The Effect upon State Crime Rates of the Legalization of Recreational Marijuana in California

This work examines criminal effects of the legalization of recreational marijuana in the state of California in 2016. While multiple states have legalized marijuana for recreational purposes, there is little empirical evidence to determine the criminal effect, if any, of introducing marijuana products into the legal market. The research analyzes crime rates pre and post legalization. Crime rates from the years 1990-2018 are taken from the California Attorney General Office “Crime in California” annual report, and consist of FBI Part I offenses: murder and non-negligent homicide, rape, robbery, aggravated assault, burglary, motor vehicle theft, larceny-theft, and arson. Misdemeanor drug arrests, marijuana felony arrests, and non-marijuana felony drug arrests are also included. DUI arrests are sourced from the California Department of Motor Vehicles DUI management information annual report. Interrupted time-series analysis is the primary analytic strategy, in conjunction with descriptive statistics. Results suggest that legalization has had a non-trivial impact on some offenses, although there are severe data limitations in place

Courage in Mississippi (short)

Letter to the editor praising James Silver\u27s courage in speaking out about racial problems in Mississippi; Source: St. Louis Post-Dispatchhttps://egrove.olemiss.edu/jws_clip/1247/thumbnail.jp

A Novel Reconfigurable Vector-Processed Interleaving Algorithm for a DVB-RCS2 Turbo Encoder

Turbo-Codes (TC) are a family of convolutional codes enabling Forward-Error-Correction (FEC) while approaching the theoretical limit of channel capacity predicted by Shannons theorem. One of the bottlenecks of a Turbo Encoder (TE) lies in the non-uniform interleaving stage. Interleaving algorithms require stalling the input vector bits before the bit rearrangement causing a delay in the overall process. This paper presents performance enhancement via a parallel algorithm for the interleaving stage of a Turbo Encoder application compliant with the DVB-RCS2 standard. The algorithm efficiently implements the interleaving operation while utilizing attributes of a given DSP. We will discuss and compare a serial model for the TE, with the presented parallel processed algorithm. Results showed a speed-up factor of up to 3.4 Total-Cycles, 4.8 Write and 7.3 Read

Biofunktionalisierung von Gold-Nanostrukturen mit Plasma-Fibronektin

Im Rahmen dieser Arbeit wird das Fibronektin (Fn) Dimer (welches im Blut vorkommt und zur Fibrillenbildung fähig ist) oder Monomer (welches nach der Reduktion von Dimeren erhalten wird) an unterschiedlich dicht verteilte und circa 7 nm große Gold-Nanopartikel auf Oberflächen gebunden. Die Herstellung dieser Oberflächen erfolgt mittels Diblockcopolymer-Mizellen-Nanolithographie (engl.: block copolymer micelle lithography (BCML)). Eine Herausforderung ist hierbei die effiziente und reproduzierbare Anbindung einzelner, unmodifizierter Fn Dimere oder Monomere an einzelne Gold-Nanopartikel auf Oberflächen sowie deren Charakterisierung. Hierfür wird die Effizienz a) einer direkten Anbindungsstrategie, bei der das Molekül statistisch orientiert an Gold-Nanopartikel gebunden wird, und b) einer indirekten Anbindungsstrategie, bei der das Molekül gerichtet orientiert über einen Linker an Gold-Nanopartikel gebunden wird, mittels der Schwingquarzmikrowaage mit Bestimmung des Dissipationsfaktors (engl. quartz crystal microbalance with dissipation (QCM-D)), einer Kombination von QCM-D und Reflektometrie, Fluoreszenzmikroskopie, Rasterelektronenmikroskopie (REM), Transmissions-elektronenmikroskopie (TEM) und Rasterkraftmikroskopie (engl. atomic force microscope (AFM)) untersucht. Ein Vergleich der Hydrophilie von Oberflächen untereinander geschieht hier mit Hilfe der statischen Kontaktwinkelmessung

Cerebral Infarct/Intracranial Cerebrovascular Disease

Imaging goals for intracranial cerebral vascular disease are (1) to assess the degree of parenchymal injury and identify intraparenchymal hemorrhage; (2) to determine if there are areas of altered perfusion that may be at risk for future injury; and (3) to assess the intracranial arteries (patency as well as direction of flow). This unit describes a Basic Protocol that can be used to evaluate stable patients with acute, subacute, or chronic cerebrovascular symptoms. An Alternate Protocol is also given for cases of hyperacute strokes or cerebrovascular symptoms in an unstable patient.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/145411/1/cpmia0101.pd

Estimate of vascular permeability and cerebral blood volume using Gd-DTPA contrast enhancement and dynamic T2*-weighted MRI

Purpose To develop a numerical approach for estimation of vascular permeability from dynamic T2*-weighted imaging, a technique routinely used to measure cerebral blood volume (CBV) and flow in gliomas. Materials and Methods This study describes a process for estimating both the gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) transvascular transfer constant and CBV from dynamic T2*-weighted images. The algorithm was applied to data from the brains of 12 patients with grade IV gliomas. The stability of the method was assessed. Estimates of CBV by this technique were compared to those of the conventional method. Results The algorithm was found to be insensitive to noise and to generate stable voxel-by-voxel estimates of permeability and CBV. Conclusion Using a single imaging acquisition, the three most important vascular properties, CBV, cerebral blood flow (CBF), and permeability, can be estimated. This approach may have potential in clinical evaluation of patients with brain tumor or acute ischemic stroke. J. Magn. Reson. Imaging 2006. © 2006 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/55796/1/20634_ftp.pd

FUNCTIONAL MR OF BRAIN ACTIVITY AND PERFUSION IN PATIENTS WITH CHRONIC CORTICAL STROKE

PURPOSE: (1) To determine whether functional MR can reliably map functional deficits in patients with stroke in the primary visual cortex; (2) to determine whether functional MR can reliably map perfusion deficits; and (3) to determine whether functional MR can give any additional diagnostic information beyond conventional MR. METHODS: Seven patients who had had a stroke in their primary visual system were examined using two functional MR techniques: (1) dynamic susceptibility contrast imaging, and (2) cortical activation mapping during full-field visual stimulation. Maps of relative cerebral blood volume and activation were created and compared with visual field examinations and conventional T2-weighted images on a quadrant-by-quadrant basis in five of these patients. RESULTS: Visual field mapping matched with both T2-weighted conventional images and activation mapping of 16 of 18 quadrants. In two quadrants, the activation maps detected abnormalities that were present on the visual field examination but not present on the T2-weighted images nor on the relative cerebral blood volume maps, which may indicate abnormal function without frank infarction. In addition, the activation maps demonstrated decreased activation in extrastriate cortex and had normal T2 signal and relative cerebral blood volume but was adjacent to infarcted primary cortex, mapping in vivo how stroke in one location can affect the function of distant tissue. CONCLUSION: Functional MR techniques can accurately map functional and perfusion deficits and thereby provide additional clinically useful information. Additional studies will be needed to determine the prognostic utility of functional MR in stroke patients

Arterial input function and gray matter cerebral blood volume measurements in children

Purpose To investigate how arterial input functions (AIFs) vary with age in children and compare the use of individual and population AIFs for calculating gray matter CBV values. Quantitative measures of cerebral blood volume (CBV) using dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) require measurement of an AIF. AIFs are affected by numerous factors including patient age. Few data presenting AIFs in the pediatric population exists. Materials and Methods Twenty‐two previously treated pediatric brain tumor patients (mean age, 6.3 years; range, 2.0–15.3 years) underwent DSC‐MRI scans on a 3T MRI scanner over 36 visits. AIFs were measured in the middle cerebral artery. A functional form of an adult population AIF was fitted to each AIF to obtain parameters reflecting AIF shape. The relationship between parameters and age was assessed. Correlations between gray matter CBV values calculated using the resulting population and individual patient AIFs were explored. Results There was a large variation in individual patient AIFs but correlations between AIF shape and age were observed. The center (r = 0.596, P < 0.001) and width of the first‐pass peak (r = 0.441, P = 0.007) were found to correlate significantly with age. Intrapatient coefficients of variation were significantly lower than interpatient values for all parameters (P < 0.001). Differences in CBV values calculated with an overall population and age‐specific population AIF compared to those calculated with individual AIFs were 31.3% and 31.0%, respectively. Conclusion Parameters describing AIF shape correlate with patient age in line with expected changes in cardiac output. In pediatric DSC‐MRI studies individual patient AIFs are recommended