Counting Highly Cited Papers for University Research Assessment: Conceptual and Technical Issues

A Kuhnian approach to research assessment requires us to consider that the important scientific breakthroughs that drive scientific progress are infrequent and that the progress of science does not depend on normal research. Consequently, indicators of research performance based on the total number of papers do not accurately measure scientific progress. Similarly, those universities with the best reputations in terms of scientific progress differ widely from other universities in terms of the scale of investments made in research and in the higher concentrations of outstanding scientists present, but less so in terms of the total number of papers or citations. This study argues that indicators for the 1% high-citation tail of the citation distribution reveal the contribution of universities to the progress of science and provide quantifiable justification for the large investments in research made by elite research universities. In this tail, which follows a power low, the number of the less frequent and highly cited important breakthroughs can be predicted from the frequencies of papers in the upper part of the tail. This study quantifies the false impression of excellence produced by multinational papers, and by other types of papers that do not contribute to the progress of science. Many of these papers are concentrated in and dominate lists of highly cited papers, especially in lower-ranked universities. The h-index obscures the differences between higher- and lower-ranked universities because the proportion of h-core papers in the 1% high-citation tail is not proportional to the value of the h-index

Mechanisms of fibrous cap formation in atherosclerosis.

The fibrous cap is formed by smooth muscle cells that accumulate beneath the plaque endothelium. Cap rupture is the main cause of coronary thrombosis, leading to infarction and sudden cardiac death. Therefore, the qualities of the cap are primary determinants of the clinical outcome of coronary and carotid atherosclerosis. In this mini-review, we discuss current knowledge about the formation of the fibrous cap, including cell recruitment, clonal expansion, and central molecular signaling pathways. We also examine the differences between mouse and human fibrous caps and explore the impact of anti-atherosclerotic therapies on the state of the fibrous cap. We propose that the cap should be understood as a neo-media to substitute for the original media that becomes separated from the surface endothelium during atherogenesis and that embryonic pathways involved in the development of the arteria media contribute to cap formation.LA-H is supported by a grant from the Danish Cardiovascular Academy (PD2Y-2022003-DCA), JA-J by a grant from the Aarhus University Research Foundation (Starting Grant, AUFF-E-201 9-7- 23) and JB by grants from the Novo Nordisk Foundation (NNF17OC0030688), Ministerio de Ciencia e Innovación with cofunding from the European Regional Development Fund (PID2019-108568RB-I00), and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 866240). The Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia e Innovación (MICIN) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (grant CEX2020- 001041-S funded by MICIN/AEI/10.13039/501100011033).S

THE AVIFAUNA OF THE RÍO TIGRE BASIN, NORTHERN PERÚ

ABSTRACT ∙ The Tigre river basin in the Amazonian lowlands of northern Perú harbors a hyperdiverse avifauna that remains under‐surveyed and poorly known. We conducted the first comprehensive ornithological inventory of the basin. Observational fieldwork at 42 sites spread across the Peruvian portion of the basin resulted in a bird list of 584 species, reflecting several noteworthy patterns in the avian biogeography of northern Perú. These patterns include the distribution of several species that specialize on nutrient‐poor habitats, such as weathered clay terraces and peatlands. Peatland forests are especially poorly studied in Perú and represent a novel habitat association for these species. We also report on the presence of a suite of species with primarily montane distributions that occur in low density across the Amazonian lowlands and in the study area. Current conservation challenges in the Tigre basin include deforestation and pollution associated with hydrocarbons extraction and infrastructure projects.RESUMEN ∙ Avifauna de la cuenca del río Tigre, Perú La cuenca del río Tigre en las tierras bajas del norte de la Amazonía peruana tiene una avifauna súper diversa que sin embargo es muy poco conocida. Realizamos el primer inventario ornitológico de la cuenca. Observaciones de aves en 42 sitios resultaron en una lista de 584 especies de aves registradas en la zona de estudio. Un grupo particular de esta comunidad de aves son aquellas que se distribuyen en los bosques arcillosos pobres a lo largo del río Pucacuro y sobre bosques de turberas en el bajo río Tigre. Reportamos especies generalmente consideradas como especies facultativas u obligadas de hábitats de suelos de arena blanca en la zona de estudio. Los bosques sobre turberas aún se encuentran muy poco estudiados por los ornitólogos y representan un nuevo espacio para las especies que por lo general encontramos sobre los bosques de arena blanca. Adicionalmente reportamos un grupo de especies que generalmente son comunes en el pie de monte andino, pero que ocurren en bajas densidades en el área de estudio. Las amenazas actuales a la conservación de la zona incluyen la deforestación y la contaminación asociada con actividades petroleras y proyectos de infraestructura

Caso maestro Herasto

The Autonomous University of Chiriquí, has in its academic offer the Master’s Degree in Human Rights and Constitutional Justice, which within its curriculum has the subject “Inter-American System and Compliance with the Judgments of the Inter-American Court”, which is being taught by the Dr. Julia Saenz, who with care and detachment has taken the reins to promote the first electronic magazine called “Society and Human Rights”, which in this first edition has a special emphasis on human rights. The central axis of the article is the analysis of events that took place during the military coup of 1968, a historic moment that allows the development of the “Case of the Master Herasto”, which allows us to file a complaint before the Inter-American Commission on Human Rights, in order to request the responsibility of the Panamanian State. It is necessary to point out that the responsibility of the State for violation of the human rights of citizens arises from the acceptanceThe Autonomous University of Chiriquí, has in its academic offer the Master’s Degree in Human Rights and Constitutional Justice, which within its curriculum has the subject “Inter-American System and Compliance with the Judgments of the Inter-American Court”, which is being taught by the Dr. Julia Saenz, who with care and detachment has taken the reins to promote the first electronic magazine called “Society and Human Rights”, which in this first edition has a special emphasis on human rights. The central axis of the article is the analysis of events that took place during the military coup of 1968, a historic moment that allows the development of the “Case of the Master Herasto”, which allows us to file a complaint before the Inter-American Commission on Human Rights, in order to request the responsibility of the Panamanian State. It is necessary to point out that the responsibility of the State for violation of the human rights of citizens arises from the acceptanc

Impaired autoregulation of renal blood flow in the fawn-hooded rat

The responses to changes in renal perfusion pressure (RPP) were compared in 12-wk-old fawn-hooded hypertensive (FHH), fawn-hooded low blood pressure (FHL), and August Copenhagen Irish (ACI) rats to determine whether autoregulation of renal blood flow (RBF) is altered in the FHH rat. Mean arterial pressure was significantly higher in conscious, chronically instrumented FHH rats than in FHL rats (121 +/- 4 vs. 109 +/- 6 mmHg). Baseline arterial pressures measured in ketamine-Inactin-anesthetized rats averaged 147 +/- 2 mmHg (n = 9) in FHH, 132 +/- 2 mmHg (n = 10) in FHL, and 123 +/- 4 mmHg (n = 9) in ACI rats. Baseline RBF was significantly higher in FHH than in FHL and ACI rats and averaged 9.6 +/- 0.7, 7.4 +/- 0.5, and 7.8 +/- 0.9 ml. min-1. g kidney wt-1, respectively. RBF was autoregulated in ACI and FHL but not in FHH rats. Autoregulatory indexes in the range of RPPs from 100 to 150 mmHg averaged 0.96 +/- 0.12 in FHH vs. 0.42 +/- 0.04 in FHL and 0.30 +/- 0.02 in ACI rats. Glomerular filtration rate was 20-30% higher in FHH than in FHL and ACI rats. Elevations in RPP from 100 to 150 mmHg increased urinary protein excretion in FHH rats from 27 +/- 2 to 87 +/- 3 microg/min, whereas it was not significantly altered in FHL or ACI rats. The percentage of glomeruli exhibiting histological evidence of injury was not significantly different in the three strains of rats. These results indicate that autoregulation of RBF is impaired in FHH rats before the development of glomerulosclerosis and suggest that an abnormality in the control of renal vascular resistance may contribute to the development of proteinuria and renal failure in this strain of rats

Mechanisms of fibrous cap formation in atherosclerosis

The fibrous cap is formed by smooth muscle cells that accumulate beneath the plaque endothelium. Cap rupture is the main cause of coronary thrombosis, leading to infarction and sudden cardiac death. Therefore, the qualities of the cap are primary determinants of the clinical outcome of coronary and carotid atherosclerosis. In this mini-review, we discuss current knowledge about the formation of the fibrous cap, including cell recruitment, clonal expansion, and central molecular signaling pathways. We also examine the differences between mouse and human fibrous caps and explore the impact of anti-atherosclerotic therapies on the state of the fibrous cap. We propose that the cap should be understood as a neo-media to substitute for the original media that becomes separated from the surface endothelium during atherogenesis and that embryonic pathways involved in the development of the arteria media contribute to cap formation

Occupational health of immigrant workers in Spain (ITSAL Project): key informants survey

Objetivo: Caracterizar colectivos de inmigrantes trabajadores en España y conocer sus condiciones de salud laboral mediante informantes clave. Método: Estudio cualitativo exploratorio-descriptivo con entrevistas en profundidad realizado en 2006. Se identificaron organizaciones, asociaciones y colectivos relacionados con la población inmigrante en Alicante, Barcelona, Huelva, Madrid y Valencia, y se seleccionaron los más accesibles y representativos. Se entrevistó a 43 informantes clave procedentes de 34 asociaciones u organismos. Se realizó un análisis narrativo del contenido. Resultados: Se señalan dificultades para el reconocimiento de los daños a la salud derivados del trabajo por las situaciones de irregularidad y precariedad, por resistencia por parte de los contratadores o las entidades aseguradoras, y por desconocimiento de los inmigrantes. Los informantes coinciden en que los riesgos laborales en los inmigrantes no difieren de los riesgos de los trabajadores autóctonos en similares circunstancias, pero los inmigrantes padecerían exposiciones más frecuentes e intensas por el acceso mayoritario a puestos menos cualificados y por la necesidad de prolongar las jornadas de trabajo. También se destaca su desconocimiento general en relación con los derechos de protección y de salud en el trabajo, aunque algunos informantes detectan un crecimiento de su actividad reivindicativa a través de los sindicatos. Conclusiones: Este primer acercamiento ha permitido definir algunos condicionantes generales que influirán en la salud laboral de los inmigrantes. La información obtenida servirá de base para profundizar, mediante técnicas adicionales de carácter cualitativo y cuantitativo, en los problemas de salud laboral de los inmigrantes trabajadores en España dentro del marco del Proyecto Inmigración, Trabajo y Salud (ITSAL), actualmente en desarrollo.Objective: To describe the characteristics, working conditions, and occupational health situation of immigrant workers in Spain through key informants. Method: We performed a qualitative, exploratory and descriptive study using indepth interviews carried out in 2006. Organizations and associations working with immigrant collectives in Alicante, Barcelona, Huelva, Madrid and Valencia were identified and the most representative and accessible entities in each location were selected. Fortythree interviews were performed with key informants from 34 different organisms. A narrative content analysis was performed. Results: Informants described difficulties in having health problems recognized as workrelated, due to irregular and precarious employment, employers' and insurance companies' reluctance, and immigrants' lack of knowledge. Informants coincided in reporting that the occupational risks for immigrant workers did not differ from those affecting Spanish workers in the same occupations and circumstances. However, exposure to occupational risks was exacerbated in immigrants because of their greater presence in unqualified jobs and their economic need to prolong working hours. Immigrants had little knowledge of their occupational health and safetyrelated rights, although some informants detected an increase in empowerment in this area, mostly through greater participation in trade unions. Conclusions: This first step allowed us to identify some of the general factors influencing the health and safety of immigrant workers in Spain. This information will be used in a longterm, ongoing research project [Project Immigration, Work and Health (Proyecto Inmigración, Trabajo y Salud [ITSAL]), which aims to evaluate occupational health problems in inmigrants working in Spain through both qualitative and quantitative methods

Year-round individual specialization in the feeding ecology of a long-lived seabird

Many generalist species are composed of individuals varying in the size of their realized niches within a population. To understand the underlying causes and implications of this phenomenon, repeated samplings on the same individuals subjected to different environmental conditions are needed. Here, we studied individual specialization of feeding strategies in breeding and non-breeding grounds of Cory's shearwaters (Calonectris borealis) for 2-8 years, and its relationship with fitness. Individuals were relatively flexible in non-breeding destinations, but specialized in diet, habitat use and daily activity across years. Daily activity was also consistent throughout the year for the same individual, suggesting that it is driven by individual constraints, whereas individual diet and habitat use changed between breeding and non-breeding grounds, indicating that these specializations may be learned at each area. Moreover, individuals that were intermediate specialized in their diet tended to show higher breeding success than those with weakly and highly specialized diets, suggesting stabilizing selection. Overall, this study suggests that the development of individual specialization is more flexible than previously thought, i.e. it emerges under specific environmental conditions and can develop differently when environmental conditions vary. However, once established, individual specialization may compromise the ability of individuals to cope with environmental stochasticity

The yeast homologue of the microtubule-associated protein Lis1 interacts with the sumoylation machinery and a SUMO-targeted ubiquitin ligase

Microtubules and microtubule-associated proteins are fundamental for multiple cellular processes, including mitosis and intracellular motility, but the factors that control microtubule-associated proteins (MAPs) are poorly understood. Here we show that two MAPs - the CLIP-170 homologue Bik1p and the Lis1 homologue Pac1p - interact with several proteins in the sumoylation pathway. Bik1p and Pac1p interact with Smt3p, the yeast SUMO; Ubc9p, an E2; and Nfi1p, an E3. Bik1p interacts directly with SUMO in vitro, and overexpression of Smt3p and Bik1p results in its in vivo sumoylation. Modified Pac1p is observed when the SUMO protease Ulp1p is inactivated. Both ubiquitin and Smt3p copurify with Pac1p. In contrast to ubiquitination, sumoylation does not directly tag the substrate for degradation. However, SUMO-targeted ubiquitin ligases (STUbLs) can recognize a sumoylated substrate and promote its degradation via ubiquitination and the proteasome. Both Pac1p and Bik1p interact with the STUbL Nis1p-Ris1p and the protease Wss1p. Strains deleted for RIS1 or WSS1 accumulate Pac1p conjugates. This suggests a novel model in which the abundance of these MAPs may be regulated via STUbLs. Pac1p modification is also altered by Kar9p and the dynein regulator She1p. This work has implications for the regulation of dynein\u27s interaction with various cargoes, including its off-loading to the cortex. © 2012 Alonso et al

Tests of stellar model atmospheres by optical interferometry III: NPOI and VINCI interferometry of the M0 giant gamma Sge covering 0.5 - 2.2 microns

Aims: We present a comparison of the visual and NIR intensity profile of the M0 giant gamma Sagittae to plane-parallel ATLAS 9 as well as to plane-parallel & spherical PHOENIX model atmospheres. Methods: We use previously described visual interferometric data obtained with the NPOI in July 2000. We apply the recently developed technique of coherent integration, and thereby obtain visibility data of more spectral channels and with higher precision than before. In addition, we employ new measurements of the K-band diameter of gamma Sagittae obtained with the instrument VINCI at the VLTI in 2002. Results: The spherical PHOENIX model leads to a precise definition of the Rosseland angular diameter and a consistent high-precision diameter value for our NPOI and VLTI/VINCI data sets of Theta_Ross=6.06 pm 0.02 mas, with the Hipparcos parallax corresponding to R_Ross=55 pm 4 R_sun, and with the bolometric flux corresponding to an effective temperature T_eff=3805 pm 55 K. Our visual visibility data close to the first minimum and in the second lobe constrain the limb-darkening effect and are generally consistent with the model atmosphere predictions. The visual closure phases exhibit a smooth transition between 0 and pi. Conclusions: The agreement between the NPOI and VINCI diameter values increases the confidence in the model atmosphere predictions from optical to NIR wavelengths as well as in the calibration and accuracy of both interferometric facilities. The consistent night-by-night diameter values of VINCI give additional confidence in the given uncertainties. The closure phases suggest a slight deviation from circular symmetry, which may be due to surface features, an asymmetric extended layer, or a faint unknown companion.Comment: 12 pages, 9 figures, accepted by A&A. Also available from http://www.aanda.org/articles/aa/pdf/forth/aa5853_06.pd