Vertical integration and exclusivities in maritime freight transport

A key recent theme in maritime freight transport is the involvement of shipping lines in terminal management. Such investments are costly but allow liners to provide better service. Most of these new terminals are dedicated terminals but some are non-exclusive and let rivals access them for a fee. In this paper, we show that a shipping line that builds its own terminal finds it strategically profitable i) to continue routing part of its cargo through the open port facilities, and ii) to keep its terminal non-exclusive. In this way, the liner investor pushes part of the rival's freight from the open to the new terminal. Besides, under non-exclusivities, the shipping lines offer a wider variety of services, total freight increases and the resulting equilibrium fares are higher than with a dedicated terminal.freight transport, shipping lines, vertical integration

Analytical model for BTEX natural attenuation in the presence of fuel ethanol and its anaerobic metabolite acetate

Copyright © 2013 Elsevier. NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Contaminant Hydrology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Contaminant Hydrology Vol. 146 (2013), DOI: 10.1016/j.jconhyd.2012.12.006Flow-through column studies were conducted to mimic the natural attenuation of ethanol and BTEX mixtures, and to consider potential inhibitory effects of ethanol and its anaerobic metabolite acetate on BTEX biodegradation. Results were analyzed using a one-dimensional analytical model that was developed using consecutive reaction differential equations based on first-order kinetics. Decrease in pH due to acetogenesis was also modeled, using charge balance equations under CaCO3 dissolution conditions. Delay in BTEX removal was observed and simulated in the presence of ethanol and acetate. Acetate was the major volatile fatty acid intermediate produced during anaerobic ethanol biodegradation (accounting for about 58% of the volatile fatty acid mass) as suggested by the model data fit. Acetate accumulation (up to 1.1 g/L) near the source zone contributed to a pH decrease by almost one unit. The anaerobic degradation of ethanol (2 g/L influent concentration) at the source zone produced methane at concentrations exceeding its solubility (≅ 26 mg/L). Overall, this simple analytical model adequately described ethanol degradation, acetate accumulation and methane production patterns, suggesting that it could be used as a screening tool to simulate lag times in BTEX biodegradation, changes in groundwater pH and methane generation following ethanol-blended fuel releases

A RAPID PLATFORM TO GENERATE LIPOFUSCIN AND SCREEN THERAPEUTIC DRUGS FOR EFFICACY IN LIPOFUSCIN REMOVAL

Abstract Lipofuscin is a brown-yellow, autofluorescen

Nitrate addition to groundwater impacted by ethanol-blended fuel accelerates ethanol removal and mitigates the associated metabolic flux dilution and inhibition of BTEX biodegradation

A comparison of two controlled ethanol-blended fuel releases under monitored natural attenuation (MNA) versus nitrate biostimulation (NB) illustrates the potential benefits of augmenting the electron acceptor pool with nitrate to accelerate ethanol removal and thus mitigate its inhibitory effects on BTEX biodegradation. Groundwater concentrations of ethanol and BTEX were measured 2 m downgradient of the source zones. In both field experiments, initial source-zone BTEX concentrations represented less than 5% of the dissolved total organic carbon (TOC) associated with the release, and measurable BTEX degradation occurred only after the ethanol fraction in the multicomponent substrate mixture decreased sharply. However, ethanol removal was faster in the nitrate amended plot (1.4 years) than under natural attenuation conditions (3.0 years), which led to faster BTEX degradation. This reflects, in part, that an abundant substrate (ethanol) can dilute the metabolic flux of target pollutants (BTEX) whose biodegradation rate eventually increases with its relative abundance after ethanol is preferentially consumed. The fate and transport of ethanol and benzene were accurately simulated in both releases using RT3D with our general substrate interaction module (GSIM) that considers metabolic flux dilution. Since source zone benzene concentrations are relatively low compared to those of ethanol (or its degradation byproduct, acetate), our simulations imply that the initial focus of cleanup efforts (after free-product recovery) should be to stimulate the degradation of ethanol (e.g., by nitrate addition) to decrease its fraction in the mixture and speed up BTEX biodegradation.Petróleo Brasileiro S/A — PETROBRASCoordination of Improvement of Higher Education Personnel (CAPES)National Council for Scientific and Technological Development (CNPq

Modeling benzene plume elongation mechanisms exerted by ethanol using RT3D with a general substrate interaction module

Copyright © 2008 American Geophysical Union (AGU)A mathematical model was developed to evaluate the effect of the common fuel additive ethanol on benzene fate and transport in fuel-contaminated groundwater and to discern the most influential benzene plume elongation mechanisms. The model, developed as a module for the Reactive Transport in 3 Dimensions (RT3D) model, includes commonly considered fate and transport processes (advection, dispersion, adsorption, biodegradation, and depletion of molecular oxygen during biodegradation) and substrate interactions previously not considered (e.g., a decrease in the specific benzene utilization rate due to metabolic flux dilution and/or catabolite repression) as well as microbial population shifts. Benzene plume elongation predictions, based on literature model parameters, were on the order of 40% for a constant source of E10 gasoline (10% vol/vol ethanol), which compares favorably to field observations. For low benzene concentrations (<1 mg/L), oxygen depletion during ethanol degradation was the principal mechanism hindering benzene natural attenuation. For higher benzene concentrations (exerting an oxygen demand higher than the available dissolved oxygen), metabolic flux dilution was the dominant plume elongation process. If oxygen were not limiting, as might be the case in zones undergoing aerobic biostimulation, model simulations showed that microbial growth on ethanol could offset negative substrate interactions and enhance benzene degradation, resulting in shorter plumes than baseline conditions without ethanol

Biodegradation of monoaromatic hydrocarbons in aquifer columns amended with hydrogen peroxide and nitrate

The ability of indigenous microorganisms to degrade benzene, toluene, ethylbenzene and xylenes (BTEX) in laboratory scale flow-through aquifer columns was tested separately with hydrogen peroxide (110 mg/l) and nitrate (330 mg/l as NO3-) amendments to air-saturated influent nutrient solution. The continuous removal of individual components from all columns relative to the sterile controls provided evidence for biodegradation. In the presence of hydrogen peroxide, the indigeneous microorganisms degraded benzene and toluene ( &gt; 95%), meta- plus para-xylene (80%) and ortho-xylene (70%). Nitrate addition resulted in 90% removal of toluene and 25% removal of ortho-xylene. However, benzene, ethylbenzene, meta- and para-xylene concentrations were not significantly reduced after 42 days of operation. Following this experiment, low dissolved oxygen ( 90%), and more than 25% of the benzene, 40% of the ethylbenzene, 50% of the meta- plus para-xylenes and 60% of the ortho-xylene were removed after several months of operation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/30890/1/0000559.pd

Experiences Developing Safe and Fault-Tolerant Tele-Operated Service Robots. A Case Study in Shipyards

Human operators use tele-operated service robots for performing more or less hazardous operations (manipulation of heavy and/or dangerous products) in more or less hostile environments (nuclear reactors, space missions, warehouses, etc). Anyway, independently of the operation, the robot has to interact with both the environment it is working on and with human operators. Therefore, it is essential that the design (which include both software and hardware) of the robot involves no risk, or at least an acceptable level of risk, neither for the operators, nor for the environment nor for the robot itself. Nevertheless, it is not always possible to make a system free of failures in its design or operation. Apart from the risk inherent to the use of the mechanisms themselves, these systems work in hazardous environments, where the probability of the risk is higher than normal. Should a failure happen, its consequences could even involve the loss of human lives. (Neumann, 1994) documents many cases of computer-related failures, such as the Therac-25 (a radiation-therapy device), the missiles shield in Saudi Arabia, etc. Nevertheless, safety aspects are seldom included in the early phases of the system design process from the beginning, even though they are a critic aspect. Generally, safety has to conform and adapt to the already designed system and not vice versa, when it is widely known that safety involves not only the design of the software but also the hardware. Even more, a simple hardware solution can eliminate a hazard or simplify the software design in many situations.This research has been funded by the Spanish CICYT project MEDWSA (TIN2006-15175- C05-02) and the Regional Government of Murcia Séneca Program (02998-PI-05)

Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia

Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a difficult-to-diagnose cause of sudden cardiac death (SCD). We identified a family of 1400 individuals with multiple cases of CPVT, including 36 SCDs during youth. Objectives We sought to identify the genetic cause of CPVT in this family, to preventively treat and clinically characterize the mutation-positive individuals, and to functionally characterize the pathogenic mechanisms of the mutation. Methods Genetic testing was performed for 1404 relatives. Mutation-positive individuals were preventively treated with β-blockers and clinically characterized with a serial exercise treadmill test (ETT) and Holter monitoring. In vitro functional studies included caffeine sensitivity and store overload–induced calcium release activity of the mutant channel in HEK293 cells. Results We identified the p.G357S_RyR2 mutation, in the cardiac ryanodine receptor, in 179 family members and in 6 SCD cases. No SCD was observed among treated mutation-positive individuals over a median follow-up of 37 months; however, 3 relatives who had refused genetic testing (confirmed mutation-positive individuals) experienced SCD. Holter monitoring did not provide relevant information for CPVT diagnosis. One single ETT was unable to detect complex cardiac arrhythmias in 72% of mutation-positive individuals, though the serial ETT improved the accuracy. Functional studies showed that the G357S mutation increased caffeine sensitivity and store overload–induced calcium release activity under conditions that mimic catecholaminergic stress. Conclusion Our study supports the use of genetic testing to identify individuals at risk of SCD to undertake prophylactic interventions. We also show that the pathogenic mechanisms of p.G357S_RyR2 appear to depend on β-adrenergic stimulation

Relativistic collapse and explosion of rotating supermassive stars with thermonuclear effects

We present results of general relativistic simulations of collapsing supermassive stars with and without rotation using the two-dimensional general relativistic numerical code Nada, which solves the Einstein equations written in the BSSN formalism and the general relativistic hydrodynamics equations with high resolution shock capturing schemes. These numerical simulations use an equation of state which includes effects of gas pressure, and in a tabulated form those associated with radiation and the electron-positron pairs. We also take into account the effect of thermonuclear energy released by hydrogen and helium burning. We find that objects with a mass of 5x10^{5} solar mass and an initial metallicity greater than Z_{CNO}~0.007 do explode if non-rotating, while the threshold metallicity for an explosion is reduced to Z_{CNO}~0.001 for objects uniformly rotating. The critical initial metallicity for a thermonuclear explosion increases for stars with mass ~10^{6} solar mass. For those stars that do not explode we follow the evolution beyond the phase of black hole formation. We compute the neutrino energy loss rates due to several processes that may be relevant during the gravitational collapse of these objects. The peak luminosities of neutrinos and antineutrinos of all flavors for models collapsing to a BH are ~10^{55} erg/s. The total radiated energy in neutrinos varies between ~10^{56} ergs for models collapsing to a BH, and ~10^{45}-10^{46} ergs for models exploding.Comment: 15 pages, 11 figures, accepted by ApJ; including more comparisons with previous works upon referee's reques