Compressive Hyperspectral Imaging Using Progressive Total Variation

Compressed Sensing (CS) is suitable for remote acquisition of hyperspectral images for earth observation, since it could exploit the strong spatial and spectral correlations, llowing to simplify the architecture of the onboard sensors. Solutions proposed so far tend to decouple spatial and spectral dimensions to reduce the complexity of the reconstruction, not taking into account that onboard sensors progressively acquire spectral rows rather than acquiring spectral channels. For this reason, we propose a novel progressive CS architecture based on separate sensing of spectral rows and joint reconstruction employing Total Variation. Experimental results run on raw AVIRIS and AIRS images confirm the validity of the proposed system.Comment: To be published on ICASSP 2014 proceeding

Block-sparsity-based localization in wireless sensor networks

In this paper, we deal with the localization problem in wireless sensor networks, where a target sensor location must be estimated starting from few measurements of the power present in a radio signal received from sensors with known locations. Inspired by the recent advances in sparse approximation, the localization problem is recast as a block-sparse signal recovery problem in the discrete spatial domain. In this paper, we develop different RSS-fingerprinting localization algorithms and propose a dictionary optimization based on the notion of the coherence to improve the reconstruction efficiency. The proposed protocols are then compared with traditional fingerprinting methods both via simulation and on-field experiments. The results prove that our methods outperform the existing ones in terms of the achieved localization accuracy

Bone marrow-derived cells can acquire cardiac stem cells properties in damaged heart

Experimental data suggest that cell-based therapies may be useful for cardiac regeneration following ischaemic heart disease. Bone marrow (BM) cells have been reported to contribute to tissue repair after myocardial infarction (MI) by a variety of humoural and cellular mechanisms. However, there is no direct evidence, so far, that BM cells can generate cardiac stem cells (CSCs). To investigate whether BM cells contribute to repopulate the Kit+ CSCs pool, we transplanted BM cells from transgenic mice, expressing green fluorescent protein under the control of Kit regulatory elements, into wild-type irradiated recipients. Following haematological reconstitution and MI, CSCs were cultured from cardiac explants to generate 'cardiospheres', a microtissue normally originating in vitro from CSCs. These were all green fluorescent (i.e. BM derived) and contained cells capable of initiating differentiation into cells expressing the cardiac marker Nkx2.5. These findings indicate that, at least in conditions of local acute cardiac damage, BM cells can home into the heart and give rise to cells that share properties of resident Kit+ CSCs

Differentiation-dependent lysine 4 acetylation enhances MEF2C binding to DNA in skeletal muscle cells

Myocyte enhancer factor 2 (MEF2) proteins play a key role in promoting the expression of muscle-specific genes in differentiated muscle cells. MEF2 activity is regulated by the association with several transcriptional co-factors and by post-translational modifications. In the present report, we provide evidence for a novel regulatory mechanism of MEF2C activity, which occurs at the onset of skeletal muscle differentiation and is based on Lys4 acetylation. This covalent modification results in the enhancement of MEF2C binding to DNA and chromatin. In particular, we report that the kinetic parameters of MEF2/DNA association change substantially upon induction of differentiation to give a more stable complex and that this effect is mediated by Lys4 acetylation. We also show that Lys4 acetylation plays a prominent role in the p300-dependent activation of MEF2C

Stereotactic Radiotherapy and Androgen Deprivation Therapy for Localized Prostate Cancer: A Retrospective Mono-institutional Experience

Background/Aim: Stereotactic radiotherapy (SRT) is an effective treatment for localized prostate cancer. However, is it not clear whether the addition of androgen deprivation therapy (ADT) to SRT is beneficial. The aim of this study was to analyze the outcomes of a series of patients treated with SRT plus ADT for localized prostate cancer. Patients and Methods: Patients were treated with SRT with 42 Gy in 7 fractions with volumetric-modulated arc therapy plus Image Guided Radiotherapy (V-MAT IGRT) technique. ADT was administered to patients with intermediate unfavorable-and high-risk disease. Study endpoints were biochemical disease-free survival (bDFS), overall survival (OS), acute and late toxicity and patient-reported outcomes (PROs) using international prostate cancer symptoms scale (IPSS) and international index of erectile function (IIEF). Results: A total of 170 consecutive patients were identified, of which 49 (28.8%) with low-risk, 15 (8.8%) with favorable intermediate-risk 76 (44.7%) with unfavorable intermediate risk and 30 (17.6%) with high-risk class. All patients of unfavorable intermediate-and high-risk groups were for administered LHRH analogue concurrently to SRT and for at least 6 months. Patients with unfavorable intermediate and high-risk presented a 5-year bDFS of 81.7% and 76.9%, respectively. Conclusion: SRT consisting of 42 Gy in seven fractions with short-term ADT represents a safe and effective treatment for unfavorable intermediate and high risk prostate cancer. Our results support the need of high quality studies to test the efficacy of ADT combined with SRT for unfavorable intermediate-and high-risk localized prostate cancer

Detection of Coronal Mass Ejections at L1 and Forecast of Their Geoeffectiveness

A novel tool aimed to detect solar coronal mass ejections (CMEs) at the Lagrangian point L1 and to forecast their geoeffectiveness is presented in this paper. This approach is based on the analysis of in situ magnetic field and plasma measurements to compute some important magnetohydrodynamic quantities of the solar wind (the total pressure, the magnetic helicity, and the magnetic and kinetic energy), which are used to identify the CME events, that is their arrival and transit times, and to assess their likelihood for impacting the Earths magnetosphere. The method is essentially based on the comparison of the topological properties of the CME magnetic field configuration and of the CME energetic budget with those of the quasi-steady ambient solar wind. The algorithm performances are estimated by testing the tool on solar wind data collected in situ by the Wind spacecraft from 2005 to 2016. In the scanned 12 yr time interval, it results that (i) the procedure efficiency is of 86% for the weakest magnetospheric disturbances, increasing with the level of the geomagnetic storming, up to 100% for the most intense geomagnetic events, (ii) zero false positive predictions are produced by the algorithm, and (iii) the mean delay between the potentially geoeffective CME detection and the geomagnetic storm onset if of 4 hr, with a 98% 2-8 hr confidence interval. Hence, this new technique appears to be very promising in forecasting space weather phenomena associated to CMEs

Myogenic Cell Transplantation in Genetic and Acquired Diseases of Skeletal Muscle

From Frontiers via Jisc Publications RouterHistory: collection 2021, received 2021-04-29, accepted 2021-06-16, epub 2021-08-02Publication status: PublishedThis article will review myogenic cell transplantation for congenital and acquired diseases of skeletal muscle. There are already a number of excellent reviews on this topic, but they are mostly focused on a specific disease, muscular dystrophies and in particular Duchenne Muscular Dystrophy. There are also recent reviews on cell transplantation for inflammatory myopathies, volumetric muscle loss (VML) (this usually with biomaterials), sarcopenia and sphincter incontinence, mainly urinary but also fecal. We believe it would be useful at this stage, to compare the same strategy as adopted in all these different diseases, in order to outline similarities and differences in cell source, pre-clinical models, administration route, and outcome measures. This in turn may help to understand which common or disease-specific problems have so far limited clinical success of cell transplantation in this area, especially when compared to other fields, such as epithelial cell transplantation. We also hope that this may be useful to people outside the field to get a comprehensive view in a single review. As for any cell transplantation procedure, the choice between autologous and heterologous cells is dictated by a number of criteria, such as cell availability, possibility of in vitro expansion to reach the number required, need for genetic correction for many but not necessarily all muscular dystrophies, and immune reaction, mainly to a heterologous, even if HLA-matched cells and, to a minor extent, to the therapeutic gene product, a possible antigen for the patient. Finally, induced pluripotent stem cell derivatives, that have entered clinical experimentation for other diseases, may in the future offer a bank of immune-privileged cells, available for all patients and after a genetic correction for muscular dystrophies and other myopathies

Hypofractionated simultaneous integrated boost (IMRT-SIB) with pelvic nodal irradiation and concurrent androgen deprivation therapy for high-risk prostate cancer: results of a prospective phase II trial

n/