An Ontology Based Method to Solve Query Identifier Heterogeneity in Post-Genomic Clinical Trials

The increasing amount of information available for biomedical research has led to issues related to knowledge discovery in large collections of data. Moreover, Information Retrieval techniques must consider heterogeneities present in databases, initially belonging to different domains—e.g. clinical and genetic data. One of the goals, among others, of the ACGT European is to provide seamless and homogeneous access to integrated databases. In this work, we describe an approach to overcome heterogeneities in identifiers inside queries. We present an ontology classifying the most common identifier semantic heterogeneities, and a service that makes use of it to cope with the problem using the described approach. Finally, we illustrate the solution by analysing a set of real queries

Theoretical parameters of trailing vortices versus aspect ratio of wing models

We perform 2D-PIV measurements to characterize trailing vortices in NACA0012 wing models for aspect ratios ranging between 1 and 2.5, and for chord-based Reynolds numbers from 7000 to 40000. Firstly, and regarding the influence of the Reynolds number, the increase of this dimensionless parameter generates a more concentrated and intense vortex, presenting, therefore, an increase in all its characteristic magnitudes: maximum azimuthal velocity and vorticity. Secondly, the greater the aspect ratio, the greater the vortex strength is observed. Thirdly, the radial location of the peak of the azimuthal velocity has a strong decay as the aspect ratio increases for Re=7000, but it changes its trend for Re=40000.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.. Ministerio de Economía y Competitividad (Spain) Grant No. DPI2013-40479-P and DPI2016-76151-C2-1-R and Junta de Andalucía Grant No. P11-TEP-7776

Estudio experimental y numérico del comportamiento de un modelo de difusor de aire por desplazamiento acoplado a un suelo frío

En la última década se han realizado muchos trabajos sobre sistemas de refrigeración para grandes superficies usando ventilación por desplazamiento con suelos radiantes (por ejemplo en aeropuertos y estaciones). De especial interés tiene el conocimiento de los campos de velocidad y de temperatura. De forma simplificada, en este estudio se presentan los resultados de un difusor a escala que utiliza ventilación por desplazamiento con suelo radiante frío. Tres son los parámetros que se modifican: el caudal (Q), la diferencia entre la temperatura ambiente y el aire de impulsión (dT1) y la diferencia entre la temperatura del suelo y el aire de impulsión (dT2). Las visualizaciones y mediciones del campo de velocidad del flujo se han realizado para un régimen laminar en estado estacionario. Además, las simulaciones numéricas del campo de temperatura representado en la figura muestran buena concordancia con los datos experimentales. Las zonas de mayor interés en este estudio son: la salida del difusor, la zona cercana al suelo y la zona lejos del difusor sobre el suelo, donde las condiciones de contorno se discuten con detalle. La distancia radial (r) para la que cada difusor afecta a su alrededor en los términos de gradiente de temperatura y de velocidad es un parámetro importante para el diseño de la distribución espacial de estos difusores. Los principales resultados de este trabajo se basan en la relación r = f (Q, dT1, dT2).AIRZON

p-medicine: a medical informatics platform for integrated large scale heterogeneous patient data

Secure access to patient data is becoming of increasing importance, as medical informatics grows in significance, to both assist with population health studies, and patient specific medicine in support of treatment. However, assembling the many different types of data emanating from the clinic is in itself a difficulty, and doing so across national borders compounds the problem. In this paper we present our solution: an easy to use distributed informatics platform embedding a state of the art data warehouse incorporating a secure pseudonymisation system protecting access to personal healthcare data. Using this system, a whole range of patient derived data, from genomics to imaging to clinical records, can be assembled and linked, and then connected with analytics tools that help us to understand the data. Research performed in this environment will have immediate clinical impact for personalised patient healthcare

Automatic Generation of Integration and Preprocessing Ontologies for Biomedical Sources in a Distributed Scenario

Access to a large number of remote data sources has boosted research in biomedicine, where different biological and clinical research projects are based on collaborative efforts among international organizations. In this scenario, the authors have developed various methods and tools in the area of database integration, using an ontological approach. This paper describes a method to automatically generate preprocessing structures (ontologies) within an ontology-based KDD model. These ontologies are obtained from the analysis of data sources, searching for: (i) valid numerical ranges (using clustering techniques), (ii) different scales, (iii) synonym transformations based on known dictionaries and (iv)typographical errors. To test the method, experiments were carried out with four biomedical databases―containing rheumatoid arthritis, gene expression patterns, biological processes and breast cancer patients― proving the performance of the approach. This method supports experts in data analysis processes, facilitating the detection of inconsistencies

Ontology Based Integration of Distributed and Heterogeneous Data Sources in ACGT.

In this work, we describe the set of tools comprising the Data Access Infrastructure within Advancing Clinic-genomic Trials on Cancer (ACGT), a R&D Project funded in part by the European. This infrastructure aims at improving Post-genomic clinical trials by providing seamless access to integrated clinical, genetic, and image databases. A data access layer, based on OGSA-DAI, has been developed in order to cope with syntactic heterogeneities in databases. The semantic problems present in data sources with different nature are tackled by two core tools, namely the Semantic Mediator and the Master Ontology on Cancer. The ontology is used as a common framework for semantics, modeling the domain and acting as giving support to homogenization. SPARQL has been selected as query language for the Data Access Services and the Mediator. Two experiments have been carried out in order to test the suitability of the selected approach, integrating clinical and DICOM image databases

CLASH: Precise New Constraints on the Mass Profile of Abell 2261

We precisely constrain the inner mass profile of Abell 2261 (z=0.225) for the first time and determine this cluster is not "over-concentrated" as found previously, implying a formation time in agreement with {\Lambda}CDM expectations. These results are based on strong lensing analyses of new 16-band HST imaging obtained as part of the Cluster Lensing and Supernova survey with Hubble (CLASH). Combining this with revised weak lensing analyses of Subaru wide field imaging with 5-band Subaru + KPNO photometry, we place tight new constraints on the halo virial mass M_vir = 2.2\pm0.2\times10^15 M\odot/h70 (within r \approx 3 Mpc/h70) and concentration c = 6.2 \pm 0.3 when assuming a spherical halo. This agrees broadly with average c(M,z) predictions from recent {\Lambda}CDM simulations which span 5 <~ 8. Our most significant systematic uncertainty is halo elongation along the line of sight. To estimate this, we also derive a mass profile based on archival Chandra X-ray observations and find it to be ~35% lower than our lensing-derived profile at r2500 ~ 600 kpc. Agreement can be achieved by a halo elongated with a ~2:1 axis ratio along our line of sight. For this elongated halo model, we find M_vir = 1.7\pm0.2\times10^15 M\odot/h70 and c_vir = 4.6\pm0.2, placing rough lower limits on these values. The need for halo elongation can be partially obviated by non-thermal pressure support and, perhaps entirely, by systematic errors in the X-ray mass measurements. We estimate the effect of background structures based on MMT/Hectospec spectroscopic redshifts and find these tend to lower Mvir further by ~7% and increase cvir by ~5%.Comment: Submitted to the Astrophysical Journal. 19 pages, 14 figure

CLASH: Mass Distribution in and around MACS J1206.2-0847 from a Full Cluster Lensing Analysis

We derive an accurate mass distribution of the galaxy cluster MACS J1206.2-0847 (z=0.439) from a combined weak-lensing distortion, magnification, and strong-lensing analysis of wide-field Subaru BVRIz' imaging and our recent 16-band Hubble Space Telescope observations taken as part of the Cluster Lensing And Supernova survey with Hubble (CLASH) program. We find good agreement in the regions of overlap between several weak and strong lensing mass reconstructions using a wide variety of modeling methods, ensuring consistency. The Subaru data reveal the presence of a surrounding large scale structure with the major axis running approximately north-west south-east (NW-SE), aligned with the cluster and its brightest galaxy shapes, showing elongation with a \sim 2:1 axis ratio in the plane of the sky. Our full-lensing mass profile exhibits a shallow profile slope dln\Sigma/dlnR\sim -1 at cluster outskirts (R>1Mpc/h), whereas the mass distribution excluding the NW-SE excess regions steepens further out, well described by the Navarro-Frenk-White form. Assuming a spherical halo, we obtain a virial mass M_{vir}=(1.1\pm 0.2\pm 0.1)\times 10^{15} M_{sun}/h and a halo concentration c_{vir} = 6.9\pm 1.0\pm 1.2 (\sim 5.7 when the central 50kpc/h is excluded), which falls in the range 4 <7 of average c(M,z) predictions for relaxed clusters from recent Lambda cold dark matter simulations. Our full lensing results are found to be in agreement with X-ray mass measurements where the data overlap, and when combined with Chandra gas mass measurements, yield a cumulative gas mass fraction of 13.7^{+4.5}_{-3.0}% at 0.7Mpc/h (\approx 1.7r_{2500}), a typical value observed for high mass clusters.Comment: Accepted by ApJ (30 pages, 17 figures), one new figure (Figure 10) added, minor text changes; a version with high resolution figures available at http://www.asiaa.sinica.edu.tw/~keiichi/upfiles/MACS1206/ms_highreso.pd

Del juramento o promesa de acatar la Constitución en el ámbito parlamentario

The introduction, in the legal and regulatory field, of the requirement of the oath or promise to acquire full parliamentary status has generated in recent years an interesting controversy since this procedure, whose legal and political significance is debatable, has been used by the parliamentarians to carry out proclamations and claims of all kinds, thus distorting the constitutional limits set by the Constitutional Court regarding compliancewith this requirement.Summary:I. Introduction. II. Legal Transcendence. III. Relevance of the formula used. IV. Maintaining or eliminating the requirement of the oath or promise? V. Conclusions.La introducción, en el ámbito legal y reglamentario, del requisito del juramento o promesa para adquirir la plena condición de parlamentario ha suscitado en los últimos años una interesante polémica dado que este trámite, cuya trascendencia jurídica y política es discutible, ha sido utilizado por los parlamentarios para llevar a cabo proclamas y reivindicaciones de todo tipo, desvirtuándose de esta forma los límites constitucionales marcados por el Tribunal Constitucional en cuanto al cumplimiento de este requisito