LEARNING ACTIVITIES WITH LEGO ROBOTICS EV3

From May 8th to 12th, 2017 the Taccle 3 training course “Teaching coding to children” (http://www.taccle3.eu/en/tallinn-training-course-guide/) was held in Tallin (Estonia), which will focus on introducing programming in primary schools and teaching children how to code. The training has been designed by the Taccle 3 project partners. The training course aimed to develop your own coding competences and also the competences to teach coding to children from 3 to 14 years. There were five training days during which we learned together, in order to: Describe the key principles of coding; Describe the basics of computational thinking; Use appropriate terminology; Build on activities teachers and children already do; Measure progression, differentiate lessons and assess what children have learned; Link the curriculum to the Taccle3 website. The final activity developed by these participants was related to use Lego Robotics EV3 in learning activities

Body composition and somatotype in professional men's handball according to playing positions

Se realizó un estudio descriptivo transversal en 19 jugadores profesionales del Club Balonmano Valladolid. Las mediciones antropométricas fueron realizadas según el protocolo estándar. Se estimaron la masa grasa y ósea, se calculó el somatotipo y se analizaron las diferencias entre las variables en función de la posición. Como resultados, se obtuvo que los pivotes fueron los jugadores más pesados (con mayor porcentaje de masa grasa); los extremos, los más ligeros y los laterales, junto con los pivotes, los más altos. No se observaron diferencias en el IMC en los grupos. En la somatocarta los centrales y laterales se situaron en la zona central; los extremos y los pivotes en la endomorfa-mesomorfa y los porteros en la ecto-endomorfa. Así se evidenció que las variables antropométricas, los datos de composición corporal y la somatocarta de los deportistas confirman las características morfológicas básicas de los jugadores para la posición para la que son más aptosA cross-sectional descriptive study was accomplished in 19 professional players from Valladolid Handball Club. Anthropometric measurements were performed according to standard protocol. Body fat and bone mass were estimated, and the somatotype was calculated. As results, the line players were significantly the heaviest players; the wings were lightest and the backs, with the line players, the tallest. Nevertheless, no significant differences in BMI were observed. Regarding the body composition, the line players showed the highest values of fat-mass. No differences in BMI were observed in the groups. With respect to the somatochart, the center backs and backs were in the central area; wings and line players showed an endomorph-mesomorph development, and goalkeepers were in the ectoendomorph area. As conclusions, anthropometric variables, body composition data and the somatochart of the athletes evaluated confirm the basic morphological characteristics of the players for the position for which they are best suite

Toll-like receptor 4 contributes to vascular remodelling and endothelial dysfunction in angiotensin II-induced hypertension

This is the peer-reviewed version of the following article: "Toll-like receptor 4 contributes to vascular remodelling and endothelial dysfunction in angiotensin II-induced hypertension", British Journal of Pharmacology 172.12 (2015): 3159-76 which has been published in final form at http://dx.doi.org/10.1111/bph.13117 This article may be used for non-commercial purposes in accordance with Wiley-VCH Terms and Conditions for Self-ArchivingBackground and Purpose Toll-like receptor 4 (TLR4) signalling contributes to inflammatory cardiovascular diseases, but its role in hypertension and the associated vascular damage is not known. We investigated whether TLR4 activation contributed to angiotensin II (AngII)-induced hypertension and the associated vascular structural, mechanical and functional alterations. Experimental Approach AngII was infused (1.44 mg·kg−1·day−1, s.c.) for 2 weeks in C57BL6 mice, treated with a neutralizing anti-TLR4 antibody or IgG (1 μg·day−1); systolic BP (SBP) and aortic cytokine levels were measured. Structural, mechanical and contractile properties of aortic and mesenteric arterial segments were measured with myography and histology. RT-PCR and Western blotting were used to analyse these tissues and cultured vascular smooth muscle cells (VSMC) from hypertensive rats (SHR). Key Results Aortic TLR4 mRNA levels were raised by AngII infusion. Anti-TLR4 antibody treatment of AngII-treated mice normalised: (i) increased SBP and TNF-α, IL-6 and CCL2 levels; (ii) vascular structural and mechanical changes; (iii) altered aortic phenylephrine- and ACh-induced responses; (iv) increased NOX-1 mRNA levels, superoxide anion production and NAD(P)H oxidase activity and effects of catalase, apocynin, ML-171 and Mito-TEMPO on vascular responses; and (v) reduced NO release and effects of L-NAME on phenylephrine-induced contraction. In VSMC, the MyD88 inhibitor ST-2825 reduced AngII-induced NAD(P)H oxidase activity. The TLR4 inhibitor CLI-095 reduced AngII-induced increased phospho-JNK1/2 and p65 NF-κB subunit nuclear protein expression. Conclusions and Implications TLR4 up-regulation by AngII contributed to the inflammation, endothelial dysfunction, vascular remodelling and stiffness associated with hypertension by mechanisms involving oxidative stress. MyD88-dependent activation and JNK/NF-κB signalling pathways participated in these alterationsThis work was supported by Ministerio de Economía y Competitividad (SAF2012-36400), Instituto de Salud Carlos III (Red de Investigación Cardiovascular RD12/0042/0024 and RD12/0042/0033) and URJC (PRIN13_CS12). AMB was supported by the Ramón y Cajal Program (RYC-2010-06473)

La violencia contra las mujeres enfermeras en la pareja. Primeros resultados de un estudio en Andalucía

Aim. To Identify intimate partner violence (IPV) against female nurses in a sample of nurses in Cordoba, Spain.Design. Descriptive, cross-sectional study.Setting. Hospitals and primary health care in Cordoba, Spain.Participants. One hundred and two female nurses working in urban or rural, public or private health centers in Cordoba, Spain.Measures. Social-demographic characteristics and presence of abuse (psychological, physical and sexual).Results. A) A stricter recoding of the parameters of abuse: overall, 47.1% had experienced some type of IPV, of which 41.2% was psychological. B) A more permissible recoding of the parameters of abuse: 25.5% had experienced some type of IPV, of which 19.6% was psychological. C) Both recodings: 2.9% had suffered three types of abuse together (psychological, physical and sexual) and both psychological and sexual IPV; likewise, 11,8% reported more severe or more serious abuse.Conclusion. The existence of intimate partner violence in female nurses was established and it was confirmed that this was expressed through psychological aspects.Objetivo. Identificar violencia contra las mujeres enfermeras en la pareja a partir de una muestra de profesionales que prestan sus servicios en la Provincia de Córdoba.Diseño. Estudio descriptivo transversal.Emplazamiento. Hospitales y distritos sanitarios de la Provincia de Córdoba.Participantes. Mujeres enfermeras que desarrollaban sus actividades profesionales en cualquiera de los sistemas de salud, público o privado, rural o urbano, en la Provincia de Córdoba.Mediciones Principales. Características sociodemográficas y presencia de malos tratos (psíquico, físico y sexual), con el cuestionario validado por Delgado y colaboradores (2006).Resultados. La Recodificación de las variables del maltrato más estricta muestra que el 47,1% del total de enfermeras en la muestra tuvo algún tipo de maltrato, del que el 41,2% fue exclusivamente psicológico. Una Recodificación del maltrato más permisiva indica que el 25,5% tuvo algún tipo de maltrato del que 19,6% fue psicológico. Considerando ambas se puede ver que el 2,9% presentaron los tres tipos juntos (psicológico, físico y sexual) y psicológico acompañado del sexual; así como que el 11,8% presentó un maltrato más severo o de mayor gravedad.Conclusiones. Establecida la existencia de malos tratos en la mujer enfermera se constata que las manifestaciones van referidas al aspecto psicológic

Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO

AbstractThoracic aortic aneurysm, as occurs in Marfan syndrome, is generally asymptomatic until dissection or rupture, requiring surgical intervention as the only available treatment. Here, we show that nitric oxide (NO) signaling dysregulates actin cytoskeleton dynamics in Marfan Syndrome smooth muscle cells and that NO-donors induce Marfan-like aortopathy in wild-type mice, indicating that a marked increase in NO suffices to induce aortopathy. Levels of nitrated proteins are higher in plasma from Marfan patients and mice and in aortic tissue from Marfan mice than in control samples, indicating elevated circulating and tissue NO. Soluble guanylate cyclase and cGMP-dependent protein kinase are both activated in Marfan patients and mice and in wild-type mice treated with NO-donors, as shown by increased plasma cGMP and pVASP-S239 staining in aortic tissue. Marfan aortopathy in mice is reverted by pharmacological inhibition of soluble guanylate cyclase and cGMP-dependent protein kinase and lentiviral-mediated Prkg1 silencing. These findings identify potential biomarkers for monitoring Marfan Syndrome in patients and urge evaluation of cGMP-dependent protein kinase and soluble guanylate cyclase as therapeutic targets.</jats:p

Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV

The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8  TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum