Kaposi's sarcoma in a patient with erythroblastopenia and thymoma: Reactivation after topical corticosteroids

We report a 69-year-old female with erythroblastopenia and thymoma who developed lesions of Kaposi's sarcoma (KS) after thymectomy, 2 months after the initiation of therapy with methylprednisolone. Control of mucocutaneous KS lesions was obtained with radiotherapy, interferon alfa-2b and withdrawal of systemic immunosuppressive therapy. Erosive oral lichen planus appeared later, and after therapy with topical corticosteroids a new lesion of KS developed that regressed after withdrawal of topical corticosteroids. The detection of HHV-8 only in lesional skin supports the hypothesis that this virus can trigger the development of KS lesions

Supplementation Under Intensive Grazing, Silage- Or Grain-Based Diets for Beef Production on Steer Performance and Meat Fatty Acid Composition

Alfalfa (Medicago sativa L.) is the main cultivated pasture in Argentina. In beef production enhanced productivity and profit depend on high stocking rates and pasture utilisation, with grain supplementation necessary to maintain high individual live weight gains (LWG) and to increase production per ha (Ustarroz, 1999). Substitution of grazed grass by concentrate can affect meat fatty acid (FA) composition (French et al., 2000). The objective of this study was to evaluate the effects of intensifying an alfalfa-based grazing system and two confinement dietary regimens for beef steer finishing on animal performance and meat FA composition

Are the seafloors of marine protected areas sinks for marine litter? Composition and spatial distribution in Cabrera National Park

The seafloors of oceans and seas are becoming major sinks for marine litter (ML) at a global scale and especially within the Mediterranean Sea. Within global oceans and seas, Marine Protected Areas (MPAs) have been established to protect and conserve marine habitats and increase marine biodiversity. In this study, extensive coastal shallow scuba diving surveys were conducted in 2019 and 2020 to identify the distribution of ML in the MPA of Cabrera Marine-Terrestrial National Park (Cabrera MPA) in the Balearic Islands. Approximately 900 items weighing 70.1 kg were collected throughout the MPA during the underwater surveys. Glass bottles, including pieces (25–30%) and glass or ceramic fragments >2.5 cm (8–19%) were the most common identified items followed by plastic food containers and plastic bags (~8%). Overall, 75% of the abundance of collected ML was observed during the first year. In terms of the protection status of the different locations, similar abundances of ML were found in public access areas and no-take areas. Additionally, no significant differences were identified according to location indicating that ML on the seafloor was homogeneous within the studied shallow coastal areas. Overall, the results indicate that Cabrera MPA is a hotspot for ML and mitigation actions and measures, such as annual cleaning efforts, can help to prevent and minimize ML accumulation on the seafloor.En prens

Reproductive investment of the pen shell Pinna nobilis Linnaeus, 1758 in Cabrera National Park (Spain)

The spawning period can be a period of particular vulnerability for a species. In hermaphroditic species like the long-lived pen shell Pinna nobilis different costs could be associated with female, male or hermaphrodite stages. Here we evaluate gonad development in a population with few anthropogenic pressures and describe the timing and succession of developmental stages, determine the ratio of the sexes and the condition of the animals. We assess resource mobilisation and associated costs through the relationship between stable isotopes and condition indexes with reproductive parameters and evaluate the role of the adductor muscle as storage organ used in gonad maturation. In our study area only one spawning season is observed, starting in May and peaking in June-July. The onset of spawning coincides with water temperatures of 20 °C. Condition indexes drop during the spawning period and recover afterwards to reach pre-spawning values in November. Stable isotope signals are negatively related to the gonadal condition index, while the CN ratio shows a positive correlation with the same index. Additionally, the muscle condition index sharply decreases after the start of the spawning season, which suggests that P. nobilis uses the reserves stored in the adductor muscle for reproduction as in other Pinnidae species. Reproductive indices and stable isotopes ratios indicate ‘capital breeding’ as reproductive strategy of the pen shell. Decreased muscle force could mean a higher vulnerability during the summer period, coinciding with the peak in recreational activities involving poaching and anchoringVersión del edito

Population variability in some genes involving the haemostatic system: data on the general population of Corsica (France), Sardinia and Sicily (Italy)

Three different population samples from Corsica (France), Sardinia and Sicily (Italy) were studied using nine genetic markers. For the first time, allele distributions of FGA TaqI, FGB Bcl I, FGB Hind III, PAI-1 Hind III, PLAT TPA-25, GPIIIa Taq I, GPIIb I/D 9bp, FVII HVR4 and FVII -323 10 bp markers, which are thought to be associated with cardiovascular disease risk, were studied in the general population of the three islands. The frequencies of the markers analysed in the present work show some peculiarities: the locus FVII HVR4 is characterized by the presence of a rare allele (H5), found in Corsicans and in Sardinians; the locus FBG BcII shows a low frequency of the B1 allele and the absence of the B1B1 genotype. The frequencies of some alleles have a distribution that is in agreement with the low risk for cardiovascular diseases in south European countries. The results highlight a genetic differentiation between the three Mediterranean islands and the other European populations

Enhancing Business Performance Of CV Primanto Pangan Selaras Indonesian Fruit Chips Goes International

Javanis Food is a trademark of Malang kripik factory which is a form of entrepreneurship spirit, based on the processing technology of various fruits and vegetables into chips as food. We want to develop the potential of chips into a delicious and nutritious product, and perform the production stages based on non-chemical research experience and hygienic supervision. Since 2015, Javanis Food has conducted production trials and cooperated with fruit farmer groups in Malang and extends to East Java. Javanis Food learns with farmers and suppliers to produce quality standards of raw materials, through desirable quality standard education and discussion during the development and planting of fruit trees. Javanis Food wants to continue to improve the partnership standards with fruit farmers, suppliers and business partners throughout Indonesia, to produce Internationally-qualified local products

How Do Developers Refactor Code to Improve Code Reusability?

. Refactoring is the de-facto practice to optimize software health. While there has been several studies proposing refactoring strategies to optimize software design through applying design patterns and removing design defects, little is known about how developers actually refactor their code to improve its reuse. Therefore, we extract, from 1,828 open source projects, a set of refactorings which were intended to improve the software reusability. We analyze the impact of reusability refactorings on state-of-the-art reusability metrics, and we compare the distribution of reusability refactoring types, with the distribution of the remaining mainstream refactorings. Overall, we found that the distribution of refactoring types, applied in the context of reusability, is different from the distribution of refactoring types in mainstream development. In the refactorings performed to improve reusability, source files are subject to more design level types of refactorings. Reusability refactorings significantly impact, high-level code elements, such as packages, classes, and methods, while typical refactorings, impact all code elements, including identifiers, and parameter