Cement-in-cement technique of the femoral component in aseptic total hip arthroplasty revision: A systematic review of the contemporary literature

Background: Clinical outcomes of cemented femoral stems revisions using the cement-in-cement technique in aseptic conditions after total hip arthroplasty have been widely described. Methods: The US National Library of Medicine (PubMed/MEDLINE), EMBASE, and the Cochrane Database of Systematic Reviews were queried. Results: Twelve articles were included (620 revision THA). Revision rate for complications related to the femoral side was 1.4% at mid-term follow-up (5.4 years). Periprosthetic femoral fracture rate was 1.1%, aseptic loosening of the femoral component 0.3%. Conclusions: Cement-in-cement revision technique of the femoral component is associated with a high mid-term success rates (98.6%) and is potentially less challenging than other revision techniques

MMP14 as a novel downstream target of VEGFR2 in migratory glioma-tropic neural stem cells

Neural stem cell (NSC)-based carriers have been presented as promising therapeutic tools for the treatment of infiltrative brain tumors due to their intrinsic tumor homing property. They have demonstrated the ability to migrate towards distant tumor microsatellites and effectively deliver the therapeutic payload, thus significantly improving survival in experimental animal models for brain tumor. Despite such optimistic results, the efficacy of NSC-based anti-cancer therapy has been limited due to the restricted tumor homing ability of NSCs. To examine this issue, we investigated the mechanisms of tumor-tropic migration of an FDA-approved NSC line, HB1.F3.CD, by performing a gene expression analysis. We identified vascular endothelial growth factor-A (VEGFA) and membrane-bound matrix metalloproteinase (MMP14) as molecules whose expression are significantly elevated in migratory NSCs. We observed increased expression of VEGF receptor 2 (VEGFR2) in the focal adhesion complexes of migratory NSCs, with downstream activation of VEGFR2-dependent kinases such as p-PLCγ, p-FAK, and p-Akt, a signaling cascade reported to be required for cellular migration. In an in vivo orthotopic glioma xenograft model, analysis of the migratory trail showed that NSCs maintained expression of VEGFR2 and preferentially migrated within the perivascular space. Knockdown of VEGFR2 via shRNAs led to significant downregulation of MMP14 expression, which resulted in inhibited tumor-tropic migration. Overall, our results suggest, the involvement of VEGFR2-regulated MMP14 in the tumor-tropic migratory behavior of NSCs. Our data warrant investigation of MMP14 as a target for enhancing the migratory properties of NSC carriers and optimizing the delivery of therapeutic payloads to disseminated tumor burdens

Capítulo 1. Amazonía ecuatoriana: Diversidad de los desafíos y de los recursos

El petróleo: recursos y reservas actuales Marco RivadeneiraPatrice Baby La cuenca oriente del Ecuador contiene un extraordinario sistema petrolero, cuyas rocas generadoras (calizas y arcillas ricas en materia orgánica) y rocas reservorio (areniscas) se depositaron entre 115 y 105 millones de años atrás, cuando la región oriental era un mar tropical cretácico, poco profundo. El crudo generado en este sistema quedó atrapado en las estructuras que forman los campos actuales. Las reservas probada..

Light and energy based therapeutics for genitourinary syndrome of menopause: Consensus and controversies.

Gynecologist and plastic surgeons pioneered the application of lasers in medicine and surgery almost 5 decades ago, initially used to treat cervical and vaginal pathologies. Ever since, energy-based devices have been deployed to treat pelvic pathologies and improve fertility. Recent technological developments triggered an unprecedented wave of publications, assessing the efficacy of fractional laser, and radiofrequency on the vaginal wall in reversing natural aging processes. Studies have shown that a certain degree of thermal energy deposited on the vaginal wall stimulates proliferation of the glycogen-enriched epithelium, neovascularization, and collagen formation in the lamina propria, and improves natural lubrication and control of urination. This review aimed to review such data and to guide future research. A unique assembly of experts from around the globe, compiled and edited this manuscript based on a thorough literature review and personal experience. Lasers Surg. Med. 49:137-159, 2017. © 2017 Wiley Periodicals, Inc

Capítulo 2. El petróleo en la Amazonía ecuatoriana: medir los impactos ambientales y sanitarios

¿Son los hidrocarburos los únicos contaminantes relacionados con las actividades petroleras? Laurence MauriceMarie-Hélène DevierHélène Budzinski Las emisiones en el medio ambiente debido a las actividades petroleras, o son puntuales (accidentales o no) como las relacionadas con los naufragios (mareas negras), la desgasificación de buques petroleros, las fugas de petróleo en las plataformas, o durante el transporte (tuberías), es decir, son continuas en los sitios de explotación. Estos acciden..

Nuestro vivir en la Amazonía ecuatoriana: entre la finca y el petróleo

El petróleo, "sangre de la tierra", es la principal fuente de energía fósil en el mundo. La Amazonia ecuatoriana, tierra de explotación petrolera y de colonización agrίcola, es símbolo de la riqueza natural del planeta pero también un testigo del daño causado por las actividades humanas. En el corazón de este bosque, de su biodiversidad, de sus recursos y de sus habitantes, se teje el hilo de un viaje científico c interdisciplinario. Este libro comparte saberes, conocimientos e imágenes sobre los impactos y riesgos de las actividades petroleras en el medio ambiente, la salud, la sociedad y refleja las condiciones de vida en la Amazonίa.Le pétrole est le « sang de la terre » et la principale source d'énergie fossile au monde. L'Amazonie équatorienne, terre d'exploitation pétrolière et de colonisation agricole, est un symbole des richesses naturelles de la planète mais aussi un témoin des dommages causés par les activités humaines. Au cœur de cette forêt, de sa biodiversité, de ses ressources et de ses habitants, se tisse le fil d'un voyage scientifique et interdisciplinaire. Ce livre partage des savoirs, des connaissances et des images sur les impacts et risques liés aux activités pétrolières sur l'environnement, la santé, la société et dépeint les conditions de vie en Amazonie