Improving Robustness of Jet Tagging Algorithms with Adversarial Training

Deep learning is a standard tool in the field of high-energy physics, facilitating considerable sensitivity enhancements for numerous analysis strategies. In particular, in identification of physics objects, such as jet flavor tagging, complex neural network architectures play a major role. However, these methods are reliant on accurate simulations. Mismodeling can lead to non-negligible differences in performance in data that need to be measured and calibrated against. We investigate the classifier response to input data with injected mismodelings and probe the vulnerability of flavor tagging algorithms via application of adversarial attacks. Subsequently, we present an adversarial training strategy that mitigates the impact of such simulated attacks and improves the classifier robustness. We examine the relationship between performance and vulnerability and show that this method constitutes a promising approach to reduce the vulnerability to poor modeling.Comment: 17 pages, 16 figures, 2 tables. Replaced with the published version. Added the journal reference and the DOI. Code accessible under https://github.com/AnnikaStein/Adversarial-Training-for-Jet-Taggin

Strafe als Vergeltung?

Die vorliegende Dissertation trägt den Titel Strafe als Vergeltung? Der Beitrag ethischer Straftheorien zur europäischen Strafrechtsphilosophie. Es geht in dieser Arbeit vorrangig um die Darstellung bzw. Beschreibung der bedeutendsten sogenannten ethischen Vergeltungstheorien, die für viele Jahre oder zum Teil auch Jahrhunderte im (zentral)europäischem Raum maßgebend waren und somit erheblichen Einfluss auf die damalige Strafrechtsphilosophie genommen haben, was bis in die heutige Zeit hineinwirkt. Zentraler Ansatzpunkt ist dabei die fundamentale und nach wie vor aktuelle Frage des Strafrechts, warum und mit welchem Recht jemand bestraft werden soll respektive darf. Aufgezeigt werden bei Behandlung dieses Themas die noch immer zeitgemäßen und beachtenswerten Aspekte innerhalb der jeweiligen Theorie, allen voran der Gedanke der bzw. die Forderung nach einer gerechten Äquivalenz zwischen Tat und Bestrafung. Weiters soll gezeigt werden, dass die meisten der hier behandelten Strafkonzepte keineswegs auf die Berücksichtigung von Zwecken verzichten und sie nicht deswegen besonders hart oder grausam sein müssen, nur weil sie den Vergeltungsgedanken in den Vordergrund rücken. Auch (zum Teil berechtigte) Kritikpunkte werden an passenden Stellen kurz behandelt und näher ausgeführt.The title of this thesis is Strafe als Vergeltung? Der Beitrag ethischer Straftheorien zur europäischen Strafrechtsphilosophie (Punishment as Retribution? The Contribution of Ethical Theories of Punishment to European Philosophy of Criminal Law). The main point is to portray and describe the most important, so called ethical, theories of retribution, which were significant for the philosophy of criminal law in (central) Europe for years and centuries. Undoubtedly, these theories had great influence in the past and are (partly) still of importance today. In this context, the starting-point is the following important question: What gives people the right to punish? The remarkable and still relevant aspects of the different theories are shown in this thesis, especially the idea of respectively the demand for equivalence of deed and penalty: Punishment shall be appropriate to the degree of culpability. Moreover it is shown that such theories, despite claiming retribution, do not have to be cruel as well as the fact that most of them do include so called relative elements like reformation and deterrence. Also (partly justified) critique will be discussed

Sociodemographic factors and patient perceptions are associated with attitudes to kidney transplantation among haemodialysis patients

Background. Treatment decisions made by patients with chronic kidney disease are crucial in the renal transplantation process. These decisions are influenced, amongst other factors, by attitudes towards different treatment options, which are modulated by knowledge and perceptions about the disease and its treatment and many other subjective factors. Here we study the attitude of dialysis patients to renal transplantation and the association of sociodemographic characteristics, patient perceptions and experiences with this attitude. Methods. In a cross-sectional study, all patients from eight dialysis units in Budapest, Hungary, who were on haemodialysis for at least 3 months were approached to complete a self-administered questionnaire. Data collected from 459 patients younger than 70 years were analysed in this manuscript. Results. Mean age of the study population was 53 +/- 12 years, 54% were male and the prevalence of diabetes was 22%. Patients with positive attitude to renal transplantation were younger (51 +/- 11 versus 58 +/- 11 years), better educated, more likely to be employed (11% versus 4%) and had prior transplantation (15% versus 7%)(P < 0.05 for all). In a multivariate model, negative patient perceptions about transplantation, negative expectations about health outcomes after transplantation and the presence of fears about the transplant surgery were associated, in addition to incre- asing age, with unwillingness to consider transplantation. Conclusions. Negative attitudes to renal transplantation are associated with potentially modifiable factors. Based on this we suggest that it would be necessary to develop standardized, comprehensible patient information systems and personalized decision support to facilitate modality selection and to enable patients to make fully informed treatment decisions

Experiences with Glofitamab Administration following CAR T Therapy in Patients with Relapsed Mantle Cell Lymphoma.

Mantle cell lymphoma (MCL) is a rare type of B-cell Non-Hodgkin lymphoma (NHL) affecting predominantly male patients. While complete remissions following first-line treatment are frequent, most patients ultimately relapse, with a usually aggressive further disease course. The use of cytarabine-comprising induction chemotherapy and autologous stem cell transplantation, Rituximab maintenance, Bruton's tyrosine kinase (BTK) inhibitors and CAR T therapy has substantially improved survival. Still, options for patients relapsing after CAR T therapy are limited and recommendations for the treatment of these patients are lacking. We report two cases of patients with mantle cell lymphoma who relapsed after CAR T therapy and were treated with the bispecific CD20/CD3 T cell engaging antibody glofitamab. Both patients showed marked increases of circulating CAR T cells and objective responses after glofitamab administration. Therapy was tolerated without relevant side effects in both patients. One patient completed all 12 planned cycles of glofitamab therapy and was alive and without clinical progression at the last follow-up. The second patient declined further treatment after the first cycle and succumbed to disease progression. We review the literature and investigate possible mechanisms involved in the observed responses after administration of glofitamab, such as proliferation of CAR T cells, anti-tumor effects of the bispecific antibody and the role of other possibly contributing factors. Therapy with bispecific antibodies might offer an effective and well-tolerated option for patients with mantle cell lymphoma relapsing after CAR T therapy

Engaging Communities in Emergency Risk and Crisis Communication: Mixed-Method Systematic Review and Evidence Synthesis

The World Health Organization (WHO) commissioned systematic reviews to assist with the development of new emergency risk communication guidelines that will impact responses and distribution of resources at all levels. This mixed-method evidence synthesis, guided by Cochrane principles and methods, examined the extant research in countries throughout the world, published from 2003 to 2016, related to the best practices to engage communities in preparing for and responding to emergency events with public health implications. Although few studies directly examined which strategies or tactics effectively engage public participation, many studies reinforced the importance of community participation. The findings support the perspective that emergency events are communicatively understood by all publics and that they benefit from emergency risk communication before, during, and after such events, especially when grounded in local contexts. Although the importance of local context limits the generalizability of risk communication, it is important to continue studying strategies and tactics to cultivate participation among all stakeholders

Sensory Electrical Stimulation Improves Foot Placement during Targeted Stepping Post-Stroke

Proper foot placement is vital for maintaining balance during walking, requiring the integration of multiple sensory signals with motor commands. Disruption of brain structures post-stroke likely alters the processing of sensory information by motor centers, interfering with precision control of foot placement and walking function for stroke survivors. In this study, we examined whether somatosensory stimulation, which improves functional movements of the paretic hand, could be used to improve foot placement of the paretic limb. Foot placement was evaluated before, during, and after application of somatosensory electrical stimulation to the paretic foot during a targeted stepping task. Starting from standing, twelve chronic stroke participants initiated movement with the non-paretic limb and stepped to one of five target locations projected onto the floor with distances normalized to the paretic stride length. Targeting error and lower extremity kinematics were used to assess changes in foot placement and limb control due to somatosensory stimulation. Significant reductions in placement error in the medial–lateral direction (p = 0.008) were observed during the stimulation and post-stimulation blocks. Seven participants, presenting with a hip circumduction walking pattern, had reductions (p = 0.008) in the magnitude and duration of hip abduction during swing with somatosensory stimulation. Reductions in circumduction correlated with both functional and clinical measures, with larger improvements observed in participants with greater impairment. The results of this study suggest that somatosensory stimulation of the paretic foot applied during movement can improve the precision control of foot placement

Trust and Public Health Emergency Events:A Mixed-Methods Systematic Review

The systematic review examined the phenomenon of trust during public health emergency events. The literature reviewed was field studies done with people directly affected or likely to be affected by such events and included quantitative, qualitative, mixed-method, and case study primary studies in English (N = 38) as well as Arabic, Chinese, French, Russian, and Spanish (all non-English N = 30). Studies were mostly from high-and middle-income countries, and the event most covered was infectious disease. Findings from individual studies were first synthesized within methods and evaluated for certainty/confidence, and then synthesized across methods. The final set of 11 findings synthesized across methods identified a set of activities for enhancing trust and showed that it is a multi-faceted and dynamic concept

An ALMA survey of submillimetre galaxies in the COSMOS field: The extent of the radio-emitting region revealed by 3 GHz imaging with the Very Large Array

We determine the radio size distribution of a large sample of 152 SMGs in COSMOS that were detected with ALMA at 1.3 mm. For this purpose, we used the observations taken by the VLA-COSMOS 3 GHz Large Project. One hundred and fifteen of the 152 target SMGs were found to have a 3 GHz counterpart. The median value of the major axis FWHM at 3 GHz is derived to be $4.6\pm0.4$ kpc. The radio sizes show no evolutionary trend with redshift, or difference between different galaxy morphologies. We also derived the spectral indices between 1.4 and 3 GHz, and 3 GHz brightness temperatures for the sources, and the median values were found to be $\alpha=-0.67$ and $T_{\rm B}=12.6\pm2$ K. Three of the target SMGs, which are also detected with the VLBA, show clearly higher brightness temperatures than the typical values. Although the observed radio emission appears to be predominantly powered by star formation and supernova activity, our results provide a strong indication of the presence of an AGN in the VLBA and X-ray-detected SMG AzTEC/C61. The median radio-emitting size we have derived is 1.5-3 times larger than the typical FIR dust-emitting sizes of SMGs, but similar to that of the SMGs' molecular gas component traced through mid-$J$ line emission of CO. The physical conditions of SMGs probably render the diffusion of cosmic-ray electrons inefficient, and hence an unlikely process to lead to the observed extended radio sizes. Instead, our results point towards a scenario where SMGs are driven by galaxy interactions and mergers. Besides triggering vigorous starbursts, galaxy collisions can also pull out the magnetised fluids from the interacting disks, and give rise to a taffy-like synchrotron-emitting bridge. This provides an explanation for the spatially extended radio emission of SMGs, and can also cause a deviation from the well-known IR-radio correlation.Comment: 32 pages (incl. 5 appendices), 17 figures, 7 tables; accepted for publication in A&A; abstract abridged for arXi