Tanacetum vahlii DC. (Asteraceae) en la provincia de Burgos. Nuevas aportaciones

Se precisa el área de distribución de Tanacetum vahlii para la provincia de Burgos, aportando numerosas localizaciones que duplican el área actual hacia el Oeste, con la contribución de 7 nuevas cuadrículas UTM de 10 × 10 km. Se analiza el hábitat y se aportan algunos datos sobre las características de las poblaciones y criterios con los que valorar su figura de protecció

Primera cita de Coronopus navasii Pau (Brassicaceae) para la provincia de Soria

Se aporta una nueva localidad de Coronopus navasii Pau (Brassicaceae), situada en el páramo de Layna, provincia de Soria, en el extremo noroeste del Sistema Ibérico, España. Esta localidad es actualmente la más septentrional de las conocidas. Se discute la potencialidad de su hábitat en el Páramo de Layna y sus perspectivas de futuro a la luz de los últimos trabajos de campo y publicaciones sobre esta especie.First citation of Coronopus navasii Pau (Brassicaceae) for the province of Soria. Here we provide with new data concerning the presence of Coronopus navasii Pau (Brassicaceae) at Páramo de Layna, Soria province, at the northwestern extreme of the Iberian System, Spain. This is currently the northernmost locality known for the species. The potential of its habitat at Páramo de Layna is discussed to the light of recent field works and studies on the specie

Novedades de flora soriana, 1

We initiate a series of publications on the flora of the province of Soria, Spain, which are previous to the review and reedition of the Floristic Catalogue of Soria (SEGURA & al., 2000), to incorporate 50 taxa corresponding to vascular plants which had not previously been recorded for the flora of province of Soria. Since the level of prospection in the Province is currently very high, these recent findings are all rare and scarce taxa in the province?s territorial context; some are peripheral or much localized, others are restricted to scarce environments and require them to be well preserved; in general, they show a presence extent very diffuse or fragmented in the Province. Another part are taxa recently described, commonly of a sub specific rank. All of them provide with an enlargement of their known distribution area, or with an improvement in their demarcation. Some floristic rarities and some regional novelties stand out, such as Beta maritima, Hippocrepis bourgaei or Lappula patula, besides other species that are very scarce, peripheral, relict or showing a fragmented area of distribution in the Province, such as Arbutus unedo, Hieracium prenanthoides, Gagea foliosa subsp. durieui or Hyacinthoides non-scripta

Novedades de flora soriana, IV

We continue with this series of publications on the flora of the province of Soria (NC Spain), before the review and reedition of the Floristic Catalogue of Soria. About a dozen species are incorporated as new, the known distribution is extended for many others and one is eliminated because it was based on misinterpreted dat

Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-alpha 2 in 10 patients: IFN-alpha 2 only in three, IFN-alpha 2 plus IFN-omega in five, and IFN-alpha 2, IFN-omega plus IFN-beta in two; IFN-omega only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-alpha 2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-omega in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-alpha 2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-. only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-omega and/or IFN-alpha 2

Novedades de flora soriana V

We continue with this series of publications on the flora of the province of Soria (NC Spain), before the review and reedition of the Floristic Catalogue of Soria. 34 taxa are incorporated as new and the known distribution is extended for many others

Palbociclib and ribociclib in breast cancer: consensus workshop on the management of concomitant medication

Drug-drug interactions are of significant concern in clinical practice in oncology, particularly in patients receiving Cyclin-dependent kinase (CDK) 4/6 inhibitors, which are typically exposed to long-term regimens. This article presents the highlights from the 'First Workshop on Pharmacology and Management of CDK4/6 Inhibitors: Consensus about Concomitant Medications'. The article is structured into two modules. The educational module includes background information regarding drug metabolism, corrected QT (QTc) interval abnormalities, management of psychotropic drugs and a comprehensive review of selected adverse effects of palbociclib and ribociclib. The collaborative module presents the conclusions of the five working groups, each of which comprised five experts from different fields. From these conclusions positive lists of drugs for treating common comorbid conditions that can be safely administered concomitantly with palbociclib and/or ribociclib were developed