Evaluation of prevalence of Haller cells and their relationship with maxilofacial changes

Introdução: As células de Haller são descritas como células etmoidais aeradas, localizadas na margem inferior da órbita, próximas aos óstios dos seios maxilares. A tomografia computadorizada de feixe cônico (TCFC) tem amplo uso na odontologia, permitindo aquisição de imagens da região craniofacial. Objetivo: Identificar, em exames de TCFC, a relação da célula de Haller com as seguintes condições: sinusopatia, desvio de septo nasal ósseo, tratamento endodôntico e lesões periapicais. Materiais e métodos: Foram utilizados 99 exames de TCFC, sendo 51 incluídos nos critérios da pesquisa. As imagens foram analisadas no software Xelis Dental®, de maneira a identificar a presença ou não da célula de Haller, bem como sua relação com as condições citadas. Resultados: Dentre os 51 exames de TCFC avaliados, 35,3% apresentaram célula de Haller do lado direito e 23,5% no lado esquerdo. Levando-se em conta a relação das células de Haller com uma ou mais alterações aqui citadas, no lado direito a tivemos em 72% dos casos, enquanto no lado esquerdo tal relação se fez presente em 75% dos casos. Conclusão: Exames de TCFC que apresentam a margem infraorbital permitem verificar a presença ou ausência da célula de Haller. Nessa amostra, verificamos maior presença de casos de endodontia, desvio de septo e sinusopatia nos indivíduos que apresentaram células de Haller.Introduction: The Haller Cells are described as aerated ethmoidal cells, located in the inferior margin of the orbit, near the ostia of the maxillary sinuses. The Cone Beam Computed Tomography (CBCT) is widely used in dentistry, allowing acquisition of images of the craniofacial region. Objective: to identify in CBCT exams the Haller´s cell relationship with the following conditions: sinus disease, bony nasal septum deviation, endodontic treatment and periapical lesions. Materials and methods: 99 CBCT exams were used, from which 51 were included in the research criteria. The images were analyzed in the Xelis Dental® software to identify the presence or absence of the Haller Cell, as well as the relationship with the mentioned conditions. Results: Among the 51 CFCT exams evaluated, 35.3% presented Haller´s Cell on the right side and 23.5% on the left side. Whereas the relationship of the Haller Cells with one or more alterations mentioned here, on the right side we had it in 72% of the cases, while on the left side such relationship was present in 75% of the cases. Conclusion: CBCT exams that present the infraorbital margin allow to verify the presence or absence of the Haller Cell. In this sample, we verified a greater presence of endodontic cases, bony nasal septum deviation and sinus disease cases in individuals who presented Haller Cells

Silver nanoparticles-composing alginate/gelatine hydrogel improves wound healing in vivo

Polymer hydrogels have been suggested as dressing materials for the treatment of cutaneous wounds and tissue revitalization. In this work, we report the development of a hydrogel composed of natural polymers (sodium alginate and gelatin) and silver nanoparticles (AgNPs) with recognized antimicrobial activity for healing cutaneous lesions. For the development of the hydrogel, different ratios of sodium alginate and gelatin have been tested, while different concentrations of AgNO3 precursor (1.0, 2.0, and 4.0 mM) were assayed for the production of AgNPs. The obtained AgNPs exhibited a characteristic peak between 430450 nm in the ultraviolet-visible (UVVis) spectrum suggesting a spheroidal form, which was confirmed by Transmission Electron Microscopy (TEM). Fourier Transform Infra-red (FTIR) analysis suggested the formation of strong intermolecular interactions as hydrogen bonds and electrostatic attractions between polymers, showing bands at 2920, 2852, 1500, and 1640 cm1. Significant bactericidal activity was observed for the hydrogel, with a Minimum Inhibitory Concentration (MIC) of 0.50 µg/mL against Pseudomonas aeruginosa and 53.0 µg/mL against Staphylococcus aureus. AgNPs were shown to be non-cytotoxic against fibroblast cells. The in vivo studies in female Wister rats confirmed the capacity of the AgNP-loaded hydrogels to reduce the wound size compared to uncoated injuries promoting histological changes in the healing tissue over the time course of wound healing, as in earlier development and maturation of granulation tissue. The developed hydrogel with AgNPs has healing potential for clinical applications.This research received funding from the Coordenação Aperfeiçoamento de Pessoal de Nivel Superior (CAPES), Fundação de Amparo à Pesquisa do Estado de Sergipe (FAPITEC), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, #443238/2014-6, #470388/2014-5), and from the Portuguese Science and Technology Foundation (FCT) projects M-ERA-NET/0004/2015 (PAIRED) and UIDB/04469/2020 (strategic fund).info:eu-repo/semantics/publishedVersio

Correction: Diniz et al. Silver Nanoparticles-Composing Alginate/Gelatine Hydrogel Improves Wound Healing In Vivo. Nanomaterials 2020, 10, 390

In the original publication, there was a mistake in Figure 6 as published [...]info:eu-repo/semantics/publishedVersio

Direitos humanos e justiciabilidade: pesquisa no Tribunal de Justiça do Rio de Janeiro

Publicado em português, espanhol e inglês.Título em espanhol: Derechos humanos y justiciabilidad: una investigación en Rio de Janeiro. -- Título em inglês: Human rights and justiciability: a survey conducted in Rio de Janeiro."A proposta deste artigo é analisar as informações obtidas no âmbito da pesquisa intitulada “Direitos Humanos no Tribunal de Justiça do Rio de Janeiro: concepção, aplicação e formação”, que tem por objetivo investigar o grau de justiciabilidade dos direitos humanos na prestação jurisdicional dos magistrados de primeira instância da Comarca da Capital do Tribunal de Justiça do Estado do Rio de Janeiro. O estudo conclui que o tipo de vara e a cor do juiz, bem como o grau de conhecimento a respeito dos sistemas internacionais de proteção dos direitos humanos da OEA e da ONU, constituem variáveis significativas para explicar o comportamento dos magistrados no tocante à utilização das normativas internacionais para a fundamentação das sentenças. A elucidação empírica das variáveis supramencionadas revela-se de grande valia na implementação de programas destinados a ampliar o conhecimento dos magistrados na matéria. A pesquisa foi contemplada com o apoio da Faperj.

Controversial issues in the management of hyperprolactinemia and prolactinomas : an overview by the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism

Prolactinomas are the most common pituitary adenomas (approximately 40% of cases), and they represent an important cause of hypogonadism and infertility in both sexes. The magnitude of prolactin (PRL) elevation can be useful in determining the etiology of hyperprolactinemia. Indeed, PRL levels > 250 ng/mL are highly suggestive of the presence of a prolactinoma. In contrast, most patients with stalk dysfunction, drug-induced hyperprolactinemia or systemic diseases present with PRL levels < 100 ng/mL. However, exceptions to these rules are not rare. On the other hand, among patients with macroprolactinomas (MACs), artificially low PRL levels may result from the so-called “hook effect”. Patients harboring cystic MACs may also present with a mild PRL elevation. The screening for macroprolactin is mostly indicated for asymptomatic patients and those with apparent idiopathic hyperprolactinemia. Dopamine agonists (DAs) are the treatment of choice for prolactinomas, particularly cabergoline, which is more effective and better tolerated than bromocriptine. After 2 years of successful treatment, DA withdrawal should be considered in all cases of microprolactinomas and in selected cases of MACs. In this publication, the goal of the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism (SBEM) is to provide a review of the diagnosis and treatment of hyperprolactinemia and prolactinomas, emphasizing controversial issues regarding these topics. This review is based on data published in the literature and the authors' experience