Sufficient conditions for unique global solutions in optimal control of semilinear equations with C1−C^1-nonlinearity

We consider a $C^1-$semilinear elliptic optimal control problem possibly subject to control and/or state constraints. Generalizing previous work we provide a condition which guarantees that a solution of the necessary first order conditions is a global minimum. A similiar result also holds at the discrete level where the corresponding condition can be evaluated explicitly. Our investigations are motivated by G\"unter Leugering, who raised the question whether our previous results can be extended to the nonlinearity $\phi(s)=s|s|$. We develop a corresponding analysis and present several numerical test examples demonstrating its usefulness in practice

Designing an Appointment Management System for the Mother and Child Health Department of the Klinik Kesihatan Changlun

Information and Communication Technology has been changing the way things have been carried out. Traditionally many work required people to visit the location where the work has been carried out. ICT has been making these services available at their fingertips by hosting these applications online. Klinik Kesihatan Changlun is a public general clinic in the state of Kedah. The appointment management which is one of the most important services of a clinic is presently carried out manually here. Both patients and the staff have to face a lot of problems due to the inefficiency of the manual system. If the system can be automated and made available on the internet, it will solve a lot of problems currently faced by them. This project proposes to design an appointment management system for the Mother and Child Health Department of the Klinik Kesihatan Changlun. The project has been proposed to follow the formal research methodology proposed by Kuchler and Vaishnavi due to its suitability for small to medium sized development projects. Finally it has been proposed conduct a usability test on the prototype developed for ease of use and user friendliness with the aid of the questionnaire

Industrial Sector Input Demand Responsiveness and Policy Interventions

In Pakistan, government intervention in the input market of the industrial sector is considerable. It regulates prices of virtually all energy and certain other non-labour inputs. To stimulate industrial production and output growth, it also encourages the provision of extended credit facilities to the industrial producers. Further, it has also often announced adjustments/reductions in duties and tariffs on products used in industrial production. Conversely, government also imposes taxes on outputs. It may desire to levy new taxes on the industrial inputs. All interventions have profound implications for producers, consumers and the government alike. Therefore, it is important to know how they may affect the industrial input demand. Further, it is equally important to know how effective they may be for the government in the realisation of its objectives. The most pertinent approach to ascertain the industrial input demand responsiveness to government interventions is to obtain valid estimates of price elasticities. In fact, competent elasticity estimates of the producer input demand derived with a sound methodology can serve as a solid basis to predict producer responsiveness to market changes and thereby the effectiveness and desirability of government interventions. While the price elasticities of products over the years have been estimated for Pakistan, renewed interest on estimating responsiveness of producer input demand with modern estimation procedures has recently surged. Idrees (1997) and Khan (1998) have determined elasticities for the domestic large-scale manufacturing sector from a demand system. Although these research studies make a good addition to the literature, their scope is extremely limited because they have combined industrial inputs into large aggregates. At present, there is no study that has investigated the input demand elasticities of the domestic industrial sector at the dis-aggregated level.

CENP-C unwraps the human CENP-A nucleosome through the H2A C-terminal tail

Centromeres are defined epigenetically by nucleosomes containing the histone H3 variant CENP-A, upon which the constitutive centromere-associated network of proteins (CCAN) is built. CENP-C is considered to be a central organizer of the CCAN. We provide new molecular insights into the structure of human CENP-A nucleosomes, in isolation and in complex with the CENP-C central region (CENP-C-CR), the main CENP-A binding module of human CENP-C. We establish that the short alpha N helix of CENP-A promotes DNA flexibility at the nucleosome ends, independently of the sequence it wraps. Furthermore, we show that, in vitro, two regions of human CENP-C (CENP-C-CR and CENP-C-motif) both bind exclusively to the CENP-A nucleosome. We find CENP-C-CR to bind with high affinity due to an extended hydrophobic area made up of CENP-A(V)(532) and CENP-A(V)(533). Importantly, we identify two key conformational changes within the CENP-A nucleosome upon CENP-C binding. First, the loose DNA wrapping of CENP-A nucleosomes is further exacerbated, through destabilization of the H2A C-terminal tail. Second, CENP-C-CR rigidifies the N-terminal tail of H4 in the conformation favoring H4(K20) monomethylation, essential for a functional centromere

E-Commerce to Improve Homemaker Productivity (Women Entrepreneur Empowerment at Meruya Utara, Kembangan District, West Jakarta, Indonesia)

Saat ini banyak ibu rumah tangga memiliki bisnis sampingan yang sesuai dengan keterampilan dan hobi mereka. Adapun tujuan dari bisnis sampingan tersebut adalah untuk membantu kebutuhan keuangan rumah tangga mereka. Penelitian sebelumnya telah menunjukkan bahwa ibu rumah tangga yang juga pengusaha perempuan memiliki kontribusi yang signifikan terhadap kesejahteraan keluarga. Namun demikian, terdapat kesulitan dari ibu rumah tangga dalam memasarkan produk dan layanan mereka. Pengabdian ini melaksanakan sosialisasi terkait cara membuat akun e-commerce dan menggunakannya sebagai alternatif untuk menjual produk dan layanan mereka. Selain itu, hasil dari kegiatan layanan masyarakat Internasional ini adalah bahwa ibu rumah tangga dapat menjual produk dan layanan mereka melalui e-commerce. Menurut hasil survei pada kegiatan sosialisasi ini, diketahui bahwa hambatan bagi ibu rumah tangga adalah masih rendahnya pendidikan mereka dimana 65% dari mereka memiliki pendidikan sekolah menengah. Juga, kepemilikan aplikasi internet banking dan mobile banking masih rendah, yaitu 35%. Dengan demikian, kepemilikan yang rendah atas aplikasi internet banking dan mobile banking membuat mereka kesulitan untuk menjual produk dan layanannya melalui e-commerce. Semua peserta sosialisasi menyatakan bahwa kegiatan ini bermanfaat dan menambah pengetahuan mereka. Selanjutnya untuk dapat meningkatkan omset penjualan mereka adalah melalui perbaikan kemasan produk dan layanan mereka untuk membuatnya lebih menarik bagi pembeli.  Kata kunci: Ibu Rumah Tangga, Pengusaha Wanita, Mobile Banking, Internet Banking, E-Commerce. &nbsp

Penggunaan Model 4D dalam Pembuatan Video Tutorial Menggambar Alam Benda di SMP Negeri 1 Tonra

This research aims to describe the development of video tutorials for learning to draw natural objects for students of class VII SMPN 1 Tonra. This research is a type of research and development (R&D). Development models use 4D models consisting of Define (definition), Design (design), Develop (development), Dissemination (dissemination). But in this study it only reached the stage of Develop. From the results of assessments or validations conducted by material experts and media experts on the resulting video tutorial media, obtained a rating score of 95.15% from material experts, and 89.7% from media experts. Based on the results obtained, it can be concluded that the video tutorial media for learning to draw nature is worth using and developing, and is expected to help teachers and students in the learning process.Keywords: learning media, video tutorials, drawing natural objects. AbstrakPenelitian ini bertujuan untuk mendeskripsikan pengembangan video tutorial untuk pembelajaran menggambar alam benda bagi peserta didik kelas VII SMPN 1 Tonra. Penelitian ini merupakan jenis penelitian dan pengembangan atau Research and Development (R&D). Model pengembangan menggunakan model 4D yang terdiri dari Define (pendefinisian), Design (perancangan), Develop (pengembangan), Dissemination (penyebarluasan). Namun pada penelitian ini hanya sampai pada tahap Develop. Dari hasil penilaian atau validasi yang dilakukan oleh ahli materi dan ahli media terhadap media video tutorial yang dihasilkan, diperoleh skor penilaian sebesar 95,15% dari ahli materi, dan 89,7% dari ahli media. Berdasarkan hasil yang diperoleh, maka dapat disimpulkan bahwa media video tutorial untuk pembelajaran menggambar alam benda ini layak digunakan dan dikembangkan, serta diharapkan dapat membantu pendidik dan peserta didik dalam proses pembelajaran.Kata kunci : media pembelajaran, video tutorial, menggambar alam benda