221 research outputs found
Lean Burning Spark-Ignition Engines -- An Overview
Means of improving the thermal efficiency of spark-ignition internal combustion engines through fuel-lean combustion at part-load are discussed. For purposes of comparison and evaluation, lean-burning engines are classified as modified conventional engines, stratified charge engines, and engines using alternative fuels. Particular attention is given to automobile applications because of their importance for conservation of fuels
Efficient implementation of finite volume methods in Numerical Relativity
Centered finite volume methods are considered in the context of Numerical
Relativity. A specific formulation is presented, in which third-order space
accuracy is reached by using a piecewise-linear reconstruction. This
formulation can be interpreted as an 'adaptive viscosity' modification of
centered finite difference algorithms. These points are fully confirmed by 1D
black-hole simulations. In the 3D case, evidence is found that the use of a
conformal decomposition is a key ingredient for the robustness of black hole
numerical codes.Comment: Revised version, 10 pages, 6 figures. To appear in Phys. Rev.
Implementation of standard testbeds for numerical relativity
We discuss results that have been obtained from the implementation of the
initial round of testbeds for numerical relativity which was proposed in the
first paper of the Apples with Apples Alliance. We present benchmark results
for various codes which provide templates for analyzing the testbeds and to
draw conclusions about various features of the codes. This allows us to sharpen
the initial test specifications, design a new test and add theoretical insight.Comment: Corrected versio
Issues potentially affecting quality of life arising from long-term medicines use: a qualitative study
Background Polypharmacy is increasing and managing large number of medicines may create a burden for patients. Many patients have negative views of medicines and their use can adversely affect quality of life. No studies have specifically explored the impact of general long-term medicines use on quality of life. Objective To determine the issues which patients taking long-term medicines consider affect their day-to-day lives, including quality of life. Setting Four primary care general practices in North West England Methods Face-to-face interviews with adults living at home, prescribed four or more regular medicines for at least 1 year. Interviewees were identified from primary care medical records and purposively selected to ensure different types of medicines use. Interviews were recorded, transcribed and analysed thematically. Results Twenty-one interviews were conducted and analysed. Patients used an average of 7.8 medicines, 51 % were preventive, 40 % for symptom relief and 9 % treatment. Eight themes emerged: relationships with health professionals, practicalities, information, efficacy, side effects, attitudes, impact and control. Ability to discuss medicines with health professionals varied and many views were coloured by negative experiences, mainly with doctors. All interviewees had developed routines for using multiple medicines, some requiring considerable effort. Few felt able to exert control over medicines routines specified by health professionals. Over half sought additional information about medicines whereas others avoided this, trusting in doctors to guide their medicines use. Patients recognised their inability to assess efficacy for many medicines, notably those used for prophylaxis. All were concerned about possible side effects and some had poor experiences of discussing concerns with doctors. Medicines led to restrictions on social activities and personal life to the extent that, for some, life can revolve around medicines. Conclusion There is a multiplicity and complexity of issues surrounding medicines use, which impact on day-to-day lives for patients with long-term conditions. While most patients adapt to long-term medicines use, others did so at some cost to their quality of life
From Geometry to Numerics: interdisciplinary aspects in mathematical and numerical relativity
This article reviews some aspects in the current relationship between
mathematical and numerical General Relativity. Focus is placed on the
description of isolated systems, with a particular emphasis on recent
developments in the study of black holes. Ideas concerning asymptotic flatness,
the initial value problem, the constraint equations, evolution formalisms,
geometric inequalities and quasi-local black hole horizons are discussed on the
light of the interaction between numerical and mathematical relativists.Comment: Topical review commissioned by Classical and Quantum Gravity.
Discussion inspired by the workshop "From Geometry to Numerics" (Paris, 20-24
November, 2006), part of the "General Relativity Trimester" at the Institut
Henri Poincare (Fall 2006). Comments and references added. Typos corrected.
Submitted to Classical and Quantum Gravit
Three little pieces for computer and relativity
Numerical relativity has made big strides over the last decade. A number of
problems that have plagued the field for years have now been mostly solved.
This progress has transformed numerical relativity into a powerful tool to
explore fundamental problems in physics and astrophysics, and I present here
three representative examples. These "three little pieces" reflect a personal
choice and describe work that I am particularly familiar with. However, many
more examples could be made.Comment: 42 pages, 11 figures. Plenary talk at "Relativity and Gravitation:
100 Years after Einstein in Prague", June 25 - 29, 2012, Prague, Czech
Republic. To appear in the Proceedings (Edition Open Access). Collects
results appeared in journal articles [72,73, 122-124
Different Reactive Oxygen Species Lead to Distinct Changes of Cellular Metal Ions in the Eukaryotic Model Organism Saccharomyces cerevisiae
Elemental uptake and export of the cell are tightly regulated thereby maintaining the ionomic homeostasis. This equilibrium can be disrupted upon exposure to exogenous reactive oxygen species (ROS), leading to reduction or elevation of the intracellular metal ions. In this study, the ionomic composition in the eukaryotic model organism Saccharomyces cerevisiae was profiled using the inductively-coupled plasma optical emission spectrometer (ICP-OES) following the treatment with individual ROS, including hydrogen peroxide, cumen hydroperoxide, linoleic acid hydroperoxide (LAH), the superoxide-generating agent menadione, the thiol-oxidising agent diamide [diazine-dicarboxylic acid-bis(dimethylamide)], dimedone and peroxynitrite. The findings demonstrated that different ROS resulted in distinct changes in cellular metal ions. Aluminium (Al3+) level rose up to 50-fold after the diamide treatment. Cellular potassium (K+) in LAH-treated cells was 26-fold less compared to the non-treated controls. The diamide-induced Al3+ accumulation was further validated by the enhanced Al3+ uptake along the time course and diamide doses. Pre-incubation of yeast with individual elements including iron, copper, manganese and magnesium failed to block diamide-induced Al3+ uptake, suggesting Al3+-specific transporters could be involved in Al3+ uptake. Furthermore, LAH-induced potassium depletion was validated by a rescue experiment in which addition of potassium increased yeast growth in LAH-containing media by 26% compared to LAH alone. Taken together, the data, for the first time, demonstrated the linkage between ionomic profiles and individual oxidative conditions
Supermassive Black Hole Binaries: The Search Continues
Gravitationally bound supermassive black hole binaries (SBHBs) are thought to
be a natural product of galactic mergers and growth of the large scale
structure in the universe. They however remain observationally elusive, thus
raising a question about characteristic observational signatures associated
with these systems. In this conference proceeding I discuss current theoretical
understanding and latest advances and prospects in observational searches for
SBHBs.Comment: 17 pages, 4 figures. To appear in the Proceedings of 2014 Sant Cugat
Forum on Astrophysics. Astrophysics and Space Science Proceedings, ed.
C.Sopuerta (Berlin: Springer-Verlag
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