Psycholinguistic Correlates of Symbol Grounding in Dictionaries

A dictionary can be represented as a directed graph with links from defining to defined words. The minimal feedback vertex sets (MinSets, Ms) of a dictionary graph are the smallest sets of words from which all the rest can be defined. We computed Ms for four English dictionaries. The words in the dictionary components revealed by our graph-theoretic analysis differ in their psycholinguistic correlates. Every MinSet has a C-part that is younger and more frequent and an S-part, that is more concrete. To understand the functional role of these components will require a close study of the words themselves, and how they are combined into definitions. We can already conclude that the closer a word is to the MinSets that can define all other words, the more concrete and frequent the word is likely to be, and the earlier it is likely to have been learned. This is what one would expect if the words in the MinSets were the ones that had been acquired through direct sensorimotor grounding

Hidden Structure and Function in the Lexicon

How many words are needed to define all the words in a dictionary? Graph-theoretic analysis reveals that about 10% of a dictionary is a unique Kernel of words that define one another and all the rest, but this is not the smallest such subset. The Kernel consists of one huge strongly connected component (SCC), about half its size, the Core, surrounded by many small SCCs, the Satellites. Core words can define one another but not the rest of the dictionary. The Kernel also contains many overlapping Minimal Grounding Sets (MGSs), each about the same size as the Core, each part-Core, part-Satellite. MGS words can define all the rest of the dictionary. They are learned earlier, more concrete and more frequent than the rest of the dictionary. Satellite words, not correlated with age or frequency, are less concrete (more abstract) words that are also needed for full lexical power.Comment: 11 pages, 5 figures, 2 table

The Latent Structure of Dictionaries

How many words (and which ones) are sufficient to define all other words? When dictionaries are analyzed as directed graphs with links from defining words to defined words, they reveal a latent structure. Recursively removing all words that are reachable by definition but that do not define any further words reduces the dictionary to a Kernel of about 10%. This is still not the smallest number of words that can define all the rest. About 75% of the Kernel turns out to be its Core, a Strongly Connected Subset of words with a definitional path to and from any pair of its words and no word’s definition depending on a word outside the set. But the Core cannot define all the rest of the dictionary. The 25% of the Kernel surrounding the Core consists of small strongly connected subsets of words: the Satellites. The size of the smallest set of words that can define all the rest (the graph’s Minimum Feedback Vertex Set or MinSet) is about 1% of the dictionary, 15% of the Kernel, and half-Core, half-Satellite. But every dictionary has a huge number of MinSets. The Core words are learned earlier, more frequent, and less concrete than the Satellites, which in turn are learned earlier and more frequent but more concrete than the rest of the Dictionary. In principle, only one MinSet’s words would need to be grounded through the sensorimotor capacity to recognize and categorize their referents. In a dual-code sensorimotor-symbolic model of the mental lexicon, the symbolic code could do all the rest via re-combinatory definition

CLNA and glucose tolerance in neonatal pigs

Purpose: There is an increased interest in the benefits of conjugated α-linolenic acid (CLNA) on obesity-related complications such as insulin resistance and diabetes. The aim of the study was to investigate whether a 1 % dietary supplementation of mono-CLNA isomers (c9-t11-c15-18:3 + c9-t13-c15-18:3) improved glucose and lipid metabolism in neonatal pigs. Methods: Since mono-CLNA isomers combine one conjugated two-double-bond system with an n-3 polyunsaturated fatty acid (PUFA) structure, the experimental protocol was designed to isolate the dietary structural characteristics of the molecules by comparing a CLNA diet with three other dietary fats: (1) conjugated linoleic acid (c9-t11-18:2 + t10-c12-18:2; CLA), (2) non-conjugated n-3 PUFA, and (3) n-6 PUFA. Thirty-two piglets weaned at 3 weeks of age were distributed among the four dietary groups. Diets were isoenergetic and food intake was controlled by a gastric tube. After 2 weeks of supplementation, gastro-enteral (OGTT) and parenteral (IVGTT) glucose tolerance tests were conducted. Results: Dietary supplementation with mono-CLNA did not modify body weight/fat or blood lipid profiles (p > 0.82 and p > 0.57, respectively) compared with other dietary groups. Plasma glucose, insulin, and C-peptide responses to OGTT and IVGTT in the CLNA group were not different from the three other dietary groups (p > 0.18 and p > 0.15, respectively). Compared to the non-conjugated n-3 PUFA diet, CLNA-fed animals had decreased liver composition in three n-3 fatty acids (18:3n-3; 20:3n-3; 22:5n-3; p < 0.001). Conclusions: These results suggest that providing 1 % mono-CLNA is not effective in improving insulin sensitivity in neonatal pigs

MMP-2 expression in uveal melanoma : differential activation status dictated by the cellular environment

Purpose: MMPs are recognized to play a major role in tumor progression and metastasis of many forms of cancers. The purpose of this study was to compare the expression and activity of MMP-2 in uveal melanoma cell lines grown either in vitro on plastic culture plates or in vivo as tumors produced in chick embryos. Methods: The chick chorioallantoic membrane (CAM) model was used to evaluate the tumorigenic potential of uveal melanoma cell lines derived either from the primary uveal melanoma tumor isolated from three different patients (cell lines SP6.5, SP8.0, and TP31) or from a metastatic lesion derived from the liver of a patient diagnosed with uveal melanoma (cell line H79). The presence of MMP-2 in the vicinity of the tumor cells was determined by immunofluorescence analyses. Gelatin zymography was used for the detection of latent and activated forms of MMP-2 in uveal melanoma cell lines when grown in vitro on plastic, or in the solid tumors these cell lines produced in vivo on the CAM of the chick embryo. The gelatinase activity was quantified by densitometric analyses and the active/(active+pro-form) ratio was calculated as the MMP-2 activation ratio. Western blot analyses were performed to confirm the zymographic profile. Results: Only the inactive form of MMP-2 was expressed and secreted in vitro by all uveal melanoma cell lines, higher levels being found for the liver-derived H79 cell line whereas SP8.0 only expressed MMP-2 to a very low level. On the other hand, all solid tumors produced in the CAM from these cell lines expressed and secreted, although to varying levels (SP6.5 and SP8.0, TP31 and H79), primarily the active form of MMP-2. Gelatinolytic activities of active MMP-2 were significantly higher in uveal melanoma tissues than in the non-neoplastic CAM, as revealed by the measurement of the activation ratio. The immunolocalization of MMP-2 revealed that all cell lines were MMP-2-positive although a reduced and more diffuse staining was observed for H79 and SP6.5 than in SP8.0 and TP31 cells. Conclusions: These results suggest the activation of proMMP-2 as an important event in the process of uveal melanoma progression. An elevated active to inactive MMP-2 ratio in the tumor environment of uveal melanoma suggests that a potential MMP-2 activity could be related to the progression of this type of cancer

Jagged1 intracellular domain-mediated inhibition of Notch1 signalling regulates cardiac homeostasis in the postnatal heart

Aims Notch1 signalling in the heart is mainly activated via expression of Jagged1 on the surface of cardiomyocytes. Notch controls cardiomyocyte proliferation and differentiation in the developing heart and regulates cardiac remodelling in the stressed adult heart. Besides canonical Notch receptor activation in signal-receiving cells, Notch ligands can also activate Notch receptor-independent responses in signal-sending cells via release of their intracellular domain. We evaluated therefore the importance of Jagged1 (J1) intracellular domain (ICD)-mediated pathways in the postnatal heart. Methods and results In cardiomyocytes, Jagged1 releases J1ICD, which then translocates into the nucleus and down-regulates Notch transcriptional activity. To study the importance of J1ICD in cardiac homeostasis, we generated transgenic mice expressing a tamoxifen-inducible form of J1ICD, specifically in cardiomyocytes. Using this model, we demonstrate that J1ICD-mediated Notch inhibition diminishes proliferation in the neonatal cardiomyocyte population and promotes maturation. In the neonatal heart, a response via Wnt and Akt pathway activation is elicited as an attempt to compensate for the deficit in cardiomyocyte number resulting from J1ICD activation. In the stressed adult heart, J1ICD activation results in a dramatic reduction of the number of Notch signalling cardiomyocytes, blunts the hypertrophic response, and reduces the number of apoptotic cardiomyocytes. Consistently, this occurs concomitantly with a significant down-regulation of the phosphorylation of the Akt effectors ribosomal S6 protein (S6) and eukaryotic initiation factor 4E binding protein1 (4EBP1) controlling protein synthesis. Conclusions Altogether, these data demonstrate the importance of J1ICD in the modulation of physiological and pathological hypertrophy, and reveal the existence of a novel pathway regulating cardiac homeostasi

Changes on wood powder morphology and flowability due to thermal pretreatment,

National audienceTorrefaction is a thermal pretreatment of lignocellulosic biomass before gasification. This mild form of pyrolysis, carried out at temperatures between 200 and 300 °C, changes the physical and chemical properties of the material. In particular, it improves the feedstocks homogenisation, enhances the aeration ability and makes the grinding easier. Our project deals with the study of the effects of the combined torrefaction and grinding processes on (i) the major particle behaviour: grindability, surface state, particle size, shape distribution (ii) and the major powder behaviour: bulk density, compressibility, aerability. In this article, the studied parameter is the torrefaction temperature. The characterisation of the particles and powders is performed using the following techniques: optical microscopy, Flodex® methodology and powder rheometry. The rheological behaviours of spruce torrefied at different temperatures then ground in the same apparatus (a knife mill with a sieving grid of 500 µm) are compared. It is shown that spruce torrefied at 240 °C (S240) has similar rheological properties compared to natural spruce (NS) after being ground, while the one torrefied at 300 °C exhibits a different rheological behaviour. The results are correlated to reproduce the coupled effect of the torrefaction and grinding conditions on the powder rheological behaviour

Influence of torrefaction treatment on wood powder properties

International audienceTorrefaction is a thermal pretreatment of lignocellulosic biomass before gazification. This mild form of pyrolysis, carried out at temperatures between 200 and 300 °C, changes the physical and chemical properties of the material. In particular, it improves the feedstocks homogenization, enhances the fluidization ability and makes the grinding easier. Our project deals with the study of the effects of the combined torrefaction and grinding processes on (i) the main particle behavior: anhydrous weight loss (AWL), grindability, particle size distribution (ii) and the main powder behavior: bulk densities, flowability and compressibility. The studied parameters are (i) the species of the biomass (spruce and beech) (ii) the torrefaction temperature (iii) and the sieving grid size of the used knife mill (0.12 and 0.5 mm). The characterization of the particles and powders is performed using the following techniques: optical microscope and powder rheometer. The rheological behaviours of spruce torrefied at different temperatures and ground at different grid sizes are compared. It is shown that spruce torrefied at 240 °C and ground at 0.5 mm (S240/0.5) has rheological properties not as good as S240/0.12 and S300/0.5 that seem to have similar characteristics. Finally, further experiments are necessary to obtain a better morphological and rheological particle characterization

The Notch pathway controls fibrotic and regenerative repair in the adult heart

Aims In the adult heart, Notch signalling regulates the response to injury. Notch inhibition leads to increased cardiomyocyte apoptosis, and exacerbates the development of cardiac hypertrophy and fibrosis. The role of Notch in the mesenchymal stromal cell fraction, which contains cardiac fibroblasts and cardiac precursor cells, is, however, largely unknown. In the present study, we evaluate, therefore, whether forced activation of the Notch pathway in mesenchymal stromal cells regulates pathological cardiac remodelling. Methods and results We generated transgenic mice overexpressing the Notch ligand Jagged1 on the surface of cardiomyocytes to activate Notch signalling in adjacent myocyte and non-myocyte cells. In neonatal transgenic mice, activated Notch sustained cardiac precursor and myocyte proliferation after birth, and led to increased numbers of cardiac myocytes in adult mice. In the adult heart under pressure overload, Notch inhibited the development of cardiomyocyte hypertrophy and transforming growth factor-β/connective tissue growth factor-mediated cardiac fibrosis. Most importantly, Notch activation in the stressed adult heart reduced the proliferation of myofibroblasts and stimulated the expansion of stem cell antigen-1-positive cells, and in particular of Nkx2.5-positive cardiac precursor cells. Conclusions We conclude that Notch is pivotal in the healing process of the injured heart. Specifically, Notch regulates key cellular mechanisms in the mesenchymal stromal cell population, and thereby controls the balance between fibrotic and regenerative repair in the adult heart. Altogether, these findings indicate that Notch represents a unique therapeutic target for inducing regeneration in the adult heart via mobilization of cardiac precursor cell

The Application of X-Band Radar for Characterisation of Nearshore Dynamics on a Mixed Sand and Gravel Beach

Remote sensing using X-band radar allows the estimation of wave parameters, near surface currents and the underlying bathymetry. This paper explores the use of radar to derive nearshore bathymetry at a complex site, at Thorpeness in Suffolk, UK. The site has a history of sporadic and focused erosion events along the beach frontage and as part of the X-Com project (X-band Radar and Evidence-Based Coastal Management Decisions) a radar system was deployed with the aim of further understanding the complex nearshore sediment processes influencing erosion. Initially, the bathymetric variation at the site is quantified through analysis of current and historic multibeam surveys. These indicate depth changes approaching 3 m. Subsequently, validation of the radar data against concurrent multibeam survey data has been undertaken. Results show that the radar derived bathymetry has a precision of ±1m at the site, with the largest errors being associated with areas of more complex bathymetry and where wave data quality was less suitable for analysis by the X-band radar bathymetry algorithms. It is concluded that although the accuracy of radar-derived bathymetry is lower than traditional multibeam survey, the low cost for high temporal coverage can be utilised for long-term monitoring of coastal sites where a cost-effective means of quantifying large-scale bathymetric changes is required