The Behaviors of some Counting Functions of ‎g-primes and g-integers as x goes to Infinity‎

 في هذا البحث نركز على تصرفات الدوال الحسابية الموسعة للأعداد الاولية (x) وللأعداد الصحيحة   (x) وكذلك الرابط بينهما عندما x      . هنا دالة ريمان زيتا    (s) ( =  , (s)  > 1 ), تلعب دورا مهما كرابط بين (x) و   (x) . هذا العمل سيتم من خلال سلوك طريقة العالم بلنزاريو ]بلنزاريو،  1998 [   ليست بالتفاصيل والتي عممت من خلال المعموري ] المعموري ، 2013 [ . بالنهاية سوف نرسم مخططا يحدد العلاقة بين  و  ( حيث  و  هما القوى للحدود الخطأ H1(x)  و H2(x) من (x) و   (x) على التوالي . الغرض من هذا البحث هو تحليل تصرفات (x) و   (x) عندما x      . ملاحظة : من المهم والنافع الاشارة بان جهدنا في هذا البحث ليست تغيير بعض قيم الدوال التي استخدمت في طريقة بلنزاريو حيث ان تغيير اي قيمة مهما كانت صغيرة لإحدى دوال طريقة بلنزاريو ربما تقودنا الى خسارة هدف الموضوع بأكمله . ولهذا نبين ايضا قابلية التغيير المسموح بها في قيم بعض الدوال . كذلك سوف نختم البحث بفتح باب لعمل مستقبلي  In this article  we  focus on the behaviors of  the generalised counting  function of primes (x)  and  the counting  function of integers   (x) as well as  the link between them as  x      . Here the Riemann zeta function  (s) ( =  , (s)  > 1 )  play an  important  role  as  a link between   (x)  and  (x)  .  This  work  will  go  through  the  method  ( not  in  details )  adapted  by Balanzario  [Balanzario , 1998]   and  later  generalised  by  AL- Maamori [AL- Maamori , 2013 ] . Finally we shall draw a diagram in order to determine the relation between   and    , (where  and   are the power of the error terms H1(x) , H2(x) of (x) and (x) respectively) . The aim of this work is to analysis  the behaviour of (x)  and   (x) as  x    .   Note that : ʺ  It’s a beneficial to point out that our effort in this paper is not to exchange the values of some functions of  Balanzarioʹs  method . Since , changing any small value of one of the functions of  Balanzarioʹs method may be leads to loss the aim of the work  ʺ  . Therefore , in this article we show  the ability of  changing  the values of  some functions and in which places in the proof we should sort out

A Case Study on Expansive Soils and Rocks of Al-Khod in Northern Oman

A case study of damage due to expansive soils and rocks in Northern Oman has been studied. Geological and geotechnical investigation revealed the presence of very stiff to hard silty clay with mudstone. Swell pressures up to 330 kPa, and swell percent values up to 70 were measured. Smectite (montmorillonite) and illite clay minerals were identified as being the main clay minerals present in the soils and rocks. A detailed investigation into the damage to the different building elements has been undertaken to study the mechanism of structural damage to establish the cause of such damage and to recommend the appropriate measures to be taken for the construction of buildings founded on expansive soils and rocks in Oman

Substituent Effect on Pyridine Efficacy as a Chelating Stabilizer

Owing to the growing interest and unique properties of pyridines as bases, effects of substitution and substituent modification on electron density enrichment of the pyridyl nitrogen, and thus the effectiveness of pyridine as metal ion-stabilizers will be introduced in this chapter. Pyridines of the structure C5(S)nH5-nN (S = substituent) that have been intensively studied theoretically were selected as examples to prove the concept of this chapter. Computational results in the reviewed reports showed that: substitution and substituent modification significantly affect the electronic enrichment of nitrogen atom of the pyridine. The conclusions extracted from the covered investigations were employed to promote pyridines to act as efficient stabilizers for the coordinated metal ions. In coordination chemistry, these kinds of coordinated complexes are highly demanded in the field of chemosensation

Boosting the Item-Based Collaborative Filtering Model with Novel Similarity Measures

Collaborative filtering (CF), one of the most widely employed methodologies for recommender systems, has drawn undeniable attention due to its effectiveness and simplicity. Nevertheless, a few papers have been published on the CF-based item-based model using similarity measures than the user-based model due to the model\u27s complexity and the time required to build it. Additionally, the substantial shortcomings in the user-based measurements when the item-based model is taken into account motivated us to create stronger models in this work. Not to mention that the common trickiest challenge is dealing with the cold-start problem, in which users\u27 history of item-buying behavior is missing (i.e., new users) or items for which activity is not provided (i.e., new items). Therefore, our novel five similarity measures, which have the potential to solve sparse data, are developed to alleviate the impact of this important problem. Most importantly, a thorough empirical analysis of how the item-based model affects the CF-based recommendation system’s performance has also been a critical part of this work, which presents a benchmarking study for thirty similarity metrics. The MAE, MSE, and accuracy metrics, together with fivefold cross-validation, are used to properly assess and examine the influence of all considered similarity measures using the Movie-lens 100 K and Film Trust datasets. The findings demonstrate how competitive the proposed similarity measures are in comparison to their alternatives. Surprisingly, some of the top state-of-the-art performers (such as SMD and NHSM) have been unable to fiercely compete with our proposed rivals when utilizing the item-based model

Performance Evaluation of Routing Protocols in Wireless Sensor Networks

The efficiency of sensor networks strongly depends on the routing protocol used. In this paper, we analyze three different types of routing protocols: LEACH, PEGASIS, and VGA. Sensor networks are simulated using Sensoria simulator. Several simulations are conducted to analyze the performance of these protocols including the power consumption and overall network performance. The simulation results, using same limited sensing range value, show that PEGASIS outperforms all other protocols while LEACH has better performance than VGA. Furthermore, the paper investigates the power consumption for all protocols. On the average, VGA has the worst power consumption when the sensing range is limited, while VGA is the best when the sensing range is increased

Generalized Pustular Figurate Erythema in Patients with COVID-19 Treated with Hydroxychloroquine: A Systematic Review

A severe distinctive cutaneous drug reaction, generalized pustular figu- rate erythema, closely linked with hydroxychloroquine (HCQ), has been documented. It is distinguishable from AGEP by its longer incubation, more varied morphology (initially urticarial and later targetoid, arcuate plaques), recalcitrance to therapy and longer disease course. Aim of the article is to review the recognized entity associated with ingestion of hy- droxychloroquine in patients infected with COVID-19. A systematic review using electronic search was performed. Inclusion criteria: n pa- tients with COVID-19 demonstrated by PCR, with typical clinical features of AGEP/ GPFE or atypical features associated with typical histopathology. We used the (JBI) Critical Appraisal Checklist for Case Reports for the qualitive assessment. We included 13 publications. Their overall quality was good to moderate. Only 27.3% of the patients had a severe COVID-19 course. The mean lag time between trigger exposure and rash development was 24 days. Only 15.38% of the reported AGEP were clinically typical, while the remaining 69.23 % were suggestive of GPFE. Unfortunate- ly, 2 patients died secondary to massive pulmonary embolism. In COVID-19 infection, we suggest reconsidering treating established COVID-19 em- pirically with HCQ, as both triggers can augment the subsequent cytokine storm, in- ducing a severe drug reaction and possibly increasing the risk of thrombo-embolic events

Generalized Pustular Figurate Erythema in Patients with COVID-19 Treated with Hydroxychloroquine: A Systematic Review

A severe distinctive cutaneous drug reaction, generalized pustular figu- rate erythema, closely linked with hydroxychloroquine (HCQ), has been documented. It is distinguishable from AGEP by its longer incubation, more varied morphology (initially urticarial and later targetoid, arcuate plaques), recalcitrance to therapy and longer disease course. Aim of the article is to review the recognized entity associated with ingestion of hy- droxychloroquine in patients infected with COVID-19. A systematic review using electronic search was performed. Inclusion criteria: n pa- tients with COVID-19 demonstrated by PCR, with typical clinical features of AGEP/ GPFE or atypical features associated with typical histopathology. We used the (JBI) Critical Appraisal Checklist for Case Reports for the qualitive assessment. We included 13 publications. Their overall quality was good to moderate. Only 27.3% of the patients had a severe COVID-19 course. The mean lag time between trigger exposure and rash development was 24 days. Only 15.38% of the reported AGEP were clinically typical, while the remaining 69.23 % were suggestive of GPFE. Unfortunate- ly, 2 patients died secondary to massive pulmonary embolism. In COVID-19 infection, we suggest reconsidering treating established COVID-19 em- pirically with HCQ, as both triggers can augment the subsequent cytokine storm, in- ducing a severe drug reaction and possibly increasing the risk of thrombo-embolic events

EVOLVING ROLE OF CAR T-CELL IN CANCER IMMUNOTHERAPY

Safety profiles of newly developed anti-cancer therapies is the main goal for efficient treatments to improve survival rates. Therefore, continuous efforts carried out to develop a therapeutic strategy with better outcomes. The concept of immune-oncology, which utilizes and enhances the capacity of human immune system was developed as an eventual opportunity to enhance remissions and limit the relaps of the disease. Later progression of cellular immunetherapies involve the introduction of genetically engineered T cells having chimeric antigen receptors (CARs) that embraced an antibody-derived antigen recognition domain connected to an internal T-cell signaling domain, so can recognize their targets with high degree of tumor selectivity. This approach showed vigorous antitumor outcomes and full recovery in end-stage patients suffering from liquid cancers as leukemia and lymphoma. However, still there is a challenge for bringing genetically modified T-cell immunotherapy to many patients with different tumor types including solid tumor. On other hand, studies indicated the potential to broaden T-cell–based therapies and foster for other possible applications beyond oncology as organ transplantation and autoimmunity. Therefore, this review aimed to illustrate the clinical applications, challenges, and approaches for more efficient clinical employment of CAR T cell therapies

Parameterized Affect of Transmission-Range on Lost of Network Connectivity (LNC) of Wireless Sensor Networks

Wireless Sensor Networks, referred to as WSNs, are made up of various types of sensor nodes. Recent developments in micro electro-mechanical technology have given rise to new integrated circuitry, microprocessor hardware and nanotechnology, wireless technology, and advanced networking routing protocols. Hospitals and health service facilities, the armed forces, and even residential customers represent a potential huge market for these devices. The problem is that existing sensor network nodes are incapable of providing the support needed to maximize usage of wireless technology. For this reason, there are many novel routing protocols for the wireless sensor networks proposed recently. One is Hierarchical or cluster-based routing. In this paper, we analyze three different types of hierarchical routing protocols: Low Energy Adaptive Clustering Hierarchy (LEACH), Power-Efficient Gathering in Sensor Information Systems (PEGASIS), and Virtual Grid Architecture (VGA). We tried to analyze the performance of these protocols, including the power consumption and overall network performance. We also compared the routing protocol together. This comparison reveals the important features that need to be taken into consideration while designing and evaluating new routing protocols for sensor networks. The simulation results, using same limited sensing range value, show that PEGASIS outperforms all other protocols while LEACH has better performance than VGA. Furthermore, the paper investigates the power consumption for all protocols. On the average, VGA has the worst power consumption when the sensing range is limited, while VGA is the best when the sensing range is increased. Using homogeneous nodes can greatly prolong sensor network’s life time. Also, the network lifetime increases as the number of clusters decreases

Inference of Adaptive methods for Multi-Stage skew-t Simulated Data

Multilevel models can be used to account for clustering in data from multi-stage surveys. In some cases, the intra-cluster correlation may be close to zero, so that it may seem reasonable to ignore clustering and fit a single level model. This article proposes several adaptive strategies for allowing for clustering in regression analysis of multi-stage survey data. The approach is based on testing whether the cluster-level variance component is zero. If this hypothesis is retained, then variance estimates are calculated ignoring clustering; otherwise, clustering is reflected in variance estimation. A simple simulation study is used to evaluate the various procedures