427 research outputs found
Uncovering functional brain signature via random matrix theory
The brain is organized in a modular way, serving multiple functionalities. This multiplicity requires that both positive (e.g. excitatory, phase-coherent) and negative (e.g. inhibitory, phase-opposing) interactions take place across brain modules. Unfortunately, most methods to detect modules from time series either neglect or convert to positive any measured negative correlation. This may leave a significant part of the sign-dependent functional structure undetected. Here we present a novel method, based on random matrix theory, for the identification of sign-dependent modules in the brain. Our method filters out the joint effects of local (unit-specific) noise and global (system-wide) dependencies that empirically obfuscate such structure. The method is guaranteed to identify an optimally contrasted functional `signature', i.e. a partition into modules that are positively correlated internally and negatively correlated across. The method is purely data-driven, does not use any arbitrary threshold or network projection, and outputs only statistically significant structure. In measurements of neuronal gene expression in the biological clock of mice, the method systematically uncovers two otherwise undetectable, negatively correlated modules whose relative size and mutual interaction strength are found to depend on photoperiod. The neurons alternating between the two modules define a candidate region of functional plasticity for circadian modulation
Evidence for Weakened Intercellular Coupling in the Mammalian Circadian Clock under Long Photoperiod
Implantable photonic neural probes for light-sheet fluorescence brain imaging
Significance: Light-sheet fluorescence microscopy (LSFM) is a powerful technique for highspeed volumetric functional imaging. However, in typical light-sheet microscopes, the illumination and collection optics impose significant constraints upon the imaging of non-transparent brain tissues. We demonstrate that these constraints can be surmounted using a new class of implantable photonic neural probes.Aim: Mass manufacturable, silicon-based light-sheet photonic neural probes can generate planar patterned illumination at arbitrary depths in brain tissues without any additional micro-optic components.Approach: We develop implantable photonic neural probes that generate light sheets in tissue. The probes were fabricated in a photonics foundry on 200-mm-diameter silicon wafers. The light sheets were characterized in fluorescein and in free space. The probe-enabled imaging approach was tested in fixed, in vitro, and in vivo mouse brain tissues. Imaging tests were also performed using fluorescent beads suspended in agarose.Results: The probes had 5 to 10 addressable sheets and average sheet thicknesses Conclusions: The neural probes can lead to new variants of LSFM for deep brain imaging and experiments in freely moving animals
Illumination in symbiotic binary stars: Non-LTE photoionization models. II. Wind case
We describe a non-LTE photoionization code to calculate the wind structure
and emergent spectrum of a red giant wind illuminated by the hot component of a
symbiotic binary system. We consider spherically symmetric winds with several
different velocity and temperature laws and derive predicted line fluxes as a
function of the red giant mass loss rate, \mdot. Our models generally match
observations of the symbiotic stars EG And and AG Peg for \mdot about 10^{-8}
\msunyr to 10^{-7} \msunyr. The optically thick cross- section of the red giant
wind as viewed from the hot component is a crucial parameter in these models.
Winds with cross-sections of 2--3 red giant radii reproduce the observed
fluxes, because the wind density is then high, about 10^9 cm^{-3}. Our models
favor winds with acceleration regions that either lie far from the red giant
photosphere or extend for 2--3 red giant radii.Comment: 51 pages, LaTeX including three tables, requires 15 Encapsulated
Postscript figures, to appear in Ap
Long-time Low-latency Quantum Memory by Dynamical Decoupling
Quantum memory is a central component for quantum information processing
devices, and will be required to provide high-fidelity storage of arbitrary
states, long storage times and small access latencies. Despite growing interest
in applying physical-layer error-suppression strategies to boost fidelities, it
has not previously been possible to meet such competing demands with a single
approach. Here we use an experimentally validated theoretical framework to
identify periodic repetition of a high-order dynamical decoupling sequence as a
systematic strategy to meet these challenges. We provide analytic
bounds-validated by numerical calculations-on the characteristics of the
relevant control sequences and show that a "stroboscopic saturation" of
coherence, or coherence plateau, can be engineered, even in the presence of
experimental imperfection. This permits high-fidelity storage for times that
can be exceptionally long, meaning that our device-independent results should
prove instrumental in producing practically useful quantum technologies.Comment: abstract and authors list fixe
Theories of Reference: What Was the Question?
The new theory of reference has won popularity. However, a number of noted philosophers have also attempted to reply to the critical arguments of Kripke and others, and aimed to vindicate the description theory of reference. Such responses are often based on ingenious novel kinds of descriptions, such as rigidified descriptions, causal descriptions, and metalinguistic descriptions. This prolonged debate raises the doubt whether different parties really have any shared understanding of what the central question of the philosophical theory of reference is: what is the main question to which descriptivism and the causal-historical theory have presented competing answers. One aim of the paper is to clarify this issue. The most influential objections to the new theory of reference are critically reviewed. Special attention is also paid to certain important later advances in the new theory of reference, due to Devitt and others
SN 2011hw: Helium-Rich Circumstellar Gas and the Luminous Blue Variable to Wolf-Rayet Transition in Supernova Progenitors
We present optical photometry and spectroscopy of the peculiar Type IIn/Ibn
supernova SN2011hw. Its light curve exhibits a slower decline rate than normal
SNeIbc, with a peak absolute magnitude of -19.5 (unfiltered) and a secondary
peak of -18.3 mag (R). Spectra of SN2011hw are unusual compared to normal SN
types, most closely resembling the spectra of SNeIbn. We center our analysis on
comparing SN 2011hw to the well-studied TypeIbn SN2006jc. While the two SNe
have many important similarities, the differences are quite telling: compared
to SN2006jc, SN2011hw has weaker HeI and CaII lines and relatively stronger H
lines, its light curve has a higher luminosity and slower decline rate, and
emission lines associated with the progenitor's CSM are narrower. One can
reproduce the unusual continuum shape of SN2011hw with equal contributions of a
6000K blackbody and a spectrum of SN2006jc. We attribute this emission
component and many other differences between the two SNe to extra opacity from
a small amount of additional H in SN2011hw, analogous to the small H mass that
makes SNeIIb differ from SNeIb. Slower speeds in the CSM and elevated H content
suggest a connection between the progenitor of SN2011hw and the class of
Ofpe/WN9 stars, which have been associated with LBVs in their hot quiescent
phases between outbursts, and are H-poor - but not H-free like classical
Wolf-Rayet (WR) stars. We conclude that the similarities and differences
between SN2011hw and SN2006jc can be largely understood if their progenitors
exploded at different points in the transitional evolution from an LBV to a WR
star.Comment: 11 pages, 7 figures, submitted to MNRA
Non-accretive Schrödinger operators and exponential decay of their eigenfunctions
International audienceWe consider non-self-adjoint electromagnetic Schrödinger operators on arbitrary open sets with complex scalar potentials whose real part is not necessarily bounded from below. Under a suitable sufficient condition on the electromagnetic potential, we introduce a Dirichlet realisation as a closed densely defined operator with non-empty resolvent set and show that the eigenfunctions corresponding to discrete eigenvalues satisfy an Agmon-type exponential decay
Ultrasound screening for asymptomatic carotid stenosis in subjects with calcifications in the area of the carotid arteries on panoramic radiographs: a cross-sectional study
<p>Abstract</p> <p>Background</p> <p>Directed ultrasonic screening for carotid stenosis is cost-effective in populations with > 5% prevalence of the diagnosis. Occasionally, calcifications in the area of the carotid arteries are incidentally detected on odontological panoramic radiographs. We aimed to determine if directed screening for carotid stenosis with ultrasound is indicated in individuals with such calcifications.</p> <p>Methods</p> <p>This was a cross-sectional study. Carotid ultrasound examinations were performed on consecutive persons, with findings of calcifications in the area of the carotid arteries on panoramic radiography that were otherwise eligible for asymptomatic carotid endarterectomy.</p> <p>Results</p> <p>Calcification in the area of the carotid arteries was seen in 176 of 1182 persons undergoing panoramic radiography. Of these, 117 fulfilled the inclusion criterion and were examined with carotid ultrasound. Eight persons (6.8%; 95% CI 2.2-11.5%) had a carotid stenosis - not significant over the 5% pre-specified threshold (p = 0.232, Binomial test). However, there was a significant sex difference (p = 0.008), as all stenoses were found in men. Among men, 12.5% (95%CI 4.2-20.8%) had carotid stenosis - significantly over the 5% pre-specified threshold (p = 0.014, Binomial test).</p> <p>Conclusions</p> <p>The incidental finding of calcification in the area of the carotid arteries on panoramic radiographs should be followed up with carotid screening in men that are otherwise eligible for asymptomatic carotid endarterectomy.</p> <p>Trial Registration</p> <p>The study was registered at <url>http://www.clinicaltrials.gov</url>; <a href="http://www.clinicaltrials.gov/ct2/show/NCT00514644">NCT00514644</a></p
The Symbiotic Neutron Star Binary GX 1+4/V2116 Ophiuchi
We present multiwavelength observations of this S-type symbiotic LMXB which
consists of a 2-min X-ray pulsar accreting from an M6 III giant. This is the
only symbiotic system definitely known to contain a neutron star. The steady
interstellar extinction toward the binary (Av=5) contrasts the variable N_H
inferred from X-ray measurements, most likely evidence for a stellar wind. The
mass donor is probably near the tip of the first-ascent red giant branch, in
which case the system is 3-6 kpc distant and has an X-ray luminosity of 10^37
erg/s. It is also possible, though less likely, that the donor star is just
beginning its ascent of the asymptotic giant branch, in which case the system
is 12-15 kpc distant and has an X-ray luminosity of 10^38 erg/s. However, our
measured Av argues against such a large distance. We show that the dense (10^9
cm^-3) emission-line nebula enshrouding the binary is powered by UV radiation
from an accretion disk. The emission-line spectrum constrains the temperature
and inner radius of the disk (and thus the pulsar's magnetic field strength),
and we discuss this in the context of the accretion torque reversals observed
in the pulsar. We also show that the binary period must be >100 d and is most
likely >260 d, making GX 1+4 the only known LMXB with Porb>10 d. If the mass
donor fills its Roche lobe, the mass transfer must be highly super-Eddington,
requiring much mass loss from the binary. We discuss the alternative that the
disk forms from the slow, dense stellar wind expected from the red giant.Comment: 46 pages including 7 PS figures. Accepted for publication in Ap
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