5 research outputs found
Alignment of multiple glial cell populations in 3D nanofiber scaffolds: toward the development of multicellular implantable scaffolds for repair of neural injury
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/02/2014
- Field of study
Non-neuronal cells of the central nervous system (CNS), termed "neuroglia," play critical roles in neural regeneration; therefore, replacement of glial populations via implantable nanofabricated devices (providing a growth-permissive niche) is a promising strategy to enhance repair. Most constructs developed to date have lacked three-dimensionality, multiple glial populations and control over spatial orientations, limiting their ability to mimic in vivo neurocytoarchitecture. We describe a facile technique to incorporate multiple glial cell populations [astrocytes, oligodendrocyte precursor cells (OPCs) and oligodendrocytes] within a three-dimensional (3D) nanofabricated construct. Highly aligned nanofibers could induce elongation of astrocytes, while OPC survival, elongation and maturation required pre-aligned astrocytes. The potential to scale-up the numbers of constituent nanofiber layers is demonstrated with astrocytes. Such complex implantable constructs with multiple glial sub-populations in defined 3D orientations could represent an effective approach to reconstruct glial circuitry in neural injury sites
An in vitro spinal cord injury model to screen neuroregenerative materials
- Author
- Alan P. Weightman
- Ardelt
- Bonnici
- Boomkamp
- Bradbury
- Chen
- Cheng
- Cho
- Cho
- Coltman
- Daviaud
- Divya M. Chari
- Dong
- Duff
- Fawcett
- Foran
- Gelain
- Gähwiler
- Gähwiler
- Hailer
- Hulsebosch
- Hurtado
- Hurtado
- Jeong
- Jin
- Kadoya
- Kim
- Kitayama
- Kosuge
- Krassioukov
- Kubinová
- Kubinová
- Lee
- Liesi
- Loane
- Lohmann
- Lu
- Maquet
- Mark R. Pickard
- Marsh
- Menezes
- Morrison
- Neumann
- Nomura
- Oudega
- Patist
- Pêgo
- Rogers
- Ruff
- Russell
- Seidl
- Silver
- Spaethling
- Stoppini
- Straley
- Talac
- Tsai
- Vahidi
- Wang
- Wehrle
- Wei
- Xie
- Yang
- Ying Yang
- Yiu
- Zhang
- Zhou
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/04/2014
- Field of study
Implantable 'structural bridges' based on nanofabricated polymer scaffolds have great promise to aid spinal cord regeneration. Their development (optimal formulations, surface functionalizations, safety, topographical influences and degradation profiles) is heavily reliant on live animal injury models. These have several disadvantages including invasive surgical procedures, ethical issues, high animal usage, technical complexity and expense. In vitro 3-D organotypic slice arrays could offer a solution to overcome these challenges, but their utility for nanomaterials testing is undetermined. We have developed an in vitro model of spinal cord injury that replicates stereotypical cellular responses to neurological injury in vivo, viz. reactive gliosis, microglial infiltration and limited nerve fibre outgrowth. We describe a facile method to safely incorporate aligned, poly-lactic acid nanofibre meshes (±poly-lysine + laminin coating) within injury sites using a lightweight construct. Patterns of nanotopography induced outgrowth/alignment of astrocytes and neurons in the in vitro model were strikingly similar to that induced by comparable materials in related studies in vivo. This highlights the value of our model in providing biologically-relevant readouts of the regeneration-promoting capacity of synthetic bridges within the complex environment of spinal cord lesions. Our approach can serve as a prototype to develop versatile bio-screening systems to identify materials/combinatorial strategies for regenerative medicine, whilst reducing live animal experimentation.EPSRC Doctoral Training Centre in regenerative medicine
(EP/F500491/1
Dynamics of articular joints visualised by MRI: Joint flexion, cartilage-compression and solute-perfusion
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
1994 Annual Selected Bibliography: Asian American Studies and the Crisis of Practice
- Author
- Abe Jennifer
- Abrahamse Allan F
- Abu-Lughod Janet
- Adler S. R.
- Affons Dyanne D
- Affonso Dyanne D
- Afkhami Mahnaz
- Agbayani-Siewert Pauline
- Agell Charlotte
- Agluca Jacqueline
- Agnew Vijay
- Ahlburg Dennis A
- Airriess Christopher A
- Akerman Harold
- Alan-Williams Gregory
- Aldama Frederick Luis
- Alexander G. R.
- Alexander H. A.
- Alexander Susan H
- Allen Ernest Jr
- Allison Maria T
- Almaguer
- Alston Dana
- Alva S. A.
- America
- Amott Teresa
- Anaya S. James.
- Ancheta Angelo
- Ancheta Angelo N
- Anderson J.
- Anderson Nick
- Anderton Douglas L
- Anh
- Anthias
- Anthias Floya
- Appleby Jerry L
- Archibald C. P.
- Artists
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- Asian American Literature
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- Atkinson D. R.
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- Avanzo Carolyn Erickson
- Averbach Andrew P
- Avery Patricia
- Azar Sandra T
- Azuma Eiichiro
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- Badets Jane
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- The Western Massachusetts Vietnamese Association Directory (Springfield Massachusetts
- Thobani Sunera
- Tien Liang
- Tirrito Terry
- Tobin Jeffrey
- Tohmatsu Akiko Judith
- Tong Benson
- Totten George O
- Townley Annette
- Tran Qui-Phiet
- Tran Thanh V
- Trask Haunani-Kay
- Trask Mililani
- Trevison Catherine
- Truong Monique
- Tsang Daniel C
- Tseng Yen-Fen
- Tsuchida John Nobuya
- Turner Marlene
- Tuttle C. R.
- Tworkov Helen
- U.S. Department of State
- Uba Laura
- Ueda Reed
- Uehara Edwina S
- Ueki Teruyo
- Uno Roberta
- Van Arsdale Peter W
- Van Esterik Penny
- Van Steenberg Carol
- Vander Kathryn
- Vapiwala Neha
- Vargas Luis A
- Vecoli Rudolph J
- Vera Arleen
- Veugelers John W. P.
- Vietnamese Consumers
- Villalba
- Volpp Leti
- Wake Barbara
- Waldinger Roger
- Waldinger Roger
- Waldinger Roger
- Wallace Patricia
- Walter Pierre
- Walz Eric
- Wang
- Wang Gungwu
- Wang Linna
- Wang Ping
- Wang Quingjia Edward
- Wang V.
- Wang Y .
- War
- Ward Bud
- Warren Jenifer
- Wassem
- Waters Hazel
- Watkins Keith
- Waugh Earle H
- Wax Murray L
- We
- Weatherspoon A. J.
- Webb T. D.
- Webb T. D.
- Weightman Barbara A
- Wendt Albert
- Westermeyer Joseph
- Wetherell
- Whang Patricia A
- Wharry C.
- Whistler W. Arthur.
- White Michael J
- White-Parks Annette
- Whiteley Marilyn Fardig
- Wial Howard
- Wiecha John M
- Wiesendanger B.
- Wilgoren Jodi
- Wilkinson Alec
- Willard Walter
- Williams Teresa Kay
- Winant Howard
- Winland Daphne N
- Winn Nancy Nishimura
- Wolf Eric R
- Wong Cynthia
- Wong Deborah
- Wong Gil
- Wong L. Mun.
- Wong William
- Wong-Liane Eirene Ming
- Woo Alan H
- Woods Nancy Fugate
- Workplace
- Wright Debbie Hippolite
- Wright Robert E
- Wu Edna
- Wu Jenai
- Wu T. C.
- Xiong Phua
- Ya Va Thai
- Yamamoto Hisaye
- Yamamoto Joe
- Yamamoto Yasushi
- Yamanaka Keiko
- Yamanaka Lois-Ann
- Yamashita Kanshi Stanley
- Yamato Alexander
- Yamauchi Wakako
- Yan Wenfan
- Yang Dao
- Yang Jeff
- Yang P.
- Yang Pai
- Yang Philip Q
- Yang Philip Q
- Yang Xiaoyun
- Yasmin Marziya
- Yau Jenny
- Ye Weili
- Yee A. H.
- Yee Marsha W
- Yeh May
- Yeh May
- Yep G. A.
- Yep Kathy
- Yi Jenny Kisuk
- Ying Yu-Wen
- Yinger J. Milton.
- Yong Fung L
- Yoon In-Jin
- Yoshida Ryo
- Young Wanda
- Yu Diana
- Yu Eui-Young
- Yu M. C.
- Zackrison James Willard
- Zaharlick Amy
- Zane Nolan
- Zane Nolan
- Zane Nolan
- Zhou Min
- Ziegler R. G.
- Zlotkin Hania
- Zuvekas Ann
- Publication venue
- 'UCLA American Indian Studies Center'
- Publication date
- Field of study
Bibliography
- Author
- Abel Clarke
- Abelshauser Werner
- Abernethy David
- Acemoglu Daron
- Acemoglu Daron
- Adas Michael
- Adshead S.A.M.
- Adshead S.A.M.
- Akamatsu Kaname
- Allen Douglas W
- Allen Robert C
- Allen Robert C
- Amsden Alice H
- Angster Julia
- Anstey Roger
- Antony Robert J
- Aoki M.
- Appleby Joyce
- Arrighi Giovanni
- Arrighi Giovanni
- Arrighi Giovanni
- Ashton T. S.
- Ashworth William
- Ashworth William
- Austin
- Bachinger
- Baechler Jean
- Bairoch Paul
- Balazs Etienne
- Barbier Edward B
- Barendse R.J.
- Bartlett Robert
- Bauer
- Baugh Daniel A
- Baumol William J
- Bayly Christopher
- Becker Gary S
- Beinhocker Erich D
- Belich James
- Benjamin Thomas
- Berend Ivan
- Berg
- Berg
- Berg Maxine
- Berghoff
- Berman Harold
- Berman Harold
- Bernecker Walther L
- Bernhardt Kathryn
- Bernstein William J. A
- Bernstein William J. A
- Biernacki Richard
- Black Jeremy
- Black Jeremy
- Blackburn Robin
- Blaut James M
- Blaut James M
- Bonar James
- Bonney Richard
- Bonney Richard
- Boot Max
- Borgstrom Georg
- Borsay Peter
- Boserup Ester
- Boserup Ester
- Bowen H.V.
- Braudel Fernand
- Braudel Fernand
- Braudel Fernand
- Braun
- Bray Francesca
- Bray Francesca
- Bremmer Ian
- Brenner Reuven
- Brenner Robert P
- Brewer
- Brewer
- Brewer John
- Broadberry
- Bruland Kristine
- Bryant Joseph M
- Buchanan J.
- Burbank
- Burke Peter
- Burke Peter
- BØrtola Luis
- Cain Peter J
- Campbell Gwyn
- Cardwell D.S.L.
- Caton Hiram
- Cavaciocchi Simonetta
- Cerman Markus
- Ch'ü
- Chang
- Chang
- Chang
- Chang
- Chang
- Chao Kang
- Chen
- Chen Qian
- Chirot Daniel
- Christian David
- Chua Amy
- Clarence-Smith William Gervase
- Clark Gregory
- Clark Gregory
- Cohen H. Floris
- Cohen H. Floris
- Colley Linda
- Colquhoun Patrick
- Cooper Tim
- Cooter Robert D
- Cortright Joseph
- Cosandey David
- Cotterell Roger
- Cowen Tyler
- Crawfurd J.
- Crosby Alfred W
- Crosby Alfred W
- Crosby Alfred W
- Dabringhaus Sabine
- Dam Kenneth W
- Darwin John
- Das Gupta Ashin
- Daunton Martin
- David Thomas
- Davids Karel
- Davis Lance E
- Davis Ralph
- Davis Robert C
- Deakin S.
- Deane Phyllis
- Deng Kent
- Deng Kent
- Devine T.M.
- Diamond Jared
- Diamond Jared
- Dincecco Mark
- Dixin Xu
- Drayton Richard
- Drayton Richard
- Dudley Leonard
- Dunstan Helen
- Dunstan Helen
- Easterly William
- Easterly William
- Elliott John H
- Elman B.A.
- Eltis David
- Elvin Mark
- Elvin Mark
- Emmer Pieter C
- Emsley C.
- Engelen Theo
- Engerman Stanley L
- Epstein Stephan R
- Epstein Stephan R
- Escosura Leandro
- Etemad Bouda
- Etemad Bouda
- Etemad Bouda
- Evans Eric J
- Feinstein Charles
- Feldbauer Peter
- Ferguson Niall
- Ferguson Niall
- Fernµndez-Armesto Felipe
- Feuerwerker Albert
- Feuerwerker Albert
- Findlay Ronald
- Fletcher Joseph
- Floud Roderick
- Flynn Dennis
- Foucault Michel
- Francks Penelope
- Frank Andre Gunder
- Freeman
- Friedel Robert
- Friedman
- Fukuyama Francis
- Fukuyama Francis
- Fukuyama Francis
- Furniss Edgar S
- Gaastra Femme
- Galor Oded
- Galor Oded
- Galor Oded
- Gardella Robert
- Gates Hill
- Gauci Perry
- Gellner Ernest
- GenÅ Mehmet
- Gerschenkron Alexander
- Getzer Joshua
- Gladwell Malcolm
- Glaeser Edward L
- Glass David V
- Golas Peter J
- Goldstone Jack A. A
- Goldstone Jack A. A
- Goldstone Jack A. A
- Goody
- Goody
- Gorski Philip S
- Gorski Philip S
- Gozzini Giovanni
- Graeber David
- Greenfeld Liah
- Greenfeld Liah
- Grigg D.B.
- Grigg D.B.
- Grigg D.B.
- Gruzinski Serge
- Gupta Bishnupriya
- Habakkuk J.H.
- Hall John A
- Hall John A
- Hall Peter
- Hall Peter A
- Hanley Susan B
- Hanson Victor Davis
- Harley C. Knick
- Harold Dorn
- Harrison Henrietta
- Harrison Lawrence E
- Harrison Lawrence E
- Hartog
- Hatton Tim
- Hayami A.
- Hayami Akira
- Hayami Akira
- Headrick Daniel R
- Headrick Daniel R
- Headrick Daniel R
- Heilbroner Robert L
- Helpman Elhanan
- Helpman Elhanan
- Herbst Jeffrey
- Herlihy David
- Hicks John
- Higonnet Patrice
- Hilton Rodney
- Hirschman Albert O
- Hobsbawm Eric
- Hobson John M
- Hofstede Geert
- Holton Robert J
- Hont Istvan
- Hsü Immanuel C.Y.
- Huang Philip C.C.
- Hudson Pat
- Huff Toby E
- Huff Toby E
- Hugill Peter J
- Humphries Jane
- Hunt E.H.
- Inkster Ian
- Irwin Douglas A
- Isett Christopher Mills
- Jacob Margaret C
- Jacob Margaret C
- James Lawrence
- Jay Peter
- Jeffrey Williamson
- Jevons William Stanley
- Jones Eric L
- Jones Eric L
- Jones Eric L
- Jutte Robert
- Kain Roger J.P.
- Kalberg Stephen
- Kealey Terence
- Keefer
- Kenwood A.G.
- Keynes John Maynard
- Keynes John Maynard
- Kiesewetter Hubert
- King F. H.
- Knight F.H.
- Kocka Jürgen
- Komlos John
- Krugman Paul
- Kumagai Yukihisa
- Kuran Timur
- Käsler
- Lains
- Lal Deepak
- Lampe Klaus
- Landes David
- Landes David
- Landes David
- Lane Frederic
- Langford Paul
- Langlois Rosaire
- Le Goff Jacques
- Lee James Z
- Legarda Benito J
- Lehner Georg
- Leonard Jane K
- Leonard Jane K
- Lesger ClØ
- Li Bozhong
- Lieberman Victor
- Lieberman Victor
- Lieberman Victor
- Lin China Upside
- Lindert Peter H
- Lippit Victor D
- Lipsey R.G. K.I.
- Lipton Michael
- List Friedrich
- Liu Justin Yifu
- Livi-Bacci
- Lloyd Christopher
- Lorenzetti Luigi
- Lovell Julia
- Lucas R.E.
- Lynch K.A.
- Lynn John
- Ma
- Macdonald James
- Macfarlane Alan
- Macfarlane Alan
- Macleod Christine
- Maddison Angus
- Magnusson Lars
- Magnusson Lars
- Magnusson Lars
- Malanima Paulo
- Malanima Paulo
- Mallory Walter H
- Mann Charles C
- Mann Charles C
- Mann Michael
- Mann Michael
- Mann Michael
- Mann Susan
- Manning J.M.
- Mark Overton
- Marks Robert B
- Marshall P.J.
- Mathias Peter
- Mathias Peter
- Matthee Rudy
- Mazumdar Sucheta
- McCloskey Deirdre
- McCloskey Deirdre
- McCraw Thomas K
- McNeill John R
- McNeill William H
- Meredith David
- Micklethwait
- Milanovic Branko
- Milgate Murray
- Milionakis Dimitris
- Mills Greg
- Minami Ryoshin
- Mintz Sidney
- Mitch David
- Mitch David
- Mitchell B.R.
- Mitterauer Michael
- Moe Espen
- Mokyr Joel
- Mokyr Joel
- Mokyr Joel
- Mokyr Joel
- Mokyr Joel
- Mokyr Joel
- Moore Barrington
- Morgan Kenneth
- Morris Ian
- Morris Ian
- Moulier-Boutang Yann
- Muchembled Robert
- Muldrew Craig
- Mumford Lewis
- Mumy Gene E
- Murray Charles
- Murray Williamson A
- Musson A.E.
- MØnard
- N'Diaye Tidiane
- Nasar Sylvia
- Needham Joseph
- Needham Joseph
- Needham Joseph
- Needham Joseph
- Nef John U
- Nieboer H.J.
- Nordhaus
- Norman E. Herbert
- North Douglass C
- North Douglass C
- Northrup David
- Nye John V.C.
- O'Brien
- O'Brien Patrick
- Ogilvie
- Ogilvie Sheilagh
- Olson Mancur
- Ormrod David
- Oshima H.T.
- Osterhammel Jürgen
- Osterhammel Jürgen
- Overton Mark
- Pacey Arnold
- Palmer S.H.
- Pamuk Sevket
- Parker Geoffrey
- Parthasarathi Prasannan
- Passin Herbert
- Paula Gary A
- Perdue Peter C
- Perkins Dwight
- Peyrefitte Alain
- Peyrefitte Alain
- Pinto
- Pollard Sidney
- Pollard Sidney
- Pomeranz Kenneth
- Pomeranz Kenneth
- Porter Bruce D
- Porter Roy
- Postma Johannes
- Powelson John P
- Prados de la Escosura Leandro
- Putnam Robert D
- PØtrØ-Grenouilleau Olivier
- Quataert Donald
- Quinn S.
- Rawski Evelyn S
- Reardon-Anderson James
- Ricardo David
- Ridley Matt
- Ringmar Eric
- Ringrose David A
- Rodger N.A.M.
- Rodrik Dani
- Rodrik Dani
- Romer
- Rosen William
- Rosenberg Nathan
- Ross E.A.
- Rostow Walt W
- Rowe William
- Rule John
- Sabel
- Sachs Jeffrey D
- Sassen Saskia
- Schlüter Andre
- Schumpeter Joseph A
- Schumpeter Joseph A
- Schumpeter Joseph A
- Schurz L. William
- Schwarz D. Leonard
- Sen Gautam
- Shammas Carole
- Sharma Ruchir
- Shaw William H
- Sheridan R.B.
- Sieferle
- Sieferle Rolf Peter
- Sigaut F.
- Simon Julian L
- Skidelsky Robert
- Smil Vaclav
- Smith Adam
- Smith Richard J
- Solow
- Sombart Werner
- Soto
- Sowell Thomas
- Spadafora David
- Spierenburg Pieter
- Spufford Francis
- Stangeland Charles Emil
- Stark Rodney
- Steedman Carolyn
- Steensgaard Niels
- Stein Burton
- Steinfeld Robert J
- Stiglitz Joseph
- Storrs Christopher
- Studwell Joe
- Sun Tu Zen
- Taleb Nassim Nicholas
- Teich Mikulµš
- Teltscher Kate
- Temple Robert
- Thomas Brinley
- Thomas Brinley
- Thomas R.P.
- Tilly Charles
- Tilly Charles
- Toledano E.R.
- Toledano E.R.
- Torres Sµnchez
- Tracy James D
- Tracy James D
- United Nations University International Human Dimensions Programme/United Nations Environment Programme
- Van Dyke Paul A
- Veen
- Verley Patrick
- Vittorio Antonio Di
- Voth Hans-Joachim
- Vries
- Vries
- Vries
- Vries Peer
- Vries Peer
- Vries Woude
- Wade Robert
- Wagenbreth Otfried
- Wakefield D.
- Waley-Cohen Joanna
- Wallerstein Immanuel
- Wallerstein Immanuel
- Wallerstein Immanuel
- Wallerstein Immanuel
- Wallerstein Immanuel
- Wallerstein Immanuel
- Warde Paul
- Warsh David
- Webb Walter Prescott
- Weber Max
- Weber Max
- Weber Max
- Wei Betty
- Weightman Gavin
- Weisser Michael
- White Colin
- Whitehead Alfred North
- Wiles R.C.
- Will Pierre-Étienne
- Williams Eric
- Winch Donald
- Wittfogel Karl August
- Wong Roy Bin
- Woo-Cumings Meredith
- Wood Ellen Meiksins
- Woodman Harold D
- Woodruff William
- Woods Thomas E
- Wright Gavin
- Wright John
- Wright Robert
- Wrigley E.A.
- Wrigley E.A.
- Xiaotong Fei
- Zamagni Vera
- Zanden Jan
- Zanden Jan
- Zanden Jan
- Zelin Madeleine
- Zheng Yangwen
- Zhuang Guotu
- Publication venue
- 'Vandenhoeck & Ruprecht GmbH & Co, KG'
- Publication date
- Field of study