ABJM amplitudes and WL at finite N

We evaluate ABJM observables at two loops, for any value of the rank N of the gauge group. We compute the color subleading contributions to the four-point scattering amplitude in ABJM at two loops. Contrary to the four dimensional case, IR divergent N-subleading contributions are proportional to leading poles in the regularization parameter. We then exploit the non-planar calculation for the amplitude to derive an expression for the two-loop Sudakov form factor at any N. In the planar limit the result coincides with the one recently obtained in literature by using Feynman diagrams and unitarity. Finally, we analyze the subleading contributions to the light-like four-cusps Wilson loop and interpret the result in terms of the non-abelian exponentiation theorem. All these perturbative results satisfy the uniform transcendentality principle, hinting at its validity in ABJM beyond the planar limit.Fil: Bianchi, Marco. Humboldt-Universität zu Berlin; AlemaniaFil: Leoni, Marta. Universita Degli Studi Di Milano; Italia. Istituto Nazionale di Fisica Nucleare; ItaliaFil: Leoni Olivera, Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Mauri, Andrea. Universita Degli Studi Di Milano; Italia. Istituto Nazionale di Fisica Nucleare; ItaliaFil: Penati, Silvia. Universita Degli Studi Di Milano; Italia. Istituto Nazionale di Fisica Nucleare; ItaliaFil: Santambrogio, Alberto. Istituto Nazionale di Fisica Nucleare; Itali

Diethyl 4-(6-Chloroimidazo[2,1-b]thiazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate and Ethyl 4-(6-Chloroimidazo[2,1-b]thiazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Diethyl 4-(6-chloroimidazo[2,1-b]thiazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine- 3,5-dicarboxylate and ethyl 4-(6-chloroimidazo[2,1-b]thiazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate were obtained simultaneously by the Biginelli reaction using a green protocol and curtailing reaction time

Structure and morphology of shape-controlled Pd nanocrystals

Pd nanocrystals were produced with uniform truncated-cube shape and a narrow size distribution, yielding controlled surface area fractions from low Miller index ({100}, {110}, {111}) crystalline facets. Details on the structure and morphology of the nanocrystals were obtained by combining X-ray powder diffraction line profile analysis, high-resolution transmission electron microscopy and surface electrochemistry based on Cu underpotential deposition.ML acknowledges support from the Italian government (Ministero dell’Istruzione, dell’Università e della Ricerca) through the project FIRB Futuro in Ricerca RBFR10CWDA. JMF acknowledges financial support from the MINECO (Spain) project CTQ2013-44083-P and Generalitat Valenciana project PROMETEOII/2014/013

Infecciones del tracto urinario de la comunidad en el paciente adulto mayor

Introducción La infección del tracto urinario de la comunidad (ITUco) es frecuente. Los ancianos poseen mayor susceptibilidad, presentando dificultades diagnósticas. La etiología y sensibilidad antimicrobiana es poco conocida en nuestro medio.Objetivos Evaluar en ancianos la incidencia según sexo, signosintomatología, microorganismo recuperado, patrón de resistencia.Material y Métodos Estudio retrospectivo, descriptivo y comparativo. Se analizaron registros de urocultivos del año 2013 del Hospital Nacional de Clínicas (Córdoba- Argentina). Se incluyeron pacientes mayores de 65 años, internados con diagnóstico de ITUco, excluyéndose cateterizados.Variables analizadas: Sexo, sígnosintomatología, etiología y sensibilidad a antimicrobianos. Estudio comparativo mediante test de Chi Cuadrado para variable signosintomatología. Se determinó frecuencias en demás variables categóricas.Resultados Se analizaron 349 pacientes: 1) Urocultivo positivo 191 (caso), negativo 158 (control), 2) Edad promedio 77 años (mujeres 76%, varones 24%), 3) Signosintomatología: Fiebre (45%), sepsis (17%), depresión del sensorio (14%), descompensación cardíaca (11%), 4) Cultivo: Monomicrobiano 95.29%, 5) Identificación y porcentajes de resistencia a antimicrobianos: Escherichia coli (67,7%): ampicilina/sulbactam 52.7%, ciprofloxacina 51.9%, trimetoprima/sulfametoxazol 45.7%, cefotaxima: 12,9 %, amicacina: 3,9 %, Klebsiella pneumoniae (11,97%): ciprofloxacina 60.8%, trimetoprima/sulfametoxazol 50%, cefotaxima 47.8%, amicacina 4.7%. Enterococcus spp. (9,89%): ampicilina 0%, vancomicina 0%. Otros: Cándidas spp. (3.66%), Proteus mirabilis (2,6%), Staphylococcus aureus (2,6%), Enterobacter cloacae (1,56%), Pseudomonas aeruginosa (1,56%). Los  bacilos gramnegativos no presentaron resistencia a imipenem.Conclusiones Los aislamientos fueron mayormente monomicrobianos en mujeres. E. coli fue la bacteria predominante. Destacamos la elevada resistencia a ciprofloxacina, ampicilina/sulbactam y TMS. Se propone evitar su uso empírico, en esta población. </p

Myticalins: A novel multigenic family of linear, cationic antimicrobial peptides from marine mussels (Mytilus spp.)

The application of high-throughput sequencing technologies to non-model organisms has brought new opportunities for the identification of bioactive peptides from genomes and transcriptomes. From this point of view, marine invertebrates represent a potentially rich, yet largely unexplored resource for de novo discovery due to their adaptation to diverse challenging habitats. Bioinformatics analyses of available genomic and transcriptomic data allowed us to identify myticalins, a novel family of antimicrobial peptides (AMPs) from the mussel Mytilus galloprovincialis, and a similar family of AMPs from Modiolus spp., named modiocalins. Their coding sequence encompasses two conserved N-terminal (signal peptide) and C-terminal (propeptide) regions and a hypervariable central cationic region corresponding to the mature peptide. Myticalins are taxonomically restricted to Mytiloida and they can be classified into four subfamilies. These AMPs are subject to considerable interindividual sequence variability and possibly to presence/absence variation. Functional assays performed on selected members of this family indicate a remarkable tissue-specific expression (in gills) and broad spectrum of activity against both Gram-positive and Gram-negative bacteria. Overall, we present the first linear AMPs ever described in marine mussels and confirm the great potential of bioinformatics tools for the de novo discovery of bioactive peptides in non-model organisms

Synthesis, in vitro and in vivo biological evaluation of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones as new potent anticancer agents

A small library of 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones has been synthesized and screened according to protocols available at the National Cancer Institute (NCI). Some derivatives were potent antiproliferative agents, showing GI50 values in the nanomolar range. Remarkably, when most active compounds against leukemia cells were tested in human peripheral blood lymphocytes from healthy donors, were 100–200 times less cytotoxic. Some compounds, selected by the Biological Evaluation Committee of NCI, were examined to determine tubulin assembly inhibition. Furthermore, flow cytometric studies performed on HeLa, HT-29, and A549 cells, showed that compounds 14 and 25 caused a block in the G2/M phase. Interestingly, these derivatives induced apoptosis through the mitochondrial death pathway, causing in parallel significant activation of both caspase-3 and -9, PARP cleavage and down-regulation of the anti-apoptotic proteins Bcl-2 and Mcl-1. Finally, compound 25 was also tested in vivo in the murine BL6-B16 melanoma and E0771 breast cancer cells, causing in both cases a significant reduction in tumor volume