Appraisal of the housing, renewal and sustainability needs of rural areas of Gateshead

Gateshead Council commissioned Sustainable Cities Research Institute (SCRI) and Banks of Wear Community Projects Ltd (BOW) to carry out a housing, renewal and sustainability appraisal of rural areas of Gateshead Borough between May and August 2006. The work involved: A desk-based review of relevant strategies and documents. A door-to-door survey of 2,342 households in Gateshead’s six rural wards (Birtley; Lamesley; Ryton, Crookhill and Stella; Crawcrook and Greenside; Chopwell and Rowlands Gill; and Whickham South and Sunniside). The survey covered approximately 10% of the 23,266 households in these wards. Consultation with residents and other key stakeholders through focus groups and interviews. This process targeted: harder to reach groups such as younger and aspiring households, people who work, older people, and recent incomers to the area; estate agents, developers and other property professionals; local shopkeepers and traders; local businesses; public sector professionals active in relevant fields such as education, leisure, social and community services; elected members; and transport providers. SCRI managed the project and delivered the desk-based review and survey, while BOW carried out the consultation with stakeholders as a sub-contractor to SCRI

Being ‘with woman’ in contemporary midwifery practice: one Trust's response to the Francis report

Whilst the Report of the Mid Staffordshire NHS Foundation Trust (Francis, 2013a) largely focussed on the failings in the nursing and medical professions, it was also a reminder to maternity services to review its systems and the quality of its care in line with the Code (NMC, 2015). This article will outline an initiative set up by two labour ward matrons at Kettering General Hospital Foundation Trust entitled ‘Back to Basics’. Sue and Kathy reviewed clinical practises in their maternity unit and put in place an initiative to raise standards of care and ensure best practice was recognised, maintained and disseminated

Natural background levels of primary biogenic amines in water samples from lakes and rivers around Stoke-on-Trent

Searching for victims of crime who have been buried in hidden (clandestine) graves or dumped into water courses currently utilises a number of techniques such as victim recovery dogs or ground penetrating radar. The development of chemical techniques would offer further assistance in body location and previous research has shown that primary biogenic amines are potential chemical markers of decomposition. There is a paucity of information about the natural abundance of the primary biogenic amines cadaverine, methylamine and putrescine in different water courses and an understanding of this natural abundance would allow for more accurate detection. This work aimed to chemically detect the natural background levels of primary biogenic amines (cadaverine, methylamine, and putrescine) in water samples taken from canals, lakes and rivers around Stoke-on-Trent (UK), These amines were quantified using gas chromatography-mass spectrometry (GC-MS). Water samples from the Hanley Park in Stoke-on-Trent were examined. In Hanley Park, there is a lake fed by a canal. It was determined that 0.002 mM putrescine was present in the analysed water samples from the park; cadaverine could not be detected. For comparison, in previously analysed leachate samples of buried porcine material with a post-burial interval of 350 days, putrescine had a concentration of 0.374 mM and cadaverine had a concentration of 0.323 mM. These data suggest that background levels of key bioamines are much lower than those found from buried material and it expected that this will be the scenario for bodies found in water

Age-related differences in breast cancer mortality according to race/ethnicity, insurance, and socioeconomic status.

BackgroundWe assessed breast cancer mortality in older versus younger women according to race/ethnicity, neighborhood socioeconomic status (nSES), and health insurance status.MethodsThe study included female breast cancer cases 18 years of age and older, diagnosed between 2005 and 2015 in the California Cancer Registry. Multivariable Cox proportional hazards modeling was used to generate hazard ratios (HR) of breast cancer specific deaths and 95% confidence intervals (CI) for older (60+ years) versus younger (< 60 years) patients separately by race/ethnicity, nSES, and health insurance status.ResultsRisk of dying from breast cancer was higher in older than younger patients after multivariable adjustment, which varied in magnitude by race/ethnicity (P-interaction< 0.0001). Comparing older to younger patients, higher mortality differences were shown for non-Hispanic White (HR = 1.43; 95% CI, 1.36-1.51) and Hispanic women (HR = 1.37; 95% CI, 1.26-1.50) and lower differences for non-Hispanic Blacks (HR = 1.17; 95% CI, 1.04-1.31) and Asians/Pacific Islanders (HR = 1.15; 95% CI, 1.02-1.31). HRs comparing older to younger patients varied by insurance status (P-interaction< 0.0001), with largest mortality differences observed for privately insured women (HR = 1.51; 95% CI, 1.43-1.59) and lowest in Medicaid/military/other public insurance (HR = 1.18; 95% CI, 1.10-1.26). No age differences were shown for uninsured women. HRs comparing older to younger patients were similar across nSES strata.ConclusionOur results provide evidence for the continued disparity in Black-White breast cancer mortality, which is magnified in younger women. Moreover, insurance status continues to play a role in breast cancer mortality, with uninsured women having the highest risk for breast cancer death, regardless of age

Household malaria knowledge and its association with bednet ownership in settings without large–scale distribution programs: Evidence from rural Madagascar

Background: Insecticide–treated bednets are effective at preventing malaria. This study focuses on household–level factors that are associated with bednet ownership in a rural area of Madagascar which had not been a recipient of large–scale ITN distribution. Methods: Data were gathered on individual and household characteristics, malaria knowledge, household assets and bednet ownership. Principal components analysis was used to construct both a wealth index based on household assets and a malaria knowledge index based on responses to questions about malaria. Bivariate and multivariate regressions were used to determine predictors of household bednet ownership and malaria knowledge. Results: Forty–seven of 560 households (8.4%) owned a bednet. In multivariate analysis, higher level of malaria knowledge among household members was the only variable significantly associated with bednet ownership (odds ratio 3.72, P < 0.001). Among respondents, predictors of higher malaria knowledge included higher education levels, female sex and reporting fever as the most frequent or dangerous illness in the community. Household wealth was not a significant predictor of bednet ownership or respondent malaria knowledge. Conclusion: In this setting of limited supply of affordable bednets, malaria knowledge was associated with an increased probability of household bednet ownership. Further studies should determine how such malaria knowledge evolves and if malaria–specific education programs could help overcome the barriers to bednet ownership among at–risk households living outside the reach of large–scale bednet distribution programs

Primary Paediatric Bronchial Airway Epithelial Cell in Vitro Responses to Environmental Exposures

Acknowledgments: The authors are grateful to the children who participated in this study and their parents. The authors would like to thank the following colleagues in the department of Ear Nose and Throat Surgery at NHS Grampian for allowing us to recruit their patients: Nicola Kryle, Derek Veitch, Kim Ah-See, Bhaskar Ram, Sangeeta Maini and Clive Brewis. We are also grateful to Tenovus Scotland whose funds enabled analysis of the samples (Grant reference G13_17) but did not include open access publishing fees.Peer reviewedPublisher PD

Soapmaking 101 - Exploiting COVID-19 to teach practical science and analytical skills remotely

Peer reviewedPublisher PD

A novel isolator-based system promotes viability of human embryos during laboratory processing

In vitro fertilisation (IVF) and related technologies are arguably the most challenging of all cell culture applications. The starting material is a single cell from which one aims to produce an embryo capable of establishing a pregnancy eventually leading to a live birth. Laboratory processing during IVF treatment requires open manipulations of gametes and embryos, which typically involves exposure to ambient conditions. To reduce the risk of cellular stress, we have developed a totally enclosed system of interlinked isolator-based workstations designed to maintain oocytes and embryos in a physiological environment throughout the IVF process. Comparison of clinical and laboratory data before and after the introduction of the new system revealed that significantly more embryos developed to the blastocyst stage in the enclosed isolator-based system compared with conventional open-fronted laminar flow hoods. Moreover, blastocysts produced in the isolator-based system contained significantly more cells and their development was accelerated. Consistent with this, the introduction of the enclosed system was accompanied by a significant increase in the clinical pregnancy rate and in the proportion of embryos implanting following transfer to the uterus. The data indicate that protection from ambient conditions promotes improved development of human embryos. Importantly, we found that it was entirely feasible to conduct all IVF-related procedures in the isolator-based workstations

To pee or not to pee? A urine-free renal practical

Peer reviewedPublisher PD

The prevalence and incidence of mental ill-health in adults with autism and intellectual disabilities

The prevalence, and incidence, of mental ill-health in adults with intellectual disabilities and autism were compared with the whole population with intellectual disabilities, and with controls, matched individually for age, gender, ability-level, and Down syndrome. Although the adults with autism had a higher point prevalence of problem behaviours compared with the whole adult population with intellectual disabilities, compared with individually matched controls there was no difference in prevalence, or incidence of either problem behaviours or other mental ill-health. Adults with autism who had problem behaviours were less likely to recover over a two-year period than were their matched controls. Apparent differences in rates of mental ill-health are accounted for by factors other than autism, including Down syndrome and ability level