Abdominal wall desmoid tumor mimicking a subserosal uterine leiomyoma

Desmoid tumors are cytologically bland fibrous neoplasms originating from musculoaponeurotic structures throughout the body. The cause of desmoid tumors is uncertain, but may be related to trauma or hormonal factors, or may have a genetic association. These tumors can be found in some young women during pregnancy or just after giving birth. We report herein a case of desmoid tumor on the inner aspect of the abdominal wall that mimicked a large subserosal uterine leiomyoma. Initial clinical examination of the patient suggested a large abdominal wall tumor, while the imaging techniques including transabdominal ultrasound and magnetic resonance imaging suggested a large subserosal uterine leiomyoma as the initial diagnosis. This case emphasizes the importance of clinical examination during the diagnostic process

Research Priorities for Endometriosis:Recommendations From a Global Consortium of Investigators in Endometriosis

The 3rd International Consensus Workshop on Research Priorities in Endometriosis was held in São Paulo on May 4, 2014, following the 12th World Congress on Endometriosis. The workshop was attended by 60 participants from 19 countries and was divided into 5 main sessions covering pathogenesis/pathophysiology, symptoms, diagnosis/classification/prognosis, disease/symptom management, and research policy. This research priorities consensus statement builds on earlier efforts to develop research directions for endometriosis. Of the 56 research recommendations from the 2011 meeting in Montpellier, a total of 41 remained unchanged, 13 were updated, and 2 were deemed to be completed. Fifty-three new research recommendations were made at the 2014 meeting in Sao Paulo, which in addition to the 13 updated recommendations resulted in a total of 66 new recommendations for research. The research recommendations published herein, as well as those from the 2 previous papers from international consensus workshops, are an attempt to promote high-quality research in endometriosis by identifying and agreeing on key issues that require investigation. New areas included in the 2014 recommendations include infertility, patient stratification, and research in emerging nations, in addition to an increased focus on translational research. A revised and updated set of research priorities that builds on this document will be developed at the 13th World Congress on Endometriosis to be held on May 17-20, 2017, in Vancouver, British Columbia, Canada.Peter A. W. Rogers, G. David Adamson, Moamar Al-Jefout, Christian M. Becker, Thomas M. D, Hooghe, Gerard A. J. Dunselman, Asgerally Fazleabas, Linda C. Giudice, Andrew W. Horne, M. Louise Hull, Lone Hummelshoj, Stacey A. Missmer, Grant W. Montgomery, Pamela Stratton, Robert N. Taylor, Luk Rombauts, Philippa T. Saunders, Katy Vincent, Krina T. Zondervan for the WES/WERF Consortium for Research Priorities in Endometriosi

Brief update on endometriosis treatment

Endometriosis is a chronic debilitating disease with features of chronic inflammation. Endometriosis is defined as the presence of endometrial like stroma and glands outside the uterine cavity (1). Medical professionals dealing with endometriosis face a lot of problems; in diagnosis, treatment and follow up of patients. Recent advances in molecular and clinical sciences offered a wide range of modalities for treatment. However, up to date there is no single very successful option for the ultimate treatment. In this review I have searched the literature using Medline, Pubmed, text books and other search engines to look for the most updated modalities for the treatment of endometriosis both surgical and medical ones. It seems to be that for fertility purposes surgical treatment followed by ART is the best available most beneficial way of dealing with endometriosis, while medical treatment is the best way to treat pain symptoms associated with endometriosis

Endometrial nerve fibres in endometriosis

Endometriosis is a common gynaecological disease that can cause severe pelvic pain such as dysmenorrhoea and dyspareunia, however the mechanisms by which pain is generated are not well understood. Nerve fibres in endometriotic plaques have been reported by several authors. We have recently demonstrated the presence of unmyelinated sensory nerve fibres (using the pan-neuronal marker PGP9.5) in the functional layer of endometrium in women with endometriosis and a significantly increased nerve fibre density in endometrium and myometrium in women with endometriosis compared with women without endometriosis. Sensory C nerve fibres were only detected in the functional layer of endometrium of women with endometriosis and never in women without endometriosis. This finding is so consistent that it may become an effective means of making the diagnosis of endometriosis. Nerve fibres expressing a range of neuronal markers and an over-expression of nerve growth factor (NGF) and nerve growth factor receptor (NGFRp75) were also demonstrated in peritoneal endometrial plaques in women with endometriosis. Effects of currently available medications for endometriosis on nerve fibres in eutopic endometrium in hormonally treated women have been also studied. This review will describe nerve fibres in eutopic endometrium and ectopic endometriotic plaques in women with endometriosis

Research Priorities for Endometriosis.

The 3rd International Consensus Workshop on Research Priorities in Endometriosis was held in São Paulo on May 4, 2014, following the 12th World Congress on Endometriosis. The workshop was attended by 60 participants from 19 countries and was divided into 5 main sessions covering pathogenesis/pathophysiology, symptoms, diagnosis/classification/prognosis, disease/symptom management, and research policy. This research priorities consensus statement builds on earlier efforts to develop research directions for endometriosis. Of the 56 research recommendations from the 2011 meeting in Montpellier, a total of 41 remained unchanged, 13 were updated, and 2 were deemed to be completed. Fifty-three new research recommendations were made at the 2014 meeting in Sao Paulo, which in addition to the 13 updated recommendations resulted in a total of 66 new recommendations for research. The research recommendations published herein, as well as those from the 2 previous papers from international consensus workshops, are an attempt to promote high-quality research in endometriosis by identifying and agreeing on key issues that require investigation. New areas included in the 2014 recommendations include infertility, patient stratification, and research in emerging nations, in addition to an increased focus on translational research. A revised and updated set of research priorities that builds on this document will be developed at the 13th World Congress on Endometriosis to be held on May 17-20, 2017, in Vancouver, British Columbia, Canada