Moyo Vol. VII N 1

Durica, Paul. Editor\u27s Letter . 4 Lemke, Angelica. Paxil, Effexor, and Prozac, Oh My! Is Depression Awareness Day Going Too Far? 5. Frey, Randall. Just Be: How to Make Money Without Really Doing Anything . 6. Purks, Robert. 007, Missing The Action. Dalton\u27s Bond Reconsidered . 7. Stine, Alison. Hatching A masterpiece: Jeffery Hatcher Talks of Writing, Melville, Woody Allen, and Denison . 8. Levine, Robert. Dial DU For Murder: Cinema Student Shuffles Off The Mortal Coil, and Finds it an Acquired Taste . 13. Almirall, Sarah. Dial DU For Murder: Cinema Student Shuffles Off The Mortal Coil, and Finds it an Acquired Taste, Photographs . 13. Werne, Kirsten. Back in the Day (Mom and Pop Alums Reflect on the Sixties Social Scene) . 18. Kohlbecker, Matthew. Between a Rock and a Hard Place (A Geological Excursion Into the Wilds of Canada) . 20. Lammont, Jean. Where\u27s Waldon? Comments on the Homestead . 21. Frey, Randall. Me Experimenting with Berry Beer . 25. Frey, Randall. Shoes for Mr. Jordan . 28. Porcheddu, Fred. My Late Adolescence . 30. Combe, Clayton. The Modern Guinea Pig . 31

Identifying optimal level-of-care placement decisions for adolescent substance use treatment

Background: Adolescents respond differentially to substance use treatment based on their individual needs and goals. Providers may benefit from guidance (via decision rules) for personalizing aspects of treatment, such as level-of-care (LOC) placements, like choosing between outpatient or inpatient care. The field lacks an empirically-supported foundation to inform the development of an adaptive LOC-placement protocol. This work begins to build the evidence base for adaptive protocols by estimating them from a large observational dataset. Methods: We estimated two-stage LOC-placement protocols adapted to individual adolescent characteristics collected from the Global Appraisal of Individual Needs assessment tool (n = 10,131 adolescents). We used a modified version of Q-learning, a regression-based method for estimating personalized treatment rules over time, to estimate four protocols, each targeting a potentially distinct treatment goal: one primary outcome (a composite of ten positive treatment outcomes) and three secondary (substance frequency, substance problems, and emotional problems). We compared the adaptive protocols to non-adaptive protocols using an independent dataset. Results: Intensive outpatient was recommended for all adolescents at intake for the primary outcome, while low-risk adolescents were recommended for no further treatment at followup while higher-risk patients were recommended to inpatient. Our adaptive protocols outperformed static protocols by an average of 0.4 standard deviations (95 % confidence interval 0.2-0.6) of the primary outcome. Conclusions: Adaptive protocols provide a simple one-to-one guide between adolescents' needs and recommended treatment which can be used as decision support for clinicians making LOC-placement decisions

The Impact of HAART on the Respiratory Complications of HIV Infection: Longitudinal Trends in the MACS and WIHS Cohorts

Objective: To review the incidence of respiratory conditions and their effect on mortality in HIV-infected and uninfected individuals prior to and during the era of highly active antiretroviral therapy (HAART). Design: Two large observational cohorts of HIV-infected and HIV-uninfected men (Multicenter AIDS Cohort Study [MACS]) and women (Women's Interagency HIV Study [WIHS]), followed since 1984 and 1994, respectively. Methods: Adjusted odds or hazards ratios for incident respiratory infections or non-infectious respiratory diagnoses, respectively, in HIV-infected compared to HIV-uninfected individuals in both the pre-HAART (MACS only) and HAART eras; and adjusted Cox proportional hazard ratios for mortality in HIV-infected persons with lung disease during the HAART era. Results: Compared to HIV-uninfected participants, HIV-infected individuals had more incident respiratory infections both pre-HAART (MACS, odds ratio [adjusted-OR], 2.4; 95% confidence interval [CI], 2.2-2.7; p<0.001) and after HAART availability (MACS, adjusted-OR, 1.5; 95%CI 1.3-1.7; p<0.001; WIHS adjusted-OR, 2.2; 95%CI 1.8-2.7; p<0.001). Chronic obstructive pulmonary disease was more common in MACS HIV-infected vs. HIV-uninfected participants pre-HAART (hazard ratio [adjusted-HR] 2.9; 95%CI, 1.02-8.4; p = 0.046). After HAART availability, non-infectious lung diseases were not significantly more common in HIV-infected participants in either MACS or WIHS participants. HIV-infected participants in the HAART era with respiratory infections had an increased risk of death compared to those without infections (MACS adjusted-HR, 1.5; 95%CI, 1.3-1.7; p<0.001; WIHS adjusted-HR, 1.9; 95%CI, 1.5-2.4; p<0.001). Conclusion: HIV infection remained a significant risk for infectious respiratory diseases after the introduction of HAART, and infectious respiratory diseases were associated with an increased risk of mortality. © 2013 Gingo et al

Règlement concernant les fourrages qui seront fournis, en temps de paix, aux régimens de cavalerie, dragons, hussards & troupes légères . Du 25 mars 1763

[Acte royal. 1763-03-25. Versailles]Avec mode text

The development of a novel adsorbent for collecting ignitable liquid residues from a fire scene

Different ad-hoc materials are being used to recover ignitable liquid residues (ILRs) when direct sampling is difficult at a fire scene. Our investigations have shown that these are unable to recover all target compounds specified in the ASTM method for the positive identification of ILRs. A novel adsorbent (limestone and British Fuller’s earth; 10:1 w/w) has been developed that is capable of recovering all of the target compounds, applicable to a wide range of ignitable liquids. It does not interfere with the analysis and can easily be used on different surface types. The novel adsorbent was also tested at a cold fire scene where all ILRs were identified. This investigation has proved that ad-hoc materials used by fire investigators are not fit for purpose and could lead to the misinterpretation of evidence in court. Here we propose an inexpensive, innovative and universal adsorbent that could be adopted by fire investigators globally

Profiling of heroin and assignment of provenance by 87Sr/86Sr isotope ratio analysis

[Display omitted] Heroin manufacturing and distribution by criminal and terrorist organizations produce illicit economic benefits from the opium and heroin trade and result in devastating societal problems. Heroin chemical signatures provide important information to law enforcement and the intelligence community in order to combat the national and international heroin epidemic. Authentic (known origin) heroin samples from Southeast Asia (SEA), Southwest Asia (SWA), South America (SA) and SA-like heroin manufactured in Mexico (MEX-SA), were prepared for chemical analysis by microwave-assisted acid digestion. Strontium concentration data were acquired using inductively-coupled plasma mass spectrometry (ICP-MS). The samples having sufficient [88Sr] (1.25µg/g in the solid sample) were purified by ion exchange resin and strontium isotope ratio (87Sr/86Sr) values were measured using multi-collector inductively-coupled plasma mass spectrometry (MC-ICP-MS). South American and MEX-SA heroin samples are presently the most challenging regions to differentiate by analysis of their organic compositions. The SA and MEX-SA heroin samples were correctly classified 82% and 77% of the time, respectively, when the 87Sr/86Sr values of individual authentic samples were compared to the overall mean values from the four regions. This is the first reporting on the use of 87Sr/86Sr analysis of heroin for the profiling of samples from specific geographic regions. In addition, a value of 87Sr/86Sr for the National Institute of Standards and Testing’s standard reference material NIST SRM 1570a (spinach leaves) of 0.70905±0.00002 (95% confidence interval, n=3) is also reported for the first time