Identification of the formation of resonant tones in compressible cavity flows

Identification of the fluid dynamic mechanisms responsible for the formation of resonant tones in a cavity flow is challenging. Time-frequency non-linear analysis techniques were applied to the post-processing of pressure signals recorded on the floor of a rectangular cavity at a transonic Mach number. The results obtained, confirmed that the resonant peaks in the spectrum were produced by the interaction of a carrier frequency (and its harmonics) and a modulating frequency. High-order spectral analysis, based on the instantaneous wavelet bi-coherence method, was able to identify, at individual samples in the pressure–time signal, that the interaction between the fundamental frequency and the amplitude modulation frequency was responsible for the creation of the Rossier–Heller tones. The same technique was also able to correlate the mode switching phenomenon, as well as the deactivation of the resonant tones during the temporal evolution of the signal

Wavelet analysis of complex geometry transonic cavity flows

The aero-acoustic analysis of a weapon bay of an Unmanned Combat Air Vehicle (UCAV) was predicted using Computational Fluid Dynamics (CFD) methods. Along the reference geometry, consisting in the installation of the Boeing M219 modified type cavity in the Boeing UCAV1303 airframe, two additional configurations, developed modifying the leading and trailing edge geometries of the bay, were tested. Pressure signals inside the cavity were post-processed using Joint Time Frequency Analysis (JTFA) techniques, consisting in a combination of frequency domain and time-frequency domain techniques based respectively on the Fourier and wavelet transform. Results showed an intermittency nature of the modes present in the spectra as well as a continuous change, during the temporal evolution of the signal, of the dominant mode. Also were recorded, using second order wavelet spectral moments, non-linear phenomena between the main modes like phase coupling

The effect of angle of attack on the aeroacoustic environment within the weapons bay of a generic UCAV

Cavity flow studies are generally concerned with observing the effect of geometry changes whilst maintaining a fixed zero angle of attack. Cavities employed as weapons bays will, however, experience a range of angles of attack. This paper presents the first known results showing the effect of flight angle of attack on the aeroacoustic characteristics of an internal weapons bay installed in an uninhabited combat air vehicle (UCAV). The UCAV geometry consisted of a Boeing M219-type cavity in a Boeing UCAV1303 airframe. Numerical simulation was conducted using a full-scale detached eddy simulation model and representative transonic flight conditions. As well as the reference case of zero degrees, data for angles of attack of 3.0, 4.5 and 6.0 degrees were analysed. Experimental data was used to validate the reference computational model, which agreed with the overall fluctuating sound pressure level (OAFPL) to within the experimental uncertainty of 4 dB. Data from the computational model was post-processed with frequency-domain and time-frequency-domain techniques showing that the flow structure within the weapons bay was altered significantly by the angle of attack changes, affecting the mean pressure distribution, frequency spectra and resonant modes. Overall, increasing the angle of attack from 0.0 to 3.0 degrees produced an increment in the acoustic load whilst a further increase tended to affect the resonance mechanism and thereby reduce the coherence and the temporal footprints of the resonant modes

The Cardiac Atlas Project—an imaging database for computational modeling and statistical atlases of the heart

Motivation: Integrative mathematical and statistical models of cardiac anatomy and physiology can play a vital role in understanding cardiac disease phenotype and planning therapeutic strategies. However, the accuracy and predictive power of such models is dependent upon the breadth and depth of noninvasive imaging datasets. The Cardiac Atlas Project (CAP) has established a large-scale database of cardiac imaging examinations and associated clinical data in order to develop a shareable, web-accessible, structural and functional atlas of the normal and pathological heart for clinical, research and educational purposes. A goal of CAP is to facilitate collaborative statistical analysis of regional heart shape and wall motion and characterize cardiac function among and within population groups

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist