Recognition of facial expression of emotions in Parkinson’s disease: a theoretical review

Introducción. La expresión facial emocional constituye una guía básica en la interacción social y, por ello, las alteraciones en su expresión o reconocimiento suponen una importante limitación para la comunicación. Objetivo. Examinar las capacidades de reconocimiento de expresiones faciales y su posible deterioro en la enfermedad de Parkinson. Desarrollo. En primer lugar, se revisan las investigaciones sobre este tema y que no han encontrado resultados totalmente afines. En segundo lugar, se analizan los factores que pueden explicar estas divergencias y, en particular, como tercer objetivo, se valora la relación entre los problemas en el reconocimiento emocional y el deterioro cognitivo asociado a la enfermedad. Por último, se proponen estrategias alternativas para el desarrollo de estudios que contribuyan a clarificar el estado de estas habilidades en la enfermedad de Parkinson. Conclusiones. La mayoría de los estudios indica deficiencias en el reconocimiento de expresiones, sobre todo en las de contenido emocional negativo. No obstante, es posible que dichas alteraciones estén relacionadas con las que también aparecen en otros procesos perceptivos y ejecutivos propios de la enfermedad. Para avanzar en esta cuestión, consideramos necesario diseñar estudios sobre reconocimiento emocional que impliquen diferencialmente a los procesos cognitivos mencionados o que contrasten la ejecución de los individuos con estímulos no emocionales y con expresiones faciales. Además de incrementar nuestro conocimiento sobre las consecuencias funcionales del deterioro cerebral característico de la enfermedad, estos estudios pueden indicarnos si debe prestarse atención adicional a su rehabilitación dentro de los programas que se aplicanEmotional facial expression is a basic guide during social interaction and, therefore, alterations in their expression or recognition are important limitations for communication. Aim. To examine facial expression recognition abilities and their possible impairment in Parkinson’s disease. Development. First, we review the studies on this topic which have not found entirely similar results. Second, we analyze the factors that may explain these discrepancies and, in particular, as third objective, we consider the relationship between emotional recognition problems and cognitive impairment associated with the disease. Finally, we propose alternatives strategies for the development of studies that could clarify the state of these abilities in Parkinson’s disease. Conclusions. Most studies suggest deficits in facial expression recognition, especially in those with negative emotional content. However, it is possible that these alterations are related to those that also appear in the course of the disease in other perceptual and executive processes. To advance in this issue, we consider necessary to design emotional recognition studies implicating differentially the executive or visuospatial processes, and/or contrasting cognitive abilities with facial expressions and non emotional stimuli. The precision of the status of these abilities, as well as increase our knowledge of the functional consequences of the characteristic brain damage in the disease, may indicate if we should pay special attention in their rehabilitation inside the programs implementedProyecto ref. PSI2009-09067, financiado por el Ministerio de Ciencia e Innovación

Significant year-round effect of small mixotrophic flagellates on bacterioplankton in an oligotrophic coastal system

14 pages, 7 figures, 1 tableThe seasonal variation in the grazing effect of mixotrophic flagellates on bacterioplankton was assessed during an annual cycle in an oligotrophic coastal station in the northwest Mediterranean Sea. Ingestion rates of fluorescently labeled bacteria were estimated for different size categories of phytoflagellates (PF) and heterotrophic flagellates (HF) in short-term experiments and compared with long-term grazing estimates and published empirical models. The mixotrophic flagellates included haptophyte-like cells, cryptophytes, and dinoflagellates. The group-specific grazing rates (SGR) averaged 1.1 (3–5 µm PF), 1.3 (5–20 µm PF), 4.0 (<5 µm HF), and 15.4 bacteria individual-1 h-1 (5–20 µm HF). Lower SGR but higher abundances of PF resulted in an average mixotroph contribution of 50% to the total flagellate grazing. Remarkably, the effect was relatively high all through the year (35–65%). Regardless of the presence of chloroplasts, flagellates <5 mm in size accounted, on average, for about 80% of total flagellate bacterivory and ingested a large percentage of their cell carbon per day from bacteria. Soluble reactive phosphorus concentration was negatively correlated with the ingestion rate of both groups of PF, suggesting that mixotrophic flagellates would be using their phagotrophic capability to obtain phosphorus when this nutrient is limiting. HF grazing activity showed a marked seasonality, with grazing being higher during the warmer seasons, and clearance rates were positively correlated with water temperature. Total bacterivory accounted for most of the bacterial production. Short-term and long-term bacterivory measurements were highly correlated, confirming that the smallest flagellates were the main causative agent of bacterial loss. The bacterivory values were also well correlated to a published empirical model that considers HF as the only bacterivorous. However, this model underestimated (up to 50%) total flagellate grazing during periods of high effect of mixotrophic flagellatesThis study was supported mainly by a EU project (EVK3-CT-2002-00078) and a Spanish post-doctoral fellowship (SB2001-0166) and also partially funded by three projects supported by the Spanish government (REN2001-2120/MAR; CTM2004-12631/MAR; CTM2004-02586/MAR)Peer reviewe

A common framework for the robust design of tuned mass damper techniques to mitigate pedestrian-induced vibrations in lively footbridges

The dynamic response of modern slender footbridges is usually sensitive to both the pedestrian actions and the uncertainties associated with their inherent structural behavior. Thus, tuned mass dampers have been widely integrated in the design of these structures to guarantee the fulfillment of the vibration serviceability limit state during their overall life cycle. Three different techniques of tuned mass dampers (active, semi-active and passive) are usually considered for this purpose. Although there are algorithms for the robust design of each particular technique, however, this specificity makes difficult the implementation of all these techniques in practical en gineering applications. Herein, the motion-based design method under uncertainty conditions is proposed and further implemented to create a common framework for the robust design of all these techniques when they are employed to mitigate pedestrian-induced vibrations in slender footbridges. According to this method, the design problem may be transformed into the combination of two sequential sub-problems: (i) a reliability multi objective optimization sub-problem; and (ii) a decision-making sub-problem. Subsequently, the performance of this proposal has been validated through a numerical case study in which the dynamic response of a steel footbridge has been controlled by three different tuned mass damper techniques designed according to the proposed common framework.Ministerio de Economía y Competitividad ( España) RTI2018-094945-B-C21Ministerio de Ciencia, Innovación y Universidades (España) RTI2018-099639-B-I0

Neural correlates of phonological, orthographic and semantic reading processing in dyslexia

Developmental dyslexia is one of the most prevalent learning disabilities, thought to be associated with dysfunction in the neural systems underlying typical reading acquisition. Neuroimaging research has shown that readers with dyslexia exhibit regional hypoactivation in left hemisphere reading nodes, relative to control counterparts. This evidence, however, comes from studies that have focused only on isolated aspects of reading. The present study aims to characterize left hemisphere regional hypoactivation in readers with dyslexia for the main processes involved in successful reading: phonological, orthographic and semantic. Forty-one participants performed a demanding reading task during MRI scanning. Results showed that readers with dyslexia exhibited hypoactivation associated with phonological processing in parietal regions; with orthographic processing in parietal regions, Broca's area, ventral occipitotemporal cortex and thalamus; and with semantic processing in angular gyrus and hippocampus. Stronger functional connectivity was observed for readers with dyslexia than for control readers 1) between the thalamus and the inferior parietal cortex/ventral occipitotemporal cortex during pseudoword reading; and, 2) between the hippocampus and the pars opercularis during word reading. These findings constitute the strongest evidence to date for the interplay between regional hypoactivation and functional connectivity in the main processes supporting reading in dyslexia. Keywords: Dyslexia, Reading, Hypoactivation, Functional connectivity, Thalamus, Hippocampu

Building and exploiting a Digital Twin for the management of drinking water distribution networks

[EN] Digital Twins (DTs) are starting to be exploited to improve the management of water distribution systems (WDSs) and, in the future, they will be crucial for decision making. In this paper, the authors propose several requirements that a DT of a water distribution system should accomplish. Developing a DT is a challenge, and a continuous process of adjustments and learning is required. Due to the advantages of having a DT of the WDS always available, during the last years a strategy to build and maintain a DT of the water distribution network of Valencia (Spain) and its Metropolitan Area (1.6 million inhabitants) was developed. This is one of the first DTs built of a water utility, being currently in operation. The great benefits of their use in the daily operation of the system ensure that they will begin to be usual in the most advanced smart cities.Conejos Fuertes, P.; Martínez Alzamora, F.; Hervás-Carot, M.; Alonso Campos, JC. (2020). Building and exploiting a Digital Twin for the management of drinking water distribution networks. Urban Water Journal. 17(8):704-713. https://doi.org/10.1080/1573062X.2020.1771382S704713178Chacón Ramírez, E., Albarrán, J. C., & Cruz Salazar, L. A. (2019). The Control of Water Distribution Systems as a Holonic System. Studies in Computational Intelligence, 352-365. doi:10.1007/978-3-030-27477-1_27Grieves, M., et al. 2015. Virtually Intelligent Product Systems: Digital and Physical Twins. In Complex Systems Engineering: Theory and Practice, edited by S. Flumerfelt, et al., 175–200. American Institute of Aeronautics and Astronautics.Hatchett, S., J. Uber, D. Boccelli, T. Haxton, R. Janke, A. Kramer, A. Matracia, and S. Panguluri. 2011. “Real-Time Distribution System Modeling: Development, Application, and Insights.” Urban Water Management: Challenges and Oppurtunities - 11thInternational Conference on Computing and Control for the Water Industry, CCWI 2011 July.Kartakis, S., Abraham, E., & McCann, J. A. (2015). WaterBox. Proceedings of the 1st ACM International Workshop on Cyber-Physical Systems for Smart Water Networks. doi:10.1145/2738935.2738939Lin, J., Sedigh, S., & Miller, A. (2009). Towards Integrated Simulation of Cyber-Physical Systems: A Case Study on Intelligent Water Distribution. 2009 Eighth IEEE International Conference on Dependable, Autonomic and Secure Computing. doi:10.1109/dasc.2009.140Qi, Q., & Tao, F. (2018). Digital Twin and Big Data Towards Smart Manufacturing and Industry 4.0: 360 Degree Comparison. IEEE Access, 6, 3585-3593. doi:10.1109/access.2018.2793265Alac, M. (2008). Working with Brain Scans. Social Studies of Science, 38(4), 483-508. doi:10.1177/0306312708089715Shi, Y., Xu, J., & Du, W. (2019). Discussion on the New Operation Management Mode of Hydraulic Engineering Based on the Digital Twin Technique. Journal of Physics: Conference Series, 1168, 022044. doi:10.1088/1742-6596/1168/2/022044Tao, F., Zhang, H., Liu, A., & Nee, A. Y. C. (2019). Digital Twin in Industry: State-of-the-Art. IEEE Transactions on Industrial Informatics, 15(4), 2405-2415. doi:10.1109/tii.2018.2873186Tao, F., Cheng, J., Qi, Q., Zhang, M., Zhang, H., & Sui, F. (2017). Digital twin-driven product design, manufacturing and service with big data. The International Journal of Advanced Manufacturing Technology, 94(9-12), 3563-3576. doi:10.1007/s00170-017-0233-1Tao, F., & Qi, Q. (2019). Make more digital twins. Nature, 573(7775), 490-491. doi:10.1038/d41586-019-02849-1Uber, J., S. Hatchett, S. Hooper, D. Boccelli, H. Woo, and R. Janke. 2014. Water Utility Case Study of Real-Time Network Hydaulic and Water Qualilty Modeling Using EPANET-RTX Libraries. EPA 6007R-14/350 Report. Cincinnati, Ohio: Environmental Protection Agency.Wang, Z., Song, H., Watkins, D. W., Ong, K. G., Xue, P., Yang, Q., & Shi, X. (2015). Cyber-physical systems for water sustainability: challenges and opportunities. IEEE Communications Magazine, 53(5), 216-222. doi:10.1109/mcom.2015.710566

Variable order porous media equations: Application on modeling the S&P500 and Bitcoin price return

This article reveals a specific category of solutions for the $1+1$ Variable Order (VO) nonlinear fractional Fokker-Planck equations. These solutions are formulated using VO $q$-Gaussian functions, granting them significant versatility in their application to various real-world systems, such as financial economy areas spanning from conventional stock markets to cryptocurrencies. The VO $q$-Gaussian functions provide a more robust expression for the distribution function of price returns in real-world systems. Additionally, we analyzed the temporal evolution of the anomalous characteristic exponents derived from our study, which are associated with the long-range memory in time series data and autocorrelation patterns.Comment: 15 Pages, 3 Figures. Submitted to Physical Review

Tissue factor as a novel marker for detection of circulating cancer cells

Tissue factor (TF) is a molecular marker that is up-regulated in cancer cells and aids tumoral dissemination. Our purpose was to develop a nested RT-PCR strategy against TF for detecting blood-borne tumour cells. Our method detected TF expression in a minimum of 1.5 pg total RNA from MCF7 cells. A preliminary study in blood samples from 16 advanced breast carcinoma patients showed that 80% of patients with high TF load progressed and died, while only 18% with low TF load showed the same behaviour. Kaplan-Meier analysis confirmed worse overall survival in patients with high TF load.Fil: Otero, L. L.. Universidad Nacional de Quilmes; ArgentinaFil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Castro, M.. Universidad de Buenos Aires; ArgentinaFil: Cinat, G.. Universidad de Buenos Aires; ArgentinaFil: Gabri, M. R.. Universidad Nacional de Quilmes; ArgentinaFil: Gomez, Daniel Eduardo. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Experimental set-up for exciting and detecting magneto-optical effects and surface plasmon resonance simultaneously

We present here an experimental set-up system to excite and measure simultaneously surface plasmon resonance (SPR) and magneto-optic signal in hybrid magneto-plasmonic systems using two independent light sources. The system can be used to excite and measure both types of SPR, localized surface plasmons in nanostructures and surface plasmon polaritons in thin films. It also allows measuring SPR in presence of magnetic fields and recording magnetooptical hysteresis loops while exciting SPR

Self-control of a lively footbridge under pedestrian flow

Congreso celebrado en la Escuela de Arquitectura de la Universidad de Sevilla desde el 24 hasta el 26 de junio de 2015.In this paper, a case study about a lively footbridge is developed; the vibration levels caused by the pedestrian action are controlled by the change of the modal parameters of the structure due to the pedestrian-structure interaction. A detailed finite element model of the structure has been updated from an operational modal analysis. The updated model has been used to obtain the numerical acceleration at the mid-span of the footbridge under different pedestrian flows. A relation between the maximum acceleration and the pedestrian density on the deck has been obtained numerically, pointing out an improvement in the comfort level of the structure when the number of pedestrians increases. This result validates a design rule for cable-stayed footbridges in order to avoid vibratory problems, since the first vertical natural frequency of the structure remains below the range that characterizes the pedestrian walking action

Diseño y construcción de un sistema de archivo personal computadorizado para clínicas odontológicas

El objetivo del sistema es gestionar de manera automática y flexible el archivo profesional de los odontólogos. Los requisitos que debía cumplir el sistema fueron obtenidos mediante consultas a distintos especialistas odontólogos, fruto de las cuales fue la especificación de los tipos de información y los procesos de la misma que - tienen lugar en la consulta del odontólogo