Has natural variability a lagged influence on global temperature? A multi-horizon Granger causality analysis

At present, the role of natural variability in influencing climate behaviour is widely discussed. The generally accepted view is that atmosphere-ocean coupled circulation patterns are able to amplify or reduce temperature increase from interannual to multidecadal time ranges, leaving the principal driving role to anthropogenic forcings. In this framework, the influence of these circulation patterns is considered synchronous with global temperature changes. Here, we would like to investigate if there exists a lagged influence of these indices on temperature. In doing so, an extension of the Granger causality technique, which permits to test both direct and indirect causal influences, is applied. A lagged influence of natural variability is not evident in our analysis, if we except weak influences of some peculiar circulation indices in specific periods

Clarifying the Roles of Greenhouse Gases and ENSO in Recent Global Warming through Their Prediction Performance

Abstract It is well known that natural external forcings and decadal-to-millennial variability drove changes in the climate system throughout the Holocene. Regarding recent times, attribution studies have shown that greenhouse gases (GHGs) determined the trend of temperature (T) in the last half century, while circulation patterns contributed to modify its interannual, decadal, or multidecadal behavior over this period. Here temperature predictions based on vector autoregressive models (VARs) have been used to study the influence of GHGs and El Niño–Southern Oscillation (ENSO) on recent temperature behavior. It is found that in the last decades of steep temperature increase, ENSO shows just a very short-range influence on T, while GHGs are dominant for each forecast horizon. Conversely and quite surprisingly, in the previous quasi-stationary period the influences of GHGs and ENSO are comparable, even at longer range. Therefore, if the recent hiatus in global temperatures should persist into the near future, an enhancement of the role of ENSO can be expected. Finally, the predictive ability of GHGs is more evident in the Southern Hemisphere, where the temperature series is smoother

Process Parameters Optimization in Micromilling of Watch Mechanism Features

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Design of biodegradable bi-compartmental microneedles for the stabilization and the controlled release of the labile molecule collagenase for skin healthcare.

Polymeric microneedles (MNs) have emerged as a novel class of drug delivery system thanks to their ability in penetrating the skin with no pain, encapsulate active proteins and in particular, proposed bicompartimental MNs can tune protein release

Beware of Pickpockets: A Practical Attack against Blocking Cards

peer reviewedToday, we rely on contactless smart cards to perform several critical operations (e.g., payments and accessing buildings). Attacking smart cards can have severe consequences, such as losing money or leaking sensitive information. Although the security protections embedded in smart cards have evolved over the years, those with weak security properties are still commonly used. Among the different solutions, blocking cards are affordable devices to protect smart cards. These devices are placed close to the smart cards, generating a noisy jamming signal or shielding them. Whereas vendors claim the reliability of their blocking cards, no previous study has ever focused on evaluating their effectiveness. In this paper, we shed light on the security threats on smart cards in the presence of blocking cards, showing the possibility of being bypassed by an attacker. We analyze blocking cards by inspecting their emitted signal and assessing a vulnerability in their internal design.We propose a novel attack that bypasses the jamming signal emitted by a blocking card and reads the content of the smart card. We evaluate the effectiveness of 11 blocking cards when protecting a MIFARE Ultralight smart card and a MIFARE Classic card. Of these 11 cards, we managed to bypass 8 of them and successfully dump the content of a smart card despite the presence of the blocking card. Our findings highlight that the noise type implemented by the blocking cards highly affects the protection level achieved by them. Based on this observation, we propose a countermeasure that may lead to the design of effective blocking cards. To further improve security, we released the tool we developed to inspect the spectrum emitted by blocking cards and set up our attack

Impact of COVID-19 pandemic on 2-[18F]FDG PET/CT imaging work-flow in a single medical institution: comparison among the three Italian waves

Purpose: To compare the impact of COVID-19 pandemic on 2-[18F]FDG PET/CT imaging work-flow during the three waves in a medical institution of southern of Italy. Methods: We retrospectively reviewed the numbers and results of 2-[18F]FDG PET/CT studies acquired during the following three periods of the COVID-19 waves: 1) February 3-April 30, 2020; 2) October 15, 2020–January 15, 2021; and 3) January 18-April 16, 2021. Results: A total of 861 PET/CT studies in 725 patients (388 men, mean age 64 +/- 4 years) was acquired during the three waves of COVID-19 pandemic. The majority (94%) was performed for diagnosis/staging (n = 300) or follow-up (n = 512) of neoplastic diseases. The remaining 49 studies (6%) were acquired for non-oncological patients. The distribution of number and type of clinical indications for PET/CT studies in the three waves were comparable (p < 0.06). Conversely, the occurrence of patients positive for COVID-19 infection progressively increased (p < 0.0001) from the first to third wave; in particular, patients with COVID-19 had active infection before PET/CT study as confirmed by molecular oro/nasopharyngeal swab. Conclusion: Despite the restrictive medical measures for the emergency, the number of 2-[18F]FDG PET/CT studies was unchanged during the three waves guaranteeing the diagnostic performance of PET/CT imaging for oncological patients

DPY30 loss leads to DNA re-replication and immunoediting in pancreatic ductal adenocarcinoma

View full abstracthttps://openworks.mdanderson.org/leading-edge/1036/thumbnail.jp

A pharmacoeconomic analysis from Italian guidelines for the management of prolactinomas

Background: Prolactinoma, the most common pituitary adenoma, is usually treated with dopamine agonist (DA) therapy like cabergoline. Surgery is second-line therapy, and radiotherapy is used if surgical treatment fails or in relapsing macroprolactinoma. Objective: This study aimed to provide economic evidence for the management of prolactinoma in Italy, using a cost-of-illness and cost-utility analysis that considered various treatment options, including cabergoline, bromocriptine, temozolomide, radiation therapy, and surgical strategies. Methods: The researchers conducted a systematic literature review for each research question on scientific data- bases and surveyed a panel of experts for each therapeutic procedure's specific drivers that contributed to its total cost. Results: The average cost of the first year of treatment was euro2,558.91 and euro3,287.40 for subjects with micro- prolactinoma and macroprolactinoma, respectively. Follow-up costs from the second to the fifth year after ini- tial treatment were euro798.13 and euro1,084.59 per year in both groups. Cabergoline had an adequate cost-utility profile, with an incremental cost-effectiveness ratio (ICER) of euro3,201.15 compared to bromocriptine, based on a willingness-to-pay of euro40,000 per quality-adjusted life year (QALY) in the reference economy. Endoscopic sur- gery was more cost-effective than cabergoline, with an ICER of euro44,846.64. Considering a willingness-to-pay of euro40,000/QALY, the baseline findings show cabergoline to have high cost utility and endoscopic surgery just a tad above that. Conclusions: Due to the favorable cost-utility profile and safety of surgical treatment, pituitary surgery should be considered more frequently as the initial therapeutic approach. This management choice could lead to better outcomes and an appropriate allocation of healthcare resources