Genetic Basis of Attention Deficit Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common neuropsychiatric disorders of childhood. Due to studies reporting that the effects of ADHD diagnosis on functioning may last throughout life, this disorder, which has great importance for child and adolescent psychiatry, started to attract greater attention recently in terms of adult psychiatry. A review, evaluating the results of studies conducted on the genetic basis of ADHD, which started to attract increasing attention both in our country and the world, was thought to help clinicians working in this field. PubMed and Turkish Psychiatry Index online search engines were screened using “attention deficit hyperactivity disorder”, “ADHD”, “genetics” as key words. The data obtained were combined with information gleaned from several textbooks. Based on previous studies, it could easily be concluded that ADHD is one of the most common heritable psychiatric disorder with distinguished genetic features. Despite its importance for diagnosis and treatment, the etiology of ADHD is still not clear and the disorder seems to be a complex problem arising from the effects of both genetic and environmental factors. Although previous studies revealed that ADHD displayed familial and hereditary transmission, stable patterns of Mendelian inheritance could not be discriminated by evaluation of pedigrees. Therefore, many studies have been conducted on the molecular genetic basis of ADHD recently. The previous studies did not report consistent results in identification of the genes responsible for ADHD which has been partially linked to heterogeneity of the disorder. Grouping relevant patients according to comorbidities and persistence in adolescence rather than DSM-IV subtypes could be an important alternative method for overcoming this limitation in the research studies

Profiles of Parental Burnout Around the Globe: Similarities and Differences Across 36 Countries

Parental burnout (PB) is a pervasive phenomenon. Parenting is embedded in cultural values, and previous research has shown the role of individualism in PB. In this paper, we reanalyze previously collected data to identify profiles based on the four dimensions of PB, and explore whether these profiles vary across countries’ levels of collectivistic-individualistic (COL-IND) values. Our sample comprised 16,885 individuals from 36 countries (73% women; 27% men), and we used a latent profile approach to uncover PB profiles. The findings showed five profiles: Fulfilled, Not in PB, Low risk of PB, High risk of PB and Burned out. The profiles pointed to climbing levels of PB in the total sample and in each of the three country groups (High COL/Low IND, Medium COL-IND, Low COL/High IND). Exploratory analyses revealed that distinct dimensions of PB had the most prominent roles in the climbing pattern, depending on the countries’ levels of COL/IND. In particular, we found contrast to be a hallmark dimension and an indicator of severe burnout for individualistic countries. Contrary to our predictions, emotional distance and saturation did not allow a clear differentiation across collectivistic countries. Our findings support several research avenues regarding PB measurement and intervention

Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence data from the World Health Organization European Region available until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation, compare the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2

Investigation of the comfort properties of traditional woven fabrics with different structural parameters

Turkish traditional Buldan weavings are known as special fabrics in terms of providing comfortable clothes which are known to be natural and healthy in Denizli, Turkey. The research presented in this paper assesses the effects of different fabric structural parameters of Buldan fabrics on comfort properties such as thermal resistance, thermal absorptivity, water vapour permeability and air permeability. Five different Buldan fabrics woven with different fabric structural parameters were produced. According to test results, cotton/Tencel Buldan fabrics indicated similar comfort properties with the 100% cotton Buldan fabric properties. Additionally, the lowest thermal absorptivity was observed from 100% cotton Buldan fabrics which give the warmth feeling among the evaluated samples. © 2020 Inst. Nat. Cercetare-Dezvoltare Text. Pielarie. All rights reserved

Importance of MACC1 expression in breast cancer and its relationship with pathological prognostic markers.

Background: Metastasis associated colon cancer gene 1 (MACC1) is a gene that was first described as a c-Met transcription regulator causing the progression of colon cancer. In this study, protein and messenger RNA (mRNA) expression of MACC1 in breast cancer and its relationship with clinicopathological prognostic parameters were investigated

Foreign body punctured the spleen: An incidental diagnosis

A foreign body can enter the body via penetration through the skin. In the presented case, a broken syringe needle was found and removed from the splenic parenchyma. In order to prevent such iatrogenic injuries, which could have fatal consequences, the hospital staff must give particular care in the handling of sharp FBs

The effect of intraperitoneal n-acetylcysteine on postoperative adhesions in rat models

Acer-Demir, Tugba/0000-0001-5391-9094WOS: 000410463400015PubMed: 28874629ATM: In this study, we researched the effect of local administration of N-acetylcysteine (NAC) on postoperative intra-abdominal adhesion formation in the rat models. METHODS: 20 female Wistar Albino rats which were 5-7 months old are used for the study. The rats were divided into two equal groups. Group one was administered saline solution (n=10) while group two was administered NAC (n=10) after caecal abrasion. They were dissected on postoperative tenth day and were examined macroscopically and microscopically for the adhesion formation. Intraperitoneal adhesion formation was scored blinded with Evans model. The most adherent bowel section was excised for histopathologic examination. Mann Whitney U test were used for statistical analysis. RESULTS: In Group one, all rats have had adhesions. None of the rats in Group two had either severe inflammatory cell reaction or dense interstitial fibrosis. Macroscopic adhesion formation and microscopic inflammatory cell reaction and interstitial fibrosis formation after surgery were less at the group two (NAC applied) (p<0.05, p<0.05, p<0.05). CONCLUSION: We believe that the intraperitoneal single dose usage of NAC may be promising for decreasing the postoperative intraabdominal adhesions

The relationship between the inflammatory severity of the mesoappendix and complicated appendicitis

BackgroundAcute appendicitis is the most common reason for emergency abdominal surgery worldwide. While complicated appendicitis is associated with increased morbidity and mortality, the process leading to complicated disease remains unclear. The mesentery plays a key role in the immunologic and inflammatory processes of gastrointestinal disorders. In this study, we tried to reveal the role of the mesoappendix in subjects with acute appendicitis and its relationship to inflammatory severity in complicated appendicitis.Methods101 patients with acute appendicitis were retrospectively re-examined. The patients’ mean age, gender, and appendicitis status were recorded. Appendicolith status, neutrophilic inflammation, and grade of the lumen and the mesoappendix were analysed.ResultsThere was no statistically significant relationship between fecalith and complicated appendicitis (p&nbsp;&gt; 0.05). There was a statistically significant relation between the degree of inflammation in the mesoappendix and complicated appendicitis (p&nbsp;&lt; 0.001). Furthermore, there was a statistically significant relation between the severity of neutrophilic inflammation in the lumen and complicated appendicitis (p&nbsp;&lt; 0.01).ConclusionThe severity of neutrophilic inflammation in the mesentery may predict complicated appendicitis, while the presence of fecalith does not. These results show the pathogenetic importance of the mesoappendix in the development of complicated appendicitis.</div

Relationship Between CIP2A and Endometrium Cancer

Objective: To determine whether there is a relationship between endometrium cancer and the oncoprotein cancerous inhibitor of protein phosphatase 2A (CIP2A)