5,339 research outputs found
Epidemiological Prevalence Of Viral Hepatitis And HIV Infection Among Volunteer Blood Donors In Kinshasa
The objective of this work was to determine the epidemiological profile and the seroprevalence of hepatitis B and C infections as well as that of HIV among volunteer donors of the National Blood Transfusion Center of Kinshasa. To achieve this, a prospective, epidemiological and descriptive study was undertaken at the laboratory department of the National Blood Transfusion Center in October 2019, by collecting 464 donors who attended the CNTS during the period from November 24 to December 23, 2019. Profiles The epidemiological incidence rates of HBV, HCV and HIV were respectively 11.4% 95% CI [10.6% 34.0%]. 401 subjects or 86.4% were male against 63 subjects or 13.6% female
Bursty egocentric network evolution in Skype
In this study we analyze the dynamics of the contact list evolution of
millions of users of the Skype communication network. We find that egocentric
networks evolve heterogeneously in time as events of edge additions and
deletions of individuals are grouped in long bursty clusters, which are
separated by long inactive periods. We classify users by their link creation
dynamics and show that bursty peaks of contact additions are likely to appear
shortly after user account creation. We also study possible relations between
bursty contact addition activity and other user-initiated actions like free and
paid service adoption events. We show that bursts of contact additions are
associated with increases in activity and adoption - an observation that can
inform the design of targeted marketing tactics.Comment: 7 pages, 6 figures. Social Network Analysis and Mining (2013
Social networks and labour productivity in Europe: An empirical investigation
This paper uses firm-level data recorded in the AMADEUS database to
investigate the distribution of labour productivity in different European
countries. We find that the upper tail of the empirical productivity
distributions follows a decaying power-law, whose exponent is obtained
by a semi-parametric estimation technique recently developed by Clementi et al.
(2006). The emergence of "fat tails" in productivity distribution has already
been detected in Di Matteo et al. (2005) and explained by means of a model of
social network. Here we show that this model is tested on a broader sample of
countries having different patterns of social network structure. These
different social attitudes, measured using a social capital indicator, reflect
in the power-law exponent estimates, verifying in this way the existence of
linkages among firms' productivity performance and social network.Comment: LaTeX2e; 18 pages with 3 figures; Journal of Economic Interaction and
Coordination, in pres
The binding characteristics and orientation of a novel radioligand with distinct properties at 5-HT3A and 5-HT3AB receptors.
VUF10166 (2-chloro-3-(4-methyl piperazin-1-yl)quinoxaline) is a ligand that binds with high affinity to 5-HT3 receptors. Here we synthesise [(3)H]VUF10166 and characterise its binding properties at 5-HT3A and 5-HT3AB receptors. At 5-HT3A receptors [(3)H]VUF10166 displayed saturable binding with a Kd of 0.18 nM. Kinetic measurements gave monophasic association (6.25 × 10(7) M(-1) min(-1)) and dissociation (0.01 min(-1)) rates that yielded a similar Kd value (0.16 nM). At 5-HT3AB receptors two association (6.15 × 10(-7), 7.23 M(-1) min(-1)) and dissociation (0.024, 0.162 min(-1)) rates were seen, yielding Kd values (0.38 nM and 22 nM) that were consistent with values obtained in saturation (Kd = 0.74 nM) and competition (Ki = 37 nM) binding experiments respectively. At both receptor types, specific binding was inhibited by classical 5-HT3 receptor-selective orthosteric ligands (5-HT, allosetron, d-tubocurarine, granisetron, mCPBG, MDL72222, quipazine), but not by non-competitive antagonists (bilobalide, ginkgolide B, picrotoxin) or competitive ligands of other Cys-loop receptors (ACh, bicuculline, glycine, gabazine). To explore VUF10166 ligand-receptor interactions we used in silico modelling and docking, and tested the predictions using site directed mutagenesis. The data suggest that VUF10166 adopts a similar orientation to 5-HT3 receptor agonists bound in AChBP (varenicline) and 5HTBP (5-HT) crystal structures.This is the final version. It was first published by Elsevier at http://www.sciencedirect.com/science/article/pii/S002839081400291
Characterizing the community structure of complex networks
Community structure is one of the key properties of complex networks and
plays a crucial role in their topology and function. While an impressive amount
of work has been done on the issue of community detection, very little
attention has been so far devoted to the investigation of communities in real
networks. We present a systematic empirical analysis of the statistical
properties of communities in large information, communication, technological,
biological, and social networks. We find that the mesoscopic organization of
networks of the same category is remarkably similar. This is reflected in
several characteristics of community structure, which can be used as
``fingerprints'' of specific network categories. While community size
distributions are always broad, certain categories of networks consist mainly
of tree-like communities, while others have denser modules. Average path
lengths within communities initially grow logarithmically with community size,
but the growth saturates or slows down for communities larger than a
characteristic size. This behaviour is related to the presence of hubs within
communities, whose roles differ across categories. Also the community
embeddedness of nodes, measured in terms of the fraction of links within their
communities, has a characteristic distribution for each category. Our findings
are verified by the use of two fundamentally different community detection
methods.Comment: 15 pages, 20 figures, 4 table
Three Dimensional Electrical Impedance Tomography
The electrical resistivity of mammalian tissues varies widely and is correlated with physiological
function. Electrical impedance tomography (EIT) can be used to probe such variations in vivo, and offers a
non-invasive means of imaging the internal conductivity distribution of the human body. But the
computational complexity of EIT has severe practical limitations, and previous work has been restricted to
considering image reconstruction as an essentially two-dimensional problem. This simplification can limit
significantly the imaging capabilities of EIT, as the electric currents used to determine the conductivity variations will not in general be confined to a two-dimensional plane. A few studies have attempted three-dimensional EIT image reconstruction, but have not yet succeeded in generating images of a quality suitable for clinical applications. Here we report the development of a three-dimensional EIT system with greatly improved imaging capabilities, which combines our 64-electrode data-collection apparatus with customized matrix inversion techniques. Our results demonstrate the practical potential of EIT for clinical applications, such as lung or brain imaging and diagnostic screening
A universal model for mobility and migration patterns
Introduced in its contemporary form by George Kingsley Zipf in 1946, but with
roots that go back to the work of Gaspard Monge in the 18th century, the
gravity law is the prevailing framework to predict population movement, cargo
shipping volume, inter-city phone calls, as well as bilateral trade flows
between nations. Despite its widespread use, it relies on adjustable parameters
that vary from region to region and suffers from known analytic
inconsistencies. Here we introduce a stochastic process capturing local
mobility decisions that helps us analytically derive commuting and mobility
fluxes that require as input only information on the population distribution.
The resulting radiation model predicts mobility patterns in good agreement with
mobility and transport patterns observed in a wide range of phenomena, from
long-term migration patterns to communication volume between different regions.
Given its parameter-free nature, the model can be applied in areas where we
lack previous mobility measurements, significantly improving the predictive
accuracy of most of phenomena affected by mobility and transport processes.Comment: Main text and supplementary informatio
Interpolating the Sherrington-Kirkpatrick replica trick
The interpolation techniques have become, in the past decades, a powerful
approach to lighten several properties of spin glasses within a simple
mathematical framework. Intrinsically, for their construction, these schemes
were naturally implemented into the cavity field technique, or its variants as
the stochastic stability or the random overlap structures. However the first
and most famous approach to mean field statistical mechanics with quenched
disorder is the replica trick. Among the models where these methods have been
used (namely, dealing with frustration and complexity), probably the best known
is the Sherrington-Kirkpatrick spin glass: In this paper we are pleased to
apply the interpolation scheme to the replica trick framework and test it
directly to the cited paradigmatic model: interestingly this allows to obtain
easily the replica-symmetric control and, synergically with the broken replica
bounds, a description of the full RSB scenario, both coupled with several minor
theorems. Furthermore, by treating the amount of replicas as an
interpolating parameter (far from its original interpretation) this can be
though of as a quenching temperature close to the one introduce in
off-equilibrium approaches and, within this viewpoint, the proof of the
attended commutativity of the zero replica and the infinite volume limits can
be obtained.Comment: This article is dedicated to David Sherrington on the occasion of his
seventieth birthda
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