Lean construction y su incidencia en la productividad en la Constructora Jatun Atecc E.I.R.L, Lima - 2021

La presente tesis titulada “Lean Construction y su incidencia en la productividad en la constructora Jatun Atecc E.I.R.L.,”. Lean Construction tiene como finalidad definir el alcance, planificar entregables, controlar el alcance, la planificación de actividades y de costos, permitiendo la medición de pérdidas, por tal razón tuvo como objetivo principal aplicar Lean Construction y su incidencia en la productividad en la constructora Jatun Atecc E.I.R.L., Lima – 2021. Como metodología se consideró el método hipotético deductivo, de tipo aplicada. El nivel explicativo y diseño no experimental de corte transversal, puesto a que no se manipuló ni se sometió a prueba las variables de estudio. En el proyecto presentado la población está conformada por 90 trabajadores (Gerencia de proyectos; ingenieros residentes de obra e ingenieros supervisores de obra, colaboradores como asistentes de obra; contratista y subcontratistas) de una empresa Constructora. Con resultados obtenidos al aplicar la metodología de Lean Construction y su incidencia en la productividad, en la constructora Jatun Atecc E.I.R.L, Lima – 2021, se evidenció que la metodología Lean Construction permitió la incidencia del Lean Construction en la productividad, en la constructora Jatun Atecc E.I.R.L, Lima – 2021. Concluyendo que la metodología de Lean Construction influye favorablemente en la productividad en la constructora Jatun Atecc E.I.R.L., Lima – 2021

Tendencias del sector agrícola, Estado de México

En este estudio se analizan las variables de producción, superficie sembrada, superficie cosechada,volumen y valor de la producción de flores, hortalizas, forrajes y maíz; se establece el diagnósticoy la prospectiva de las tendencias del sector agrícola en el Estado de México. Los resultadosadvierten escenarios de vulnerabilidad y rendimientos decrecientes, los cuales cuestionan lascompetencias apropiadas y la autonomía productiva del sector agrícola en el Estado de México.Se utilizaron datos estadísticos, leyes reglamentarias, planes y programas, tasas de crecimiento ydiagnóstico de las fortalezas, oportunidades, debilidades y amenazas

Otra visión de la formación del alumno universitario: factores de riesgo de Diabetes Mellitus

La formación universitaria debe tener un enfoque de atención integral, no solo académico, por lo que surge la importancia de identificar factores de riesgo de Diabetes Mellitus, situación que afectaría su aprovechamiento académico por ser patología principal de problemas de salud pública en México. Esto permitirá atender a los alumnos en un estilo de vida y prácticas de salud, que promoverán en su vida profesional y en la sociedad. Se presenta un estudio investigativo con enfoque cuantitativo de tipo descriptivo y transversal, donde participaron 50 alumnos entre 20 a 23 años; 20% de los alumnos tienen un bajo riesgo de padecer Diabetes Mellitus 2, 42 % poco riesgo, 22% riesgo moderado, 12% alto riesgo, muy alto riesgo 4%. Se requiere una intervención para disminuir riesgos del 40% a través de programas de salud

Deciphering the degree of proton-transfer in pyrido-cyclophanes by chiroptical outcomes in non-aqueous solvents

Proton transfer equilibria are of pivotal importance due to the role they play in a plethora of biological and phamaceutical processes. With the aim of explaining the relative position of the hydrogen to be transferred, we investigated the behavior of chiral pyrido-cyclophanes with different morphologies using circular dichroism in the presence of different acids in acetonitrile. The results showed that all three compounds underwent double protonation and formation of cascade ion-pairs, leading to the appearance of diagnostic signals in their ECD spectra. The presence of water fosters the crystallization of several intermediates that do not correspond to those in solution. By using Brønsted correlations, it was found that proton transfer from the acid to the pyridine occurred regardless of the acid's p K a .Agencia Estatal de Investigación | Ref. PID2021-128057NB-I00Xunta de Galicia | Ref. EC431C 2021/4

Photochemically driven tandem process in the construction of a biscyclopropylcage from 2,5-dimethoxy-p-benzoquinone and terminal acetylenes

A photochemical two-step one-pot synthesis of novel biscyclopropyl-box-shaped compounds via the reaction of 2,5-dimethoxy-para-benzoquinone and monosubstituted alkynes is reported. The reaction mechanism for a process in which six new C–C bonds are formed is explored by means of experimental and computational techniques. The whole process occurs with complete selectivity, and only one densely decorated diastereomer is obtained; such a degree of control and substitution makes for a rather powerful and complexity-building process.Agencia Estatal de Investigación | Ref. CTQ2017-85919-RXunta de Galicia | Ref. ED431E 2018/07Xunta de Galicia | Ref. EDC431C 2017/7

Meta-analysis: implications of interleukin-28B polymorphisms in spontaneous and treatment-related clearance for patients with hepatitis C

BACKGROUND: Since 2009, several studies have identified single-nucleotide polymorphisms (SNPs) near the gene encoding for interleukin (IL)-28 (IL28B) that are strongly associated with spontaneous and treatment-induced hepatitis C virus (HCV) clearance. Because this large amount of data includes some inconsistencies, we consider assessment of the global estimate for each SNP to be essential. METHODS: Relevant studies assessing IL28B polymorphisms associated with sustained virologic response (SVR) and spontaneous clearance (SC) were identified from a literature search of PubMed up to 9 July, 2012. Studies were eligible studies if they included patients infected with HCV or HCV/HIV, or assessed any SNP located within or near the IL28B gene, SVR data available under standard treatment, and/or SC data in patients with acute HCV infection. Pooled odds ratios were estimated by fixed or random effects models when appropriate. Variables such as HCV genotype, ethnicity, and type of co-infection were studied. RESULTS: Of 282 screened studies, 67 were selected for SVR and 10 for SC. In total, 20,163 patients were studied for SVR and 3,554 for SC. For SVR, we found that all SNPs showed strong associations in patients with HCV genotypes 1 and 4, whereas the pooled ORs were almost three times lower for genotypes 2 and 3 (rs12979860 and rs8099917). Regarding ethnicity, the SNP most associated with SVR was rs12979860 in white patients, whereas in East Asians it seemed to be rs8099917. The most studied SNP (rs12979860) showed similar results for patients co-infected with HCV/HIV, as for those infected with HCV only. Finally, rs12979860 and rs8099917 both appeared to be associated with SC. CONCLUSIONS: IL28B polymorphisms influence both the outcome of interferon treatment and the natural clearance of HCV. However we did not identify a universal predictor SNP, as the best genetic markers differed depending on patient ethnicity, genotype, and type of infection. Nevertheless, our results may be useful for more precise treatment decision-making.This work was supported by grants from the 'Health Institute Carlos III (ISCIII)' [PI08/0738 and PI11/00245]. MAJS, AFR MGF and MGA were supported by the after grants [CM10/00105, PI08/0738, CM09/00031, and CM08/00101 respectively].S

El uso de las Tecnologías de la Información y la Comunicación en el desarrollo académico de los alumnos universitarios: caso Facultad de Enfermería y Obstetricia

Los dispositivos, que brindan acceso a Internet, facilitan la comunicación y la información, convertidas en complementos indispensables en la vida de los alumnos, donde su uso contribuye con el aprendizaje y la educación. Se hizo un estudio cuantitativo, no experimental, transversal. Instrumento dividido en tres categorías: actitudes, uso y dominio de las tecnologías. La muestra fue de 299 estudiantes. 56% están completamente de acuerdo en que son una herramienta efectiva para el aprendizaje. 50% de acuerdo en que mejorarán la calidad educativa en clase. Un 41% de acuerdo en que son un complemento positivo para los libros, y un 42% a las bases de datos de bibliotecas virtuales y obtener información profesional. 62%, que optimizan el proceso de aprendizaje, y 39% plantean usarlas en lo académico. Las TIC benefician su desarrollo académico

Double protonation of a cis-Bipyridoallenophane detected via Chiral-Sensing Switch: the role of Ion Pairs

We prove that the confinement of the conformational space of pyridoallenophanes leads to intense chiroptical responses. Unlike the cyclic dimer [142], single-conformation [141]pyridoallenophanes isomerize under thermal and photochemical conditions. Yet, less-strained [141]-bipyridoallenophanes are stable and are prepared successfully. They, unexpectedly, undergo double protonation as a result of cooperative ion-pairing and hydrogen bonding. The complex formation forces a single configuration of the axis connecting both pyridyl rings recognized by a diagnostic circular dichroism (CD) signal at 330 nm.Agencia Estatal de Investigación | Ref. CTQ2017-84354-PAgencia Estatal de Investigación | Ref. CTQ2017-85919-RXunta de Galicia | Ref. IN607C 2016/03Xunta de Galicia | Ref. ED431C 2017/70Xunta de Galicia | Ref. Ref. ED431G/0

Oregano essential oil-pectin edible films as anti-quorum sensing and food antimicrobial agents

Edible films can be used as carriers for antimicrobial compounds to assure food safety andquality; in addition, pathogenesis of food bacteria is related to a cell to cell communicationmechanism calledquorum sensing(QS). Oregano essential oil (OEO) has proved to beuseful as food antimicrobial; however, its foodapplications can be compromised by thevolatile character of its active constituents.Therefore, formulation of edible films containingOEO can be an alternative to improve its food usages. QS inhibitory activity of OEO andpectin-OEO films was evaluated usingChromobacterium violaceumas bacterial model.Additionally, antibacterial activity was tested againstEscherichia coliO157:H7,SalmonellaCholeraesuis,Staphylococcus aureus,andListeria monocytogenes. OEO was effective toinhibit bacterial growth at MIC of 0.24 mg/mL for all tested bacteria and MBC of 0.24,0.24, 0.48, and 0.24 mg/mL againstE. coliO157:H7,S.Choleraesuis,S. aureus, andL.monocytogenes, respectively. Pectin-films incorporated with 36.1 and 25.9 mg/mL of OEOshowed inhibition diameters of 16.3 and 15.2 mm forE. coliO157:H7; 18.1 and 24.2 mm forS.Choleraesuis; 20.8 and 20.3 mm forS. aureus; 21.3 and 19.3 mm forL. monocytogenes,respectively. Pectin-OEO film (15.7 mg/mL) was effective againstE. coliO157:H7 (9.3 mm),S. aureus(9.7 mm), andL. monocytogenes(9.2 mm), but not forS.Choleraesuis. Allconcentrations of OEO (0.0156, 0.0312, 0.0625 and 0.125 mg/mL) and pectin-OEO films(15.7, 25.9 and 36.1 mg/mL) showed a significant anti-QS activity expressed as inhibition ofviolacein production byC. violaceum. Additionally, the application of pectin-OEO films waseffective reducing total coliforms, yeast, and molds of shrimp and cucumber slices storedat 4◦C during 15 d.These results demonstrated the potential of pectin films enriched withOEO as food related microorganisms and QS inhibitorsFil: Alvarez, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Ingeniería Química. Grupo de Investigación en Ingeniería En Alimentos; ArgentinaFil: Ortega Ramirez, Luis Alberto. Centro de Investigación en Alimentación y Desarrollo. Hermosillo; MéxicoFil: Gutierrez Pacheco, Maria Melissa. Centro de Investigación en Alimentación y Desarrollo. Hermosillo; MéxicoFil: Bernal Mercado, Thalia. Centro de Investigación en Alimentación y Desarrollo. Hermosillo; MéxicoFil: Rodriguez Garcia, Isela. Centro de Investigación en Alimentación y Desarrollo. Hermosillo; MéxicoFil: Ponce, Alejandra Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Ingeniería Química. Grupo de Investigación en Ingeniería En Alimentos; ArgentinaFil: Moreira, Maria del Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Ingeniería Química. Grupo de Investigación en Ingeniería En Alimentos; ArgentinaFil: Roura, Sara Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Ingeniería Química. Grupo de Investigación en Ingeniería En Alimentos; ArgentinaFil: Ayala Zavala, Jesús Fernando. Centro de Investigación en Alimentación y Desarrollo. Hermosillo; Méxic

Relationship Between the Quorum Network (Sensing/Quenching) and Clinical Features of Pneumonia and Bacteraemia Caused by A. baumannii

Acinetobacter baumannii (Ab) is one of the most important pathogens associated with nosocomial infections, especially pneumonia. Interest in the Quorum network, i.e., Quorum Sensing (QS)/Quorum Quenching (QQ), in this pathogen has grown in recent years. The Quorum network plays an important role in regulating diverse virulence factors such as surface motility and bacterial competition through the type VI secretion system (T6SS), which is associated with bacterial invasiveness. In the present study, we investigated 30 clinical strains of A. baumannii isolated in the “II Spanish Study of A. baumannii GEIH-REIPI 2000-2010” (Genbank Umbrella Bioproject PRJNA422585), a multicentre study describing the relationship between the Quorum network in A. baumannii and the development of pneumonia and associated bacteraemia. Expression of the aidA gene (encoding the AidA protein, QQ enzyme) was lower (P < 0.001) in strains of A. baumannii isolated from patients with bacteraemic pneumonia than in strains isolated from patients with non-bacteraemic pneumonia. Moreover, aidA expression in the first type of strain was not regulated in the presence of environmental stress factors such as the 3-oxo-C12-HSL molecule (substrate of AidA protein, QQ activation) or H2O2 (inhibitor of AidA protein, QS activation). However, in the A. baumannii strains isolated from patients with non-bacteraemic pneumonia, aidA gene expression was regulated by stressors such as 3-oxo-C12-HSL and H2O2. In an in vivo Galleria mellonella model of A. baumannii infection, the A. baumannii ATCC 17978 strain was associated with higher mortality (100% at 24 h) than the mutant, abaI-deficient, strain (carrying a synthetase enzyme of Acyl homoserine lactone molecules) (70% at 24 h). These data suggest that the QS (abaR and abaI genes)/QQ (aidA gene) network affects the development of secondary bacteraemia in pneumonia patients and also the virulence of A. baumannii.National Plan for Scientific ResearchTechnological Development and Innovation PI16/01163ISCIII-Deputy General Directorate for Evaluation and Promotion of Research-European Regional Development Fund A way of Making EuropeInstituto de Salud Carlos IIIMiguel Servet Research Programme SERGAS and ISCIIIXunta de Galicia (GAIN, Axencia de Innovación