Impact of Female Genital Mutilation on second stage of labour in Primigravida at Omdurman Maternity Hospital, Sudan 2010

Objective: To find out the impact of female genital mutilation (FGM) on the second stage of labour at Omdurman Maternity Hospital (OMH).Methodology: A descriptive cross-sectional study, for primigravidae delivered vaginally in 2010. After an informed consent circumcised women, were included as study group and uncircumcised ladies as control group. Data was collected by trained registrars using a structured questionnaire to collect frequency of postpartum haemorrhage (PPH), perineal tear, birth asphyxia, neonatal death and hospital stay.Results: A total of 1961 primigravidae, delivered in 2010 at OMH, 629(32.1%) were circumcised and 1332(67.9%) were uncircumcised. There was no significant difference in the mode of delivery and episiotomy.Conclusion: FGM places women at a greater risk during childbirth, endangering their health and their babies compared to uncircumcised.Key words: Female Genital Mutilation, second stage of labor, Sudan

Potential Dependent Frictional Schrodinger Equation

By treating particles as harmonic oscillator is obtained the friction energy related to the momentum. The energy and the corresponding Newtonian operator is found. This result in a new Schrodinger equation accounting for the effect of friction. This new equation shows that the energy and mass are quantized, if one treats particles as strings. The radioactive decay law and collision probability is also derived

Human agency, entrepreneurship and regional development: a behavioural perspective on economic evolution and innovative transformation

An emerging position within theories of entrepreneurship and regional development concerns the role of human behaviour. This paper argues that the type and nature of human agency related to entrepreneurship is a significant factor in explaining the capacity of regions to achieve economic evolution through renewal and innovative transformation. It is argued that regional economic ecosystems are a primary result of the agency of a particular cadre of individuals; with the nature of these ecosystems being contingent on the underlying culture and institutional environment within a specific region. Furthermore, it is proposed that the confluence of group-level culture within a city or region and the personality psychology of individuals within these places results in a psychocultural environment that creates certain forms of human agency determining the nature of entrepreneurship. Similarly, the propensity towards entrepreneurial agency will be at least partly determined by the nature of the underlying regional economic ecosystems, especially with regards to apparent opportunity and economic returns. Drawing on these insights, the study outlines the implications for policies that seek to support entrepreneurship at the regional level, while also identifying future research required to further effective policy intervention

Annexin A3 in sepsis: novel perspectives from an exploration of public transcriptome data

According to publicly available transcriptome datasets, the abundance of Annexin A3 (ANXA3) is robustly increased during the course of sepsis; however, no studies have examined the biological significance or clinical relevance of ANXA3 in this pathology. Here we explored this interpretation gap and identified possible directions for future research. Based on reference transcriptome datasets, we found that ANXA3 expression is restricted to neutrophils, is upregulatedin vitroafter exposure to plasma obtained from septic patients, and is associated with adverse clinical outcomes. Secondly, an increase in ANXA3 transcript abundance was also observedin vivo, in the blood of septic patients in multiple independent studies. ANXA3 is known to mediate calcium-dependent granules-phagosome fusion in support of microbicidal activity in neutrophils. More recent work has also shown that ANXA3 enhances proliferation and survival of tumour cells via a Caspase-3-dependent mechanism. And this same molecule is also known to play a critical role in regulation of apoptotic events in neutrophils. Thus, we posit that during sepsis ANXA3 might either play a beneficial role, by facilitating microbial clearance and resolution of the infection; or a detrimental role, by prolonging neutrophil survival, which is known to contribute to sepsis-mediated organ damage

WASA-FRS experiments in FAIR Phase-0 at GSI

We have developed a new and unique experimental setup integrating the central part of the Wide Angle Shower Apparatus (WASA) into the Fragment Separator (FRS) at GSI. This combination opens up possibilities of new experiments with high-resolution spectroscopy at forward and measurements of light decay particles with nearly full solid-angle acceptance in coincidence. The first series of the WASA-FRS experiments have been successfully carried out in 2022. The developed experimental setup and two physics experiments performed in 2022 including the status of the preliminary data analysis are introduced

Demand response opportunities in residential sector incorporated with smart load monitoring system

For a successful implementation of demand response in the residential sector, access to real electricity consumption data and load profiles of major household appliances is crucial. With the advancement of the communication technologies and smart load monitoring devices, access to this information become simpler. This paper investigates characteristic of different communication technologies and their suitability for use in demand response implementation in the residential sector. A smart monitoring and controlling system is integrated into a household's electric appliances to study their daily energy consumption profiles and identify their potential demand response capacity. This paper intends to draw interest on the benefits from using the smart monitoring and controlling system, for instance, it provides real-time energy consumption feedbacks, standby power consumption information and remote load control flexibility. Using these information, the total demand response opportunity and standby energy loss are calculated for selected major appliances

Evaluation of patient safety culture as perceived by nurses during the COVID-19 pandemic

Objectives: A good patient safety culture (PSC) is linked to a reduced risk of patient problems and minimal undesirable occurrences. This study investigated the PSC levels from nurses’ perspectives during the COVID-19 pandemic

Long-Chain Acyl-CoA Synthetase 1 Role in Sepsis and Immunity: Perspectives From a Parallel Review of Public Transcriptome Datasets and of the Literature

open13A potential role for the long-chain acyl-CoA synthetase family member 1 (ACSL1) in the immunobiology of sepsis was explored during a hands-on training workshop. Participants first assessed the robustness of the potential gap in biomedical knowledge identified via an initial screen of public transcriptome data and of the literature associated with ACSL1. Increase in ACSL1 transcript abundance during sepsis was confirmed in several independent datasets. Querying the ACSL1 literature also confirmed the absence of reports associating ACSL1 with sepsis. Inferences drawn from both the literature (via indirect associations) and public transcriptome data (via correlation) point to the likely participation of ACSL1 and ACSL4, another family member, in inflammasome activation in neutrophils during sepsis. Furthermore, available clinical data indicate that levels of ACSL1 and ACSL4 induction was significantly higher in fatal cases of sepsis. This denotes potential translational relevance and is consistent with involvement in pathways driving potentially deleterious systemic inflammation. Finally, while ACSL1 expression was induced in blood in vitro by a wide range of pathogen-derived factors as well as TNF, induction of ACSL4 appeared restricted to flagellated bacteria and pathogen-derived TLR5 agonists and IFNG. Taken together, this joint review of public literature and omics data records points to two members of the acyl-CoA synthetase family potentially playing a role in inflammasome activation in neutrophils. Translational relevance of these observations in the context of sepsis and other inflammatory conditions remain to be investigated.openRoelands J.; Garand M.; Hinchcliff E.; Ma Y.; Shah P.; Toufiq M.; Alfaki M.; Hendrickx W.; Boughorbel S.; Rinchai D.; Jazaeri A.; Bedognetti D.; Chaussabel D.Roelands, J.; Garand, M.; Hinchcliff, E.; Ma, Y.; Shah, P.; Toufiq, M.; Alfaki, M.; Hendrickx, W.; Boughorbel, S.; Rinchai, D.; Jazaeri, A.; Bedognetti, D.; Chaussabel, D

Patient’s effective dose and performance assessment of computed radiography systems

Computed tomography is widely used for planar imaging. Previous studies showed that CR systems involve higher patient radiation doses compared to digital systems. Therefore, assessing the patient’s dose and CR system performance is necessary to ensure that patients received minimal dose with the highest possible image quality. The study was performed at three medical diagnostic centers in Sudan: Medical Corps Hospital (MCH), Advance Diagnostic Center (ADC), and Advance Medical Center (AMC). The following tools were used in this study: Tape measure, Adhesive tape, 1.5 mm copper filtration (>10 × 10 cm), TO 20 threshold contrast test object, Resolution test object (e.g., Huttner 18), MI geometry test object or lead ruler, Contact mish, Piranha (semiconductor detector), Small lead or copper block (~5 × 5 cm), and Steel ruler, to do a different type of tests (Dark Noise, Erasure cycle efficiency, Sensitivity Index calibration, Sensitivity Index consistency, Uniformity, Scaling errors, Blurring, Limiting spatial Resolution, Threshold, and Laser beam Function. Entrance surface air kerma (ESAK (mGy) was calculated from patient exposure parameters using DosCal software for three imaging modalities. A total of 199 patients were examined (112 chest X rays, 77 lumbar spine). The mean and standard deviation (sd) for patients ESAK (mGy) were 2.56 ± 0.1 mGy and 1.6 mGy for the Anteroposterior (AP) and lateral projections for the lumbar spine, respectively. The mean and sd for the patient’s chest doses were 0.1 ± 0.01 for the chest X-ray procedures. The three medical diagnostic centers’ CR system performance was evaluated and found that all of the three centers have good CR system functions. All the centers satisfy all the criteria of acceptable visual tests. CR’s image quality and sensitivity were evaluated, and the CR image is good because it has good contrast and resolution. All the CR system available in the medical centers and upgraded from old X-ray systems to new systems, has been found to work well. The patient’s doses were comparable for the chest X-ray procedures, while patients’ doses from the lumbar spine showed variation up to 2 folds due to the variation in patients’ weight and X-ray machine setting. Patients dose optimization is recommended to ensure the patients received a minimal dose while obtaining the diagnostic findings