protocol.

Clinical Practice Guidelines recommend using peripheral blood pulse measuring as a screening test for Atrial Fibrillation. However, there is no adequate evidence supporting the efficacy of such procedure in primary care clinical practice. This paper describes a study protocol designed to verify whether early opportunistic screening for Atrial Fibrillation by measuring blood pulse is more effective than regular practice in subjects aged 65 years attending primary care centers.post-print290 K

Case-Control Analysis of the Impact of Anemia on Quality of Life in Patients with Cancer: A Qca Study Analysis

The impact of anemia on the quality of life (QoL) in cancer patients has been studied previously; however, the cut-off point used to define anemia differed among studies, thus providing inconsistent results. Therefore, we analysed the clinical impact of anemia on QoL using the same cut-off point for hemoglobin level to define anemia as that used in ESMO clinical practice guidelines. This post-hoc analysis aimed to determine the impact of anemia on QoL in cancer patients through the European Organization for Research and Treatment of Cancer Quality of life questionnaire version 3.0 (EORTC QLQ-C30) and Euro QoL 5-dimension 3-level (EQ-5D-3L) questionnaire. We found that cancer patients with anemia had significantly worse QoL in clinical terms. In addition, anemic patients had more pronounced symptoms than those in non-anemic patients. Anemia is a common condition in cancer patients and is associated with a wide variety of symptoms that impair quality of life (QoL). However, exactly how anemia affects QoL in cancer patients is unclear because of the inconsistencies in its definition in previous reports. We aimed to examine the clinical impact of anemia on the QoL of cancer patients using specific questionnaires. We performed a post-hoc analysis of a multicenter, prospective, case-control study. We included patients with cancer with (cases) or without (controls) anemia. Participants completed the European Organization for Research and Treatment of Cancer Quality of Life questionnaire version 3.0 (EORTC QLQ-C30) and Euro QoL 5-dimension 3-level (EQ-5D-3L) questionnaire. Statistically significant and clinically relevant differences in the global health status were examined. From 2015 to 2018, 365 patients were included (90 cases and 275 controls). We found minimally important differences in global health status according to the EORTC QLQ-C30 questionnaire (case vs. controls: 45.6 vs. 58%, respectively; mean difference: -12.4, p < 0.001). Regarding symptoms, cancer patients with anemia had more pronounced symptoms in six out of nine scales in comparison with those without anemia. In conclusion, cancer patients with anemia had a worse QoL both clinically and statistically