Neurotic lyrical subjects: textual indicators and personality traits

In the present essay, I study the textual inscription of neurotic features in lyrical discourse. I want to see if it is possible to use neuroticism as a category of analysis when studying lyrical subjects. For this, I try to detect the textual indicators of neuroticism. Textual production of Sylvia Plath’s and Alejandra Pizarnik’s lyrical subject is analyzed on the basis of the theory of self-characterization. Direct and indirect techniques of self-characterization help me to explore how the reader constructs the lyrical subject. Eventually, the textual inscription of both lyrical subjects is put into comparison to show how it is possible to shed light on a theory based on textual indicators common to all neurotic lyrical subjects.En el presente ensayo me dedico a estudiar la inscripción textual de rasgos neuróticos en el discurso lírico. Pretendo dilucidar si es posible utilizar el neuroticismo como categoría de análisis para el estudio de sujetos líricos. De tal forma, resulta necesario detectar los posibles indicadores textuales del neuroticismo. La producción textual de los sujetos líricos de Sylvia Plath y Alejandra Pizarnik es analizada sobre la base de la teoría de la auto-caracterización. A su vez, las técnicas de autocaracterización directas e indirectas me permiten explorar el proceso por el cual el lector construye al sujeto lírico. Finalmente, la inscripción textual de ambos sujetos líricos es comparada para demonstrar que es posible aportar luz sobre una teoría sustentada en una serie de indicadores textuales comunes a cualquier sujeto lírico neurótico.Departamento de Filología InglesaGrado en Estudios Inglese

4-ethyphenol detection in wine by fullerene modified screen-printed carbon electrodes

This work shows the potential of modified screen-printed carbon electrodes (SPCEs) for sensitive and selective detection of 4-ethylphenol in wine. Gold nanoparticles (AuNPs) and fullerene C60 (C60), modified sensors have been compared. pH of the supporting electrolyte, deposition time and working temperature have been optimized considering their influence in the voltammetric pulse response of 4-ethylphenol. Under the optimal conditions of measurement, the developed activated C60/SPCE (AC60/SPCE) shows the best performance, with a detection capability of 400 μg/L and 700 μg/L, when using deposition times of 14 min and 6 min, respectively (α = β = 0.05). The reproducibility of the developed sensor resulted better when a deposition time of 6 min was used (5.4 %, n = 3). The influence of different interferents on the analytical response has been studied, as well as their application in the determination of 4-ethylphenol in different wine samples.Authors would like to acknowledge funding obtained by Junta de Castilla y León (BU018G19) and Agencia Estatal de Investigación (PID2020-117095RB-I00)

Electrochemical devices for cholesterol detection

Cholesterol can be considered as a biomarker of illnesses such as heart and coronary artery diseases or arteriosclerosis. Therefore, the fast determination of its concentration in blood is interesting as a means of achieving an early diagnosis of these unhealthy conditions. Electrochemical sensors and biosensors have become a potential tool for selective and sensitive detection of this biomolecule, combining the analytical advantages of electrochemical techniques with the selective recognition features of modified electrodes. This review covers the different approaches carried out in the development of electrochemical sensors for cholesterol, differentiating between enzymatic biosensors and non-enzymatic systems, highlighting lab-on-a-chip devices. A description of the different modification procedures of the working electrode has been included and the role of the different functional materials used has been discussed

Determination of aluminium using different techniques based on the Al(III)-morin complex

Three different methods for the determination of Al(III) in aqueous samples were compared. The different described procedures were based on the formation of the Al(III)-morin complex. UV–Vis spectrophotometry, spectrofluorimetry and differential pulse adsorptive stripping voltammetry (DPAdSV) techniques were compared under optimized experimental conditions. The DPAdSV method showed a better performance for the analysis of Al(III) in terms of capability of detection (70 nM) in comparison with the value obtained for UV–Vis spectrophotometric (300 nM) and spectrofluorimetic (110 nM) techniques. Thus, DPAdSV method was selected for the analysis of aluminium in river, tap and bottled water samples under the following optimized experimental conditions: pH = 4.4, deposition potential = +243 mV, deposition time = 210 s, giving satisfactory results

A Disposable Alkaline Phosphatase-Based Biosensor for Vanadium Chronoamperometric Determination

A chronoamperometric method for vanadium ion determination, based on the inhibition of the enzyme alkaline phosphatase, is reported. Screen-printed carbon electrodes modified with gold nanoparticles were used as transducers for the immobilization of the enzyme. The enzymatic activity over 4-nitrophenyl phosphate sodium salt is affected by vanadium ions, which results in a decrease in the chronoamperometric current registered. The developed method has a detection limit of 0.39 ± 0.06 µM, a repeatability of 7.7% (n = 4) and a reproducibility of 8% (n = 3). A study of the possible interferences shows that the presence of Mo(VI), Cr(III), Ca(II) and W(VI), may affect vanadium determination at concentration higher than 1.0 mM. The method was successfully applied to the determination of vanadium in spiked tap waterResearch Vicerrectory of Costa Rica University (Project 804-B0-058) and Spanish Ministry of Science and Innovation (TEC-2009/12029). This work was supported by the Spanish Ministry of Science and Innovation (MICINN) 410 and the European Regional Development Fund (FEDER) (INNPACTO SERIBIO 2011-411 2014) and TEC2009-12029, as well as through Junta de Castilla y León (BU212A12-2)

Validity of a Clinical Scale in Predicting the Failure of Non-Invasive Ventilation in Hypoxemic Patients

Introduction: The HACOR scale is a clinical score that can predict early failure of NIV in hypoxemic acute respiratory failure (ARF) The aim of this study is to analyze the validity of the HACOR scale. Methods: A retrospective study of a cohort of over 2749 episodes on 2711 consecutive patients requiring NIV for hypoxemic ARF in a polyvalent intensive care unit. The scale was measured before starting NIV and at 1, 6, 12, 24 and 48 h after the initiation of NIV. Results: NIV failure occurred in 963 patients (35%). The value of the HACOR scale before NIV did not differ between success and failure. However, at 1, 6, 12, 24 and 48 h of NIV, the scale values clearly differed between the two groups. The HACOR scale at NIV initiation accurately predicts NIV failure in the first hour, with an optimal cut-off value of 8 points. The AUC for predicting NIV failure with HACOR at 1 h is greater than 0.9 in patients with pneumonia and adult respiratory distress syndrome (ARDS). Conclusions: The HACOR scale measured at 1 h after NIV initiation accurately predicts NIV failure, especially in pneumonia and ARDS.info:eu-repo/semantics/publishedVersio

A Chronoamperometric Screen Printed Carbon Biosensor Based on Alkaline Phosphatase Inhibition for W(VI) Determination in Water, Using 2-Phospho-L-Ascorbic Acid Trisodium Salt as a Substrate

This paper presents a chronoamperometric method to determine tungsten in water using screen-printed carbon electrodes modified with gold nanoparticles and cross linked alkaline phosphatase immobilized in the working electrode. Enzymatic activity over 2-phospho-L-ascorbic acid trisodium salt, used as substrate, was affected by tungsten ions, which resulted in a decrease of chronoamperometric current, when a potential of 200 mV was applied on 10 mM of substrate in a Tris HCl buffer pH 8.00 and 0.36 M of KCl. Calibration curves for the electrochemical method validation, give a reproducibility of 5.2% (n = 3), a repeatability of 9.4% (n = 3) and a detection limit of 0.29 ± 0.01 μM. Enriched tap water, purified laboratory water and bottled drinking water, with a certified tungsten reference solution traceable to NIST, gave a recovery of 97.1%, 99.1% and 99.1% respectively (n = 4 in each case) and a dynamic range from 0.6 to 30 μM. This study was performed by means of a Lineweaver–Burk plot, showing a mixed kinetic inhibition.Vicerrectorìa de Investigación de la Universidad de Costa Rica (Project 804-B2-297), via Junta de Castilla y León (BU212A12-2), Ministerio de Ciencia e Innovación (MICINN) (TEC2009-12029) and MICINN and Fondo Europeo de Desarrollo Regional (FEDER) (INNPACTO SERIBIO 2011-2014)

Thermal-fluid characterization of alternative liquids of power transformers: a numerical approach

The transformers lifespan depends importantly on its refrigeration. Mineral oils perform this work in the majority of the power transformers. However, this type of coolant has two main drawbacks: low biodegradability and low ignition point. Several alternative liquids are being developed in order to overcome these drawbacks. This paper compares their thermal-fluid behavior with a mineral oil by means of several parameters, such as temperature, flow rate, fluids velocity, convective heat transfer coefficient (h) and the cooling criterion (P). These are calculated using the numerical results of the simulation of a 3D-model of a Low Voltage Winding that belongs to a power transformer with ONAN cooling. The software COMSOL Multiphysics has allowed the simulation of the geometry using a physical model in which buoyancies and viscous forces are the only considered establishing the natural convection. As a result of the comparison, it is clear that the mineral oil is the best coolant liquid. Among the alternative liquids, silicone oil would be the second best coolant fluid, followed by the synthetic and natural esters, respectively. On the other hand, it seems to be clear that the 3D simulations can be used to compare properly the cooling capacities of the liquids.The research leading to these results has received funding from multiple sources during years but we would specifically like to acknowledge the support received in the later stages from the Spanish Plan Estatal de I+D under the grant agreement DPI2013-43897-P

La imagen como materia y material. Arquitecturas avanzadas y experimentación audiovisual desde la mirada inclusiva de Herbert Bayer.

Producción CientíficaDesde mediados del siglo XX se observa una proliferación de singulares prácticas arquitectónicas basadas en la incorporación de sistemas de información mediática como ingrediente fundamental. En este contexto, la investigación busca revelar el hilo de Ariadna que nos conduce desde la figura de Herbert Bayer y su influyente esquema gráfico de Fundamentals of Exhibition Design (1939), hasta la presencia de la imagen en movimiento en el diseño arquitectónico más contemporáneo, entendida ésta, como materia y material conceptual. Concretamente mediante el análisis de tres líneas principales cuya relación se pretende desarrollar: por una parte, las aportaciones de Herbert Bayer en el campo visual y del diseño expositivo; por otra, las experiencias pioneras de hibridación entre arquitectura, teatro y video proyecciones de los años 50; y finalmente, el estudio de proyectos de fin de siglo en los que lo audiovisual constituye un soporte decisivo en la definición arquitectónica. Mediante la revisión bibliográfica como método de trabajo, apoyada de un análisis intencional de ejemplos, se procura justificar el vínculo entre los anteriores enfoques. Las conclusiones apuntan al linaje de la fusión de los mundos físico y virtual en la arquitectura, a través de la imagen en movimiento insertada en su diseño.Proyecto I D i “Paisajes Audiovisuales en la Arquitectura de la Ciudad Media” Ref. VA127G18. Junta de Castilla y León

CMV hyperimmune globulin as salvage therapy for recurrent or refractory CMV infection in children undergoing hematopoietic stem cell transplantation

Children; Cytomegalovirus; Hematopoietic stem cell transplantationNens; Citomegalovirus; Trasplantament de cèl·lules mare hematopoètiquesNiños; Citomegalovirus; Trasplante de células madre hematopoyéticasCytomegalovirus (CMV) is a major cause of allogeneic hematopoietic stem cell transplant (HSCT)-related morbidity and mortality. Treatment failure continues to be a major issue in patients with CMV infection due to both drug resistance and intolerance. This single-center brief retrospective analysis of a case series aims to investigate the safety and efficacy of CMV-hyperimmune globulin as salvage therapy for CMV infection in children undergoing HSCT. Fifteen pediatric patients received human CMV-specific immunoglobulin (CMVIG) between July 2018 and December 2021 as a salvage therapy for refractory or recurrent CMV infection. At the time of CMVIG prescription, eight children presented with recurrent CMV infection and seven with refractory CMV infection. The overall response rate was 67% at 50 days from the CMVIG administration [95% confidence interval (CI): 44–88]. Overall survival (OS) from CMVIG administration at 100 days was 87% (95% CI: 56–96), and OS from HSCT at 1 year was 80% (95% CI: 50–93). Four patients died, three unrelated to CMV infection and one due to CMV pneumonia. CMVIG as salvage therapy was well tolerated, and no infusion-related adverse events were observed.Biotest supported the English revision of the manuscript