Prospective randomized controlled pilot study on the effects of almond consumption on skin lipids and wrinkles.

ObjectiveAlmonds are a rich source of fatty acids and antioxidants, and their supplementation is known to significantly modulate serum lipids. The effects of almond on the skin's lipid barrier and the appearance of wrinkles have not yet been elucidated. The aim of this study was to investigate the effects of almond consumption on facial sebum production and wrinkles.MethodsThis was a prospective, investigator-blinded, randomized controlled trial in which subjects consumed 20% of their daily energy consumption in either almonds or a calorie-matched snack for 16 weeks. This study was completed at the UC Davis Dermatology clinic. Participants were a volunteer sample of generally healthy postmenopausal females with Fitzpatrick skin types 1 and 2. A facial photograph and image analysis system was used to obtain standardized photographs and information on wrinkle width and severity at 0, 8, and 16 weeks. Measurements of transepidermal water loss and sebum production were also completed at 0, 8, and 16 weeks.ResultsFifty healthy postmenopausal females were recruited, 31 participants were enrolled, and 28 completed the study. Under photographic analysis, the almond group had significantly decreased wrinkle severity and width compared with the control group at 16 weeks (p < .02). Changes in skin barrier function were nonsignificant, measured by the transepidermal water loss (p = .65) between the almond and control groups relative to baseline after 16 weeks. No adverse effects were reported.ConclusionOur study demonstrates that daily almond consumption may reduce wrinkle severity in postmenopausal females to potentially have natural antiaging benefits

How the U.S. Air Force Space Command Optimizes Long-Term Investment in Space Systems

Interfaces, 33, p.p. 1-14.United States Air Force Space Command spends billions of dollars each year acquiring and developing launch vehicles and space systems. The space systems in orbit must continually meet defensive and offensive requirements and remain interoperable over time. Space command can launch additional space systems only if it has a launch vehicle of sufficient capacity. Space planners using space and missile optimization analysis (SAMOA) consider a 24-year time horizon when determining which space assets and launch vehicles to fund and procure. A key tool which in SAMOA is an integer linear program called the space command optimizer of utility toolkit (SCOUT) that Space Command uses for long-range planning. SCOUT gives planner insight into the annual funding profiles needed to meet Space Command's acquisition goals. The 1999 portfolio of 74 systems will cost about #310 billion and includes systems that can lift satellites into orbit; yield information on space, surface, and subsurface events, activities, and threats; and destroy terrestrial, airborne, and space targets

Methods and ethics in qualitative research exploring young children’s voice : A systematic review

Young children have rights; they are agents and active constructors of their social worlds. Despite well-established theoretical foundations, the ‘methods’ and ‘ethics’ of qualitative research to elicit young children’s voice require further exploration to ensure young children are central to our research endeavors. This systematic review examined studies that sought to capture young children’s (3–6 years) voice in Early Childhood Education and Care settings. Fifty-eight studies met the inclusion criteria. Interview was found to be the most common strategy; this is often coupled with other child-friendly methods. Findings suggest that young children are increasingly listened to; however, there appears to be a need to further promote children’s agency and the inclusion of assent-seeking as an ongoing process. Gaps in methods supporting the inclusion of children with additional needs and Indigenous children are also evident. In addition, advancing non-permanent methods of meaning making to support children’s participation appears ripe for methodological innovation

Underground mine scheduling under uncertainty

17 USC 105 interim-entered record; under review.The article of record as published may be found at http://dx.doi.org/10.1016/j.ejor.2021.01.011Underground mine schedules seek to determine start dates for activities related to the extraction of ore, often with an objective of maximizing net present value; constraints enforce geotechnical precedence between activities, and restrict resource consumption on a per-time-period basis, e.g., development footage and extracted tons. Strategic schedules address these start dates at a coarse level, whereas tactical schedules must account for the day-to-day variability of underground mine operations, such as unanticipated equipment breakdowns and ground conditions, both of which might slow production. At the time of this writing, the underground mine scheduling literature is dominated by a deterministic treatment of the problem, usually modeled as a Resource Constrained Project Scheduling Problem (RCPSP), which precludes mine operators from reacting to unforeseen circumstances. Therefore, we propose a stochastic integer programming framework that: (i) characterizes uncertainty in duration and economic value for each underground mining activity; (ii) formulates a new stochastic variant of the RCPSP; (iii) suggests an optimization-based heuristic; and, (iv) produces implementable, tactical schedules in a practical amount of time and provides corresponding managerial insights.National Institute of Occupational Safety and HealthNational Agency for Research and Development (ANID

Impaired Effective Connectivity During a Cerebellar-Mediated Sensorimotor Synchronization Task in Schizophrenia

Prominent conceptual models characterize schizophrenia as a dysconnectivity syndrome, with recent research focusing on the contributions of the cerebellum in this framework. The present study examined the role of the cerebellum and its effective connectivity to the cerebrum during sensorimotor synchronization in schizophrenia. Specifically, the role of the cerebellum in temporally coordinating cerebral motor activity was examined through path analysis. Thirty-one individuals diagnosed with schizophrenia and 40 healthy controls completed a finger-tapping fMRI task including tone-paced synchronization and self-paced continuation tapping at a 500 ms intertap interval (ITI). Behavioral data revealed shorter and more variable ITIs during self-paced continuation, greater clock (vs motor) variance, and greater force of tapping in the schizophrenia group. In a whole-brain analysis, groups showed robust activation of the cerebellum during self-paced continuation but not during tone-paced synchronization. However, effective connectivity analysis revealed decreased connectivity in individuals with schizophrenia between the cerebellum and primary motor cortex but increased connectivity between cerebellum and thalamus during self-paced continuation compared with healthy controls. These findings in schizophrenia indicate diminished temporal coordination of cerebral motor activity by cerebellum during the continuation tapping portion of sensorimotor synchronization. Taken together with the behavioral finding of greater temporal variability in schizophrenia, these effective connectivity results are consistent with structural and temporal models of dysconnectivity in the disorder