Synergy and Group Size in Microbial Cooperation

Microbes produce many molecules that are important for their growth and development, and the consumption of these secretions by nonproducers has recently become an important paradigm in microbial social evolution. Though the production of these public goods molecules has been studied intensely, little is known of how the benefits accrued and costs incurred depend on the quantity of public good molecules produced. We focus here on the relationship between the shape of the benefit curve and cellular density with a model assuming three types of benefit functions: diminishing, accelerating, and sigmoidal (accelerating then diminishing). We classify the latter two as being synergistic and argue that sigmoidal curves are common in microbial systems. Synergistic benefit curves interact with group sizes to give very different expected evolutionary dynamics. In particular, we show that whether or not and to what extent microbes evolve to produce public goods depends strongly on group size. We show that synergy can create an “evolutionary trap” which can stymie the establishment and maintenance of cooperation. By allowing density dependent regulation of production (quorum sensing), we show how this trap may be avoided. We discuss the implications of our results for experimental design

The monomial representations of the Clifford group

We show that the Clifford group - the normaliser of the Weyl-Heisenberg group - can be represented by monomial phase-permutation matrices if and only if the dimension is a square number. This simplifies expressions for SIC vectors, and has other applications to SICs and to Mutually Unbiased Bases. Exact solutions for SICs in dimension 16 are presented for the first time.Comment: Additional author and exact solutions to the SIC problem in dimension 16 adde

A Contraction Based Solution for the Improvement of Fish Ladder Attraction Flow

A new, potentially cost efficient, concept for improving the attraction flow to a fish ladder has been investigated in a case study. For the upstream migrating Atlantic salmon to reach the fish ladder and by-pass the case study hydropower plant, it must be able to localize the attraction flow where it enters the main flow from the tailrace of the hydropower plant in the so-called confluence area. Here the comparatively small and limited attraction flow from the old river channel must be improved in order to be able compete with the substantially larger main flow. The objective of the present study is to investigate the feasibility of a new concept for further improvement of the attraction flow using guiding walls forming a contraction channel. Field measurements were performed tracing tagged fish in the confluence area downstream of the case study hydropower plant in order to understand the movement pattern of the fish. Based on the results, and results from bathymetry measurements in the same area, a physical scale model was constructed where it was experimentally demonstrated that it is hydraulically feasible to construct guiding walls, forming a contraction, which accelerate the attraction flow and generate a concentrated turbulent jet with a higher velocity, while keeping the flow rate unchanged. The attraction flow penetrates about half-way (70 m) into the main flow and reaches the position where most fish are positioned according to fish position measurements and therefore potentially has a good ability to attract upstream migrating fish. There is no negative impact on the water level in the confluence area and thereby not on electricity production. It was shown that the results can be scaled up to prototype conditions and the strategy can presumably be generalized to similar flow situations, existing at other hydropower plants, allowing for improved upstream fish migration in coexistence with a sound hydropower production

Local helioseismology and correlation tracking analysis of surface structures in realistic simulations of solar convection

We apply time-distance helioseismology, local correlation tracking and Fourier spatial-temporal filtering methods to realistic supergranule scale simulations of solar convection and compare the results with high-resolution observations from the SOHO Michelson Doppler Imager (MDI). Our objective is to investigate the surface and sub-surface convective structures and test helioseismic measurements. The size and grid of the computational domain are sufficient to resolve various convective scales from granulation to supergranulation. The spatial velocity spectrum is approximately a power law for scales larger than granules, with a continuous decrease in velocity amplitude with increasing size. Aside from granulation no special scales exist, although a small enhancement in power at supergranulation scales can be seen. We calculate the time-distance diagram for f- and p-modes and show that it is consistent with the SOHO/MDI observations. From the simulation data we calculate travel time maps for surface gravity waves (f-mode). We also apply correlation tracking to the simulated vertical velocity in the photosphere to calculate the corresponding horizontal flows. We compare both of these to the actual large-scale (filtered) simulation velocities. All three methods reveal similar large scale convective patterns and provide an initial test of time-distance methods.Comment: 15 pages, 9 figures (.ps format); accepted to ApJ (tentatively scheduled to appear in March 10, 2007 n2 issue); included files ms.bbl, aabib.bst, aabib.sty, aastex.cl

Position Statement Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus

Background: Multiple laboratory tests are used in the diagnosis and management of patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. Approach: An expert committee compiled evidence-based recommendations for the use of laboratory analysis in patients with diabetes. A new system was developed to grade the overall quality of the evidence and the strength of the recommendations. A draft of the guidelines was posted on the Internet, and the document was modified in response to comments. The guidelines were reviewed by the joint Evidence-Based Laboratory Medicine Committee of the AACC and the National Academy of Clinical Biochemistry and were accepted after revisions by the Professional Practice Committee and subsequent approval by the Executive Committee of the American Diabetes Association. Content: In addition to the long-standing criteria based on measurement of venous plasma glucose, diabetes can be diagnosed by demonstrating increased hemoglobin A1c (HbA1c) concentrations in the blood. Monitoring of glycemic control is performed by the patients measuring their own plasma or blood glucose with meters and by laboratory analysis of HbA1c. The potential roles of noninvasive glucose monitoring, genetic testing, and measurement of autoantibodies, urine albumin, insulin, proinsulin, C-peptide, and other analytes are addressed. Summary: The guidelines provide specific recommendations based on published data or derived from expert consensus. Several analytes are found to have minimal clinical value at the present time, and measurement of them is not recommended

Approaches to manage 'affordability' of high budget impact medicines in key EU countries

Background: The launch of hepatitis C (HCV) drugs such as sofosbuvir or ledipasvir has fostered the question of affordability of novel high budget impact therapies even in countries with high domestic product. European countries have developed a variety of mechanisms to improve affordability of such therapies, including 'affordability thresholds', price volume agreements or caps on individual product sales, and special budgets for innovative drugs. While some of these mechanisms may help limit budget impact, there are still significant progresses to be made in the definition and implementation of approaches to ensure affordability, especially in health systems where the growth potential in drug spending and/or in the patient contribution to health insurance are limited. Objectives: In this article, we will review how seven countries in western Europe are approaching the question of affordability of novel therapies and are developing approaches to continue to reward new sciences while limiting budget impact. We will also discuss the question of affordability of cost-effective but hugely expensive therapies and the implications for payers and for the pharmaceutical industry. Results: There is clearly not one solution that is used consistently across countries but rather a number of 'tools' that are combined differently in each country. This illustrates the difficulty of managing affordability within different legal frameworks and within different health care system architectures.</p

Herschel HIFI observations of O2_2 toward Orion: special conditions for shock enhanced emission

We report observations of molecular oxygen (O$_2$) rotational transitions at 487 GHz, 774 GHz, and 1121 GHz toward Orion Peak A. The O2 lines at 487 GHz and 774 GHz are detected at velocities of 10-12 km/s with line widths 3 km/s; however, the transition at 1121 GHz is not detected. The observed line characteristics, combined with the results of earlier observations, suggest that the region responsible for the O$_2$ emission is 9" (6e16 cm) in size, and is located close to the H2 Peak 1position (where vibrationally-excited H$_2$ emission peaks), and not at Peak A, 23" away. The peak O2 column density is 1.1e18/cm2. The line velocity is close to that of 621 GHz water maser emission found in this portion of the Orion Molecular Cloud, and having a shock with velocity vector lying nearly in the plane of the sky is consistent with producing maximum maser gain along the line-of-sight. The enhanced O$_2$ abundance compared to that generally found in dense interstellar clouds can be explained by passage of a low-velocity C-shock through a clump with preshock density 2e4/cm3, if a reasonable flux of UV radiation is present. The postshock O$_2$ can explain the emission from the source if its line of sight dimension is ~10 times larger than its size on the plane of the sky. The special geometry and conditions required may explain why O$_2$ emission has not been detected in the cores of other massive star-forming molecular clouds.Comment: 28 pages, 13 figure

Swings and roundabouts: the vagaries of democratic consolidation and ‘electoral rituals’ in Sierra Leone

YesThe history of the electoral process in Sierra Leone is at the same time tortuous and substantial. From relatively open competitive multi-party politics in the 1960s, which led to the first turnover of power at the ballot box, through the de facto and de jure one-party era, which nonetheless had elements of electoral competition, and finally to contemporary post-conflict times, which has seen three elections and a second electoral turnover in 2007, one can discern evolving patterns. Evidence from the latest local and national elections in 2012 suggests that there is some democratic consolidation, at least in an electoral sense. However, one might also see simultaneous steps forward and backward – What you gain on the swings, you may lose on the roundabouts. This is particularly so in terms of institutional capacities, fraud and violence, and one would need to enquire of the precise ingredients – in terms of political culture or in other words the attitudes and motivations of electors and the elected – of this evolving Sierra Leonean, rather than specifically liberal type, of democracy. Equally, the development of ‘electoral rituals’, whether peculiar to Sierra Leone or not and whether deemed consolidatory or not, has something to say as part of an investigation into the electoral element of democratic consolidation.1 The literature on elections in Africa most often depicts a number of broad features, such as patronage, ethno-regionalism, fraud and violence, and it is the intention of this article to locate contemporary Sierra Leone, as precisely as possible, within the various strands of this discourse

The magnificent seven : A proposal for modest revision of the Van der Voo (1990) quality index

Thirty years ago, Rob Van der Voo proposed an elegant and simple system for evaluating the quality of paleomagnetic data. As a second-year Ph.D. student, the lead author remembers Rob waxing philosophical about the need to have an appropriate, but not overly rigid evaluation system. The end result was a 7-point system that assigned a (1) or (0) for any paleomagnetic result based on objective criteria. The goal was never to reject or blindly accept any particular result, but merely to indicate the degree of quality for any paleomagnetic pole. At the time, the global paleomagnetic database was burgeoning and it was deemed useful to rank older paleo magnetic results with the newer data being developed in modern laboratories. Van der Voo's, 1990 paper launched a silent revolution in paleomagnetism. Researchers began to evaluate their data against those seven criteria with the anticipation that reviewers would be similarly critical. Today, paleomagnetism is a mature science. Our methods, analyses, and results are more sophisticated than they were 30 years ago. Therefore, we feel it is appropriate to revisit the Van der Voo (1990) criteria in light of those developments. We hope to honor the intention of the original paper by keeping the criteria simple and easy to evaluate while also acknowledging the advances in science. This paper aims to update the criteria and modernize the process. We base our changes on advances in paleomagnetism and geochronology with a faithful adherence to the simplicity of the original publication. We offer the "Reliability" or "R" index as the next generation of the Van der Voo "Quality" or "Q" index. The new R-criteria evaluate seven different information items for each paleomagnetic pole including age, statistical requirements, identification of magnetic carriers, field tests, structural integrity, presence of reversals and an evaluation for possible remagnetization.Peer reviewe