626 research outputs found
In-flight radiometric calibration of the Airborne Visible/Infrared Imaging Spectrometer (AVIRIS)
A reflectance-based method was used to provide an analysis of the in-flight radiometric performance of AVIRIS. Field spectral reflectance measurements of the surface and extinction measurements of the atmosphere using solar radiation were used as input to atmospheric radiative transfer calculations. Five separate codes were used in the analysis. Four include multiple scattering, and the computed radiances from these for flight conditions were in good agreement. Code-generated radiances were compared with AVIRIS-predicted radiances based on two laboratory calibrations (pre- and post-season of flight) for a uniform highly reflecting natural dry lake target. For one spectrometer (C), the pre- and post-season calibration factors were found to give identical results, and to be in agreement with the atmospheric models that include multiple scattering. This positive result validates the field and laboratory calibration technique. Results for the other spectrometers (A, B and D) were widely at variance with the models no matter which calibration factors were used. Potential causes of these discrepancies are discussed
Realistic Calculation of the hep Astrophysical Factor
The astrophysical factor for the proton weak capture on 3He is calculated
with correlated-hyperspherical-harmonics bound and continuum wave functions
corresponding to a realistic Hamiltonian consisting of the Argonne v18
two-nucleon and Urbana-IX three-nucleon interactions. The nuclear weak charge
and current operators have vector and axial-vector components, that include
one- and many-body terms. All possible multipole transitions connecting any of
the p-3He S- and P-wave channels to the 4He bound state are considered. The
S-factor at a p-3He center-of-mass energy of 10 keV, close to the Gamow-peak
energy, is predicted to be 10.1 10^{-20} keV b, a factor of five larger than
the standard-solar-model value. The P-wave transitions are found to be
important, contributing about 40 % of the calculated S-factor.Comment: 8 pages RevTex file, submitted to Phys. Rev. Let
A mathematical framework for critical transitions: normal forms, variance and applications
Critical transitions occur in a wide variety of applications including
mathematical biology, climate change, human physiology and economics. Therefore
it is highly desirable to find early-warning signs. We show that it is possible
to classify critical transitions by using bifurcation theory and normal forms
in the singular limit. Based on this elementary classification, we analyze
stochastic fluctuations and calculate scaling laws of the variance of
stochastic sample paths near critical transitions for fast subsystem
bifurcations up to codimension two. The theory is applied to several models:
the Stommel-Cessi box model for the thermohaline circulation from geoscience,
an epidemic-spreading model on an adaptive network, an activator-inhibitor
switch from systems biology, a predator-prey system from ecology and to the
Euler buckling problem from classical mechanics. For the Stommel-Cessi model we
compare different detrending techniques to calculate early-warning signs. In
the epidemics model we show that link densities could be better variables for
prediction than population densities. The activator-inhibitor switch
demonstrates effects in three time-scale systems and points out that excitable
cells and molecular units have information for subthreshold prediction. In the
predator-prey model explosive population growth near a codimension two
bifurcation is investigated and we show that early-warnings from normal forms
can be misleading in this context. In the biomechanical model we demonstrate
that early-warning signs for buckling depend crucially on the control strategy
near the instability which illustrates the effect of multiplicative noise.Comment: minor corrections to previous versio
Nonlinear Hydrodynamics of a Hard Sphere Fluid Near the Glass Transition
We conduct a numerical study of the dynamic behavior of a dense hard sphere
fluid by deriving and integrating a set of Langevin equations. The statics of
the system is described by a free energy functional of the
Ramakrishnan-Yussouff form. We find that the system exhibits glassy behavior as
evidenced through stretched exponential decay and two-stage relaxation of the
density correlation function. The characteristic times grow with increasing
density according to the Vogel-Fulcher law. The wavenumber dependence of the
kinetics is extensively explored. The connection of our results with
experiment, mode coupling theory, and molecular dynamics results is discussed.Comment: 34 Pages, Plain TeX, 12 PostScript Figures (not included, available
on request
Generalized hydrodynamics and extended irreversible thermodynamics
The thermodynamic implications of the first deviations with respect to the classical hydrodynamic behavior in high-frequency, short-wavelength phenomena are examined. The constitutive equations arising from an extended irreversible-thermodynamic formalism taking into account spatial inhomogeneities in the space of state variables are compared with those used in generalized hydrodynamics. The so-called exponential model for the memory function of the transverse-velocity correlation function is derived under the assumptions of extended irreversible thermodynamics only. Furthermore, it is also shown how more complicated memory functions can be derived. The results are carefully analyzed and compared with some microscopic derivations
Opalized archosaur remains from the Bulldog Shale (Aptian: Lower Cretaceous) of South Australia
Experimental delayed-choice entanglement swapping
Motivated by the question, which kind of physical interactions and processes
are needed for the production of quantum entanglement, Peres has put forward
the radical idea of delayed-choice entanglement swapping. There, entanglement
can be "produced a posteriori, after the entangled particles have been measured
and may no longer exist". In this work we report the first realization of
Peres' gedanken experiment. Using four photons, we can actively delay the
choice of measurement-implemented via a high-speed tunable bipartite state
analyzer and a quantum random number generator-on two of the photons into the
time-like future of the registration of the other two photons. This effectively
projects the two already registered photons onto one definite of two mutually
exclusive quantum states in which either the photons are entangled (quantum
correlations) or separable (classical correlations). This can also be viewed as
"quantum steering into the past"
Deep diversification of an AAV capsid protein by machine learning.
Modern experimental technologies can assay large numbers of biological sequences, but engineered protein libraries rarely exceed the sequence diversity of natural protein families. Machine learning (ML) models trained directly on experimental data without biophysical modeling provide one route to accessing the full potential diversity of engineered proteins. Here we apply deep learning to design highly diverse adeno-associated virus 2 (AAV2) capsid protein variants that remain viable for packaging of a DNA payload. Focusing on a 28-amino acid segment, we generated 201,426 variants of the AAV2 wild-type (WT) sequence yielding 110,689 viable engineered capsids, 57,348 of which surpass the average diversity of natural AAV serotype sequences, with 12-29 mutations across this region. Even when trained on limited data, deep neural network models accurately predict capsid viability across diverse variants. This approach unlocks vast areas of functional but previously unreachable sequence space, with many potential applications for the generation of improved viral vectors and protein therapeutics
Socio-economic inequalities in C-reactive protein and fibrinogen across the adult age span: Findings from Understanding Society
Systemic inflammation has been proposed as a physiological process linking socio-economic position (SEP) to health. We examined how SEP inequalities in inflammation -assessed using C-reactive protein (CRP) and fibrinogen- varied across the adult age span. Current (household income) and distal (education) markers of SEP were used. Data from 7,943 participants (aged 25+) of Understanding Society (wave 2, 1/2010-3/2012) were employed. We found that SEP inequalities in inflammation followed heterogeneous patterns by age, which differed by the inflammatory marker examined rather than by SEP measures. SEP inequalities in CRP emerged in 30s, increased up to mid-50s or early 60 s when they peaked and then decreased with age. SEP inequalities in fibrinogen decreased with age. Body mass index (BMI), smoking, physical activity and healthy diet explained part, but not all, of the SEP inequalities in inflammation; in general, BMI exerted the largest attenuation. Cumulative advantage theories and those considering age as a leveler for the accumulation of health and economic advantages across the life-span should be dynamically integrated to better understand the observed heterogeneity in SEP differences in health across the lifespan. The attenuating roles of health-related lifestyle indicators suggest that targeting health promotion policies may help reduce SEP inequalities in health
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