Análisis del consumidor femenino como método para la elaboración de una estrategia en la empresa Fútbol Emotion.

En este trabajo se realiza el análisis de las preferencias de compra de las mujeres futbolistas, a través de una encuesta para la empresa Fútbol Emotion. Para conocer la importancia y el motivo de dicha estrategia, se comienza con una introducción a la situación actual en la que se encuentran las mujeres futbolistas a nivel global así como, de una forma más concreta, en la empresa Fútbol Emotion. Una vez contextualizada la situación, se comienza con el análisis de los resultados obtenidos y se procede a la elaboración de un DAFO, mediante el cual se identifican aquellas características a mejorar por la empresa Fútbol Emotion, y se proporciona una posible solución a las mismas.<br /

Análisis de la distribución de hidrógeno en contención y pozo seco de C.N. Cofrentes.

El desarrollo del modelo de la Contención de C.N. Cofrentes mediante GOTHIC se ha llevado a cabo introduciendo todos los datos geométricos y de estructuras de la Contención, pudiendo así modelar todos los recintos interiores y habitaciones que la componen. De esta forma se ha obtenido un modelo 3D detallado y con la precisión suficiente para el estudio global de la gestión del hidrógeno, permitiendo tener en cuenta, a la hora de la distribución del hidrógeno, la asimetría tanto de la contención como de las descargas de masa y en energía que en ella se realizan, permitiendo simular la distribución del vapor y el hidrógeno presentes en el accidente severo para poder determinar las zonas de mayor riesgo de deflagración o detonación durante la evolución del accident

Infección cutánea por Alternaria triticina en un paciente con trasplante bilateral de pulmón

We report the case of a 60-year-old man who was receiving immunosuppressive therapy for a bilateral lung transplant and presented with a crusted, violaceous plaque on the left hand. Based on histopathology and microbiological culture the patient was diagnosed with infection by Alternaria species. Treatment with itraconazole led to complete resolution of the skin lesion. Forty months later he developed four reddish, nodular, skin lesions on the left leg. Analysis of a biopsy from one of these lesions using histopathologic and molecular techniques identified a mold that shared 98% homology with a strain of Alternaria triticina. Alternaria species belong to a group of dematiaceous fungi that cause opportunistic infections in humans. The incidence of these infections is increasing, mainly in transplant centers. To the best of our knowledge, this is the first reported case of a human infection caused by A. triticinaPresentamos el caso de un hombre de 60 años en tratamiento inmunosupresor por un trasplante pulmonar bilateral que presentó una placa violácea costrosa en la mano. Se diagnosticó de infección por Alternaria spp mediante estudio histopatológico y cultivo microbiológico. El tratamiento con itraconazol condujo a la resolución completa de la lesión cutánea. Cuarenta meses más tarde el paciente desarrolló 4 lesiones nodulares rojizas en la pierna izquierda. Las muestras obtenidas de una de las lesiones fueron estudiadas mediante histopatología y técnicas moleculares. La secuencia de ADN que se obtuvo del germen causal mostraba una homología del 98% con una cepa de Alternaria triticina. Las especies de Alternaria forman parte del grupo de hongos que componen las feohifomicosis susceptibles de causar infecciones oportunísticas humanas. La incidencia de estas infecciones está aumentando, sobre todo en centros de trasplante. De acuerdo con nuestra información el presente caso es el primero en el que A. triticina es causante de una infección humanaAcknowledgement: We thank Manuel Cuenca Estrella and Emilia Mellado of the Instituto Nacional de Salud Carlos III in Madrid for confirmation of the identity of the fungus

Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress

Atherosclerosis remains the underlying process responsible for cardiovascular diseases and the high mortality rates associated. This chronic inflammatory disease progresses with the formation of occlusive atherosclerotic plaques over the inner walls of vascular vessels, with oxidative stress being an important element of this pathology. Oxidation of low-density lipoproteins (ox-LDL) induces endothelial dysfunction, foam cell activation, and inflammatory response, resulting in the formation of fatty streaks in the atherosclerotic wall. With this in mind, different approaches aim to reduce oxidative damage as a strategy to tackle the progression of atherosclerosis. Special attention has been paid in recent years to the transcription factor Nrf2 and its downstream-regulated protein heme oxygenase-1 (HO-1), both known to provide protection against atherosclerotic injury. In the current review, we summarize the involvement of oxidative stress in atherosclerosis, focusing on the role that these antioxidant molecules exert, as well as the potential therapeutic strategies applied to enhance their antioxidant and antiatherogenic properties

COVID-19 patients with psoriasis and psoriatic arthritis on biologic immunosuppressant therapy versus apremilast in North Spain

Immunosuppressive and immunomodulatory treatments are critical for the management of inflammatory and autoimmune conditions such as psoriasis or psoriatic arthritis. Similar to those illnesses, the lung injury and acute respiratory distress shown in coronavirus disease 2019 (COVID‐19) patients are the result of a disruption in the balance of pro‐ and anti‐inflammatory cytokines. This hyperinflammatory response to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), associated with the severity of the coronavirus disease, is called the cytokine storm. There is a growing concern regarding how patients on immunosuppressant biologic therapies might be at higher risk of being infected and whether they need to discontinue their treatment preemptively. Clinical data on COVID‐19‐infected patients with psoriasis or psoriatic arthritis are still scarce. Here, we presented seven cases of these type of patients. The patient infected with COVID‐19 on apremilast and the one on apremilast with infected spouse showed the best safety profile and mildest symptoms. One of the secukinumab patients also presented a relatively good outcome. Infliximab patients and the one with serious comorbidities showed the worst outcome. Even though more clinical data are yet needed to draw strong conclusions, apremilast could be a safer alternative for dermatology and rheumatology patients in case of clinically important active infection

Small hydropower plants in Spain: a case study

A small hydropower plant in Spain is studied from an energetic and economic perspective. The viability of the facility is examined using the freeware software RETScreen. Calculated and standard operational data are compared, thereby demonstrating the feasibility of the project from all points of view. The study highlights the growing interest in renewable energies.research project BU019A08 supported by the Department of Culture and Education of the Regional Government of Castilla y León, Spai

Efficiency of the Triage in the attention to the prison population in the hospital emergency service

Introducción: Para adaptarse al incremento de demanda asistencial los hospitales han implantado un sistema de Triage, considerado indicador de calidad. Objetivo: Conocer el cumplimiento de objetivos de calidad en tiempos medios de espera triage–asistencia médica. Metodología: Estudio descriptivo, observacional y retrospectivo. Población a estudio: pacientes penitenciarios, excluyendo menores de 18 años y embarazadas. Resultados: Los tiempos medios admisión–triage fueron: 5,58 minutos, triage: 1,17 minutos y triage–asistencia médica en prioridad II-Naranja 22,23 minutos, III-Amarillo 35,65 minutos y IV-Verde 36,08 minutos. Conclusiones: Se cumplen en la mayor parte los objetivos de calidad en tiempos medios admisión–triage–asistencia.Introduction: In order to adapt to the increase in healthcare demand, hospitals have implemented a Triage system, considered an indicator of quality. Objective: To know the fulfillment of quality objectives in average waiting times triage-medical assistance. Methodology: Descriptive, observational and retrospective study. Population under study: penitentiary patients, excluding children under 18 and pregnant. Results: The average admission-triage times were: 5.58 minutes, triage: 1.17 minutes and triage-medical assistance in priority II-Orange 22.23 minutes, III-Yellow 35.65 minutes and IV-Green 36.08 minutes Conclusions: The objectives of quality in average times admission-triage-assistance are fulfilled in most part

Mathematical interpolation methods for spatial estimation of global horizontal irradiation in Castilla-León, Spain: a case study

Four spatial interpolation methods (Inverse Distance Weighted, Spline, Kriging and Natural Neighbor) and their different variations are employed to map Global Horizontal Irradiation (GHI) in Castilla-León, Spain. The work has been performed using the software ArcGis, widely used in geostatistical applications, showing the versatility of the system and its applicability to climate data. The measuring network consists of 71 ground meteorological stations that use seven complete years of half-hourly data sets, yielding annual daily averages of GHI. The interpolation results are tested against data from the four Spanish National Meteorological Agency (AEMET) stations available in the region using standard statistical indicators (RMSE, MBE, MAPE and MAE). An additional partial cross validation of the results, which excludes five stations from the measuring network, employs different criteria to verify the results of the interpolation methods applied. This work contributes to the classification of interpolation methods to obtain climatological data across large areas with a low number of irregularly distributed of measurement points and with a low topographic complexity. The Universal Kriging method with quadratic semi-variogram shows the best results taking into account the RMSE and MAE statistical indicatorsSpanish Government (Grant ENE2014-54601-R) and Junta de Castilla- León (BU034U16). One of the authors, David González Peña, thanks to Junta de Castilla-León and European Social Fund (Orden EDU/310/2015) for financial support

Pharmaceutical Products and Pesticides Toxicity Associated with Microplastics (Polyvinyl Chloride) in Artemia salina

Pharmaceutical products, as well as insecticides and antimicrobials, have been extensively studied, but knowledge of their effects—especially those caused by their mixtures with microplastics— on aquatic organisms remains limited. However, it should be borne in mind that the state of knowledge on acute and chronic effects in aquatic organisms for pharmaceuticals and pesticides is not similar. In response, this investigation analyzed the presence of microplastics (polyvinyl chloride) and their impacts on the toxicity of chlorpyrifos (an insecticide) and triclosan (an antibacterial) when they coincide in the environment, alongside the two most consumed drugs of their type (hypolipemic and anticonvulsant, respectively), namely simvastatin and carbamazepine, in Artemia salina. LC50 and cholinesterase enzyme activity were calculated to determine the possible neurotoxicity associated with emergent contaminants in the treatments. The LC50 values obtained were 0.006 mg/dm3 for chlorpyrifos, 0.012 mg/dm3 for chlorpyrifos associated with microplastics, 4.979 mg/dm3 for triclosan, 4.957 mg/dm3 for triclosan associated with microplastics, 9.35 mg/dm3 for simvastatin, 10.29 mg/dm3 for simvastatin associated with microplastics, 43.25 mg/dm3 for carbamazepine and 46.50 mg/dm3 for carbamazepine associated with microplastics in acute exposure. These results indicate that the presence of microplastics in the medium reduces toxicity, considering the LC50 values. However, exposure to chlorpyrifos and carbamazepine, both alone and associated with microplastics, showed a decline in cholinesterase activity, confirming their neurotoxic effect. Nevertheless, no significant differences were observed with the biomarker cholinesterase between the toxicant and the toxicant with microplastics.This research was funded by the Ministerio de Ciencia, Investigacion y Universidades (REF.: RTI2018-096771-B-100)

Aplicación del modelo de clase invertida a prácticas de laboratorio

Memoria ID-0148. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2016-2017