Intramolecular hydrogen-bond activation for the addition of nucleophilic imines: 2-hydroxybenzophenone as a chemical auxiliary

The addition of nucleophilic imines, using 2-hydroxybenzophenone as a chemical auxiliary, is presented. An intramolecular six-membered ring via hydrogen bonding that enhances the reactivity and selectivity is the key of this strategy, which is supported by DFT calculations and experimental trialsSpanish Government (CTQ2015-64561-R, CTQ2016-76061-P, and MDM-2014-0377), Prodep (UJAT-PTC-247) and CCC-UAM are acknowledged. A. G. thanks MINECO for a PhD fellowship (FPI) and A. M. S. thanks CAM for a postdoctoral contract (2016-T2/IND-1660

Catalog and distribution atlas of the Scarabaeoidea (Insecta: Coleoptera) of El Salvador

Menos del 1% de la literatura sobre la biodiversidad de El Salvador es sobre invertebrados terrestres, lo que limita nuestro conocimiento de la diversidad, riqueza y distribución de este grupo en el territorio. Los Scarabaeoidea son megadiversos en múltiples ecosistemas y cumplen muchas funciones. Este trabajo tiene como objetivo catalogar los Scarabaeoidea en El Salvador. Se realizó una revisión exhaustiva de la literatura publicada y se revisaron numerosas colecciones entomológicas con material relevante. Se construyeron mapas para visualizar la distribución conocida de cada especie en el país. Existen 295 especies de escarabajos (incluyendo 19 nuevos registros en el país) representando 106 géneros en 7 familias en El Salvador. Se conocen seis especies precursoras. Veintidós especies se descartan como presentes en El Salvador, ya sea porque no son especies válidas o por identificaciones erróneas o registros dudosos. Este trabajo es la primera aproximación al conocimiento de los Scarabaeoidea en El Salvador, un territorio que usualmente se considera de nula importancia para la conservación de la biodiversidad regional debido a su reducida superficie, alta tasa de deforestación y sobrepoblación. Los resultados de este trabajo refuerzan la necesidad de realizar prospección biológica en el territorio para conocer, conservar y proteger la biodiversidad remanente. 2023 Universidad Nacional Autónoma de México. Todos los derechos reservados.Less than 1% of the literature on El Salvador s biodiversity is about terrestrial invertebrates, which limits our knowledge of this group s diversity, richness, and distribution in the territory. Scarabaeoidea are megadiverse in multiple ecosystems and perform many functions. This work aims to catalog the Scarabaeoidea in El Salvador. We conducted an exhaustive review of published literature and reviewed numerous entomological collections with relevant material. Maps were constructed to visualize the known distribution of each species in the country. There are 295 scarab beetle species (including 19 new country records) representing 106 genera in 7 families in El Salvador. Six precinctive species are known. Twenty-Two species are discarded as occurring in El Salvador, either because they are not valid species or because of misidentifications or dubious records. This work is the first approach to knowing the Scarabaeoidea in El Salvador, a territory that is usually considered of no importance for the conservation of regional biodiversity due to its small area, high rate of deforestation, and overpopulation. The results of this work reinforce the need for biological prospecting in the territory to know, conserve, and protect the remaining biodiversity. © 2023 Universidad Nacional Autonoma de Mexico. All rights reserved

microbeMASST: A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data

microbeMASST, a taxonomically informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can search known and unknown MS/MS spectra and link them to their respective microbial producers via MS/MS fragmentation patterns. Identification of microbe-derived metabolites and relative producers without a priori knowledge will vastly enhance the understanding of microorganisms’ role in ecology and human health

A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data

MicrobeMASST, a taxonomically-informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can search known and unknown MS/MS spectra and link them to their respective microbial producers via MS/MS fragmentation patterns. Identification of microbial-derived metabolites and relative producers, without a priori knowledge, will vastly enhance the understanding of microorganisms’ role in ecology and human health

Asymmetric Synthesis of Rauhut–Currier type Products by a Regioselective Mukaiyama Reaction under Bifunctional Catalysis

The reactivity and the regioselective functionalization of silyl–diene enol ethers under a bifunctional organocatalyst provokes a dramatic change in the regioselectivity, from the 1,5- to the 1,3-functionalization. This variation makes possible the 1,3-addition of silyl–dienol ethers to nitroalkenes, giving access to the synthesis of tri- and tetrasubstituted double bonds in Rauhut–Currier type products. The process takes place under smooth conditions, nonanionic conditions, and with a high enantiomeric excess. A rational mechanistic pathway is presented based on DFT and mechanistic experiments

microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data

microbeMASST, a taxonomically informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can search known and unknown MS/MS spectra and link them to their respective microbial producers via MS/MS fragmentation patterns. Identification of microbe-derived metabolites and relative producers without a priori knowledge will vastly enhance the understanding of microorganisms' role in ecology and human health