Perceptions of Using Diabetic Alert Dogs to Promote Occupations and Quality of Life

This capstone project consisted of a pilot phenomenological qualitative research study with the goal of assessing diabetic alert dogs\u27 impact on their owners\u27 occupations and quality of life from the owner\u27s perspective. Individuals with type 1 diabetes that personally own a diabetic alert dog were interviewed virtually using a semi-structured approach. The goal of the interview questions was to gather information regarding health management, daily occupations, and quality of life. Gaps in the research were identified, and it was found that few research studies focused on the impact or benefits of a diabetic alert dog from the owner’s perspective. Therefore, this research study was pursued to fill the gap in the literature regarding the impact diabetic alert dogs have on their owners’ occupations and quality of life from the owner’s perspective and explore diabetic alert dogs as an intervention option that occupational therapist can educate their patients with diabetes about to help them manage their condition, be independent, and improve their quality of life.https://soar.usa.edu/otdcapstonessummer2022/1000/thumbnail.jp

Health Literacy Barriers and Occupation Based Education for Healthcare Providers serving Hispanic Americans

The purpose of the program was to shed light on addressing health literacy barriers and provide occupation-based education for healthcare providers serving Hispanic Americans, specifically in rural areas. Additionally, the purpose of the program was to close the gap by providing healthcare practitioners with tools and resources to assist in combating the barriers faced to include the lack of occupational therapy services. The pre-and post-survey during the needs assessment helped determine the participant\u27s baseline understanding of various aspects related to health literacy and guided the development of the educational modules and informative resources. Based on the outcomes of the survey, the program serves as a valuable resource for healthcare providers with limited resources and translation services due to geographical location.https://soar.usa.edu/otdcapstonessummer2023/1009/thumbnail.jp

Towards precision medicine: defining and characterizing adipose tissue dysfunction to identify early immunometabolic risk in symptom-free adults from the GEMM family study

Interactions between macrophages and adipocytes are early molecular factors influencing adipose tissue (AT) dysfunction, resulting in high leptin, low adiponectin circulating levels and low-grade metaflammation, leading to insulin resistance (IR) with increased cardiovascular risk. We report the characterization of AT dysfunction through measurements of the adiponectin/leptin ratio (ALR), the adipo-insulin resistance index (Adipo-IRi), fasting/postprandial (F/P) immunometabolic phenotyping and direct F/P differential gene expression in AT biopsies obtained from symptom-free adults from the GEMM family study. AT dysfunction was evaluated through associations of the ALR with F/P insulin-glucose axis, lipid-lipoprotein metabolism, and inflammatory markers. A relevant pattern of negative associations between decreased ALR and markers of systemic lowgrade metaflammation, HOMA, and postprandial cardiovascular risk hyperinsulinemic, triglyceride and GLP-1 curves was found. We also analysed their plasma non-coding microRNAs and shotgun lipidomics profiles finding trends that may reflect a pattern of adipose tissue dysfunction in the fed and fasted state. Direct gene differential expression data showed initial patterns of AT molecular signatures of key immunometabolic genes involved in AT expansion, angiogenic remodelling and immune cell migration. These data reinforce the central, early role of AT dysfunction at the molecular and systemic level in the pathogenesis of IR and immunometabolic disorders

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

New Perspectives on Faculty Stress: Its Relationship with Work Engagement, Teaching Effectiveness, and Program Preferences to Manage Stress

The purpose of the study was to analyze faculty stress with three interrelated parts. First, the study examined the relationship between work engagement, stress factors, stress outcomes, and faculty characteristics. Next, the study analyzed the relationship between students’ perception of faculty stress, faculty teaching effectiveness, class size, and student classification. Finally, the study investigated faculty preferences for health and wellness programs in the workplace. The study used two anonymous online questionnaires to collect data from 45 faculty participants and 119 student participants from a U.S. public, four-year research university. For faculty, the results demonstrated statistically significant strong relationships between all the stress factors and outcomes indicating faculty who experience any of these stressors are more likely to disengage from work. Work disengagement, stress factors, and stress outcomes had statistically significant correlations with age, tenure status, and gender. Younger faculty are more likely to experience burnout, issues with cognitive concerns, and disengage from work tasks. Non-tenure-track faculty are more likely to disengage from work, experience higher levels of stress and burnout, and experience physical, cognitive, and mental health concerns. The results also indicated that female faculty are more likely to present with cognitive concerns. For students, the study found that students are more likely to perceive a faculty member is less effective when the faculty member is perceived as sad or tense. Students are also more likely to perceive faculty who display sadness as the class size increases or as students move up in classification. The study fills gaps that enhance the understanding of faculty stress and various dimensions that contribute to work disengagement, teaching effectiveness, and managing stress

Assessment of the environmental impact of an abandoned mine using an integrative approach: a case-study of the “Las Musas” mine (Extremadura, Spain).

The mine abandonment is generally associated with the release of potentially toxic metals into the environment, which may depend on metals speciation, soil properties and climate conditions. The goal of the present work was to assess the environmental impact of the abandoned Pb-Zn mine “Las Musas” (Spain) using an integrative approach. The impact on soils and surface waters was performed using: chemical parameters, quantification of potentially toxic metals (Cd, Cu, Pb and Zn), and ecotoxicological responses using lethal and sub-lethal bioassays with organisms’ representative of different trophic level ((soil: Eisenia fetida (mortality and reproduction test); Latuca sativa and Lollium perenne (seedling emergence); and water: Vibrio fischeri (luminescence inhibition), Daphnia magna (immobility and reproduction test), Thamnocephalus platyurus (mortality), Pseudokirchneriella subcapitata (growth inhibition)). The results showed soils with neutral to slight alkaline pH (7.64-8.18), low electric conductivity (125-953 µS/cm) and low organic matter levels (0.20-1.85%). For most of the soil samples, Pb was the only metal which surpassed the limit proposed by the Canadian soil quality guidelines, with values ranging from 42.2 to 181.4 mg/kg. The ecotoxicological results showed that the soils with the highest levels of Pb induced a decrease on E. fetida reproduction and on L. sativa germination, indicating negative impacts on the habitat function. The analysis of the surface waters showed levels of Zn surpassing the legal limit adopted from the Water Framework Directive (37.0 to 69.0 µg/L). The ecotoxicological results highlight the importance of bioassays that evaluate the behavior of species, when assessing the risk of mining areas with non-acid soils and waters with high nutrients/ organic matter concentrations and low concentrations of potentially toxic metals. The results indicated a moderate environmental risk from potentially toxic metals, at the areas analyzed around the Azuaga mine

New Variant in Placophilin-2 Gene Causing Arrhythmogenic Myocardiopathy

Introduction: Arrhythmogenic cardiomyopathy (ACM) is an inherited disease characterized by progressive fibroadipose replacement of cardiomyocytes. Its diagnosis is based on imaging, electrocardiographic, histological and genetic/familial criteria. The development of the disease is based mainly on desmosomal genes. Knowledge of the phenotypic expression of each of these genes will help in both diagnosis and prognosis. The objective of this study is to describe the genotype–phenotype association of an unknown PKP2 gene variant in a family diagnosed with ACM. Methods: Clinical and genetic study of a big family carrying the p.Tyr168* variant in the PKP2 gene, in order to demonstrate pathogenicity of this variant, causing ACM. Results: Twenty-two patients (proband and relatives) were evaluated. This variant presented with high arrhythmic load at an early age, but without evidence of structural heart disease after 20 years of follow-up, with low risk in predictive scores. We demonstrate evidence of its pathogenicity. Conclusions: The p.Tyr168* variant in the PKP2 gene causes ACM with a high arrhythmic load and with an absence of structural heart disease. This fact emphasizes the value of knowing the phenotypic expression of each variant