Antia-Buch flap reconstruction for helical rim defects. Case report

Introducción y objetivo: El colgajo Antia-Buch es un procedimiento en el que se utilizan dos colgajos condrocutáneos para reconstruir la región helicial del pabellón auricular. La laxitud del tejido se confiere, en gran medida, por el colgajo inferior y se requiere la resección condrocutánea de la escafa para el cierre. Esto da como resultado la pérdida de la altura de la oreja. Nuestro objetivo es realizar la exéresis de una lesión de mediano tamaño sin comprometer la morfología del pabellón auricular. Descripción: Realizamos una reconstrucción por colgajo de Antia-Buch en paciente con carcinoma espinocelular de hélix derecho. Resultados: Se extirpa carcinoma epidermode con márgenes libres obteniendo un buen resultado estético del pabellón auricular. Discusión: El colgajo de Antia-Buch es utilizado para defectos de mediano tamaño de la región helicial. Entre los distintos pasos quirúrgicos hay que destacar las descargas V-Y para evitar tensión en los tejidos y conservar el pericondrio del colgajo para la nutrición condral. Conclusiones: Técnica en la que se obtiene buen resultado estético, sin comprometer la radicalidad de la excisión.Introduction and objective: The Antia-Buch flap is a procedure in which two chondrocutaneous flaps are used to reconstruct the helicial region of the auricular pinna. The laxity of the tissue is conferred, to a large extent, by the inferior flap and the chondrocutaneous resection of the scafa is required for closure. This results in the loss of the height of the ear. Our objective is to perform the exeresis of a medium-sized lesion without compromising the morphology of the auricular pinna. Description: We performed an Antia-Buch flap reconstruction in a patient with spinocellular carcinoma of the right helix. Results: Squamous cell carcinoma with free margins was removed obtaining a good aesthetic result of the auricular pinna. Discussion: The Antia-Buch flap is used for medium size defects of the helicial region. Among the different surgical steps, highlight the V-Y discharges to avoid tension in the tissues and conserve the perichondrium of the flap for chondral nutrition. Conclusions: Technique in which good aesthetic results are obtained, without compromising the radicality of the excision

Review of helical rim reconstruction techniques

Introducción y objetivo: En este artículo se revisan los resultados de la reconstrucción de los defectos de la superficie del borde helicial después de la extirpación del cáncer de piel. Analizaremos los distintos métodos de reconstrucción y modalidades de tratamiento. Método: Revisión en las base de datos PubMed con estrategia de búsqueda: ((((((helical rim) OR helix)) AND defects) AND reconstruction) AND skin cancer. Se obtuvieron 46 artículos en idioma inglés o español de los que se seleccionaron 19 para el estudio cualitativo. Resultados: Más de la mitad de los pacientes se reconstruyeron mediante cierre directo en un primer tiempo; el resto precisaron de varios tiempos de reconstrucción. Discusión: Hay varios métodos para la reparación quirúrgica de los defectos del borde helicial. Los defectos pequeños del hélix generalmente se pueden cerrar tras resecciones en cuña. Para defectos de mediano tamaño, se pueden usar colgajos de avance condrocutáneos. Los defectos grandes, suelen necesitar un colgajo posterior pediculado o un colgajo fascial temporoparietal con injertos de piel y cartílago. Conclusiones: Esta pequeña revisión resume diversas las opciones de reconstrucción para los defectos que involucran el hélix, facilitando una rápida toma de decisiones para los cirujanos según la naturaleza del defecto.Introduction and objective: In this article we review the results of the reconstruction of the helical rim defects after the removal of the skin cancer. We Analyze the different methods of reconstruction and treatment modalities. Method: Narrative review in PubMed databases and search strategy: (((((((helical rim) OR helix)) AND defects) AND reconstruction) AND skin cancer. 46 articles were obtained in English or Spanish from which were selected 19 for the qualitative study. Results: More than half were reconstructed by simple single‐step techniques; others required several reconstruction times. Discussion: There are several methods of surgical repair of helical rim defects. Small defects can usually be closed primarily with various wedge resections. For medium-sized defects, chondrocutaneous advancement flaps. Large defects typically need bipediculated tubing flaps or a temporoparietal fascial flap with skin and cartilage grafts. Conclusions: This mini review summarizes various reconstruction options for defects involving helical rim defects, facilitating rapid decision for surgeons according to the nature of the defect

The somatostatin receptor-adenylate cyclase system in rat pancreatic acinar membranes after temporary pancreaticobiliary duct ligation

The mechanism whereby somatostatin (SS) produces beneficial effects in established pancreatitis induced by pancreaticobiliary duct ligation (PBDL) is still not clear. The aim of the work was to evaluate the possibility of a direct action of SS on pancreatic acinar cells from rats with acute pancreatitis. For this purpose, we studied the SS-receptor-adenylate cyclase system in pancreatic acinar membranes from both, control rats and rats with experimentally induced acute pancreatitis. On the other hand, it has been reported that cholecystokinin (CCK) diminishes the number of SS receptors in pancreatic acinar cells. Proglumide, a CCK receptor antagonist reduces the severity of acute pancreatitis in the rat. Therefore, we have also examined the effect of proglumide on the somatostatinergic system in controls and rats with acute pancreatitis. Fourteen hours after PBDL, the SS receptors, the capacity of the SS analogue SMS 201-995 to inhibit forskolin-stimulated adenylate cyclase activity and PTX-catalyzed [P-32] ADP-ribosylation of the alpha(1) subunits of Gi proteins could not be detected in pancreatic acinar membranes. One month after reopening the closed pancreaticobiliary duct (PBD), the pancreas showed regeneration of acinar cells, and the above-mentioned parameters were significantly lower than in the control group. Two months after reopening the closed PBD, all these parameters had returned to control values. The administration of proglumide (20 mg/kg i.p.), a cholecystokinin receptor antagonist, accelerated pancreatic regeneration and approached all these parameters to control values one month after reopening the closed PBD. The present study suggests that the beneficial effects of SS on established pancreatitis induced by PBDL may not be due to a direct action of the peptide on pancreatic acinar cells at least at 14 hours after PBDL. In addition, these findings suggest that in established pancreatitis the effect of proglumide on the SS receptor-adenylate cyclase system could be due to its action on pancreatic regeneration.The authors thank Ms. Carol F. Warren and Jerry Keller from the Alcala University Institution of Education Sciences and Lilian Puebla from the Department of Biochemistry of\ud Alcala University for their linguistic assistance, as well as Ms. Maria Baez for her excellent assistance with library research and Mr. Luis Monge for assistance in the preparation of the\ud illustrations. The authors are also grateful to Sandoz Ltd. (Basel, Switzerland) for generous donation of SMS 201-995 and its analogue Tyr3-SMS. This study was supported by a Grant from the Direction General de Investigación Científica y Técnica (PM95-0041) and from the University of Alcala (001/96) of Spain

Bombesin induces a reduction of somatostatin inhibition of adenylyl cyclase activity, Gi function, and somatostatin receptors in rat exocrine pancreas

To analyze the effect of bombesin on the somatostatin (SS) mechanism of action in the exocrine pancreas, male Wistar rats (250-270 g) were injected intraperitoneally with bombesin (10 ¿g/kg) three times daily at 8-h intervals for 7 or 14 days. Bombesin attenuated the ability of SS to inhibit forskolin-stimulated adenylyl cyclase activity in pancreatic acinar membranes. However, it did not decrease the ability of forskolin to stimulate the adenylyl cyclase catalytic subunit. The ability of 5'-guanylylimidodiphosphate [Gpp(NH)p] (a nonhydrolyzable GTP analog) to inhibit forskolin-stimulated adenylyl cyclase activity was diminished in pancreatic acinar cell membranes from bombesin-treated rats. Bombesin administration did not affect the ADP-ribosylation of a 41-kDa G protein catalyzed by pertussis toxin. The maximal SS binding capacity of pancreatic acinar membranes from bombesin-treated rats was decreased when compared with controls at the two time periods studied. The bombesin/gastrin-releasing peptide antagonist [D-Tpi6,Leu13¿(CH2NH)Leu14]bombesin (6-14) (RC-3095) (10 ¿g/kg ip), injected three times daily at 8-h intervals for 7 or 14 days, had a similar effect to that of bombesin on the SS mechanism of action. The combined administration of bombesin and its antagonist RC-3095 had a greater effect on the SS receptor-effector system than when administered separately. The present study indicates that the pancreatic SS receptor-effector system may be regulated by bombesin in vivo

An antihypertensive lactoferrin hydrolysate inhibits angiotensin I-converting enzyme, modifies expression of hypertension-related genes and enhances nitric oxide production in cultured human endothelial cells

This study was aimed to explore whether an antihypertensive lactoferrin hydrolysate (LFH) can inhibit angiotensin I-converting enzyme (ACE) activity and modify the expression of genes related to hypertension in human umbilical vein endothelial cells (HUVEC). LFH induced significant inhibition of ACE activity but it did not affect ACE mRNA levels after 24 h of exposure. LFH treatment significantly affected the expression of genes encoding for proteins involved in nitric oxide pathway such as soluble guanylate cyclase 1 α3 subunit (GUCY1A3; 4.42-fold increase) and nitric oxide synthase trafficking (NOSTRIN; 2.45-fold decrease). Furthermore, expression of the PTGS2/COX-2 gene encoding prostaglandin-endoperoxide synthase 2 a key component of prostaglandin synthesis was significantly increased (2.23-fold). Moreover, NOSTRIN mRNA downregulation was consistent with reduced NOSTRIN protein expression and increased NO production observed in HUVEC. The present study reveals the complexity of the effects exerted by LFH opening avenues for the better understanding of its antihypertensive effects.This work was supported by grant AGL2010-21009 from ‘Ministerio de Educación y Ciencia – FEDER’, Consolider Ingenio 2010, Fun-C-Food, CSD2007-00063 and RETICS INVICTUS RD12/0014/0004 from ‘Instituto de Salud Carlos III’. A. García-Tejedor is recipient of a predoctoral fellowship from ‘Ministerio de Educación y Ciencia’ (BES-2011-044424).Peer reviewe

Profesionalización de profesores universitarios en la gestión de la comunicación científica para el desarrollo local

In the current information society the communication of scientific knowledge is considered a priority of universities. Despite this, it is recognized that its management is still insufficient in terms of promoting local development. The objective of this work was to improve the management of scientific dissemination and disclosure carried out by university professors. The methodology was based on a participatory action research (IAP), the data were mainly managed through interviews, documentary analysis and participant observation. The main results obtained were the successful development of four editions of a postgraduate course specialized in the management of scientific publications in indexed journals and the implementation of a management strategy for scientific disclosure. It is concluded that a professionalization of university professors in the management of scientific dissemination and disclosure, favors the communication of their research results in terms of local development

Vestibular rehabilitation in patients with vertigo and personality disorder

[ES]Introducción y objetivo: La presencia de trastornos de la personalidad en pacientes con vértigo ha sido referenciada en diferentes trabajos. Las conexiones del sistema vestibular y el procesamiento de emociones es la causa que apoya dicha asociación. La rehabilitación vestibular se perfila como el tratamiento para el vértigo crónico no compensado, pero suscita la duda de si será suficiente por si sola en pacientes con trastornos de la personalidad o si debe acompañarse de otras terapias dirigidas a estas alteraciones. El objetivo del estudio es analizar la posible influencia de los trastornos de personalidad en la autopercepción de la discapacidad mediante el Dizziness Handicap Inventory (DHI) y en los parámetros de la posturografía estática, antes y después de la rehabilitación vestibular. Método: Estudio prospectivo de 55 pacientes diagnosticados de vértigo crónico periférico o central a los que se trató con ocho sesiones de rehabilitación vestibular. Los pacientes cumplimentaron el DHI y el cuestionario Salamanca al inicio y al final del tratamiento. Resultados: El 65% de los pacientes tenían trastornos de la personalidad. Los rasgos de ansiedad se asociaron a vértigo periférico y los rasgos esquizoides a vértigo central. En todos los pacientes, la puntuación del DHI mejoró (p< 0,01), al igual que algunos parámetros del control del limite de estabilidad (p<0.01). Por otro lado, no se encontró relación entre las variables independientes edad, sexo, diagnóstico clínico y trastorno de la personalidad con los resultados. Conclusiones: En nuestro estudio, los resultados muestran la eficacia de la rehabilitación vestibular en pacientes con vértigo crónico, independientemente de su asociación con trastornos de personalidad.[EN]Introduction and objective: The presence of personality disorders in patients with vertigo has been reported in several articles. The connections between the vestibular system and emotion processing are the cause that supports said association. Vestibular rehabilitation is emerging as the treatment for chronic uncompensated vertigo, but it raises the question of whether it will be sufficient by itself in patients with personality disorders or whether it should be accompanied by other therapies aimed at these alterations. The aim of the study is to analyze the possible influence of personality disorders in the self-perception of disability using the Dizziness Handicap Inventory (DHI) and the parameters of static posturography, before and after vestibular rehabilitation. Method: Prospective study of 55 patients diagnosed with chronic vertigo treated with eight sessions of vestibular rehabilitation. The patients completed the DHI and the Salamanca questionnaire before and after the treatment was administered. Results: 65% of the patients had personality disorders. Anxiety traits were associated with peripheral vertigo and schizoid traits with central vertigo. In every patient, the DHI score improved (p<0,01), as well as some parameters of the control of the limit of stability (p<0,01). On the other hand, no relationship was found between the independent variables of age, sex, clinical diagnostic, personality disorder, and the results. Conclusions: In our study, the results show the efficacy of vestibular rehabilitation in patients with chronic vertigo, regardless of its association with personality disorders

Gestión universitaria de la difusión y divulgación científica: Dos caras de una misma moneda

In the current information society the dissemination and disclosure of scientific knowledge are considered priorities of universities. Despite the importance of these processes, it is recognized that their management is still insufficient to promote local development. The objective of the present work was to systematize the experience accumulated in the improvement of said management by the Municipal University Center Contramaestre. The methodology was based on a participatory action research (PAR), the data were mainly managed through interviews, documentary analysis and participant observation. The main results obtained were the successful development of a postgraduate course specialized in the management of scientific publications in indexed journals and a management strategy for scientific disclosure. It is concluded that a professionalization of university professors in the management of dissemination and disclosure of scientific knowledge favors the promotion of local development

Gestión universitaria de la difusión y divulgación científica: Dos caras de una misma moneda

In the current information society the dissemination and disclosure of scientific knowledge are considered priorities of universities. Despite the importance of these processes, it is recognized that their management is still insufficient to promote local development. The objective of the present work was to systematize the experience accumulated in the improvement of said management by the Municipal University Center Contramaestre. The methodology was based on a participatory action research (PAR), the data were mainly managed through interviews, documentary analysis and participant observation. The main results obtained were the successful development of a postgraduate course specialized in the management of scientific publications in indexed journals and a management strategy for scientific disclosure. It is concluded that a professionalization of university professors in the management of dissemination and disclosure of scientific knowledge favors the promotion of local development

Gestión de la Formación Permanente del Profesor Universitario en Comunicación de la Ciencia Abierta Orientada al Desarrollo Sostenible / Management of the Permanent Training of the University Professor in Communication of Open Science Oriented to Sustainable Development

The doctoral research diagnosed insufficient scientific training of university professors in relation to the communication of research results, which limits their professional performance; situation revealed as a scientific problem. The object of research was the permanent training process of the university professor in science communication and, the field of action, the management of this process from the communication of open science (COS) oriented to sustainable development (SD). The objective was the development of a strategy, based on a model of this management, to enhance their professional performance. The main contributions are the proposed model and strategy, which were successfully applied at the Universidad de Oriente, Cuba. The scientific novelty consists in having revealed the integrative logic of the management of the permanent training of the university professor in COS, based on the assessment of the needs for improvement and its planning, in relation to the systematization and professionalization in management of the dissemination and dissemination of investigative results oriented to SD. The social impact lies in having favored the achievement of superior results in the permanent training of the university professor in COS oriented to SD, from the application of the strategy provided, increasing their professional performance