Vaccination anti-hépatite B par les médecins généralistes français

International audienceEn France, l'idée que le vaccin contre le virus de l'hépatite B (VHB) ait pu être associé au développement de pathologies démyélinisantes a largement circulé. Par suite, après une phase initiale d'excellente adhésion de la population à cette recommandation vaccinale, la couverture vaccinale a chuté pour devenir l'une des plus basses parmi les pays recommandant cette vaccination. Nous avons étudié les facteurs limitant l'utilisation du vaccin anti-VHB par les médecins généralistes, acteurs importants de cette vaccination. Nous avons conduit une enquête auprès de 2175 généralistes libéraux de France métropolitaine, fondée sur un questionnaire interactif adressé par courriel. Ce questionnaire visait à caractériser la perception du vaccin, les comportements et difficultés pratiques des participants dans le processus de vaccination. Leurs caractéristiques démographiques et conditions d'exercice ont également été recueillies. L'échantillon final compte 341 médecins. Sa représentativité a été vérifiée. La structure des réponses a été explorée par une Analyse des Correspondances Multiples (ACM). Des comportements-type ont été identifiés par une Classification Ascendante Hiérarchique (CAH). Certaines liaisons entre les réponses ont été recherchées et testées spécifiquement. L'étude montre que : (1) la mobilisation pour la vaccination des nourrissons s'accentue, (2) en comparaison, les rattrapages vaccinaux des adolescents sont moins proposés ; (3) l'utilité de la vaccination systématique est contestée par ¼ de l'échantillon, (4) l'obstacle principal à la vaccination dans l'opinion publique reste la crainte d'effets secondaires du vaccin, (5) parmi les médecins, un excès de précaution dans les prescriptions et des idées fausses sur l'hépatite B et la vaccination limitent celle-ci

El sistema JRODOS: una herramienta moderna y eficaz para la gestión y preparación de emergencias nucleares y radiológicas y la rehabilitación. Implementación en España.

En los últimos años se ha producido un significativo avance en el área de la gestión de las emergencias nucleares y radiológicas y la rehabilitación. Proyectos de alcance europeo como EURANOS han contribuido a mejorar los procesos de gobernanza participativa iniciados durante los anteriores Programas Marco Europeos y el desarrollo de técnicas y metodologías en todos los niveles operativos en materia nuclear y radiológica. El sistema de ayuda a la decisión (SAD) RODOS es uno de los productos desarrollados durante este periodo y que ha ido siendo mejorado hasta convertirse en un sistema de uso operacional ampliamente difundido y asumido en todo el ámbito europeo y que empieza a extenderse también a otras zonas del mundo. En España, ha sido implementado y adaptado a las características nacionales en el contexto del Proyecto ISIDRO, patrocinado por el CSN, con la participación del CIEMAT y la UPM. El objetivo de este trabajo es dar a conocer la última versión de este sistema, denominado JRODOS, centrándose en su adaptación al entorno nacional y su aplicación como herramienta operacional en la gestión y preparación de las emergencias y la rehabilitación de zonas contaminadas

Analisis Faktor yang Memengaruhi Aglomerasi Industri Unggulan Daerah dan Hubungannya dengan Daya Saing Industri Daerah

The manufacturing industry sector is a major driver of economic growth in Indonesia with the largest contribution to the components of Gross Domestic Product is 25.60 % in 2012. But the globalization and liberalization of International trade requires industries to be more competitive. Improving the competitiveness of the industry can be done through the development of regional-based industrial sector main industry that area. The purpose of this study was to analyze the competitiveness and industrial agglomeration, the causality relationship between competitiveness and agglomeration industry and the factors that influence agglomeration of province main industries. This study was using large and medium scale industry raw data. The data analysis using Location Quotient, Hoover Balassa Index, Granger Causality method and panel data method with Fixed Effect Model. The result of panel data regression shows factors that influence the agglomeration of province main industries are firm size, value added, the diversity of industry, industry competition index, competitiveness index, wages and road infastructure

Model order reduction approaches for infinite horizon optimal control problems via the HJB equation

We investigate feedback control for infinite horizon optimal control problems for partial differential equations. The method is based on the coupling between Hamilton-Jacobi-Bellman (HJB) equations and model reduction techniques. It is well-known that HJB equations suffer the so called curse of dimensionality and, therefore, a reduction of the dimension of the system is mandatory. In this report we focus on the infinite horizon optimal control problem with quadratic cost functionals. We compare several model reduction methods such as Proper Orthogonal Decomposition, Balanced Truncation and a new algebraic Riccati equation based approach. Finally, we present numerical examples and discuss several features of the different methods analyzing advantages and disadvantages of the reduction methods

A DECOMPOSITION APPROACH TO ASSESS ILUC RESULTS FROM GLOBAL MODELING EFFORTS

Environmental Economics and Policy, Resource /Energy Economics and Policy,

Mejoras en el sistema MOIRA para su aplicación a los emplazamientos nucleares fluviales españoles

Entre las posibles secuelas de un accidente nuclear hay que contar con la contaminación radiactiva a medio y largo plazo de los sistemas acuáticos de agua dulce. Frente a ese problema, es fundamental disponer de una evaluación realista del impacto radiológico, ecológico, social y económico de las posibles estrategias de gestión, para poder adoptar las decisiones más convenientes de forma racional. MOIRA es un sistema de ayuda a la decisión desarrollado en el curso de los Programas Marco Europeos con participación de la UPM, que ha sido mejorado y adaptado a los emplazamientos nucleares españoles en los últimos años en el contexto del Proyecto ISIDRO, patrocinado por el Consejo de Seguridad Nuclear, con la participación del CIEMAT y la UPM. El trabajo se centra en esos avances, principalmente relacionados con los sistemas hidráulicos complejos como los de los ríos Tajo, Ebro y Júcar, en los que se ubican varias centrales nucleares españolas

Equation of state for β\beta-stable hot nuclear matter

We provide an equation of state for hot nuclear matter in $\beta$-equilibrium by applying a momentum-dependent effective interaction. We focus on the study of the equation of state of high-density and high-temperature nuclear matter, containing leptons (electrons and muons) under the chemical equilibrium condition in which neutrinos have left the system. The conditions of charge neutrality and equilibrium under $\beta$-decay process lead first to the evaluation of proton and lepton fractions and afterwards of internal energy, free energy, pressure and in total to the equation of state of hot nuclear matter. Thermal effects on the properties and equation of state of nuclear matter are assesed and analyzed in the framework of the proposed effective interaction model. Special attention is dedicated to the study of the contribution of the components of $\beta$-stable nuclear matter to the entropy per particle, a quantity of great interest for the study of structure and collapse of supernova.Comment: 28 pages, 18 figure

Crystal Structures of a Plant Trypsin Inhibitor from Enterolobium contortisiliquum (EcTI) and of Its Complex with Bovine Trypsin

A serine protease inhibitor from Enterolobium contortisiliquum (EcTI) belongs to the Kunitz family of plant inhibitors, common in plant seeds. It was shown that EcTI inhibits the invasion of gastric cancer cells through alterations in integrin-dependent cell signaling pathway. We determined high-resolution crystal structures of free EcTI (at 1.75 angstrom) and complexed with bovine trypsin (at 2 angstrom). High quality of the resulting electron density maps and the redundancy of structural information indicated that the sequence of the crystallized isoform contained 176 residues and differed from the one published previously. the structure of the complex confirmed the standard inhibitory mechanism in which the reactive loop of the inhibitor is docked into trypsin active site with the side chains of Arg64 and Ile65 occupying the S1 and S1' pockets, respectively. the overall conformation of the reactive loop undergoes only minor adjustments upon binding to trypsin. Larger deviations are seen in the vicinity of Arg64, driven by the needs to satisfy specificity requirements. A comparison of the EcTI-trypsin complex with the complexes of related Kunitz inhibitors has shown that rigid body rotation of the inhibitors by as much as 15 degrees is required for accurate juxtaposition of the reactive loop with the active site while preserving its conformation. Modeling of the putative complexes of EcTI with several serine proteases and a comparison with equivalent models for other Kunitz inhibitors elucidated the structural basis for the fine differences in their specificity, providing tools that might allow modification of their potency towards the individual enzymes.United States Department of Energy, Office of Science, Office of Basic Energy SciencesCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)National Institutes of Health, National Cancer Institute, Center for Cancer ResearchNCI, Ctr Canc Res, Macromol Crystallog Lab, Frederick, MD 21701 USAUniversidade Federal de São Paulo, Dept Bioquim, São Paulo, BrazilInst Butantan, Lab Bioquim & Biofis, Unidade Sequenciamento Prot & Peptideos, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Bioquim, São Paulo, BrazilUnited States Department of Energy, Office of Science, Office of Basic Energy Sciences: W-31-109-Eng-38FAPESP: 09/53766-5Web of Scienc