74 research outputs found

    Current state of the Prunetalia spinosae communities in the centre and south of the Iberian Peninsula (Spain, Portugal)

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    This paper re-examines the Rhamno-Prunetea class in the centre and south of the Iberian Peninsula, especially in Andalusia. The paper also deals with the alliances Pruno-Rubion ulmifolii Lonicero-Berberidion hispanicae in the south of the Iberian Peninsula, and Berberidion vulgaris (Berberidenion seroi) in the area of Cuenca. Our analysis of 225 relevés arranged in 22 phytosociological tables helped us to re-organize the available information and subsequently propose three associations and two subassociations: Clematido vitalbae-Rosetum micranthae nova; Berberido hispanicae- Buxetum sempervirentis nova; Roso siculae-Berberidetum hispanicae Mota nova subas. prunetosum ramburii Mota nova; Lonicero arboreae-Rhamnetum cathartici Martínez-Parras and Molero 1983 subas. prunetosum ranburii nova. As a result of the study, a total of 18 syntaxa with the rank of association and four with the rank of subassociation are proposed for the south of the Iberian Peninsula

    Magnetoplasmonics: Combining Magnetic and Plasmonic Functionalities

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    Comunicación presentada en el 3rd European Workshop on Self Organized Nanomagnets, celebrado en Guadarrama del 16 al 20 de abril de 2012.Nanosystems with combined magnetic and plasmonic functionalities have in recent years become an active topic of research. In these new stn-lctures, know as magneto-plasmonics, magnetic and plasmonic properties are interlwined, allowing for example plasmonic properties to become tunable upon de application of a magnetic field (active plasmonics), or the Magneto*Optical (MO) effects to be largely increased by plasmon resonance excitation, as a consequence of the enhancement of the electromagnetic (EM) field in the MO active component of the structure. ln this last case, the study of the enhanced MO activity in structures with subwavelength dimensions is especially interesting since they may be viewed as nanoantennas in the visible range with MO functionalities. The light harvesting properties of these systems upon plasmon resonance excitation bring as a consequence an enhanced EM field in its interior, and more interestingly in the region where the MO active component is present. At this stage, optimizing the EM field distribution within the structure by maximizing it in the MO components region while simultaneously minimizingit in all the other, non MO active, lossy components, will allow for the development of novel systems with even larger MO activity with reduced optical losses .Peer Reviewe

    Influence of Menstrual Cycle Length and Age at Menarche on Symptoms, Cognition, Social Cognition, and Metacognition in Patients with First-Episode Psychosis

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    Altres ajuts: PERIS call (grant no. SLT006/17/00231); the Progress and Health Foundation of the Andalusian Regional Ministry of Health (grant no. PI-0634/2011 and PI-0193/2014); Obra Social La Caixa (RecerCaixa call 2013); CERCA Programme/Generalitat de Catalunya; Obra Social Sant Joan de Déu (BML); and FI19/00062 (Ayudas para la Contratación de Personal Predoctoral).A protective effect has traditionally been attributed to estrogen in psychotic disorders. The aim of this study was to investigate cumulative lifetime estrogen by assessing the menstrual cycle length, age at menarche, and years of difference between the onset of psychotic symptoms and the age of menarche, measuring their effects on symptoms, cognition, social cognition, and metacognition. As it was not possible to directly measure cumulative estrogen levels over the lifetime of a patient, the study sample was composed of 42 women with first-episode psychosis; estrogen levels were inferred by the menstrual cycle length, age at menarche, and years of difference between the onset of psychotic symptoms and menarche. All patients were assessed with a battery of questionnaires using the BDI, PSYRATS, PANSS, STROOP, TAVEC, WSCT, IPSAQ, and BCIS questionnaires. The results related to menstrual cycle length showed a relationship with memory; specifically, shorter cycles with semantic strategies (p = 0.046) and longer cycles with serial strategies in the short term (p = 0.005) as well as in the long term (p = 0.031). The results also showed a relationship with perseverative errors (p = 0.035) and self-certainty (p = 0.049). Only personalized bias (p = 0.030) was found to be significant in relation to the age at menarche. When analyzing the differences in years of difference between the age at menarche and the onset of psychotic symptoms, the results indicated lower scores in women with a smaller difference between both events in memory (short-term (p = 0.050), long-term (p = 0.024), intrusions (p = 0.013), and recognition (p = 0.043)) and non-perseverative errors (p = 0.024). No relationship was found between symptoms and menstrual characteristics. The investigatory outcomes seem to indicate a relationship between estrogen cumulative effects and the memory domain. More in-depth investigations in the field are necessary in order to improve personalized treatment in women with psychosis

    Optimizing light harvesting for high magneto-optical performance in metal and metal-dielectric magnetoplasmonic nanodiscs

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    Póster presentado en Nanolight, celebrado en Benasque (España).Magnetoplasmonics deals with the study of materials and/or phenomena involving both plasmonic and magneto-optical (MO) properties. A two-way path connects both properties: the MO response of the system can be modified by the presence of plasmon resonances and the plasmons properties can be modulated by means of an applied magnetic field. Here we focus on the first path, in particular on the MO activity enhancement in nano-discs due to the excitation of localized surface plasmons (LSP).EU (NMP3-SL-2008-214107-Nanomagma), Spanish Ministry (“FUNCOAT” CONSOLIDER INGENIO 2010 CSD2008-00023, MAGPLAS MAT2008-06765-C02-01/NAN, PLASMAR MAT2010-10123-E, and MAPS MAT2011-29194-C02-01), Comunidad de Madrid (“NANOBIOMAGNET”, S2009/MAT-1726 and >MICROSERES-CM”, S2009/TIC-1476), and CSIC/FSE (JAE-Doc fellowship for D. Meneses-Rodríguez, and JAE-Predoc fellowship for E. Ferreiro-Vila).Peer Reviewe

    Comprehensive cross-platform comparison of methods for non-invasive EGFR mutation testing : results of the RING observational trial.

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    Abstract Several platforms for noninvasive EGFR testing are currently used in the clinical setting with sensitivities ranging from 30% to 100%. Prospective studies evaluating agreement and sources for discordant results remain lacking. Herein, seven methodologies including two next-generation sequencing (NGS)-based methods, three high-sensitivity PCR-based platforms, and two FDA-approved methods were compared using 72 plasma samples, from EGFR-mutant non-small-cell lung cancer (NSCLC) patients progressing on a first-line tyrosine kinase inhibitor (TKI). NGS platforms as well as high-sensitivity PCR-based methodologies showed excellent agreement for EGFR-sensitizing mutations (K = 0.80-0.89) and substantial agreement for T790M testing (K = 0.77 and 0.68, respectively). Mutant allele frequencies (MAFs) obtained by different quantitative methods showed an excellent reproducibility (intraclass correlation coefficients 0.86-0.98). Among other technical factors, discordant calls mostly occurred at mutant allele frequencies (MAFs) ≤ 0.5%. Agreement significantly improved when discarding samples with MAF ≤ 0.5%. EGFR mutations were detected at significantly lower MAFs in patients with brain metastases, suggesting that these patients risk for a false-positive result. Our results support the use of liquid biopsies for noninvasive EGFR testing and highlight the need to systematically report MAFs. Keywords: NGS; circulating free DNA; epidermal growth factor receptor; non-small-cell lung cancer; osimertinib; tyrosine kinase inhibitor

    Role of age and comorbidities in mortality of patients with infective endocarditis

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    [Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

    Outpatient Parenteral Antibiotic Treatment vs Hospitalization for Infective Endocarditis: Validation of the OPAT-GAMES Criteria

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    El abrigo y la cueva de Benzú en la Prehistoria de Ceuta. Aproximación al estudio de las sociedades cazadoras-recolectoras y tribales comunitarias en el ámbito norteafricano del Estrecho de Gibraltar.

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    Extensa obra sobre los métodos, antecedentes y objetivos; observaciones preliminares y estudios anteriores, excavación y análisis de los resultados del Proyecto Benzú.Consejería de Educación, Cultura y Deporte de la Ciudad Autónoma de Ceuta. Universidad Española de Educación a Distancia. Universidad de Cádiz.419 página
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