PROJETO DE PRESERVAÇÃO DOS LIVROS DE ATAS DO CONSUNI

A lei 12.527 de 18 de novembro de 2011, mais conhecida como Lei de Acesso à Informação assim como a lei 8.159 de 08 de janeiro de 1991, a Lei de Arquivos e, sobretudo, a constituição de 1988, visam a garantir aos cidadãos o direito à informação no âmbito do Poder Executivo Federal. Neste rol inclui-se a Universidade Federal do Rio de Janeiro como entidade custodiadora de documentos e informação para atender a sociedade. Criado pela portaria 2.726 de 29 de março de 2016, o Sistema de Arquivos - SIARQ foi instituído a fim de implantar diretrizes para a política arquivística, estabelecendo padrões para procedimentos afins além de disseminar o patrimônio documental da instituição. Nesta abordagem ressalta-se o papel da Seção de Arquivo Permanente, responsável pela preservação dos conjuntos documentais de guarda permanente da universidade, isto é, os arquivos históricos. Dentre esses conjuntos destacam-se os livros de atas do Conselho Universitário (CONSUNI).  Apesar de sua grande relevância, notou-se que estas informações não poderiam ser acessadas devido às condições dos documentos conforme constatado após análise técnica. Para manter a integridade física e o acesso dos mesmos, foi elaborado um projeto de preservação. Tal projeto engloba 17 livros produzidos entre 1920 e 1967, cujos documentos são de valor informativo inestimável para a história institucional. O desenvolvimento deste ratifica o trabalho do arquivo em prol da memória, sendo de suma importância não somente para o SIARQ, mas também para a UFRJ, de modo a integrar as comemorações do centenário da instituição em 2020

Transient Analysis and Modeling of Automotive PEM Fuel Cell System Accounting for Water Transport Dynamics

ABSTRAC

Antibody-mediated blockade of JMJD6 interaction with collagen I exerts antifibrotic and antimetastatic activities

JMJD6 is known to localize in the nucleus, exerting histone arginine demethylase and lysyl hydroxylase activities. A novel localization of JMJD6 in the extracellular matrix, resulting from its secretion as a soluble protein, was unveiled by a new anti-JMJD6 mAb called P4E11, which was developed to identify new targets in the stroma. Recombinant JMJD6 binds with collagen type I (Coll-I), and distinct JMJD6 peptides interfere with collagen fibrillogenesis, collagen-fibronectin interaction, and adhesion of human tumor cells to the collagen substrate. P4E11 and collagen binding to JMJD6 are mutually exclusive because the amino acid sequences of JMJD6 necessary for the interaction with Coll-I are part of the conformational epitope recognized by P4E11. In mice injected with mouse 4T1 breast carcinoma cells, treatment with P4E11 reduced fibrosis at the primary tumor and prevented lung metastases. Reduction of fibrosis has also been documented in human breast and ovarian tumors (MDA-MB-231 and IGROV1, respectively) xenotransplanted into immunodeficient mice treated with P4E11. In summary, this study uncovers a new localization and function for JMJD6 that is most likely independent from its canonical enzymatic activities, and demonstrates that JMJD6 can functionally interact with Coll-I. P4E11 mAb, inhibiting JMJD6/Coll-I interaction, represents a new opportunity to target fibrotic and tumor diseases

Bacterial Communities in the Embryo of Maize Landraces:Relation with Susceptibility to Fusarium Ear Rot

Locally adapted maize accessions (landraces) represent an untapped resource of nutritional and resistance traits for breeding, including the shaping of distinct microbiota. Our study focused on five different maize landraces and a reference commercial hybrid, showing different susceptibility to fusarium ear rot, and whether this trait could be related to particular compositions of the bacterial microbiota in the embryo, using different approaches. Our cultivation-independent approach utilized the metabarcoding of a portion of the 16S rRNA gene to study bacterial populations in these samples. Multivariate statistical analyses indicated that the microbiota of the embryos of the accessions grouped in two different clusters: one comprising three landraces and the hybrid, one including the remaining two landraces, which showed a lower susceptibility to fusarium ear rot in field. The main discriminant between these clusters was the frequency of Firmicutes, higher in the second cluster, and this abundance was confirmed by quantification through digital PCR. The cultivation-dependent approach allowed the isolation of 70 bacterial strains, mostly Firmicutes. In vivo assays allowed the identification of five candidate biocontrol strains against fusarium ear rot. Our data revealed novel insights into the role of the maize embryo microbiota and set the stage for further studies aimed at integrating this knowledge into plant breeding programs

Psychological treatments and psychotherapies in the neurorehabilitation of pain. Evidences and recommendations from the italian consensus conference on pain in neurorehabilitation

BACKGROUND: It is increasingly recognized that treating pain is crucial for effective care within neurological rehabilitation in the setting of the neurological rehabilitation. The Italian Consensus Conference on Pain in Neurorehabilitation was constituted with the purpose identifying best practices for us in this context. Along with drug therapies and physical interventions, psychological treatments have been proven to be some of the most valuable tools that can be used within a multidisciplinary approach for fostering a reduction in pain intensity. However, there is a need to elucidate what forms of psychotherapy could be effectively matched with the specific pathologies that are typically addressed by neurorehabilitation teams. OBJECTIVES: To extensively assess the available evidence which supports the use of psychological therapies for pain reduction in neurological diseases. METHODS: A systematic review of the studies evaluating the effect of psychotherapies on pain intensity in neurological disorders was performed through an electronic search using PUBMED, EMBASE, and the Cochrane Database of Systematic Reviews. Based on the level of evidence of the included studies, recommendations were outlined separately for the different conditions. RESULTS: The literature search yielded 2352 results and the final database included 400 articles. The overall strength of the recommendations was medium/low. The different forms of psychological interventions, including Cognitive-Behavioral Therapy, cognitive or behavioral techniques, Mindfulness, hypnosis, Acceptance and Commitment Therapy (ACT), Brief Interpersonal Therapy, virtual reality interventions, various forms of biofeedback and mirror therapy were found to be effective for pain reduction in pathologies such as musculoskeletal pain, fibromyalgia, Complex Regional Pain Syndrome, Central Post-Stroke pain, Phantom Limb Pain, pain secondary to Spinal Cord Injury, multiple sclerosis and other debilitating syndromes, diabetic neuropathy, Medically Unexplained Symptoms, migraine and headache. CONCLUSIONS: Psychological interventions and psychotherapies are safe and effective treatments that can be used within an integrated approach for patients undergoing neurological rehabilitation for pain. The different interventions can be specifically selected depending on the disease being treated. A table of evidence and recommendations from the Italian Consensus Conference on Pain in Neurorehabilitation is also provided in the final part of the pape

What is the role of the placebo effect for pain relief in neurorehabilitation? Clinical implications from the Italian consensus conference on pain in neurorehabilitation

Background: It is increasingly acknowledged that the outcomes of medical treatments are influenced by the context of the clinical encounter through the mechanisms of the placebo effect. The phenomenon of placebo analgesia might be exploited to maximize the efficacy of neurorehabilitation treatments. Since its intensity varies across neurological disorders, the Italian Consensus Conference on Pain in Neurorehabilitation (ICCP) summarized the studies on this field to provide guidance on its use. Methods: A review of the existing reviews and meta-analyses was performed to assess the magnitude of the placebo effect in disorders that may undergo neurorehabilitation treatment. The search was performed on Pubmed using placebo, pain, and the names of neurological disorders as keywords. Methodological quality was assessed using a pre-existing checklist. Data about the magnitude of the placebo effect were extracted from the included reviews and were commented in a narrative form. Results: 11 articles were included in this review. Placebo treatments showed weak effects in central neuropathic pain (pain reduction from 0.44 to 0.66 on a 0-10 scale) and moderate effects in postherpetic neuralgia (1.16), in diabetic peripheral neuropathy (1.45), and in pain associated to HIV (1.82). Moderate effects were also found on pain due to fibromyalgia and migraine; only weak short-term effects were found in complex regional pain syndrome. Confounding variables might have influenced these results. Clinical implications: These estimates should be interpreted with caution, but underscore that the placebo effect can be exploited in neurorehabilitation programs. It is not necessary to conceal its use from the patient. Knowledge of placebo mechanisms can be used to shape the doctor-patient relationship, to reduce the use of analgesic drugs and to train the patient to become an active agent of the therapy

What is the role of the placebo effect for pain relief in neurorehabilitation? Clinical implications from the Italian Consensus Conference on Pain in Neurorehabilitation

Background: It is increasingly acknowledged that the outcomes of medical treatments are influenced by the context of the clinical encounter through the mechanisms of the placebo effect. The phenomenon of placebo analgesia might be exploited to maximize the efficacy of neurorehabilitation treatments. Since its intensity varies across neurological disorders, the Italian Consensus Conference on Pain in Neurorehabilitation (ICCP) summarized the studies on this field to provide guidance on its use. Methods: A review of the existing reviews and meta-analyses was performed to assess the magnitude of the placebo effect in disorders that may undergo neurorehabilitation treatment. The search was performed on Pubmed using placebo, pain, and the names of neurological disorders as keywords. Methodological quality was assessed using a pre-existing checklist. Data about the magnitude of the placebo effect were extracted from the included reviews and were commented in a narrative form. Results: 11 articles were included in this review. Placebo treatments showed weak effects in central neuropathic pain (pain reduction from 0.44 to 0.66 on a 0-10 scale) and moderate effects in postherpetic neuralgia (1.16), in diabetic peripheral neuropathy (1.45), and in pain associated to HIV (1.82). Moderate effects were also found on pain due to fibromyalgia and migraine; only weak short-term effects were found in complex regional pain syndrome. Confounding variables might have influenced these results. Clinical implications: These estimates should be interpreted with caution, but underscore that the placebo effect can be exploited in neurorehabilitation programs. It is not necessary to conceal its use from the patient. Knowledge of placebo mechanisms can be used to shape the doctor-patient relationship, to reduce the use of analgesic drugs and to train the patient to become an active agent of the therapy

Livros de atas do CONSUNI: Projeto de preservação da memória institucional da UFRJ

A lei 12.527 de 18 de novembro de 2011, mais conhecida como Lei de Acesso à Informação assim como a lei 8.159 de 08 de janeiro de 1991, a Lei de Arquivos e, sobretudo, a Constituição de 1988, visam a garantir aos cidadãos o direito à informação no âmbito do Poder Executivo Federal. Neste rol inclui-se a Universidade Federal do Rio de Janeiro como entidade custodiadora de documentos com fins de prova e informação para atender a sociedade. Criado pela portaria 2.726 de 29 de março de 2016, o Sistema de Arquivos – SIARQ foi instituído a fim de implantar diretrizes para a política arquivística, estabelecendo padrões para procedimentos afins além de disseminar o patrimônio documental da instituição. Nesta abordagem ressalta-se o papel da Seção de Arquivo Permanente, responsável pela preservação dos conjuntos documentais de guarda permanente da universidade, isto é, os arquivos históricos. Dentre esses conjuntos destacam-se os livros de atas do Conselho Universitário (CONSUNI), cujo teor se dá por deliberações e decisões que envolvem os campos administrativo e acadêmico, abrangendo os três momentos da universidade, a saber - Universidade do Rio de Janeiro, Universidade do Brasil até a denominação atual, Universidade Federal do Rio de Janeiro. Tal projeto engloba 17 livros produzidos entre 1920 e 1967, cujos documentos são de valor informativo inestimável para a história institucional - como, por exemplo, a ata da primeira reunião datada de 11 de outubro de 1920 com a finalidade de aprovação do regimento da universidade, de acordo com o decreto 14.343 de 07 de setembro de 1920. Apesar de sua grande relevância, notou-se que estas informações não poderiam ser acessadas devido às condições dos documentos conforme constatado após análise técnica. Para manter a integridade física dos mesmos, medidas de higienização e conservação reparadora têm sido aplicadas paralelamente ao processo de digitalização, em formato indicado para a preservação, visando futuramente ao acesso e à difusão de informações através da base de dados Mnemosine. O desenvolvimento deste projeto ratifica o trabalho do arquivo em prol da memória, sendo de suma importância não somente para o SIARQ mas também para a UFRJ, de modo a integrar as comemorações do centenário da instituição em 2020.