40 research outputs found
TCT-281 Usefulness of a systematic "Crossover wire Technique" to improve percutaneous treatment of vascular complications in Transfemoral Transcatheter Aortic Valve Implantation
TCT-794 Percutaneous clousure of para valvular mitral prosthetic regurgitation with AVPIII device
Control of occult hepatitis B virus infection
Background: The diagnosis of hepatitis B virus (HBV) infection requires HBV DNA testing and serologic testing for detection of the surface antigen (HBsAg) and the hepatitis B core antibody (anti-HBc). There is a population of patients with occult HBV infection (OBI), which is not detected by HBsAg or HBV DNA quantification in blood, despite the presence of active replication in the liver.Scope: This document provides a definition of OBI and describes the diagnostic techniques currently used. It also addresses the detection of patients with risk factors and the need for screening for OBI in these patients.Summary:Correct diagnosis of OBI prevents HBV reactivation and transmission. Diagnosis of OBI is based on the detection of HBV DNA in patients with undetectable HBsAg in blood.Perspectives: A high number of patients with OBI may remain undiagnosed; therefore, screening for OBI in patients with factor risks is essential. For a correct diagnosis of OBI, it is necessary that new markers such as ultrasensitive HBsAg are incorporated, and a more comprehensive marker study is performed by including markers such as cccDNA
BiP Heterozigosity Aggravates Pathological Deterioration in Experimental Amyotrophic Lateral Sclerosis
In the present study, we investigated the involvement of the chaperone protein BiP (also known as GRP78 or Hspa5), a master regulator of intracellular proteostasis, in two mouse models of neurodegenerative diseases: amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD). To this end, we used mice bearing partial genetic deletion of the BiP gene (BiP+/− mice), which, for the ALS model, were crossed with mutant SOD1 (mSOD1) transgenic mice to generate mSOD1/BiP+/− double mutant mice. Our data revealed a more intense neurological decline in the double mutants, reflected in a greater deterioration of the neurological score and rotarod performance, with also a reduced animal survival, compared to mSOD1 transgenic mice. Such worsening was associated with higher microglial (labelled with Iba-1 immunostaining) and, to a lesser extent, astroglial (labelled with GFAP immunostaining) immunoreactivities found in the double mutants, but not with a higher loss of spinal motor neurons (labelled with Nissl staining) in the spinal cord. The morphological analysis of Iba-1 and GFAP-positive cells revealed a higher presence of activated cells, characterized by elevated cell body size and shorter processes, in double mutants compared to mSOD1 mice with normal BiP expression. In the case of the PD model, BiP+/− mice were unilaterally lesioned with the parkinsonian neurotoxin 6-hydroxydopamine (6-OHDA). In this case, however, we did not detect a greater susceptibility to damage in mutant mice, as the motor defects caused by 6-OHDA in the pole test and the cylinder rearing test, as well as the losses in tyrosine hydroxylase-containing neurons and the elevated glial reactivity (labelled with CD68 and GFAP immunostaining) detected in the substantia nigra were of similar magnitude in BiP+/− mice compared with wildtype animals. Therefore, our findings support the view that a dysregulation of the protein BiP may contribute to ALS pathogenesis. As BiP has been recently related to cannabinoid type-1 (CB1) receptor function, our work also opens the door to future studies on a possible link between BiP and the neuroprotective effects of cannabinoids that have been widely reported in this neuropathological context. In support of this possibility, preliminary data indicate that CB1 receptor levels are significantly reduced in mSOD1 mice having partial deletion of BiP gene
Seroepidemiological study of Toxoplasma gondii in wild and domestic lagomorphs in Spain
Resumen del trabajo presentado a la Joint Virtual Conference of the WDA and EWDA, celebrada del 31 de agosto al 2 de septiembre de 2021.Peer reviewe
Male-biased gastrointestinal parasitism in a nearly monomorphic mountain ungulate
Background: Pyrenean chamois (Rupicapra pyrenaica pyrenaica) is a nearly monomorphic mountain ungulate with
an unbiased sex-specific overwinter adult survival. Few differences in gastrointestinal parasitism have been reported by
coprology as yet. This study aims to assess diversity, prevalence, intensity of infection and aggregation of gastrointestinal
nematodes in male and female adult chamois. We expect no differences in the parasite infection rates between sexes.
Findings: Gastrointestinal tracts of 28 harvested Pyrenean chamois in the Catalan Pyrenees (autumn 2012 and 2013)
were necropsied and sexual differences in the diversity and structure of parasite community, prevalence, intensity of
infection, and richness were investigated. We found 25 helminth species belonging to 13 different genera.
Conclusions: Contrary to our expectations, male chamois showed different parasite communities, higher prevalence,
intensity of infection and richness than females. Such sexual differences were clear irrespective of age of individuals.
Hence, male chamois must cope with a more diverse and abundant parasite community than females, without apparent
biological cost. Further research will be required to confirm this hypothesis
Oracion sagrada que en la fiesta de colocacion del Santissimo Sacramento y dedicacion de iglesia del Convento de Venerables Madres Capuchinas fundado nuevamentente en la Villa de la Nava del Rey ...
Sign.: [calderón]-2[calderón], 3[calderón], A-D, ENo v. da p. [22] hai un grav. xilTexto con apostillas marxinai
Discurso de apertura del curso de 1906-1907 y memoria del de 1905-1906
Discurso de Carlos López Redond