Hot Horizontal Branch Stars in the Galactic Bulge. I

We present the first results of a survey of blue horizontal branch (BHB) stars in the Galactic bulge. 164 candidates with 15 < V < 17.5 in a field 7.5deg from the Galactic Center were observed in the blue at 2.4A FWHM resolution with the AAT 2dF spectrograph. Radial velocities were measured for all stars. For stars with strong Balmer lines, their profiles were matched to theoretical spectrum calculations to determine stellar temperature Teff and gravity log g; matches to metal lines yielded abundances. CTIO UBV photometry then gave the reddening and distance to each hot star. Reddening was found to be highly variable, with E(B-V) from 0.0 to 0.55 around a mean of 0.28. Forty-seven BHB candidates were identified with Teff >= 7250K, of which seven have the gravities of young stars, three are ambiguous, and 37 are HB stars. They span a wide metallicity range, from solar to 1/300 solar. The warmer BHB's are more metal-poor and loosely concentrated towards the Galactic center, while the cooler ones are of somewhat higher metallicity and closer to the center. Their red B-V colors overlap main-sequence stars, but the U-B vs. B-V diagram separates them until E(B-V) > 0.5. We detect two cool solar-metallicity HB stars in the bulge of our own Galaxy, the first such stars known. Still elusive are their hot counterparts, the metal-rich sdB/O stars causing excess UV light in metal-rich galaxies; they have V ~ 20.5 in the Bulge.Comment: 29 pages, 4 figures (the third with 4 panels, the fourth with 2 panels). To appear in the Astrophysical Journal v571n1, Jan. 20, 2000. Abstract is shortened here, and figures compresse

Familial hypercholesterolaemia: challenges in primary care

Familial hypercholesterolaemia remains largely unrecognised and undertreated in Australian primary care. A new approach involving increased awareness, early detection, lifelong treatment and cascade testing of relatives is essential to improve outcomes of patients with this disorder. Key Points Familial hypercholesterolaemia (FH) is a relatively common inherited disorder of high cholesterol levels. FH can lead to atherosclerosis, premature coronary artery disease and early death if left untreated. Cascade testing of relatives of patients with FH is cost- effective and necessary as one in two will have the condition. Innovations in primary care can improve FH detection in the community. An integrated approach to FH detection involving GPs, specialists and pathology laboratories is recommended. Primary care teams are well positioned to provide a sustainable approach to FH diagnosis and management but greater awareness of this condition is needed

Challenges in the care of familial hypercholesterolemia: a community care perspective

Familial hyperchoelsterolaemia (FH) remains under-diagnosed and under-treated in the community setting. Earlier evidence suggested prevalence of 1:500 worldwide but newer evidence suggests it is more common. Less than 15% of FH patients are ever diagnosed with children and young adults rarely tested despite having most to gain given their lifetime exposure. Increasing awareness among primary care teams is critical to improve detection profile for FH. Cascade testing in the community setting needs a sustainable approach to be developed to facilitate family tracing of index cases. The use of the Dutch Lipid Clinic Network Criteria score to facilitate a phenotypic diagnosis is the preferred approach adopted in Australia and eliminates the need to undertake genetic testing for all suspected FH cases

A Comparison of Two Open Source LiDAR Surface Classification Algorithms

With the progression of LiDAR (Light Detection and Ranging) towards a mainstream resource management tool, it has become necessary to understand how best to process and analyze the data. While most ground surface identification algorithms remain proprietary and have high purchase costs; a few are openly available, free to use, and are supported by published results. Two of the latter are the multiscale curvature classification and the Boise Center Aerospace Laboratory LiDAR (BCAL) algorithms. This study investigated the accuracy of these two algorithms (and a combination of the two) to create a digital terrain model from a raw LiDAR point cloud in a semi-arid landscape. Accuracy of each algorithm was assessed via comparison with \u3e7,000 high precision survey points stratified across six different cover types. The overall performance of both algorithms differed by only 2%; however, within specific cover types significant differences were observed in accuracy. The results highlight the accuracy of both algorithms across a variety of vegetation types, and ultimately suggest specific scenarios where one approach may outperform the other. Each algorithm produced similar results except in the ceanothus and conifer cover types where BCAL produced lower errors

Detection and management of familial hypercholesterolaemia in primary care in Australia: protocol for a pragmatic cluster intervention study with pre-post intervention comparisons

Introduction: Familial hypercholesterolaemia (FH), an autosomal dominant disorder of lipid metabolism, results in accelerated onset of atherosclerosis if left untreated. Lifelong treatment with diet, lifestyle modifications and statins enable a normal lifespan for most patients. Early diagnosis is critical. This protocol trials a primary care-based model of care (MoC) to improve detection and management of FH. Methods and analysis: Pragmatic cluster intervention study with pre-post intervention comparisons in Australian general practices. At study baseline, current FH detection practice is assessed. Medical records over 2 years are electronically scanned using a data extraction tool (TARB-Ex) to identify patients at increased risk. High-risk patients are clinically reviewed to provide definitive, phenotypic diagnosis using Dutch Lipid Clinic Network Criteria. Once an index family member with FH is identified, the primary care team undertake cascade testing of first-degree relatives to identify other patients with FH. Management guidance based on disease complexity is provided to the primary care team. Study follow-up to 12 months with TARB-Ex rerun to identify total number of new FH cases diagnosed over study period (via TARB-Ex, cascade testing and new cases presenting). At study conclusion, patient and clinical staff perceptions of enablers/barriers and suggested improvements to the approach will be examined. Resources at each stage will be traced to determine the economic implications of implementing the MoC and costed from health system perspective. Primary outcomes: increase in number of index cases clinically identified; reduction in low-density lipoprotein cholesterol of treated cases. Secondary outcomes: increase in the number of family cases detected/contacted; cost implications of the MoC. Ethics and dissemination: Study approval by The University of Notre Dame Australia Human Research Ethics Committee Protocol ID: 0 16 067F. Registration: Australian New Zealand Clinical Trials Registry ID: 12616000630415. Information will be disseminated via research seminars, conference presentations, journal articles, media releases and community forums

The top 10 research priorities in cystic fibrosis developed by a partnership between people with CF and healthcare providers

There remain many treatment uncertainties in cystic fibrosis (CF). With limited resources, research should focus on questions which are most important to the CF community. We conducted a James Lind Alliance Priority Setting Partnership in CF. Research questions were elicited and then prioritised in successive surveys. A workshop agreed the final top 10. Online methods avoided cross infection and widened participation. The elicitation survey had 482 respondents (1080 questions) and prioritisation survey 677 respondents. Participants were drawn equally from the patient and clinical communities globally. We have achieved a consensus on 10 research priorities which will be attractive to funders

Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast

Acknowledgments We thank Rebecca Shapiro for creating CaLC1819, CaLC1855 and CaLC1875, Gillian Milne for help with EM, Aaron Mitchell for generously providing the transposon insertion mutant library, Jesus Pla for generously providing the hog1 hst7 mutant, and Cathy Collins for technical assistance.Peer reviewedPublisher PD

BVRI Light Curves for 29 Type Ia Supernovae

BVRI light curves are presented for 27 Type Ia supernovae discovered during the course of the Calan/Tololo Survey and for two other SNe Ia observed during the same period. Estimates of the maximum light magnitudes in the B, V, and I bands and the initial decline rate parameter m15(B) are also given.Comment: 17 pages, figures and tables are not included (contact first author if needed), to appear in the Astronomical Journa

Small but crucial : the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans

Peer reviewedPublisher PD