Veterinary parasitology teaching: Ten years of experience with the Vetsuisse curriculum

Pursuant to the Joint Declaration by 29 European education ministers in June 1999 in the city of Bologna, Italy, the so-called ‘Bologna Process’ was officially introduced at the Vetsuisse Faculty (Universities of Zurich and Berne) in Switzerland in 2007. The long-term goal of restructuring the study programmes was to create a common European Higher Education Area (EHEA), with uniform and clearly defined standards for degrees (“diplomas”). Accordingly, the Vetsuisse curriculum was organised as a 3-year Bachelor and a 2-year Master study program. For the final Federal examination in veterinary medicine, both programs and a master thesis have to be completed. Parasitology, as a subject, is introduced with selected examples in the ecology course during the first academic year. The second and third years of the Bachelor program comprise non-organ-centred (NOC) and integrated organ-centred (OC) course modules, respectively. In the NOC modules, parasitology is taught in consecutive courses, focussing on topics including occurrence, biology, pathogenesis, clinical manifestations, diagnostics and the strategic principles of therapeutic and prophylactic interventions against major veterinary and zoonotic parasites. This syllabus is complemented with live demonstrations as well as practical laboratory exercises. Lecture notes, with defined learning objectives, are based on the textbook “Parasitology in Veterinary Medicine” which is available free of charge to students as an on-line edition in German. Furthermore, students review relevant parasitoses in the diagnostic context of OC case presentations. In another module, immunological aspects of parasitic diseases are elaborated on group sessions, supported through the use of specialist literature. The two-year Master program is divided into a core syllabus for all students, and elective subjects are chosen from six areas of specialisation (three each with clinical or non-clinical focus). Within the clinically focused specialisations, interactive teaching of control strategies against parasitoses of companion and farm animals is the focus. Students specialising in ‘Pathobiology’ experience a deep immersion in parasitology. Learning objectives are verified in different test formats. E-learning tools, including a learning management on-line platform, allow interactive student training in coproscopic diagnostic techniques and in arachno-entomology and provide case-oriented teaching. Since an aptitude test limits the number of first-year students in veterinary medicine in Switzerland (80 in Zürich, 70 in Berne), the conditions for students and teachers are similar each year. The fragmentation of teaching in veterinary parasitology, the reduction of the number of diagnostic exercises and clinically oriented day-1-skills pertaining to the control of parasitoses are critically commented upon

Self-assessment of Industry 4.0 Technologies in Intralogistics for SME’s

Part 5: Industry 4.0 ImplementationsInternational audienceThe 4th industrial revolution generates a high potential for smart production systems. Many manufacturing companies considering therefore the application of cyber-physical systems in the sector of intralogistics. The aim is to achieve better logistics performance or lower costs. However, small and medium sized enterprises (SME) are hesitant about introducing Industry 4.0 technologies. They fear high implementation costs, low benefits and the lack of know-how increases the reluctance of the companies.This paper presents a procedure which enables SME’s to assess the benefits of Industry 4.0 technologies by themselves. The model follows the recognized principle: First improve your processes, then automate them:Methodical basis is a process model intralogistics, which also considers self-controlling cyber-physical systems. In addition, the benefit aspects are assigned to the individual process steps.In the specific application, the company first determines the digitization potential of the individual activities and then the associated benefits of Industry 4.0 technologies.The procedure reduces on the one hand the uncertainty regarding of wrong decisions and creates on the other hand the possibility for companies to select Industry 4.0 technologies goal-oriented. The described procedure was validated with SMEs

Consistent success in life-supporting porcine cardiac xenotransplantation

Heart transplantation is the only cure for patients with terminal cardiac failure, but the supply of allogeneic donor organs falls far short of the clinical need1–3. Xenotransplantation of genetically modified pig hearts has been discussed as a potential alternative4. Genetically multi-modified pig hearts that lack galactose-α1,3-galactose epitopes (α1,3-galactosyltransferase knockout) and express a human membrane cofactor protein (CD46) and human thrombomodulin have survived for up to 945 days after heterotopic abdominal transplantation in baboons5. This model demonstrated long-term acceptance of discordant xenografts with safe immunosuppression but did not predict their life-supporting function. Despite 25 years of extensive research, the maximum survival of a baboon after heart replacement with a porcine xenograft was only 57 days and this was achieved, to our knowledge, only once6. Here we show that α1,3-galactosyltransferase-knockout pig hearts that express human CD46 and thrombomodulin require non-ischaemic preservation with continuous perfusion and control of post-transplantation growth to ensure long-term orthotopic function of the xenograft in baboons, the most stringent preclinical xenotransplantation model. Consistent life-supporting function of xenografted hearts for up to 195 days is a milestone on the way to clinical cardiac xenotransplantation7